The yield ratios of neutron-proton(R(n/p))and^(3)H-^(3)He(R(^(3)H∕^(3)He))with reduced rapidity from 0 to 0.5 were simulated at 50 MeV/u even-even ^(36−56)Ca+^(40)Ca,even-even ^(48−78)Ni+^(58)Ni,and ^(100−139)Sn(ever...The yield ratios of neutron-proton(R(n/p))and^(3)H-^(3)He(R(^(3)H∕^(3)He))with reduced rapidity from 0 to 0.5 were simulated at 50 MeV/u even-even ^(36−56)Ca+^(40)Ca,even-even ^(48−78)Ni+^(58)Ni,and ^(100−139)Sn(every third isotopes)+112 Sn for full reduced impact parameters using the isospin-dependent quantum molecular dynamics(IQMD)model.The neutron and proton density distributions and root-mean-square radii of the reaction systems were obtained using the Skyrme-Hartree-Fock model,which was used for the phase space initialization of the projectile and target in IQMD.We defined the unified neutron skin thickness asΔRnp=<r^(2)>^(1∕2) n−<r^(2)>^(1∕2)p,which was negative for neutron-deficient nuclei.The unifiedΔRnp values for nuclei with the same relative neutron excess from different isotopic chains were nearly equal,except for extreme neutron-rich isotopes,which is a type of scaling behavior.The yield ratios of the three isotopic chain-induced reactions,which depended on the reduced impact parameter and unified neutron skin thickness,were studied.The results showed that both R(n/p)and R(^(3)H∕^(3)He)decreased with a reduced impact parameter for extreme neutron-deficient isotopes;however,they increased with reduced impact parameters for extreme neutron-rich isotopes,and increased with theΔRnp of the projectiles for all reduced impact parameters.In addition,a scaling phenomenon was observed betweenΔR np and the yield ratios in peripheral colli-sions from different isotopic chain projectiles(except for extreme neutron-rich isotopes).Thus,R(n/p)and R(^(3)H∕^(3)He)from peripheral collisions were suggested as experimental probes for extracting the neutron or proton skin thicknesses of non-extreme neutron-rich nuclei from different isotopic chains.展开更多
Background: The signal-to-noise ratio (SNR) is recognized as an index of measurements reproducibility. We derive the maximum likelihood estimators of SNR and discuss confidence interval construction on the difference ...Background: The signal-to-noise ratio (SNR) is recognized as an index of measurements reproducibility. We derive the maximum likelihood estimators of SNR and discuss confidence interval construction on the difference between two correlated SNRs when the readings are from bivariate normal and bivariate lognormal distribution. We use the Pearsons system of curves to approximate the difference between the two estimates and use the bootstrap methods to validate the approximate distributions of the statistic of interest. Methods: The paper uses the delta method to find the first four central moments, and hence the skewness and kurtosis which are important in the determination of the parameters of the Pearsons distribution. Results: The approach is illustrated in two examples;one from veterinary microbiology and food safety data and the other on data from clinical medicine. We derived the four central moments of the target statistics, together with the bootstrap method to evaluate the parameters of Pearsons distribution. The fitted Pearsons curves of Types I and II were recommended based on the available data. The R-codes are also provided to be readily used by the readers.展开更多
Technologies for reducing corn leaf burn caused by foliar spray of urea-ammonium nitrate (UAN) during the early growing season are limited. A field experiment was carried out to evaluate the effects of humic acid on c...Technologies for reducing corn leaf burn caused by foliar spray of urea-ammonium nitrate (UAN) during the early growing season are limited. A field experiment was carried out to evaluate the effects of humic acid on corn leaf burn caused by foliar spray of undiluted UAN solution on corn canopy at Jackson, TN in 2018. Thirteen treatments of the mixtures of UAN and humic acid were evaluated at V6 of corn with different UAN application rates and different UAN/humic acid ratios. Leaf burn during 1 2, 3, 4, 5, 6, 7, and 14 days after UAN foliar spray significantly differed between with or without humic acid addition. The addition of humic acid to UAN significantly reduced leaf burn at each UAN application rate (15, 25, and 35 gal/acre). The reduction of leaf burn was enhanced as the humic acid/UAN ratio went up from 10% to 30%. Leaf burn due to foliar application of UAN became severer with higher UAN rates. The linear regression of leaf burn 14 days after application with humic acid/UAN ratio was highly significant and negative. However, the linear regression of leaf burn 14 days after application with the UAN application rate was highly significant and positive. In conclusion, adding humic acid to foliar-applied UAN is beneficial for reducing corn leaf burn during the early growing season.展开更多
This study is a contribution to improving rice productivity on acidic plateau soils of the tropical rainforest zone. It is based on taking into account the cationic balances of the soil in order to optimize the phosph...This study is a contribution to improving rice productivity on acidic plateau soils of the tropical rainforest zone. It is based on taking into account the cationic balances of the soil in order to optimize the phosphorus (P) nutrition of rice on these acidic soils, where this nutrient constitutes a limiting factor for agricultural production. Three (3) pot trials were conducted in Adiopodoumé in the forested south of Côte d’Ivoire. The interactive effects of calcium carbonate (0, 25, 50 and 75 kg Ca ha<sup>−1</sup>) and magnesium sulfate (0, 25, 50 and 75 kg Mg ha<sup>−1</sup>) were evaluated on the response of NERICA 5 rice at doses 0, 25, 50 and 75 kg P ha<sup>−1</sup> of natural phosphate from Togo, applied only once at the start of the experiment. Additional fertilizers of nitrogen (N) (100 kg N ha<sup>−1</sup>) and potassium (K) (50 kg KCl ha<sup>−1</sup>) were added to each of the tests in a split-plot device. The test results revealed a paddy production potential of approximately 3 to 5 t⋅ha<sup>−1</sup> for NERICA 5 on an acidic soil, under the effect of the interaction of P, Ca and Mg. The quadratic response of rice yield to the doses of these fertilizers would be more dependent on their balance, itself influenced by Ca nutrition. For the sustainability and maintenance of rice production in agro-ecology studied, it was recommended doses of 38 kg Ca ha<sup>−1</sup>, 34 kg Mg ha<sup>−1</sup> in a Ca/Mg ratio (1/1) with intakes of 41 kg P ha<sup>−1</sup>, overall in a ratio 1/1/1 (P/Ca/Mg) more favorable to the availability of free iron considered a guiding element of mineral nutrition. Thus, these promising results should be confirmed in a real environment for better management of the fertilization of rice cultivated on acidic plateau soils in Côte d’Ivoire.展开更多
