Visuality can be generically described as the quality of the visual,that is,as the given visual field in which a subject’s attention is concentrated.In fact,the visual is intrinsically linked to human vision,and this...Visuality can be generically described as the quality of the visual,that is,as the given visual field in which a subject’s attention is concentrated.In fact,the visual is intrinsically linked to human vision,and this presupposes the existence of a visible horizon from which(visual)images are given.However,this formulation presents something uncanny paradoxical because it forgets,on one hand,the broader status of the image(such as auditory and olfactory images)-seeing is not just a visual process(at least since Diderot we know it)and there are mental mechanisms in the visual constitution process that help to fabricate reality and that gestalt theory has explained-and on the other hand,the possibility of seeing beyond what is visible,after all,everything(or almost everything)that presents itself in a digital and virtual environment it can be quite ontologically suspect.Based on some of these premises,we will trace a path of analysis that leads us to the current blindness:unconditional faith in digital technology and the fragile hope of happiness in a way that rejects the reality of the visible.展开更多
Visual semantic segmentation aims at separating a visual sample into diverse blocks with specific semantic attributes and identifying the category for each block,and it plays a crucial role in environmental perception...Visual semantic segmentation aims at separating a visual sample into diverse blocks with specific semantic attributes and identifying the category for each block,and it plays a crucial role in environmental perception.Conventional learning-based visual semantic segmentation approaches count heavily on largescale training data with dense annotations and consistently fail to estimate accurate semantic labels for unseen categories.This obstruction spurs a craze for studying visual semantic segmentation with the assistance of few/zero-shot learning.The emergence and rapid progress of few/zero-shot visual semantic segmentation make it possible to learn unseen categories from a few labeled or even zero-labeled samples,which advances the extension to practical applications.Therefore,this paper focuses on the recently published few/zero-shot visual semantic segmentation methods varying from 2D to 3D space and explores the commonalities and discrepancies of technical settlements under different segmentation circumstances.Specifically,the preliminaries on few/zeroshot visual semantic segmentation,including the problem definitions,typical datasets,and technical remedies,are briefly reviewed and discussed.Moreover,three typical instantiations are involved to uncover the interactions of few/zero-shot learning with visual semantic segmentation,including image semantic segmentation,video object segmentation,and 3D segmentation.Finally,the future challenges of few/zero-shot visual semantic segmentation are discussed.展开更多
Dear Editor,This letter is concerned with visual perception closely related to heterogeneous images.Facing the huge challenge brought by different image modalities,we propose a visual perception framework based on het...Dear Editor,This letter is concerned with visual perception closely related to heterogeneous images.Facing the huge challenge brought by different image modalities,we propose a visual perception framework based on heterogeneous image knowledge,i.e.,the domain knowledge associated with specific vision tasks,to better address the corresponding visual perception problems.展开更多
AIM:To investigate the prevalence of visual impairment(VI)and provide an estimation of uncorrected refractive errors in school-aged children,conducted by optometry students as a community service.METHODS:The study was...AIM:To investigate the prevalence of visual impairment(VI)and provide an estimation of uncorrected refractive errors in school-aged children,conducted by optometry students as a community service.METHODS:The study was cross-sectional.Totally 3343 participants were included in the study.The initial examination involved assessing the uncorrected distance visual acuity(UDVA)and visual acuity(VA)while using a+2.00 D lens.The inclusion criteria for a subsequent comprehensive cycloplegic eye examination,performed by an optometrist,were as follows:a UDVA<0.6 decimal(0.20 logMAR)and/or a VA with+2.00 D≥0.8 decimal(0.96 logMAR).RESULTS:The sample had a mean age of 10.92±2.13y(range 4 to 17y),and 51.3%of the children were female(n=1715).The majority of the children(89.7%)fell within the age range of 8 to 14y.Among the ethnic groups,the highest representation was from the Luhya group(60.6%)followed by Luo(20.4%).Mean logMAR UDVA choosing the best eye for each student was 0.29±0.17(range 1.70 to 0.22).Out of the total,246 participants(7.4%)had a full eye examination.The estimated prevalence of myopia(defined as spherical equivalent≤-0.5 D)was found to be 1.45%of the total sample.While around 0.18%of the total sample had hyperopia value exceeding+1.75 D.Refractive astigmatism(cil<-0.75 D)was found in 0.21%(7/3343)of the children.The VI prevalence was 1.26%of the total sample.Among our cases of VI,76.2%could be attributed to uncorrected refractive error.Amblyopia was detected in 0.66%(22/3343)of the screened children.There was no statistically significant correlation observed between age or gender and refractive values.CONCLUSION:The primary cause of VI is determined to be uncorrected refractive errors,with myopia being the most prevalent refractive error observed.These findings underscore the significance of early identification and correction of refractive errors in school-aged children as a means to alleviate the impact of VI.展开更多
