BACKGROUND:Pain in the emergency department(ED)is common but undertreated.The objective of this study was to examine the efficacy and safety of intranasal(IN)ketamine used as an analgesic for patients with acute injur...BACKGROUND:Pain in the emergency department(ED)is common but undertreated.The objective of this study was to examine the efficacy and safety of intranasal(IN)ketamine used as an analgesic for patients with acute injury with moderate to severe pain.METHODS:This study was a cross sectional,observational study of patients more than 8 years old experiencing moderate to severe pain[visual analog score(VAS)>50 mm].The initial dose of IN ketamine was 0.7 mg/kg with an additional dose of 0.3 mg/kg if VAS was more than 50 mm after 15minutes.Pain scores and vital signs were recorded at 0,15,30 and 60 minutes.Side-effects,sedation level and patient's satisfaction were also recorded.The primary outcome was the number of patients achieving≥20 mm reductions in VAS at 15 minutes.Other secondary outcome measures were median reduction in VAS at 15,30 and 60 minutes,changes of vital signs,adverse events,satisfaction of patients,and need for additional ketamine.RESULTS:Thirty-four patients with a median age of 29.5 years(IQR 17.5–38)were enrolled,and they had an initial median VAS of 80 mm(IQR 67–90).The VAS decreased more than 20 mm at15 minutes in 27(80%)patients.The reduction of VAS from baseline to 40 mm(IQR 20–40),20 mm(IQR 14–20)and 20 mm(IQR 10–20)respectively at 15,30 and 60 minutes(P<0.001).No critical changes of vital signs were noted and adverse effects were mild and transient.CONCLUSION:This study showed that IN ketamine is an analgesic choice for patients with acute injury in moderate to severe pain in an overcrowded and resource limited ED.展开更多
目的探讨舒芬太尼静脉自控镇痛对宫颈癌术后患者疼痛及应激反应的影响。方法选取2020年2月至2022年3月济南市第二妇幼保健院共102例宫颈癌手术患者为研究对象,根据不同麻醉药物分成两组,对照组予地佐辛,研究组予舒芬太尼,均行静脉自控镇...目的探讨舒芬太尼静脉自控镇痛对宫颈癌术后患者疼痛及应激反应的影响。方法选取2020年2月至2022年3月济南市第二妇幼保健院共102例宫颈癌手术患者为研究对象,根据不同麻醉药物分成两组,对照组予地佐辛,研究组予舒芬太尼,均行静脉自控镇痛,比较围术期两组应激反应和炎症因子,疼痛评分,不良反应和镇痛按压次数、抑郁评分变化。结果麻醉前两组应激指标去甲肾上腺素(NE)、肾上腺素(E)、皮质醇(Cor)和炎症因子C反应蛋白(CRP)、肿瘤坏死因子⁃α(TNF⁃α)含量比较差异无统计学意义(P>0.05),术后舒芬太尼组2、6、12、24h指标含量均较同时间段地佐辛组低,差异有统计学意义(P<0.05)。麻醉前和术后2、6、12、24 h两组NRS评分比较差异无统计学意义(P>0.05);麻醉前两组VAS评分比较差异无统计学意义(P>0.05),术后舒芬太尼组6、12、24 h VAS评分均较同时间段地佐辛组低,差异有统计学意义(t=0.971、4.205、14.446、15.345,P<0.05)。舒芬太尼组不良反应发生率显著低于地佐辛组,差异有统计学意义(χ^(2)=4.320,P<0.05),舒芬太尼组镇痛按压次数、抑郁评分显著低于地佐辛组,差异有统计学意义(t=9.579、10.164,P<0.05)。结论舒芬太尼静脉自控镇痛能缓解宫颈癌术后患者疼痛程度,降低机体应激反应,这可能和该药物能抑制炎症反应有关,且不良反应轻。展开更多