Objective:We evaluated whether the blood parameters before prostate biopsy can diagnose prostate cancer(PCa)and clinically significant PCa(Gleason score[GS]7)in our hospital.Methods:This study included patients with i...Objective:We evaluated whether the blood parameters before prostate biopsy can diagnose prostate cancer(PCa)and clinically significant PCa(Gleason score[GS]7)in our hospital.Methods:This study included patients with increased prostate-specific antigen(PSA)up to 20 ng/mL.The associations of neutrophil-to-lymphocyte ratio(NLR)and platelet-tolymphocyte ratio(PLR)alone or with PSA with PCa and clinically significant PCa were analyzed.Results:We included 365 patients,of whom 52.9%(193)had PCa including 66.8%(129)with GS of≥7.PSA density(PSAD)and PSA had better the area under the curve(AUC)of 0.722 and 0.585,respectively with pZ0.001 for detecting PCa compared with other blood parameters.PSA combined with PLR(PsPLR)and PSA with NLR(PsNLR)had better AUC of 0.608 and 0.610,respectively with p<0.05,for diagnosing GS≥7 population,compared with PSA,free/total PSA,NLR,PLR,and PsNPLR(PSA combined with NLR and PLR).NLR and PLR did not predict PCa on multivariate analysis.For GS≥7 cancer detection,in the multivariate analysis,separate models with PSA and NLR(Model 1:PsNLRþbaseline parameters)or PSA and PLR(Moder 2:PsPLRþbaseline parameters)were made.Baseline parameters comprised age,digital rectal exam-positive lesions,PSA density,free/total PSA,and magnetic resonance imaging.Model 2 containing PsPLR was statistically significant(odds ratio:2.862,95% confidence interval:1.174-6.975,p=0.021)in finding aggressive PCa.The predictive accuracy of Model 2 was increased(AUC:0.734,p<0.001)than that when only baseline parameters were used(AUC:0.693,p<0.001).Conclusion:NLR or PLR,either alone or combined with PSA,did not detect PCa.However,the combined use of PSA with PLR could find the differences between clinically significant and insignificant PCa in our retrospective study limited by the small number of samples.展开更多
The resonant motion of the fluid inside a narrow gap between two fixed boxes induced by incident regular waves with various wave heights is investigated by adopting a two-dimensional numerical wave flume based on an o...The resonant motion of the fluid inside a narrow gap between two fixed boxes induced by incident regular waves with various wave heights is investigated by adopting a two-dimensional numerical wave flume based on an opensourced CFD package,OpenFOAM.The two boxes have identical draft and height,but the upstream box has a variable breadth.This article focuses on the influences of the breadth ratio,defined as the ratio of the breadth of the upstream box to that of the downstream box,on the following three aspects of hydrodynamic characteristics of gap resonance:(1)the wave height amplifications inside the gap,and in front and at the rear of the structure system,(2)the reflection,transmission,and energy loss coefficients of the structure system,and(3)the response and damping time of the fluid resonance.It is found that the fluid resonant frequency,the amplification factor of the resonant wave height inside the gap and the maximum energy loss coefficient of the structure system are shown to gradually decrease with the increase of the breadth ratio.The response time of gap resonance is shown to first increase and then decrease with the breadth ratio overall,regardless of the incident wave height,and the configuration that the two boxes have the same breadth would bring the largest response time of gap resonance.展开更多
Experiments were conducted on risers with different mass ratios to study the effect of mode conversion and spanwise correlation. The slenderness ratio of the riser model was set as 169, and the Reynolds numbers are 16...Experiments were conducted on risers with different mass ratios to study the effect of mode conversion and spanwise correlation. The slenderness ratio of the riser model was set as 169, and the Reynolds numbers are 1600-14400. The dynamic responses of riser models versus reduced velocity were analyzed, and the spanwise displacement, frequency,and trajectory of the mode conversion from the lower to the higher mode were explored. The results revealed that the riser model with a higher mass ratio excites a higher number of modes. The conversion region of multi-mode competition exists and narrows with the increasing mass ratio. Mode conversion is continuous and manifests as the transmission of peaks and troughs in mode shape: the peaks and troughs of mode shape move up in the mode stable development region and move down in the mode conversion region. The single-mode dominating vibration exhibits a standing wave feature, and the traveling wave feature is significant in the mode conversion region. Furthermore, the frequency jump is always transmitted from the trough to the peak of the mode shape, and finally, all the axial positions vibrate at the same frequency. The trajectory in the mode conversion region deviates from the 8-shape and recovers the standard8-shape at the middle and late stages of the mode stable development region.展开更多
Taking the three-riser group arranged in tandem as the research subject,an experimental study was carried out on the risers arranged in tandem.The purpose is to explore the sensitivity of the dynamic response of each ...Taking the three-riser group arranged in tandem as the research subject,an experimental study was carried out on the risers arranged in tandem.The purpose is to explore the sensitivity of the dynamic response of each riser to spacing ratio and reveal the physical mechanism of riser groups under the interference effect.The spacing ratios of the adj acent risers are 4.0,5.0,6.0,and 8.0.At the spacing between the risers of 4.0D,the strong feedback effect increases the cross-flow(CF) displacement amplitude of the upstream riser.The shielding effect is the key factor affecting the interference effect on the midstream and downstream risers.At low reduced velocities,the shielding area initially appears,the displacement amplitude of the midstream and downstream risers varies greatly,the vibration of the two risers is still dominated by the first-order mode,and the transition between adjacent vibration modes is restrained.The multi-frequency superposition phenomenon is very significant at high reduced velocities.The most sensitive interference spacing under the test conditions is obtained.Due to the separation of the incoming flow and the double shielding effect of the upstream and midstream risers,the regular vortex-induced vibration in the wake area of the downstream riser is broken,and the vibration in the two directions is weakened.In general,the interference effect is more significant for the CF vibration of the three-riser groups than the in-line(IL) vibration.展开更多