Rock-encased-backfill(RB)structures are common in underground mining,for example in the cut-andfill and stoping methods.To understand the effects of cyclic excavation and blasting activities on the damage of these RB ...Rock-encased-backfill(RB)structures are common in underground mining,for example in the cut-andfill and stoping methods.To understand the effects of cyclic excavation and blasting activities on the damage of these RB structures,a series of triaxial stepwise-increasing-amplitude cyclic loading experiments was conducted with cylindrical RB specimens(rock on outside,backfill on inside)with different volume fractions of rock(VF=0.48,0.61,0.73,and 0.84),confining pressures(0,6,9,and 12 MPa),and cyclic loading rates(200,300,400,and 500 N/s).The damage evolution and meso-crack formation during the cyclic tests were analyzed with results from stress-strain hysteresis loops,acoustic emission events,and post-failure X-ray 3D fracture morphology.The results showed significant differences between cyclic and monotonic loadings of RB specimens,particularly with regard to the generation of shear microcracks,the development of stress memory and strain hardening,and the contact forces and associated friction that develops along the rock-backfill interface.One important finding is that as a function of the number of cycles,the elastic strain increases linearly and the dissipated energy increases exponentially.Also,compared with monotonic loading,the cyclic strain hardening characteristics are more sensitive to rising confining pressures during the initial compaction stage.Another finding is that compared with monotonic loading,more shear microcracks are generated during every reloading stage,but these microcracks tend to be dispersed and lessen the likelihood of large shear fracture formation.The transition from elastic to plastic behavior varies depending on the parameters of each test(confinement,volume fraction,and cyclic rate),and an interesting finding was that the transformation to plastic behavior is significantly lower under the conditions of 0.73 rock volume fraction,400 N/s cyclic loading rate,and 9 MPa confinement.All the findings have important practical implications on the ability of backfill to support underground excavations.展开更多
The purpose of software defect prediction is to identify defect-prone code modules to assist software quality assurance teams with the appropriate allocation of resources and labor.In previous software defect predicti...The purpose of software defect prediction is to identify defect-prone code modules to assist software quality assurance teams with the appropriate allocation of resources and labor.In previous software defect prediction studies,transfer learning was effective in solving the problem of inconsistent project data distribution.However,target projects often lack sufficient data,which affects the performance of the transfer learning model.In addition,the presence of uncorrelated features between projects can decrease the prediction accuracy of the transfer learning model.To address these problems,this article propose a software defect prediction method based on stable learning(SDP-SL)that combines code visualization techniques and residual networks.This method first transforms code files into code images using code visualization techniques and then constructs a defect prediction model based on these code images.During the model training process,target project data are not required as prior knowledge.Following the principles of stable learning,this paper dynamically adjusted the weights of source project samples to eliminate dependencies between features,thereby capturing the“invariance mechanism”within the data.This approach explores the genuine relationship between code defect features and labels,thereby enhancing defect prediction performance.To evaluate the performance of SDP-SL,this article conducted comparative experiments on 10 open-source projects in the PROMISE dataset.The experimental results demonstrated that in terms of the F-measure,the proposed SDP-SL method outperformed other within-project defect prediction methods by 2.11%-44.03%.In cross-project defect prediction,the SDP-SL method provided an improvement of 5.89%-25.46% in prediction performance compared to other cross-project defect prediction methods.Therefore,SDP-SL can effectively enhance within-and cross-project defect predictions.展开更多
General anesthesia is widely applied in clinical practice.However,the precise mechanism of loss of consciousness induced by general anesthetics remains unknown.Here,we measured the dynamics of five neurotransmitters,i...General anesthesia is widely applied in clinical practice.However,the precise mechanism of loss of consciousness induced by general anesthetics remains unknown.Here,we measured the dynamics of five neurotransmitters,includingγ-aminobutyric acid,glutamate,norepinephrine,acetylcholine,and dopamine,in the medial prefrontal cortex and primary visual cortex of C57BL/6 mice through in vivo fiber photometry and genetically encoded neurotransmitter sensors under anesthesia to reveal the mechanism of general anesthesia from a neurotransmitter perspective.Results revealed that the concentrations of γ-aminobutyric acid,glutamate,norepinephrine,and acetylcholine increased in the cortex during propofol-induced loss of consciousness.Dopamine levels did not change following the hypnotic dose of propofol but increased significantly following surgical doses of propofol anesthesia.Notably,the concentrations of the five neurotransmitters generally decreased during sevoflurane-induced loss of consciousness.Furthermore,the neurotransmitter dynamic networks were not synchronized in the non-anesthesia groups but were highly synchronized in the anesthetic groups.These findings suggest that neurotransmitter dynamic network synchronization may cause anesthetic-induced loss of consciousness.展开更多