目的:探讨超声引导下收肌管阻滞联合膝关节后方浸润在膝关节镜下前交叉韧带重建术术后的镇痛作用和早期的康复作用。方法:行膝关节镜下前交叉韧带重建术患者60例,随机均分为收肌管阻滞联合膝关节后方浸润组(A组,0.375%罗哌卡因30 m L进...目的:探讨超声引导下收肌管阻滞联合膝关节后方浸润在膝关节镜下前交叉韧带重建术术后的镇痛作用和早期的康复作用。方法:行膝关节镜下前交叉韧带重建术患者60例,随机均分为收肌管阻滞联合膝关节后方浸润组(A组,0.375%罗哌卡因30 m L进行收肌管阻滞、0.2%罗哌卡因50 m L进行膝关节后方浸润)和对照组(B组,0.9%生理盐水30 m L进行收肌管阻滞、0.9%生理盐水50 m L膝关节后方浸润),观察2组患者术后2、4、8、24及48 h膝关节的静息时和活动时视觉模拟疼痛评分(VAS),比较2组患者术后24 h和48 h的膝关节活动度及患肢首次行主动直腿抬高时间及术后使用镇痛药物的不良反应。结果:术后2、4、8、24及48 h,A组患者的静息痛、活动痛VAS评分低于B组、主动膝关节活动度优于B组(P<0.05或P<0.01);2组患者均在术后早期能够进行直腿抬高锻炼,但首次直腿抬高时间比较,差异无统计学意义(P=0.077)。结论:超声引导下收肌管阻滞联合膝关节后方浸润可以为膝关节镜前交叉韧带手术患者提供良好的术后镇痛效果及术后康复。展开更多
目的:探讨肝胆外科手术患者术后疼痛及不良反应的影响因素。方法:回顾性分析2018年3月至5月我院肝胆外科就诊并实施手术患者的临床资料。记录患者术后6 h、12 h的视觉模拟评分(VAS)及不良反应发生情况。分析患者性别、年龄、体质量指数...目的:探讨肝胆外科手术患者术后疼痛及不良反应的影响因素。方法:回顾性分析2018年3月至5月我院肝胆外科就诊并实施手术患者的临床资料。记录患者术后6 h、12 h的视觉模拟评分(VAS)及不良反应发生情况。分析患者性别、年龄、体质量指数、手术方式、手术时长、住院天数、麻醉方式、自控镇痛泵配方与术后疼痛、不良反应的关系。结果:共纳入患者410例,术后6 h VAS≥4分的患者占12.2%(50/410),术后12 h VAS≥4分的患者占7.8%(32/410),差异有统计学意义(χ~2=4.390,P<0.05)。手术时长、手术方式与术后6 h中重度疼痛有关,术后恶心呕吐与患者性别有关(均P<0.05)。Logistic回归显示手术时长与手术方式是肝胆外科手术患者术后中重度疼痛的危险因素(均P<0.05)。结论:手术时长与手术方式是肝胆外科手术患者术后中重度疼痛的危险因素,女性患者更容易发生术后恶心呕吐。展开更多
文摘BACKGROUND:Pain in the emergency department(ED)is common but undertreated.The objective of this study was to examine the efficacy and safety of intranasal(IN)ketamine used as an analgesic for patients with acute injury with moderate to severe pain.METHODS:This study was a cross sectional,observational study of patients more than 8 years old experiencing moderate to severe pain[visual analog score(VAS)>50 mm].The initial dose of IN ketamine was 0.7 mg/kg with an additional dose of 0.3 mg/kg if VAS was more than 50 mm after 15minutes.Pain scores and vital signs were recorded at 0,15,30 and 60 minutes.Side-effects,sedation level and patient's satisfaction were also recorded.The primary outcome was the number of patients achieving≥20 mm reductions in VAS at 15 minutes.Other secondary outcome measures were median reduction in VAS at 15,30 and 60 minutes,changes of vital signs,adverse events,satisfaction of patients,and need for additional ketamine.RESULTS:Thirty-four patients with a median age of 29.5 years(IQR 17.5–38)were enrolled,and they had an initial median VAS of 80 mm(IQR 67–90).The VAS decreased more than 20 mm at15 minutes in 27(80%)patients.The reduction of VAS from baseline to 40 mm(IQR 20–40),20 mm(IQR 14–20)and 20 mm(IQR 10–20)respectively at 15,30 and 60 minutes(P<0.001).No critical changes of vital signs were noted and adverse effects were mild and transient.CONCLUSION:This study showed that IN ketamine is an analgesic choice for patients with acute injury in moderate to severe pain in an overcrowded and resource limited ED.