Planktonic foraminifer Globigerinoides ruber(white)and Trilobatus sacculifer are the most frequently used mixedlayer dwelling species for reconstructing past oceanic environments.Specifically,the Mg/Ca ratios of these...Planktonic foraminifer Globigerinoides ruber(white)and Trilobatus sacculifer are the most frequently used mixedlayer dwelling species for reconstructing past oceanic environments.Specifically,the Mg/Ca ratios of these two foraminiferal species have been used for reconstructing tropical/subtropical changes in sea surface temperature(SST).However,these two species have different morphotypes,of which the spatial and temporal differences in Mg/Ca ratios and their influencing factors are still unclear.Our objective is to investigate the potential differences between the Mg/Ca ratios of these different morphotypes of G.ruber(white)and T.sacculifer in the western Philippine Sea(WPS)and determine their implications for the reconstruction of SST and upper-ocean structure.Mg/Ca measurements are made on two basic morphotypes of G.ruber(white)[sensu stricto(s.s.)and sensu lato(s.l.)]and T.sacculifer[with(w)and without(w/o)a sac-like final chamber]on samples of Site MD06-3047B from the WPS.Our results reveal that Mg/Ca ratios of different G.ruber morphotypes show consistent differences;and those of T.sacculifer morphotypes show staged variations since MIS 3.It is suggested to select a single morphotype for reconstructing SST changes using the Mg/Ca ratios of G.ruber and T.sacculifer in the WPS.Furthermore,the Mg/Ca ratios between G.ruber s.s.and G.ruber s.l.[Δ(Mg/Ca)_(G.ruber s.s.-s.l.)]downcore MD06-3047B covaries with indexes of summer monsoon.Combining with the core-top results,showing regional variation of differences in theΔ(Mg/Ca)_(G.ruber s.s.-s.l.)over the western tropical Pacific,we propose thatΔ(Mg/Ca)_(G.ruber s.s.-s.l.)may tend to reflect summer mixed layer depth.展开更多
Through the theoretical analysis of overburden destabilization mechanism, FLAC 3D simplified plane numerical simulation method and field measurement method, we compared the relationship of overburden support pressure ...Through the theoretical analysis of overburden destabilization mechanism, FLAC 3D simplified plane numerical simulation method and field measurement method, we compared the relationship of overburden support pressure at 35 m of workface recovery, and the peak overburden support pressure decreased from 13.85 Mpa to 11.97 Mpa from 1:1 to 1:3. With the increase of mining ratio, the peak over-supporting pressure decreases: with the increase of top coal recovery thickness, the peak over-supporting pressure and the influence range will be further expanded, and the distance between the peak over-supporting pressure and the coal wall of the working face will be further increased and the high stress zone of the peak area will be expanded simultaneously.展开更多
Through the theoretical analysis of overburden destabilization mechanism, FLAC 3D simplified plane numerical simulation method and field measurement method, we compared the relationship of overburden support pressure ...Through the theoretical analysis of overburden destabilization mechanism, FLAC 3D simplified plane numerical simulation method and field measurement method, we compared the relationship of overburden support pressure at 35 m of workface recovery, and the peak overburden support pressure decreased from 13.85 Mpa to 11.97 Mpa from 1:1 to 1:3. With the increase of mining ratio, the peak over-supporting pressure decreases: with the increase of top coal recovery thickness, the peak over-supporting pressure and the influence range will be further expanded, and the distance between the peak over-supporting pressure and the coal wall of the working face will be further increased and the high stress zone of the peak area will be expanded simultaneously.展开更多
Primary productivity in the Antarctic aquatic environment with simple ecosystems is sensitive to climate and environmental fluctuations.We investigatedδ13C values for n-alkanoic acids derived from phototrophic organi...Primary productivity in the Antarctic aquatic environment with simple ecosystems is sensitive to climate and environmental fluctuations.We investigatedδ13C values for n-alkanoic acids derived from phototrophic organisms in a lacustrine sediment core(IIL3)to indicate primary productivity in ponds on Inexpressible Island in the western Ross Sea,Antarctica.Short-chain n-alkanoic acids(C14–C18)were abundant in the IIL3 sediment profile.The carbon isotope ratios of short-chain n-alkanoic acids in the sediment samples and floating microbial mats were similar,indicating that the short-chain n-alkanoic acids in the IIL3 sediment profile predominantly originated from phototrophic organisms.Theδ13C values for the short-chain n-alkanoic acids varied widely through the sediment profile,and 13C-enrichment of n-alkanoic acids was most likely related to high productivity due to carbon-limited conditions caused by enhanced photosynthetic efficiency.Theδ13C values for the n-alkanoic acids changed over the past 3200 years in similar ways to organic proxies for aquatic productivity(n-alkanoic acid and sterol sedimentary fluxes).C16 n-alkanoic acid was enriched in 13C in periods of high aquatic productivity~750–1650 and 3000–3200 a BP but depleted in 13C in periods of relatively low productivity~150–600 and 2500–3000 a BP.The results indicated that carbon isotope ratios of lipids from phototrophic organisms could be used as new proxies to reconstruct paleo-productivity in Antarctic lakes and ponds and therefore improve our understanding of past climate changes.展开更多