Glaucoma is a leading cause of irreve rsible blindness wo rldwide,and previous studies have shown that,in addition to affecting the eyes,it also causes abnormalities in the brain.However,it is not yet clear how the pr...Glaucoma is a leading cause of irreve rsible blindness wo rldwide,and previous studies have shown that,in addition to affecting the eyes,it also causes abnormalities in the brain.However,it is not yet clear how the primary visual cortex(V1)is altered in glaucoma.This study used DBA/2J mice as a model for spontaneous secondary glaucoma.The aim of the study was to compare the electrophysiological and histomorphological chara cteristics of neurons in the V1between 9-month-old DBA/2J mice and age-matched C57BL/6J mice.We conducted single-unit recordings in the V1 of light-anesthetized mice to measure the visually induced responses,including single-unit spiking and gamma band oscillations.The morphology of layerⅡ/Ⅲneurons was determined by neuronal nuclear antigen staining and Nissl staining of brain tissue sections.Eighty-seven neurons from eight DBA/2J mice and eighty-one neurons from eight C57BL/6J mice were examined.Compared with the C57BL/6J group,V1 neurons in the DBA/2J group exhibited weaker visual tuning and impaired spatial summation.Moreove r,fewer neuro ns were observed in the V1 of DBA/2J mice compared with C57BL/6J mice.These findings suggest that DBA/2J mice have fewer neurons in the VI compared with C57BL/6J mice,and that these neurons have impaired visual tuning.Our findings provide a better understanding of the pathological changes that occur in V1 neuron function and morphology in the DBA/2J mouse model.This study might offer some innovative perspectives regarding the treatment of glaucoma.展开更多
BACKGROUND Studies have shown a strong bidirectional association between diabetes and depression,with diabetes increasing the risk of developing depression and vice versa.Depression among patients with diabetes is ass...BACKGROUND Studies have shown a strong bidirectional association between diabetes and depression,with diabetes increasing the risk of developing depression and vice versa.Depression among patients with diabetes is associated with poor glycemic control,complications,and poor self-care.AIM To explore the present state of research globally concerning diabetes and depression,to aid understanding the current research landscape and identify potential future areas of research.METHODS A bibliometric approach was used,utilizing the Scopus database to gather pertinent research articles released from 2004 to 2023.Analyses encompassed publication patterns,significant contributors,research focal points,prevalent themes,and the most influential articles,aimed at discerning emerging research subjects.RESULTS A total of 3229 publications that met the search criteria were identified.A significant increase in the number of publications related to diabetes and depression has been observed in the past two decades.The most productive nation was the USA(n=1015;31.43%),followed by China(n=325;10.07%),the UK(n=236;7.31%),and Germany(n=218;6.75%).Three principal themes in research on depression and diabetes were delineated by the analysis.First,the exploration of the elevated prevalence and etiology of this comorbidity;second,the focus on interventions,particularly randomized controlled trials,aimed at enhancing diabetes management among individuals with depression;and finally,the investigation of the involved risk factors and biological mechanisms under-lying this bidirectional relationship.CONCLUSION There has been a recent surge of interest in the relationship between diabetes and depression.This could aid researchers to identify areas lacking in the literature and shape future research.展开更多
BACKGROUND Ultrasound guide technology,which can provide real-time visualization of the needle tip and tissues and avoid many adverse events,is widely used in mini-mally invasive therapy.However,the studies on ultraso...BACKGROUND Ultrasound guide technology,which can provide real-time visualization of the needle tip and tissues and avoid many adverse events,is widely used in mini-mally invasive therapy.However,the studies on ultrasound-guided Lateral recess block(LRB)are limited,this is probably because there is no recognized standard method for ultrasound scanning.This study aimed to evaluate the effect of ultrasound-guided LRB in patients with lateral recess stenosis(LRS).CASE SUMMARY A 65-year-old patient complained of low back pain accompanied occasionally by pain and numbness in the left lower limb.Physical examination showed ten-derness on the spinous process and paraspinal muscles from L1 to S1,extensor hallucis longus and tibialis anterior weakness(muscle strength:4-),and a positive straight leg raising test in the left lower limb(60°).Magnetic resonance imaging showed L4–L5 disc degeneration with left LRS and nerve root entrapment.Subsequently,the patient was diagnosed with LRS.This patient was treated with a novel ultrasound-guided LRB approach.The patient’s symptoms significantly improved without any complications at 1 wk postoperatively and at the 3-month follow-up.CONCLUSION This is the first report on the LRS treatment with ultrasound-guided LRB from the contralateral spinous process along the inner side of the articular process by out-plane technique.Further studies are expected to investigate the efficacy and safety of ultrasound-guided LRB for patients with LRS.展开更多
