Factors influencing improvement of visual field after trans-sphenoidal resection of pituitary macroadenomas:a retrospective cohort study

AIM: To investigate the influencing factors of visual field improvement after trans-sphenoidal resection of pituitary macroadenomas. METHODS: This retrospective cohort study included 201 patients (366 eyes) with visual field defect induced by pituitary macroadenomas. All of them were treated with trans-sphenoidal surgery. Ophthalmologic evaluation, best -corrected visual acuity (BCVA), and visual field examination were performed before and 3mo after surgery. BCVA, visual field defect index mean deviation (MD), duration of symptoms, age, sex, and volume of tumors were compared. Expression of vascular endothelial growth factor (VEGF) and Ki-67 of tumor tissue were detected by immunohistochemical technique. RESULTS: The mean age of patients was 44.23 +/- 1.29y. Ninety -three patients were female and 108 were male. The mean tumor volume was 14.36 +/- 6.23 cm(3). The mean duration of preoperative symptoms was 11.50 +/- 0.88mo. Mean preoperative MD was -17.50 +/- 0.82 dB. Mean Preoperative visual acuity was 0.64 +/- 0.04. Postoperative visual field improved in 270 (73.77%) eyes, unchanged in 96 (26.23%) eyes. Multivariate logistic regression displayed that the factors independently influencing visual field improvement were young age (OR=1.71, 95%CI: 1.325-2.387, P=0.013), low preoperative MD absolute value (OR=1.277, 95%CI: 1.205-1.355, P<0.001), small volume of tumor (OR=1.458, 95%CI: 1.060-4.289, P<0.001), low expression of VEGF in tumor tissue (OR=1.554, 95%CI: 1.089-2.457, P=0.022), and low expression of Ki-67 in tumor tissue (OR=1.552, 95%CI: 1.161-2.847, P=0.026). CONCLUSION: After pituitary macroadenomas trans sphenoidal resection, the independent influencing factors of the visual fields recovery were low preoperative MD absolute value, young age, small volume of tumor, and expression levels of VEGF/Ki-67.

Bullying among people with visual impairment: Prevalence, associated factors and relationship to self-efficacy and life satisfaction

AIM To examine associated factors of bullying and to determine associations between bullying and psychosocial outcomes among individuals with visual impairments(Ⅵ). METHODS We conducted an age-stratified cross-sectional survey of adults with Ⅵ who were recruited from the Norwegian Association of the Blind and Partially Sighted. Data were collected through structural telephone interviews in the period between February and May, 2017. Linear regression models were used to examine factors related to bullying and associations of bullying with self-efficacy and life satisfaction.RESULTS A total of 736 individuals were interviewed. The lifetime and 6-mo prevalence of bullying was 41.7% and8.2%, respectively. The majority of bullied participants reported Ⅵ-specific bullying(65.1%). Victimization of bullying was associated with young age, early onsetage of Ⅵ, and having other impairments. Participants who reported bullying had lower levels of self-efficacy[Adjusted relative risk(ARR): 0.40, 95% confidence interval(CI): 0.19-0.85] and life satisfaction(ARR: 0.68,95%CI: 0.51-0.91).CONCLUSION Bullying is highly prevalent among individuals withⅥ. Our findings suggest that interventions to reduce bullying may be beneficial for improving the well-being and life quality of people with Ⅵ.

Clinical characteristics and prognostic factors for visual outcome in 669 patients with intraocular foreign bodies

AIM: To describe the clinical characteristics and analyze prognostic factors that influence visual outcome in 669 patients with intraocular foreign bodies(IOFBs).METHODS: Medical records of 669 patients with IOFBs from West China Hospital were reviewed. Best corrected visual acuity(BCVA) values were recorded using standard Snellen acuity chart and were converted to logarithm of the minimum angle of resolution(log MAR) scale for statistical analysis. The visual outcome was defined by the final BCVA(excellent visual outcome: final BCVA of 20/40 or better;poor visual outcome: final BCVA less than 20/200). Statistical analysis of collected data was performed using IBM SPSS Statistics version 23. A 2-tailed P value of less than 0.05 was considered statistically significant throughout the study. RESULTS: The average age ranged from 1 to 79 years old(mean age, 34.8±12.7 SD) and the majority of patients were men(626, 93.6%). The major cause of ocular injury was hammering(383, 57.2%). Almost all the patients(97.8%) underwent surgeries(97.8%) and the average time interval between injury and surgery was 26.4±322.3 d(0-7300), while 327 patients received surgeries within 24 h(48.9%) and 590 patients received surgeries within seven days(88.2%) after IOFBs injury. The poor BCVA was associated with older age(P=0.013), larger IOFBs size(P<0.001), presence of complications(P<0.001) and worse presenting BCVA(P<0.001). On the contrary, younger age(P=0.005), smaller IOFBs size(P<0.001), absence of complications(P<0.001) and better presenting BCVA(P<0.001) were considered to relate to excellent BCVA.CONCLUSION: Multiple prognostic factors may influence the final visual outcome, including age, size of IOFBs, complications and presenting BCVA. Meanwhile, further education and promotion on eye protection should be taken for the improvement on self-protection and selfhealth awareness.