[Objectives]Protein energy ratio refers to the proportional relationship between protein and energy levels in animal diets,i.e.,the grams of crude protein corresponding to every megacalorie of energy,which is generall...[Objectives]Protein energy ratio refers to the proportional relationship between protein and energy levels in animal diets,i.e.,the grams of crude protein corresponding to every megacalorie of energy,which is generally expressed as CP:ME or CP:DE.This study was conducted to investigate the effects of different diets on fattening and slaughter performance and meat quality traits for"L(Large Yorkshire)×L(Landrace)"crossbred pigs.[Methods]Eighteen piglets of L×L crossbred with similar body weights about 51 kg were selected.The piglets were divided into 3 groups randomly and each group was assigned to 3 replicates with 2 piglets in a replicate.Group A was fed diet Ⅰ (control diet),group B was fed the same diet of group A in the first month of the trial but fed diet Ⅱ in second month,and group C consumed diet Ⅲ.All the pigs were fed in the same feeding condition for two months except the different diets during the trial.One pig in similar body weight from each replicate was slaughtered for the determination of slaughter performance and meat quality traits in the end of the trial.[Results]The average daily feed intake(ADFI)of pigs from group B was only(2.32±0.52)kg and significantly lower than those from group A and group C(P<0.05),but no difference was found in average daily gain(ADG) and feed/gain(P>0.05).Also,no differences occurred in the carcass length,back fat thickness,longissimus muscle (LM) area and dressing percentage(P>0.05).In addition,no differences were found in the meat quality traits of shear force,meat color,pH_(45 min),pH_(24 h) and cooking loss(P>0.05).However,the water-holding capacity of meat from group C was(2.58±0.02)ms and significantly lower than that of(2.80±0.20)ms from group A(P<0.05).Although the contents of glutamic acid and cystine in LM from group B was significantly lower than those from group A and group C(P<0.05),no differences occurred in the contents of other amino acids,the total amino acid and total flavor amino acid among the three groups(P>0.05).However,the inosine monophosphate content of LM from group C was only(331.80±11.53)mg/100 g and significantly lower than those of(361.00±6.36)and(366.37±4.80)mg/100 g from group A and B(P<0.05).Even though no differences were found in the contents of DM and CP in LM among the three groups of pigs,the content of intramuscular fat(IMF)in LM from group B and group C was increased by 45.6%and 46.58%respectively from that of group A(P<0.05),but no difference occurred between group B and C(P>0.05).[Conclusions]DietsⅡ and Ⅲ in this study caused no differences in fattening and slaughter performance of L×L crossbred pigs,but the effects on some meat traits were still significant,especially on the improvement of intramuscular fat in experimental pigs.Therefore,they could improve the meat quality of crossbred pigs to a certain extent.展开更多
AIM:To investigate systemic immune-inflammation index(SII),neutrophil-to-lymphocyte ratio(NLR),and plateletto-lymphocyte ratio(PLR)levels in patients with type 2 diabetes at different stages of diabetic retinopathy(DR...AIM:To investigate systemic immune-inflammation index(SII),neutrophil-to-lymphocyte ratio(NLR),and plateletto-lymphocyte ratio(PLR)levels in patients with type 2 diabetes at different stages of diabetic retinopathy(DR).METHODS:This retrospective study included 141 patients with type 2 diabetes mellitus(DM):45 without diabetic retinopathy(NDR),47 with non-proliferative diabetic retinopathy(NPDR),and 49 with proliferative diabetic retinopathy(PDR).Complete blood counts were obtained,and NLR,PLR,and SII were calculated.The study analysed the ability of inflammatory markers to predict DR using receiver operating characteristic(ROC)curves.The relationships between DR stages and SII,PLR,and NLP were assessed using multivariate logistic regression.RESULTS:The average NLR,PLR,and SII were higher in the PDR group than in the NPDR group(P=0.011,0.043,0.009,respectively);higher in the NPDR group than in the NDR group(P<0.001 for all);and higher in the PDR group than in the NDR group(P<0.001 for all).In the ROC curve analysis,the NLR,PLR,and SII were significant predictors of DR(P<0.001 for all).The highest area under the curve(AUC)was for the PLR(0.929 for PLR,0.925 for SII,and 0.821 for NLR).Multivariate regression analysis indicated that NLR,PLR,and SII were statistically significantly positive and independent predictors for the DR stages in patients with DM[odds ratio(OR)=1.122,95%confidence interval(CI):0.200–2.043,P<0.05;OR=0.038,95%CI:0.018–0.058,P<0.05;OR=0.007,95%CI:0.001–0.01,P<0.05,respectively).CONCLUSION:The NLR,PLR,and SII may be used as predictors of DR.展开更多
Objective Hypertriglyceridemic waist(HW),hypertriglyceridemic waist-to-height ratio(HWHtR),and waist-to-hip ratio(WHR)have been shown to be indicators of cardiometabolic risk factors.However,it is not clear which indi...Objective Hypertriglyceridemic waist(HW),hypertriglyceridemic waist-to-height ratio(HWHtR),and waist-to-hip ratio(WHR)have been shown to be indicators of cardiometabolic risk factors.However,it is not clear which indicator is more suitable for children and adolescents.We aimed to investigate the relationship between HW,HWHtR,WHR,and cardiovascular risk factors clustering to determine the best screening tools for cardiometabolic risk in children and adolescents.Methods This was a national cross-sectional study.Anthropometric and biochemical variables were assessed in approximately 70,000 participants aged 6–18 years from seven provinces in China.Demographics,physical activity,dietary intake,and family history of chronic diseases were obtained through questionnaires.ANOVA,χ2 and logistic regression analysis was conducted.Results A significant sex difference was observed for HWHtR and WHR,but not for HW phenotype.The risk of cardiometabolic health risk factor clustering with HW phenotype or the HWHtR phenotype was significantly higher than that with the non-HW or non-HWHtR phenotypes among children and adolescents(HW:OR=12.22,95%CI:9.54-15.67;HWHtR:OR=9.70,95%CI:6.93-13.58).Compared with the HW and HWHtR phenotypes,the association between risk of cardiometabolic health risk factors(CHRF)clustering and high WHR was much weaker and not significant(WHR:OR=1.14,95%CI:0.97-1.34).Conclusion Compared with HWHtR and WHR,the HW phenotype is a more convenient indicator with higher applicability to screen children and adolescents for cardiovascular risk factors.展开更多
We conducted a comprehensive review of existing prediction models pertaining to the efficacy of immune-checkpoint inhibitor(ICI)and the occurrence of immune-related adverse events(irAEs).The predictive potential of ne...We conducted a comprehensive review of existing prediction models pertaining to the efficacy of immune-checkpoint inhibitor(ICI)and the occurrence of immune-related adverse events(irAEs).The predictive potential of neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)in determining ICI effectiveness has been extensively investigated,while limited research has been conducted on predicting irAEs.Furthermore,the combined model incor-porating NLR and PLR,either with each other or in conjunction with additional markers such as carcinoembryonic antigen,exhibits superior predictive capabilities compared to individual markers alone.NLR and PLR are promising markers for clinical applications.Forthcoming models ought to incorporate established efficacious models and newly identified ones,thereby constituting a multifactor composite model.Furthermore,efforts should be made to explore effective clinical application approaches that enhance the predictive accuracy and efficiency.展开更多