In the context of multiple-target tracking and surveillance applications,this paper investigates the challenge of determining the optimal positioning of a single autonomous aerial vehicle or agent equipped with multip...In the context of multiple-target tracking and surveillance applications,this paper investigates the challenge of determining the optimal positioning of a single autonomous aerial vehicle or agent equipped with multiple independently-steerable zooming cameras to effectively monitor a set of targets of interest.Each camera is dedicated to tracking a specific target or cluster of targets.The key innovation of this study,in comparison to existing approaches,lies in incorporating the zooming factor for the onboard cameras into the optimization problem.This enhancement offers greater flexibility during mission execution by allowing the autonomous agent to adjust the focal lengths of the onboard cameras,in exchange for varying real-world distances to the corresponding targets,thereby providing additional degrees of freedom to the optimization problem.The proposed optimization framework aims to strike a balance among various factors,including distance to the targets,verticality of viewpoints,and the required focal length for each camera.The primary focus of this paper is to establish the theoretical groundwork for addressing the non-convex nature of the optimization problem arising from these considerations.To this end,we develop an original convex approximation strategy.The paper also includes simulations of diverse scenarios,featuring varying numbers of onboard tracking cameras and target motion profiles,to validate the effectiveness of the proposed approach.展开更多
High-strength steels are mainly composed of medium-or low-temperature microstructures,such as bainite or martensite,with coherent transformation characteristics.This type of microstructure has a high density of disloc...High-strength steels are mainly composed of medium-or low-temperature microstructures,such as bainite or martensite,with coherent transformation characteristics.This type of microstructure has a high density of dislocations and fine crystallographic structural units,which ease the coordinated matching of high strength,toughness,and plasticity.Meanwhile,given its excellent welding perform-ance,high-strength steel has been widely used in major engineering constructions,such as pipelines,ships,and bridges.However,visual-ization and digitization of the effective units of these coherent transformation structures using traditional methods(optical microscopy and scanning electron microscopy)is difficult due to their complex morphology.Moreover,the establishment of quantitative relationships with macroscopic mechanical properties and key process parameters presents additional difficulty.This article reviews the latest progress in microstructural visualization and digitization of high-strength steel,with a focus on the application of crystallographic methods in the development of high-strength steel plates and welding.We obtained the crystallographic data(Euler angle)of the transformed microstruc-tures through electron back-scattering diffraction and combined them with the calculation of inverse transformation from bainite or martensite to austenite to determine the reconstruction of high-temperature parent austenite and orientation relationship(OR)during con-tinuous cooling transformation.Furthermore,visualization of crystallographic packets,blocks,and variants based on actual OR and digit-ization of various grain boundaries can be effectively completed to establish quantitative relationships with alloy composition and key process parameters,thereby providing reverse design guidance for the development of high-strength steel.展开更多
文摘Visuality can be generically described as the quality of the visual,that is,as the given visual field in which a subject’s attention is concentrated.In fact,the visual is intrinsically linked to human vision,and this presupposes the existence of a visible horizon from which(visual)images are given.However,this formulation presents something uncanny paradoxical because it forgets,on one hand,the broader status of the image(such as auditory and olfactory images)-seeing is not just a visual process(at least since Diderot we know it)and there are mental mechanisms in the visual constitution process that help to fabricate reality and that gestalt theory has explained-and on the other hand,the possibility of seeing beyond what is visible,after all,everything(or almost everything)that presents itself in a digital and virtual environment it can be quite ontologically suspect.Based on some of these premises,we will trace a path of analysis that leads us to the current blindness:unconditional faith in digital technology and the fragile hope of happiness in a way that rejects the reality of the visible.