Explosive eye injuries: characteristics, traumatic mechanisms, and prognostic factors for poor visual outcomes

Background: Explosions can produce blast waves, high-speed medium, thermal radiation, and chemical spatter,leading to complex and compound eye injuries. However, few studies have comprehensively investigated the clinical features of different eye injury types or possible risk factors for poor prognosis.Methods: We retrospectively reviewed all consecutive records of explosive eye injuries(1449 eyes in 1115 inpatients)in 14 tertiary referral hospitals in China over 12 years(between January 1, 2008 and December 31, 2019). Data on demographics, eye injury types, ocular findings, treatments, and factors affecting visual prognosis were extracted from a standardized database of eye injuries and statistically analyzed.Results: Mechanical ocular trauma accounted for 94.00% of explosion-related eye injuries, among which intraocular foreign bodies(IOFBs) resulted in 55.17% of open globe injuries(OGIs) and contusion caused 60.22% of close globe injuries(CGIs). Proliferative vitreous retinopathy(PVR) was more common in perforating(47.06%) and IOFB(26.84%)than in penetrating(8.79%) injuries, and more common with laceration(24.25%) than rupture(9.22%, P<0.01).However, no difference was observed between rupture and contusion. Ultimately, 9.59% of eyes were removed and the final vision was ≤4/200 in 45.82% of patients. Poor presenting vision [odds ratio(OR)=5.789], full-thickness laceration of the eyeball ≥5 mm(OR=3.665), vitreous hemorrhage(OR=3.474), IOFB(OR=3.510), non-mechanical eye injury(NMEI, OR=2.622), rupture(OR=2.362), traumatic optic neuropathy(OR=2.102), retinal detachment(RD,OR=2.033), endophthalmitis(OR=3.281), contusion(OR=1.679), ciliary body detachment(OR=6.592), zone Ⅲ OGI(OR=1.940), and PVR(OR=1.615) were significant negative predictors for poor visual outcomes(P<0.05).Conclusions: Explosion ocular trauma has complex mechanisms, with multiple eyes involved and poor prognosis. In lethal level Ⅰ explosion injuries, eyeball rupture is a serious condition, whereas contusion is more likely to improve. In level Ⅱ injuries, IOFBs are more harmful than penetrating injuries, and level Ⅳ represents burn-related eye injuries.PVR is more associated with penetrating mechanisms than with OGI. Identifying the risk predictors for visual prognosis can guide clinicians in the evaluation and treatment of ocular blast injuries.

Bilateral same-session intravitreal injections of antivascular endothelial growth factors

AIMTo document the indications, safety and possible complications of bilateral same-session intravitreal anti-vascular endothelial growth factor (VEGF) injections performed in the ophthalmic operating room.

Efficacy of nerve growth factor on the treatment of optic nerve contusion Evaluation with visual evoked potential

BACKGROUND： Pattern- visual evoked potential （PVEP） can reflect the functional status of retinal ganglial cells （RGC） and visual cortex, and is an objective examination for visual pathway function. It is a unique method for objectively examining the optic nerve function of optic ganglion cells. OBJECTIVE： To observe the effects of nerve growth factor （NGF） on PVEF in the treatment of optic nerve contusion, evaluate the clinical efficacy of NGF, and make an efficacy comparison with vitamin B12. DESIGN： A randomly grouping, controlled observation. SETTING： Department of Ophthalmology, Tangshan Gongren Hospital Affiliated to Hebei Medical University. PARTICIPANTS： Forty patients with optic nerve contusion caused by eye trauma, who received the treatment in the Tangshan Worker Hospital Affiliated to Hebei Medical University between January 2006 and June 2007, were recruited in this study. The involved 40 patients, including 34 males and 6 females, were aged 14-59 years. They were confirmed to have optic nerve contusion by ophthalmologic consultation combined with history of disease and orbital CT examination. Informed consents of treatments and detected items were obtained from all the patients. The patients were randomly divided into 2 groups with 20 in each： NGF group and vitamin B12 group. METHODS： Conservative treatment was used in the two groups. In addition, patients in the NGF group were intramuscularly injected with NGF solution 18 μg /time, once a day. Those in the vitamin B12 group were injected by the same method with common vitamin B12 of 500 μg combined with vitamin B1 of 100 mg, once a day. MAIN OUTCOME MEASURES： PVEP examination was conducted in all the patients before, one and two weeks after treatment, and latency and amplitude at P100 were detected. RESULTS： Forty patients with optic nerve contusion participated in the final analysis. Before treatment, significant differences in the latency and amplitude at P100 were not found in patients between two groups （P 〉 0.05）. For each patient in the NGF group, the latency of PVEP at P100 was significantly shortened, and the amplitude was significantly increased one and two weeks after treatment as compared with vitamin B12 group（t =2.06-2.34, P 〈 0.05）. CONCLUSION： NGF treatment can obviously improve the visual function of patients with optic nerve contusion. The curative effect of NGF is superior to vitamin B12.