文摘目的探讨舒芬太尼静脉自控镇痛对宫颈癌术后患者疼痛及应激反应的影响。方法选取2020年2月至2022年3月济南市第二妇幼保健院共102例宫颈癌手术患者为研究对象,根据不同麻醉药物分成两组,对照组予地佐辛,研究组予舒芬太尼,均行静脉自控镇痛,比较围术期两组应激反应和炎症因子,疼痛评分,不良反应和镇痛按压次数、抑郁评分变化。结果麻醉前两组应激指标去甲肾上腺素(NE)、肾上腺素(E)、皮质醇(Cor)和炎症因子C反应蛋白(CRP)、肿瘤坏死因子⁃α(TNF⁃α)含量比较差异无统计学意义(P>0.05),术后舒芬太尼组2、6、12、24h指标含量均较同时间段地佐辛组低,差异有统计学意义(P<0.05)。麻醉前和术后2、6、12、24 h两组NRS评分比较差异无统计学意义(P>0.05);麻醉前两组VAS评分比较差异无统计学意义(P>0.05),术后舒芬太尼组6、12、24 h VAS评分均较同时间段地佐辛组低,差异有统计学意义(t=0.971、4.205、14.446、15.345,P<0.05)。舒芬太尼组不良反应发生率显著低于地佐辛组,差异有统计学意义(χ^(2)=4.320,P<0.05),舒芬太尼组镇痛按压次数、抑郁评分显著低于地佐辛组,差异有统计学意义(t=9.579、10.164,P<0.05)。结论舒芬太尼静脉自控镇痛能缓解宫颈癌术后患者疼痛程度,降低机体应激反应,这可能和该药物能抑制炎症反应有关,且不良反应轻。
文摘目的:探讨超声引导下收肌管阻滞联合膝关节后方浸润在膝关节镜下前交叉韧带重建术术后的镇痛作用和早期的康复作用。方法:行膝关节镜下前交叉韧带重建术患者60例,随机均分为收肌管阻滞联合膝关节后方浸润组(A组,0.375%罗哌卡因30 m L进行收肌管阻滞、0.2%罗哌卡因50 m L进行膝关节后方浸润)和对照组(B组,0.9%生理盐水30 m L进行收肌管阻滞、0.9%生理盐水50 m L膝关节后方浸润),观察2组患者术后2、4、8、24及48 h膝关节的静息时和活动时视觉模拟疼痛评分(VAS),比较2组患者术后24 h和48 h的膝关节活动度及患肢首次行主动直腿抬高时间及术后使用镇痛药物的不良反应。结果:术后2、4、8、24及48 h,A组患者的静息痛、活动痛VAS评分低于B组、主动膝关节活动度优于B组(P<0.05或P<0.01);2组患者均在术后早期能够进行直腿抬高锻炼,但首次直腿抬高时间比较,差异无统计学意义(P=0.077)。结论:超声引导下收肌管阻滞联合膝关节后方浸润可以为膝关节镜前交叉韧带手术患者提供良好的术后镇痛效果及术后康复。
文摘目的:探讨肝胆外科手术患者术后疼痛及不良反应的影响因素。方法:回顾性分析2018年3月至5月我院肝胆外科就诊并实施手术患者的临床资料。记录患者术后6 h、12 h的视觉模拟评分(VAS)及不良反应发生情况。分析患者性别、年龄、体质量指数、手术方式、手术时长、住院天数、麻醉方式、自控镇痛泵配方与术后疼痛、不良反应的关系。结果:共纳入患者410例,术后6 h VAS≥4分的患者占12.2%(50/410),术后12 h VAS≥4分的患者占7.8%(32/410),差异有统计学意义(χ~2=4.390,P<0.05)。手术时长、手术方式与术后6 h中重度疼痛有关,术后恶心呕吐与患者性别有关(均P<0.05)。Logistic回归显示手术时长与手术方式是肝胆外科手术患者术后中重度疼痛的危险因素(均P<0.05)。结论:手术时长与手术方式是肝胆外科手术患者术后中重度疼痛的危险因素,女性患者更容易发生术后恶心呕吐。