基金supported by National Key Research and Development Program of China(2021YFB1714300)the National Natural Science Foundation of China(62233005)+2 种基金in part by the CNPC Innovation Fund(2021D002-0902)Fundamental Research Funds for the Central Universities and Shanghai AI Labsponsored by Shanghai Gaofeng and Gaoyuan Project for University Academic Program Development。
文摘Visual semantic segmentation aims at separating a visual sample into diverse blocks with specific semantic attributes and identifying the category for each block,and it plays a crucial role in environmental perception.Conventional learning-based visual semantic segmentation approaches count heavily on largescale training data with dense annotations and consistently fail to estimate accurate semantic labels for unseen categories.This obstruction spurs a craze for studying visual semantic segmentation with the assistance of few/zero-shot learning.The emergence and rapid progress of few/zero-shot visual semantic segmentation make it possible to learn unseen categories from a few labeled or even zero-labeled samples,which advances the extension to practical applications.Therefore,this paper focuses on the recently published few/zero-shot visual semantic segmentation methods varying from 2D to 3D space and explores the commonalities and discrepancies of technical settlements under different segmentation circumstances.Specifically,the preliminaries on few/zeroshot visual semantic segmentation,including the problem definitions,typical datasets,and technical remedies,are briefly reviewed and discussed.Moreover,three typical instantiations are involved to uncover the interactions of few/zero-shot learning with visual semantic segmentation,including image semantic segmentation,video object segmentation,and 3D segmentation.Finally,the future challenges of few/zero-shot visual semantic segmentation are discussed.
基金supported in part by the National Natural Science Foundation of China(62302161,62303361)the Postdoctoral Innovative Talent Support Program of China(BX20230114)。
文摘Dear Editor,This letter is concerned with visual perception closely related to heterogeneous images.Facing the huge challenge brought by different image modalities,we propose a visual perception framework based on heterogeneous image knowledge,i.e.,the domain knowledge associated with specific vision tasks,to better address the corresponding visual perception problems.
文摘AIM:To investigate the prevalence of visual impairment(VI)and provide an estimation of uncorrected refractive errors in school-aged children,conducted by optometry students as a community service.METHODS:The study was cross-sectional.Totally 3343 participants were included in the study.The initial examination involved assessing the uncorrected distance visual acuity(UDVA)and visual acuity(VA)while using a+2.00 D lens.The inclusion criteria for a subsequent comprehensive cycloplegic eye examination,performed by an optometrist,were as follows:a UDVA<0.6 decimal(0.20 logMAR)and/or a VA with+2.00 D≥0.8 decimal(0.96 logMAR).RESULTS:The sample had a mean age of 10.92±2.13y(range 4 to 17y),and 51.3%of the children were female(n=1715).The majority of the children(89.7%)fell within the age range of 8 to 14y.Among the ethnic groups,the highest representation was from the Luhya group(60.6%)followed by Luo(20.4%).Mean logMAR UDVA choosing the best eye for each student was 0.29±0.17(range 1.70 to 0.22).Out of the total,246 participants(7.4%)had a full eye examination.The estimated prevalence of myopia(defined as spherical equivalent≤-0.5 D)was found to be 1.45%of the total sample.While around 0.18%of the total sample had hyperopia value exceeding+1.75 D.Refractive astigmatism(cil<-0.75 D)was found in 0.21%(7/3343)of the children.The VI prevalence was 1.26%of the total sample.Among our cases of VI,76.2%could be attributed to uncorrected refractive error.Amblyopia was detected in 0.66%(22/3343)of the screened children.There was no statistically significant correlation observed between age or gender and refractive values.CONCLUSION:The primary cause of VI is determined to be uncorrected refractive errors,with myopia being the most prevalent refractive error observed.These findings underscore the significance of early identification and correction of refractive errors in school-aged children as a means to alleviate the impact of VI.