Risk factors for the long-term prognosis and recurrence of HIV-negative cytomegalovirus retinitis in North China

AIM: To demonstrate the clinical features, the risk factors, the visual prognosis and the recurrence of cytomegalovirus(CMV) retinitis(CMVR) in HIV-negative patients.METHODS: HIV-negative patients with CMVR were involved in this study. Best corrected visual acuity(BCVA), intraocular pressure(IOP), CMV-DNA load in aqueous and/or serum samples, treatment, follow-up time, recurrence and complications were recorded. Ocular characteristics were evaluated by fundus photographs. Association between ocular factors and visual prognosis were analyzed by regression analysis.RESULTS: Twenty-five eyes of 16 patients were included. All 25 eyes underwent intravitreal injections of anti-viral agents. The mean log MAR BCVA improved from 0.94±0.98(0.98-0.78) initially to 0.77±0.73(0.82-0.68) at last visit, but not significantly. After antiviral treatment, the aqueous CMV DNA load significantly reduced to(3.42±1.47)×10~2 copies/m L(P=0.001), compared with(2.51±3.11)×10~5 copies/m L at baseline. Macular involvement(R~2=0.475, P=0.049) and initial visual acuity(R~2=0.475, P=0.017) were significantly associated with the poor visual prognosis(BCVA<20/400). The extent of retinal lesions(R~2=0.064, P=0.04) was significant associated with the risk of recurrence of CMVR.CONCLUSION: Intravitreal injection of anti-viral agents offers a safe and effective treatment for CMVR. Macular involvement and initial visual acuity significantly associate with visual prognosis. The extent of retinal lesions is significantly associated with the recurrence of CMVR. These ocular factors can be used as predictive risk factors for long term visual prognosis in HIV-negative CMVR patients.

Immunological factors in cirrhosis diseases from a bibliometric point of view

BACKGROUND Cirrhosis results from persistent liver injury that leads to liver fibrosis.Immunological factors play important regulatory roles in the development and progression of cirrhosis.Bibliometrics is one of the most commonly used methods for systematic evaluation of a field of study.To date,there are no bibliometric studies on the role of immunological factors in cirrhosis.AIM To provide a comprehensive overview of the knowledge structure and research hotspots of immunological factors in cirrhosis.METHODS We retrieved publications related to immunological factors in cirrhosis between 2003 to 2022 from the Web of Science Core Collection database on December 7,2022.The search strategy was TS=((Liver Cirrhosis OR hepatic cirrhosis OR liver fibrosis)AND(Immunologic*Factor*OR Immune Factor*OR Immunomodulator*OR Biological Response Modifier*OR Biomodulator*)).Only original articles and reviews were included.A total of 2873 publications were analyzed using indicators of publication and citation metrics,countries,institutes,authors,journals,references,and keywords by CiteSpace and VOSviewer.RESULTS A total of 5104 authors from 1173 institutions across 51 countries published 2873 papers on cirrhosis and immunological factors in 281 journals.In the past 20 years,the increasing number of related annual publications and citations indicates that research on immunological factors in cirrhosis has become the focus of attention and has entered a period of accelerated development.The United States(781/27.18%),China(538/18.73%),and Germany(300/10.44%)were the leading countries in this field.Most of the top 10 authors were from the United States(4)and Germany(3),with Gershwin ME contributing the most related articles(42).World Journal of Gastroenterology was the most productive journal,whereas Hepatology was the most co-cited journal.Current research hotspots regarding immunological factors in cirrhosis include fibrosis,cirrhosis,inflammation,liver fibrosis,expression,hepatocellular carcinoma,activation,primary biliary cirrhosis,disease,and hepatic stellate cells.Burst keywords(e.g.,epidemiology,gut microbiota,and pathways)represent research frontiers that have attracted the interest of researchers in recent years.CONCLUSION This bibliometric study comprehensively summarizes the research developments and directions of immunological factors in cirrhosis,providing new ideas for promoting scientific research and clinical applications.