BACKGROUND The neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)are novel inflammatory indicators that can be used to predict the severity and prognosis of various diseases.We categorize acute p...BACKGROUND The neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)are novel inflammatory indicators that can be used to predict the severity and prognosis of various diseases.We categorize acute pancreatitis by etiology into acute biliary pancreatitis(ABP)and hypertriglyceridemia-induced acute pancreatitis(HTGP).AIM To investigate the clinical significance of NLR and PLR in assessing persistent organ failure(POF)in HTGP and ABP.METHODS A total of 1450 patients diagnosed with acute pancreatitis(AP)for the first time at Shanxi Bethune Hospital between January 2012 and January 2023 were enrolled.The patients were categorized into two groups according to the etiology of AP:ABP in 530 patients and HTGP in 241 patients.We collected and compared the clinical data of the patients,including NLR,PLR,and AP prognostic scoring systems,within 48 h of hospital admission.RESULTS The NLR(9.1 vs 6.9,P<0.001)and PLR(203.1 vs 160.5,P<0.001)were significantly higher in the ABP group than in the HTGP group.In the HTGP group,both NLR and PLR were significantly increased in patients with severe AP and those with a SOFA score≥3.Likewise,in the ABP group,NLR and PLR were significantly elevated in patients with severe AP,modified computed tomography severity index score≥4,Japanese Severity Score≥3,and modified Marshall score≥2.Moreover,NLR and PLR showed predictive value for the development of POF in both the ABP and HTGP groups.CONCLUSION NLR and PLR vary between ABP and HTGP,are strongly associated with AP prognostic scoring systems,and have predictive potential for the occurrence of POF in both ABP and HTGP.展开更多
The effects of the water-cement ratio and the molding temperature on the hydration heat of cement were investigated with semi-adiabatic calorimetry.The specimens were prepared with water-cement ratios of 0.31,0.38,and...The effects of the water-cement ratio and the molding temperature on the hydration heat of cement were investigated with semi-adiabatic calorimetry.The specimens were prepared with water-cement ratios of 0.31,0.38,and 0.45,and the molding temperature was specified at 10 and 20℃.The experimental results show that,as the water-binder ratio increases,the value of the second temperature peak on the temperature curve of the cement paste decreases,and the age at which the peak appears is delayed.The higher the water-cement ratio,the higher the hydration heat release in the early period of cement hydration,but this trend reverses in the late period.There are intersection points of the total hydration heat curve of the cement pastes under the influence of the water-cement ratio,and this law can be observed at both molding temperatures.With the increase in the molding temperature,the age of the second temperature peak on the temperature curve of the cement paste will advance,but the temperature peak will decrease.The higher the molding temperature,the earlier the acceleration period of the cement hydration began,and the larger the hydration heat of the cement in the early stage,but the smaller the total heat in the late period.A subsection function calculation model of the hydration heat,which was based on the existing models,was proposed in order to predict the heat of the hydration of the concrete.展开更多
基金supported by National Natural Science Foundation of China(No.11405025).
文摘The yield ratios of neutron-proton(R(n/p))and^(3)H-^(3)He(R(^(3)H∕^(3)He))with reduced rapidity from 0 to 0.5 were simulated at 50 MeV/u even-even ^(36−56)Ca+^(40)Ca,even-even ^(48−78)Ni+^(58)Ni,and ^(100−139)Sn(every third isotopes)+112 Sn for full reduced impact parameters using the isospin-dependent quantum molecular dynamics(IQMD)model.The neutron and proton density distributions and root-mean-square radii of the reaction systems were obtained using the Skyrme-Hartree-Fock model,which was used for the phase space initialization of the projectile and target in IQMD.We defined the unified neutron skin thickness asΔRnp=<r^(2)>^(1∕2) n−<r^(2)>^(1∕2)p,which was negative for neutron-deficient nuclei.The unifiedΔRnp values for nuclei with the same relative neutron excess from different isotopic chains were nearly equal,except for extreme neutron-rich isotopes,which is a type of scaling behavior.The yield ratios of the three isotopic chain-induced reactions,which depended on the reduced impact parameter and unified neutron skin thickness,were studied.The results showed that both R(n/p)and R(^(3)H∕^(3)He)decreased with a reduced impact parameter for extreme neutron-deficient isotopes;however,they increased with reduced impact parameters for extreme neutron-rich isotopes,and increased with theΔRnp of the projectiles for all reduced impact parameters.In addition,a scaling phenomenon was observed betweenΔR np and the yield ratios in peripheral colli-sions from different isotopic chain projectiles(except for extreme neutron-rich isotopes).Thus,R(n/p)and R(^(3)H∕^(3)He)from peripheral collisions were suggested as experimental probes for extracting the neutron or proton skin thicknesses of non-extreme neutron-rich nuclei from different isotopic chains.
文摘Background: The signal-to-noise ratio (SNR) is recognized as an index of measurements reproducibility. We derive the maximum likelihood estimators of SNR and discuss confidence interval construction on the difference between two correlated SNRs when the readings are from bivariate normal and bivariate lognormal distribution. We use the Pearsons system of curves to approximate the difference between the two estimates and use the bootstrap methods to validate the approximate distributions of the statistic of interest. Methods: The paper uses the delta method to find the first four central moments, and hence the skewness and kurtosis which are important in the determination of the parameters of the Pearsons distribution. Results: The approach is illustrated in two examples;one from veterinary microbiology and food safety data and the other on data from clinical medicine. We derived the four central moments of the target statistics, together with the bootstrap method to evaluate the parameters of Pearsons distribution. The fitted Pearsons curves of Types I and II were recommended based on the available data. The R-codes are also provided to be readily used by the readers.