基金We acknowledge the funding support from the National Natural Science Foundation of China Youth Fund(Grant No.52004019)the National Natural Science Foundation of China(Grant No.41825018)China Postdoctoral Science Foundation(Grant No.2023M733481).
文摘Rock-encased-backfill(RB)structures are common in underground mining,for example in the cut-andfill and stoping methods.To understand the effects of cyclic excavation and blasting activities on the damage of these RB structures,a series of triaxial stepwise-increasing-amplitude cyclic loading experiments was conducted with cylindrical RB specimens(rock on outside,backfill on inside)with different volume fractions of rock(VF=0.48,0.61,0.73,and 0.84),confining pressures(0,6,9,and 12 MPa),and cyclic loading rates(200,300,400,and 500 N/s).The damage evolution and meso-crack formation during the cyclic tests were analyzed with results from stress-strain hysteresis loops,acoustic emission events,and post-failure X-ray 3D fracture morphology.The results showed significant differences between cyclic and monotonic loadings of RB specimens,particularly with regard to the generation of shear microcracks,the development of stress memory and strain hardening,and the contact forces and associated friction that develops along the rock-backfill interface.One important finding is that as a function of the number of cycles,the elastic strain increases linearly and the dissipated energy increases exponentially.Also,compared with monotonic loading,the cyclic strain hardening characteristics are more sensitive to rising confining pressures during the initial compaction stage.Another finding is that compared with monotonic loading,more shear microcracks are generated during every reloading stage,but these microcracks tend to be dispersed and lessen the likelihood of large shear fracture formation.The transition from elastic to plastic behavior varies depending on the parameters of each test(confinement,volume fraction,and cyclic rate),and an interesting finding was that the transformation to plastic behavior is significantly lower under the conditions of 0.73 rock volume fraction,400 N/s cyclic loading rate,and 9 MPa confinement.All the findings have important practical implications on the ability of backfill to support underground excavations.
基金supported by the NationalNatural Science Foundation of China(Grant No.61867004)the Youth Fund of the National Natural Science Foundation of China(Grant No.41801288).
文摘The purpose of software defect prediction is to identify defect-prone code modules to assist software quality assurance teams with the appropriate allocation of resources and labor.In previous software defect prediction studies,transfer learning was effective in solving the problem of inconsistent project data distribution.However,target projects often lack sufficient data,which affects the performance of the transfer learning model.In addition,the presence of uncorrelated features between projects can decrease the prediction accuracy of the transfer learning model.To address these problems,this article propose a software defect prediction method based on stable learning(SDP-SL)that combines code visualization techniques and residual networks.This method first transforms code files into code images using code visualization techniques and then constructs a defect prediction model based on these code images.During the model training process,target project data are not required as prior knowledge.Following the principles of stable learning,this paper dynamically adjusted the weights of source project samples to eliminate dependencies between features,thereby capturing the“invariance mechanism”within the data.This approach explores the genuine relationship between code defect features and labels,thereby enhancing defect prediction performance.To evaluate the performance of SDP-SL,this article conducted comparative experiments on 10 open-source projects in the PROMISE dataset.The experimental results demonstrated that in terms of the F-measure,the proposed SDP-SL method outperformed other within-project defect prediction methods by 2.11%-44.03%.In cross-project defect prediction,the SDP-SL method provided an improvement of 5.89%-25.46% in prediction performance compared to other cross-project defect prediction methods.Therefore,SDP-SL can effectively enhance within-and cross-project defect predictions.