Comment on “Evaluation of hyperreflective foci as a prognostic factor of visual outcome in retinal vein occlusion”

Dear Editor,We’re interested in the article by Mo and colleagues about＂Evaluation of hyperreflective foci as a prognostic factor of visual outcome in retinal vein occlusion＂.They performed a multiple linear regression analysis with backward elimination to analyse the association of best corrected visual acuity（BCVA）with the numbers of hyperreflective foci（HF）in different layers.

Levodopa methyl ester increases nerve growth factor expression in visual cortex area 17 in a feline model of strabismic amblyopia

In the present study, a feline model of strabismic amblyopia was established during a sensitive developmental period, and the influence of levodopa methyl ester and levodopa on nerve growth factor expression in the visual cortex （area 17） was compared. Pattern visual-evoked potential and immunohistochemistry results showed that levodopa methyl ester and levodopa treatment shortened P10o wave latency, increased Pleo amplitude, and increased the number of endogenous nerve growth factor-positive cells in visual cortex levels. In particular, the effects of levodopa methyl ester were superior to levodopa treatment.

Clustering Student Discussion Messages on Online Forumby Visualization and Non-Negative Matrix Factorization

The use of online discussion forum can?effectively engage students in their studies. As the number of messages posted on the forum is increasing, it is more difficult for instructors to read and respond to them in a prompt way. In this paper, we apply non-negative matrix factorization and visualization to clustering message data, in order to provide a summary view of messages that disclose their deep semantic relationships. In particular, the NMF is able to find the underlying issues hidden in the messages about which most of the students are concerned. Visualization is employed to estimate the initial number of clusters, showing the relation communities. The experiments and comparison on a real dataset have been reported to demonstrate the effectiveness of the approaches.

Anti-vascular endothelial growth factor drugs combined with laser photocoagulation maintain retinal ganglion cell integrity in patients with diabetic macular edema: study protocol for a prospective, non-randomized, controlled clinical trial

The integrity of retinal ganglion cells is tightly associated with diabetic macular degeneration that leads to damage and death of retinal ganglion cells,affecting vision.The major clinical treatments for diabetic macular edema are anti-vascular endothelial growth factor drugs and laser photocoagulation.However,although the macular thickness can be normalized with each of these two therapies used alone,the vision does not improve in many patients.This might result from the incomplete recovery of retinal ganglion cell injury.Therefore,a prospective,non-randomized,controlled clinical trial was designed to investigate the effect of anti-vascular endothelial growth factor drugs combined with laser photocoagulation on the integrity of retinal ganglion cells in patients with diabetic macular edema and its relationship with vision recovery.In this trial,150 patients with diabetic macular edema will be equally divided into three groups according to therapeutic methods,followed by treatment with anti-vascular endothelial growth factor drugs,laser photocoagulation therapy,and their combination.All patients will be followed up for 12 months.The primary outcome measure is retinal ganglion cell-inner plexiform layer thickness at 12 months after treatment.The secondary outcome measures include retinal ganglion cell-inner plexiform layer thickness before and 1,3,6,and 9 months after treatment,retinal nerve fiber layer thickness,best-corrected visual acuity,macular area thickness,and choroidal thickness before and 1,3,6,9,and 12 months after treatment.Safety measure is the incidence of adverse events at 1,3,6,9,and 12 months after treatment.The study protocol hopes to validate the better efficacy and safety of the combined treatment in patients with diabetic macula compared with the other two monotherapies alone during the 12-month follow-up period.The trial is designed to focus on clarifying the time-effect relationship between imaging measures related to the integrity of retinal ganglion cells and best-corrected visual acuity.The trial protocol was approved by the Medical Ethics Committee of the Affiliated Hospital of Beihua University with approval No.(2023)(26)on April 25,2023,and was registered with the Chinese Clinical Trial Registry(registration number:ChiCTR2300072478,June 14,2023,protocol version:2.0).