文摘Technologies for reducing corn leaf burn caused by foliar spray of urea-ammonium nitrate (UAN) during the early growing season are limited. A field experiment was carried out to evaluate the effects of humic acid on corn leaf burn caused by foliar spray of undiluted UAN solution on corn canopy at Jackson, TN in 2018. Thirteen treatments of the mixtures of UAN and humic acid were evaluated at V6 of corn with different UAN application rates and different UAN/humic acid ratios. Leaf burn during 1 2, 3, 4, 5, 6, 7, and 14 days after UAN foliar spray significantly differed between with or without humic acid addition. The addition of humic acid to UAN significantly reduced leaf burn at each UAN application rate (15, 25, and 35 gal/acre). The reduction of leaf burn was enhanced as the humic acid/UAN ratio went up from 10% to 30%. Leaf burn due to foliar application of UAN became severer with higher UAN rates. The linear regression of leaf burn 14 days after application with humic acid/UAN ratio was highly significant and negative. However, the linear regression of leaf burn 14 days after application with the UAN application rate was highly significant and positive. In conclusion, adding humic acid to foliar-applied UAN is beneficial for reducing corn leaf burn during the early growing season.
文摘This study is a contribution to improving rice productivity on acidic plateau soils of the tropical rainforest zone. It is based on taking into account the cationic balances of the soil in order to optimize the phosphorus (P) nutrition of rice on these acidic soils, where this nutrient constitutes a limiting factor for agricultural production. Three (3) pot trials were conducted in Adiopodoumé in the forested south of Côte d’Ivoire. The interactive effects of calcium carbonate (0, 25, 50 and 75 kg Ca ha<sup>−1</sup>) and magnesium sulfate (0, 25, 50 and 75 kg Mg ha<sup>−1</sup>) were evaluated on the response of NERICA 5 rice at doses 0, 25, 50 and 75 kg P ha<sup>−1</sup> of natural phosphate from Togo, applied only once at the start of the experiment. Additional fertilizers of nitrogen (N) (100 kg N ha<sup>−1</sup>) and potassium (K) (50 kg KCl ha<sup>−1</sup>) were added to each of the tests in a split-plot device. The test results revealed a paddy production potential of approximately 3 to 5 t⋅ha<sup>−1</sup> for NERICA 5 on an acidic soil, under the effect of the interaction of P, Ca and Mg. The quadratic response of rice yield to the doses of these fertilizers would be more dependent on their balance, itself influenced by Ca nutrition. For the sustainability and maintenance of rice production in agro-ecology studied, it was recommended doses of 38 kg Ca ha<sup>−1</sup>, 34 kg Mg ha<sup>−1</sup> in a Ca/Mg ratio (1/1) with intakes of 41 kg P ha<sup>−1</sup>, overall in a ratio 1/1/1 (P/Ca/Mg) more favorable to the availability of free iron considered a guiding element of mineral nutrition. Thus, these promising results should be confirmed in a real environment for better management of the fertilization of rice cultivated on acidic plateau soils in Côte d’Ivoire.
文摘Objective:We evaluated whether the blood parameters before prostate biopsy can diagnose prostate cancer(PCa)and clinically significant PCa(Gleason score[GS]7)in our hospital.Methods:This study included patients with increased prostate-specific antigen(PSA)up to 20 ng/mL.The associations of neutrophil-to-lymphocyte ratio(NLR)and platelet-tolymphocyte ratio(PLR)alone or with PSA with PCa and clinically significant PCa were analyzed.Results:We included 365 patients,of whom 52.9%(193)had PCa including 66.8%(129)with GS of≥7.PSA density(PSAD)and PSA had better the area under the curve(AUC)of 0.722 and 0.585,respectively with pZ0.001 for detecting PCa compared with other blood parameters.PSA combined with PLR(PsPLR)and PSA with NLR(PsNLR)had better AUC of 0.608 and 0.610,respectively with p<0.05,for diagnosing GS≥7 population,compared with PSA,free/total PSA,NLR,PLR,and PsNPLR(PSA combined with NLR and PLR).NLR and PLR did not predict PCa on multivariate analysis.For GS≥7 cancer detection,in the multivariate analysis,separate models with PSA and NLR(Model 1:PsNLRþbaseline parameters)or PSA and PLR(Moder 2:PsPLRþbaseline parameters)were made.Baseline parameters comprised age,digital rectal exam-positive lesions,PSA density,free/total PSA,and magnetic resonance imaging.Model 2 containing PsPLR was statistically significant(odds ratio:2.862,95% confidence interval:1.174-6.975,p=0.021)in finding aggressive PCa.The predictive accuracy of Model 2 was increased(AUC:0.734,p<0.001)than that when only baseline parameters were used(AUC:0.693,p<0.001).Conclusion:NLR or PLR,either alone or combined with PSA,did not detect PCa.However,the combined use of PSA with PLR could find the differences between clinically significant and insignificant PCa in our retrospective study limited by the small number of samples.
基金financially supported by the National Natural Science Foundation of China (Grant Nos.52371277 and 52001071)the State Key Laboratory of Hydraulic Engineering Intelligent Construction and Operation (Tianjin University) (Grant No.HESS-2323)+1 种基金the Postgraduate Research&Practice Innovation Program of Jiangsu Province (Grant No.KYCX23_3902)the Guangdong Basic and Applied Basic Research Foundation (Grant No.:2023A1515010890)。
文摘The resonant motion of the fluid inside a narrow gap between two fixed boxes induced by incident regular waves with various wave heights is investigated by adopting a two-dimensional numerical wave flume based on an opensourced CFD package,OpenFOAM.The two boxes have identical draft and height,but the upstream box has a variable breadth.This article focuses on the influences of the breadth ratio,defined as the ratio of the breadth of the upstream box to that of the downstream box,on the following three aspects of hydrodynamic characteristics of gap resonance:(1)the wave height amplifications inside the gap,and in front and at the rear of the structure system,(2)the reflection,transmission,and energy loss coefficients of the structure system,and(3)the response and damping time of the fluid resonance.It is found that the fluid resonant frequency,the amplification factor of the resonant wave height inside the gap and the maximum energy loss coefficient of the structure system are shown to gradually decrease with the increase of the breadth ratio.The response time of gap resonance is shown to first increase and then decrease with the breadth ratio overall,regardless of the incident wave height,and the configuration that the two boxes have the same breadth would bring the largest response time of gap resonance.