基金supported by the National Natural Science Foundation of China(81870841 and 82171192 to X.S.L.,82101349 to G.L.Q.)。
文摘General anesthesia is widely applied in clinical practice.However,the precise mechanism of loss of consciousness induced by general anesthetics remains unknown.Here,we measured the dynamics of five neurotransmitters,includingγ-aminobutyric acid,glutamate,norepinephrine,acetylcholine,and dopamine,in the medial prefrontal cortex and primary visual cortex of C57BL/6 mice through in vivo fiber photometry and genetically encoded neurotransmitter sensors under anesthesia to reveal the mechanism of general anesthesia from a neurotransmitter perspective.Results revealed that the concentrations of γ-aminobutyric acid,glutamate,norepinephrine,and acetylcholine increased in the cortex during propofol-induced loss of consciousness.Dopamine levels did not change following the hypnotic dose of propofol but increased significantly following surgical doses of propofol anesthesia.Notably,the concentrations of the five neurotransmitters generally decreased during sevoflurane-induced loss of consciousness.Furthermore,the neurotransmitter dynamic networks were not synchronized in the non-anesthesia groups but were highly synchronized in the anesthetic groups.These findings suggest that neurotransmitter dynamic network synchronization may cause anesthetic-induced loss of consciousness.
基金supported by the STI 2030-Major Projects 2022ZD0208500(to DY)the National Natural Science Foundation of China,Nos.82072011(to YX),82121003(to DY),82271120(to YS)+2 种基金Sichuan Science and Technology Program,No.2022ZYD0066(to YS)a grant from Chinese Academy of Medical Science,No.2019-12M-5-032(to YS)the Fundamental Research Funds for the Central Universities,No.ZYGX2021YGLH219(to KC)。
文摘Glaucoma is a leading cause of irreve rsible blindness wo rldwide,and previous studies have shown that,in addition to affecting the eyes,it also causes abnormalities in the brain.However,it is not yet clear how the primary visual cortex(V1)is altered in glaucoma.This study used DBA/2J mice as a model for spontaneous secondary glaucoma.The aim of the study was to compare the electrophysiological and histomorphological chara cteristics of neurons in the V1between 9-month-old DBA/2J mice and age-matched C57BL/6J mice.We conducted single-unit recordings in the V1 of light-anesthetized mice to measure the visually induced responses,including single-unit spiking and gamma band oscillations.The morphology of layerⅡ/Ⅲneurons was determined by neuronal nuclear antigen staining and Nissl staining of brain tissue sections.Eighty-seven neurons from eight DBA/2J mice and eighty-one neurons from eight C57BL/6J mice were examined.Compared with the C57BL/6J group,V1 neurons in the DBA/2J group exhibited weaker visual tuning and impaired spatial summation.Moreove r,fewer neuro ns were observed in the V1 of DBA/2J mice compared with C57BL/6J mice.These findings suggest that DBA/2J mice have fewer neurons in the VI compared with C57BL/6J mice,and that these neurons have impaired visual tuning.Our findings provide a better understanding of the pathological changes that occur in V1 neuron function and morphology in the DBA/2J mouse model.This study might offer some innovative perspectives regarding the treatment of glaucoma.
文摘BACKGROUND Studies have shown a strong bidirectional association between diabetes and depression,with diabetes increasing the risk of developing depression and vice versa.Depression among patients with diabetes is associated with poor glycemic control,complications,and poor self-care.AIM To explore the present state of research globally concerning diabetes and depression,to aid understanding the current research landscape and identify potential future areas of research.METHODS A bibliometric approach was used,utilizing the Scopus database to gather pertinent research articles released from 2004 to 2023.Analyses encompassed publication patterns,significant contributors,research focal points,prevalent themes,and the most influential articles,aimed at discerning emerging research subjects.RESULTS A total of 3229 publications that met the search criteria were identified.A significant increase in the number of publications related to diabetes and depression has been observed in the past two decades.The most productive nation was the USA(n=1015;31.43%),followed by China(n=325;10.07%),the UK(n=236;7.31%),and Germany(n=218;6.75%).Three principal themes in research on depression and diabetes were delineated by the analysis.First,the exploration of the elevated prevalence and etiology of this comorbidity;second,the focus on interventions,particularly randomized controlled trials,aimed at enhancing diabetes management among individuals with depression;and finally,the investigation of the involved risk factors and biological mechanisms under-lying this bidirectional relationship.CONCLUSION There has been a recent surge of interest in the relationship between diabetes and depression.This could aid researchers to identify areas lacking in the literature and shape future research.