Intersection capacity based on driver's visual characteristics

In order to reflect the influence of the drivers＇ characteristic differences on intersection capacity under a mixed traffic flow, a driver correction coefficient for the intersection capacity calculation according to the driver＇s visual characteristics is proposed. First, the parameters of the driver＇s visual characteristics at some real roads, including gaze fixation distribution, mean fixation duration, visual angle distribution and some other parameters at intersections, are collected. Then, the relationship between the traffic flow rate at intersections and the parameters of driver eye movements are established. The analytical results indicate that when the traffic flow is unsaturated, the parameters of driver eye movements change relatively little; however, when the traffic flow is saturated, the parameters of driver eye movements change drastically. Finally, the saturation-flow-rate model is modified according to the parameters of driver eye movements; thus, a capacity model of intersections considering the driver＇s visual characteristics is obtained.

基于VF-SIFT的SAR图像匹配算法研究

在SIFT算法中随着特征点数量的增加匹配时间急剧增加,VF-SIFT算法利用特征角来提高匹配速度。文中在原文的条件下深入推导了VF-SIFT算法的匹配效率提高因子,并将该方法用于SAR图像匹配,初步实验表明该方法在保证正确匹配率的同时大幅降低了匹配时间,并证实了文中效率提高因子的推导和实验结果相符。

共同性外斜视中眼外肌分子表达与病理组织形态变化的研究

斜视是指各种原因引起的眼外肌肌力失衡,视轴偏斜的一种眼科常见疾病。共同性外斜视是斜视的主要类型,疾病的形成被认为与遗传、眼调节功能异常、双眼解剖异常等因素有关。患者通常需要接受手术治疗,以使双眼视轴保持平行,促进立体视功能的恢复与建立。目前共同性外斜视的发病机制尚未有明确的病因学研究。文章对近年来共同性外斜视眼外肌中异常分子表达和病理学形态变化的研究情况做一总结,从分子及病理层面对共同性外斜视形成的病因进行分析,以期为疾病预防与临床治疗提供理论基础。文章围绕电镜下病理组织学变化,重链蛋白、卫星细胞、钙黏蛋白、生长因子等对眼外肌蛋白表达的影响进行讨论。

食物饱腹感研究及其测试技术进展

饱腹感,即为进食后满足感和不再渴望进食的状态,在维护正常食欲、控制体质量、预防肥胖及改善代谢性疾病方面具有重要意义。文章系统分析影响饱腹感的多种因素,包括食物成分、感官特征、能量密度、心理因素及饮食行为等,并阐述这些因素对饱腹感的作用机制。同时,重点介绍模拟视觉量表、胃肠道激素检测及闪烁扫描等新兴技术在饱腹感测试中的应用,展示这些技术在评估饱腹感方面的科学性和有效性。此外,文章还讨论饱腹感及其测试技术的研究意义与未来展望,旨在为饱腹感相关机制的深入研究、饱腹感测试技术的创新以及高饱腹感食品的开发提供理论支持和实践参考。

基于Visual Studio 2010平台的速度剖面校正因子计算方法

在分析国内普遍采用的速度剖面校正因子影响因素和计算方法的基础上,提出了基于雷诺数与速度剖面校正因子关系图版计算校正因子的方法,并阐述了采用Visual Studio 2010平台及C Sharp语言编程实现该方法的流程。通过对海上油田多口井的实际应用,证明该方法具有更广阔的适用性,尤其在单相流及两相流的产出井中应用效果良好。

Research on Visualization of Long-staple Cotton Growth in Southern Xinjiang

Base on the related researches at home and abroad, using systematic analysis principle mathematical modeling techniques, analysis model of organ collection properties, root structure model, mechanism model of spatial form of organs and dynamic model of plant topological structure in line with the growth of long-staple cotton are constructed, and three-dimensional dynamic simulation of long-staple cotton in southern Xinjiang is finally achieved. The system can promote people＇s understanding and perception on growth process of long-staple cotton in southern Xinjiang, which provides support for analysis of relationship between structure and function of long-staple cotton, design of ideal plant and regulation of growth model.

如何在VF帮助菜单中添加MSDN library

由于面向对象程序设计的封装性,用户不能直接了解基类函数的结构,这就为使用VF、VC++、VB带来了不便。以VF为实例,将MSDN提供的帮助添加到VF的帮助菜单中,为用户使用VF带来便利。对此进行了论述。

一种基于Visual FoxPro6.0中的面向对象编程技术及应用

从VisualFoxPro 6.0中的面向对象的概念出发 ,深入探讨了面向对象的编程技术 ,并结合图书馆管理系统应用程序的开发分析了面向对象方法的优点 ,提出了一种快速、高效开发应用软件的新模式。