基金financially supported by the National Natural Science Foundation of China (Grant No.U2006226)。
文摘Experiments were conducted on risers with different mass ratios to study the effect of mode conversion and spanwise correlation. The slenderness ratio of the riser model was set as 169, and the Reynolds numbers are 1600-14400. The dynamic responses of riser models versus reduced velocity were analyzed, and the spanwise displacement, frequency,and trajectory of the mode conversion from the lower to the higher mode were explored. The results revealed that the riser model with a higher mass ratio excites a higher number of modes. The conversion region of multi-mode competition exists and narrows with the increasing mass ratio. Mode conversion is continuous and manifests as the transmission of peaks and troughs in mode shape: the peaks and troughs of mode shape move up in the mode stable development region and move down in the mode conversion region. The single-mode dominating vibration exhibits a standing wave feature, and the traveling wave feature is significant in the mode conversion region. Furthermore, the frequency jump is always transmitted from the trough to the peak of the mode shape, and finally, all the axial positions vibrate at the same frequency. The trajectory in the mode conversion region deviates from the 8-shape and recovers the standard8-shape at the middle and late stages of the mode stable development region.
基金financially supported by the National Natural Science Foundation of China (Grant No. 42177167)the Natural Science Foundation of Shandong Province (Grant No. ZR2019QEE008)。
文摘Taking the three-riser group arranged in tandem as the research subject,an experimental study was carried out on the risers arranged in tandem.The purpose is to explore the sensitivity of the dynamic response of each riser to spacing ratio and reveal the physical mechanism of riser groups under the interference effect.The spacing ratios of the adj acent risers are 4.0,5.0,6.0,and 8.0.At the spacing between the risers of 4.0D,the strong feedback effect increases the cross-flow(CF) displacement amplitude of the upstream riser.The shielding effect is the key factor affecting the interference effect on the midstream and downstream risers.At low reduced velocities,the shielding area initially appears,the displacement amplitude of the midstream and downstream risers varies greatly,the vibration of the two risers is still dominated by the first-order mode,and the transition between adjacent vibration modes is restrained.The multi-frequency superposition phenomenon is very significant at high reduced velocities.The most sensitive interference spacing under the test conditions is obtained.Due to the separation of the incoming flow and the double shielding effect of the upstream and midstream risers,the regular vortex-induced vibration in the wake area of the downstream riser is broken,and the vibration in the two directions is weakened.In general,the interference effect is more significant for the CF vibration of the three-riser groups than the in-line(IL) vibration.
基金The National Natural Science Foundation of China under contract Nos 41830539 and 41906063the Marine S&T Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology(Qingdao)under contract No.2022QNLM050203the Taishan Scholars Project Funding under contract No.ts20190963。
文摘Planktonic foraminifer Globigerinoides ruber(white)and Trilobatus sacculifer are the most frequently used mixedlayer dwelling species for reconstructing past oceanic environments.Specifically,the Mg/Ca ratios of these two foraminiferal species have been used for reconstructing tropical/subtropical changes in sea surface temperature(SST).However,these two species have different morphotypes,of which the spatial and temporal differences in Mg/Ca ratios and their influencing factors are still unclear.Our objective is to investigate the potential differences between the Mg/Ca ratios of these different morphotypes of G.ruber(white)and T.sacculifer in the western Philippine Sea(WPS)and determine their implications for the reconstruction of SST and upper-ocean structure.Mg/Ca measurements are made on two basic morphotypes of G.ruber(white)[sensu stricto(s.s.)and sensu lato(s.l.)]and T.sacculifer[with(w)and without(w/o)a sac-like final chamber]on samples of Site MD06-3047B from the WPS.Our results reveal that Mg/Ca ratios of different G.ruber morphotypes show consistent differences;and those of T.sacculifer morphotypes show staged variations since MIS 3.It is suggested to select a single morphotype for reconstructing SST changes using the Mg/Ca ratios of G.ruber and T.sacculifer in the WPS.Furthermore,the Mg/Ca ratios between G.ruber s.s.and G.ruber s.l.[Δ(Mg/Ca)_(G.ruber s.s.-s.l.)]downcore MD06-3047B covaries with indexes of summer monsoon.Combining with the core-top results,showing regional variation of differences in theΔ(Mg/Ca)_(G.ruber s.s.-s.l.)over the western tropical Pacific,we propose thatΔ(Mg/Ca)_(G.ruber s.s.-s.l.)may tend to reflect summer mixed layer depth.
文摘Through the theoretical analysis of overburden destabilization mechanism, FLAC 3D simplified plane numerical simulation method and field measurement method, we compared the relationship of overburden support pressure at 35 m of workface recovery, and the peak overburden support pressure decreased from 13.85 Mpa to 11.97 Mpa from 1:1 to 1:3. With the increase of mining ratio, the peak over-supporting pressure decreases: with the increase of top coal recovery thickness, the peak over-supporting pressure and the influence range will be further expanded, and the distance between the peak over-supporting pressure and the coal wall of the working face will be further increased and the high stress zone of the peak area will be expanded simultaneously.
文摘Through the theoretical analysis of overburden destabilization mechanism, FLAC 3D simplified plane numerical simulation method and field measurement method, we compared the relationship of overburden support pressure at 35 m of workface recovery, and the peak overburden support pressure decreased from 13.85 Mpa to 11.97 Mpa from 1:1 to 1:3. With the increase of mining ratio, the peak over-supporting pressure decreases: with the increase of top coal recovery thickness, the peak over-supporting pressure and the influence range will be further expanded, and the distance between the peak over-supporting pressure and the coal wall of the working face will be further increased and the high stress zone of the peak area will be expanded simultaneously.