基金Supported by the National Natural Science Foundation of China,No.82305380The Postdoctoral Research Program,West China Hospital,Sichuan University,No.2020HXBH018.
文摘BACKGROUND Ultrasound guide technology,which can provide real-time visualization of the needle tip and tissues and avoid many adverse events,is widely used in mini-mally invasive therapy.However,the studies on ultrasound-guided Lateral recess block(LRB)are limited,this is probably because there is no recognized standard method for ultrasound scanning.This study aimed to evaluate the effect of ultrasound-guided LRB in patients with lateral recess stenosis(LRS).CASE SUMMARY A 65-year-old patient complained of low back pain accompanied occasionally by pain and numbness in the left lower limb.Physical examination showed ten-derness on the spinous process and paraspinal muscles from L1 to S1,extensor hallucis longus and tibialis anterior weakness(muscle strength:4-),and a positive straight leg raising test in the left lower limb(60°).Magnetic resonance imaging showed L4–L5 disc degeneration with left LRS and nerve root entrapment.Subsequently,the patient was diagnosed with LRS.This patient was treated with a novel ultrasound-guided LRB approach.The patient’s symptoms significantly improved without any complications at 1 wk postoperatively and at the 3-month follow-up.CONCLUSION This is the first report on the LRS treatment with ultrasound-guided LRB from the contralateral spinous process along the inner side of the articular process by out-plane technique.Further studies are expected to investigate the efficacy and safety of ultrasound-guided LRB for patients with LRS.
基金supported by grants PID2022-142946NA-I00 and PID2022-141159OB-I00funded by MICIU/AEI/10.13039/501100011033ERDF/EU
文摘In the context of multiple-target tracking and surveillance applications,this paper investigates the challenge of determining the optimal positioning of a single autonomous aerial vehicle or agent equipped with multiple independently-steerable zooming cameras to effectively monitor a set of targets of interest.Each camera is dedicated to tracking a specific target or cluster of targets.The key innovation of this study,in comparison to existing approaches,lies in incorporating the zooming factor for the onboard cameras into the optimization problem.This enhancement offers greater flexibility during mission execution by allowing the autonomous agent to adjust the focal lengths of the onboard cameras,in exchange for varying real-world distances to the corresponding targets,thereby providing additional degrees of freedom to the optimization problem.The proposed optimization framework aims to strike a balance among various factors,including distance to the targets,verticality of viewpoints,and the required focal length for each camera.The primary focus of this paper is to establish the theoretical groundwork for addressing the non-convex nature of the optimization problem arising from these considerations.To this end,we develop an original convex approximation strategy.The paper also includes simulations of diverse scenarios,featuring varying numbers of onboard tracking cameras and target motion profiles,to validate the effectiveness of the proposed approach.
基金supported by the National Key Research and Development Project of China(Nos.2022YFB3708200 and 2021YFB3703500)the National Natural Science Foundation of China(Nos.52271089 and 52001023).
文摘High-strength steels are mainly composed of medium-or low-temperature microstructures,such as bainite or martensite,with coherent transformation characteristics.This type of microstructure has a high density of dislocations and fine crystallographic structural units,which ease the coordinated matching of high strength,toughness,and plasticity.Meanwhile,given its excellent welding perform-ance,high-strength steel has been widely used in major engineering constructions,such as pipelines,ships,and bridges.However,visual-ization and digitization of the effective units of these coherent transformation structures using traditional methods(optical microscopy and scanning electron microscopy)is difficult due to their complex morphology.Moreover,the establishment of quantitative relationships with macroscopic mechanical properties and key process parameters presents additional difficulty.This article reviews the latest progress in microstructural visualization and digitization of high-strength steel,with a focus on the application of crystallographic methods in the development of high-strength steel plates and welding.We obtained the crystallographic data(Euler angle)of the transformed microstruc-tures through electron back-scattering diffraction and combined them with the calculation of inverse transformation from bainite or martensite to austenite to determine the reconstruction of high-temperature parent austenite and orientation relationship(OR)during con-tinuous cooling transformation.Furthermore,visualization of crystallographic packets,blocks,and variants based on actual OR and digit-ization of various grain boundaries can be effectively completed to establish quantitative relationships with alloy composition and key process parameters,thereby providing reverse design guidance for the development of high-strength steel.