基金supported by the National Natural Science Foundation of China (Grant nos. 42276240, 42206243, 41776188)the Strategic Priority Research Program of the Chinese Academy of Sciences (Grant no. XDB40000000)+3 种基金the Shanghai Sailing Program (Grant no. 22YF1418800)the China Postdoctoral Science Foundation (Grant no. 2022M712038)the Shanghai Frontiers Science Center of Polar Science (SCOPS)the Chinese Arctic and Antarctic Administration (CAA) for supporting the project
文摘Primary productivity in the Antarctic aquatic environment with simple ecosystems is sensitive to climate and environmental fluctuations.We investigatedδ13C values for n-alkanoic acids derived from phototrophic organisms in a lacustrine sediment core(IIL3)to indicate primary productivity in ponds on Inexpressible Island in the western Ross Sea,Antarctica.Short-chain n-alkanoic acids(C14–C18)were abundant in the IIL3 sediment profile.The carbon isotope ratios of short-chain n-alkanoic acids in the sediment samples and floating microbial mats were similar,indicating that the short-chain n-alkanoic acids in the IIL3 sediment profile predominantly originated from phototrophic organisms.Theδ13C values for the short-chain n-alkanoic acids varied widely through the sediment profile,and 13C-enrichment of n-alkanoic acids was most likely related to high productivity due to carbon-limited conditions caused by enhanced photosynthetic efficiency.Theδ13C values for the n-alkanoic acids changed over the past 3200 years in similar ways to organic proxies for aquatic productivity(n-alkanoic acid and sterol sedimentary fluxes).C16 n-alkanoic acid was enriched in 13C in periods of high aquatic productivity~750–1650 and 3000–3200 a BP but depleted in 13C in periods of relatively low productivity~150–600 and 2500–3000 a BP.The results indicated that carbon isotope ratios of lipids from phototrophic organisms could be used as new proxies to reconstruct paleo-productivity in Antarctic lakes and ponds and therefore improve our understanding of past climate changes.
基金Supported by Guangxi Agricultural Science and Technology Self-financing Project(Z2022114,Z2022111)。
文摘[Objectives]Protein energy ratio refers to the proportional relationship between protein and energy levels in animal diets,i.e.,the grams of crude protein corresponding to every megacalorie of energy,which is generally expressed as CP:ME or CP:DE.This study was conducted to investigate the effects of different diets on fattening and slaughter performance and meat quality traits for"L(Large Yorkshire)×L(Landrace)"crossbred pigs.[Methods]Eighteen piglets of L×L crossbred with similar body weights about 51 kg were selected.The piglets were divided into 3 groups randomly and each group was assigned to 3 replicates with 2 piglets in a replicate.Group A was fed diet Ⅰ (control diet),group B was fed the same diet of group A in the first month of the trial but fed diet Ⅱ in second month,and group C consumed diet Ⅲ.All the pigs were fed in the same feeding condition for two months except the different diets during the trial.One pig in similar body weight from each replicate was slaughtered for the determination of slaughter performance and meat quality traits in the end of the trial.[Results]The average daily feed intake(ADFI)of pigs from group B was only(2.32±0.52)kg and significantly lower than those from group A and group C(P<0.05),but no difference was found in average daily gain(ADG) and feed/gain(P>0.05).Also,no differences occurred in the carcass length,back fat thickness,longissimus muscle (LM) area and dressing percentage(P>0.05).In addition,no differences were found in the meat quality traits of shear force,meat color,pH_(45 min),pH_(24 h) and cooking loss(P>0.05).However,the water-holding capacity of meat from group C was(2.58±0.02)ms and significantly lower than that of(2.80±0.20)ms from group A(P<0.05).Although the contents of glutamic acid and cystine in LM from group B was significantly lower than those from group A and group C(P<0.05),no differences occurred in the contents of other amino acids,the total amino acid and total flavor amino acid among the three groups(P>0.05).However,the inosine monophosphate content of LM from group C was only(331.80±11.53)mg/100 g and significantly lower than those of(361.00±6.36)and(366.37±4.80)mg/100 g from group A and B(P<0.05).Even though no differences were found in the contents of DM and CP in LM among the three groups of pigs,the content of intramuscular fat(IMF)in LM from group B and group C was increased by 45.6%and 46.58%respectively from that of group A(P<0.05),but no difference occurred between group B and C(P>0.05).[Conclusions]DietsⅡ and Ⅲ in this study caused no differences in fattening and slaughter performance of L×L crossbred pigs,but the effects on some meat traits were still significant,especially on the improvement of intramuscular fat in experimental pigs.Therefore,they could improve the meat quality of crossbred pigs to a certain extent.
基金Affiliated Jinling Hospital,Medical School of Nanjing University(No.22JCYYYB29).
文摘AIM:To investigate systemic immune-inflammation index(SII),neutrophil-to-lymphocyte ratio(NLR),and plateletto-lymphocyte ratio(PLR)levels in patients with type 2 diabetes at different stages of diabetic retinopathy(DR).METHODS:This retrospective study included 141 patients with type 2 diabetes mellitus(DM):45 without diabetic retinopathy(NDR),47 with non-proliferative diabetic retinopathy(NPDR),and 49 with proliferative diabetic retinopathy(PDR).Complete blood counts were obtained,and NLR,PLR,and SII were calculated.The study analysed the ability of inflammatory markers to predict DR using receiver operating characteristic(ROC)curves.The relationships between DR stages and SII,PLR,and NLP were assessed using multivariate logistic regression.RESULTS:The average NLR,PLR,and SII were higher in the PDR group than in the NPDR group(P=0.011,0.043,0.009,respectively);higher in the NPDR group than in the NDR group(P<0.001 for all);and higher in the PDR group than in the NDR group(P<0.001 for all).In the ROC curve analysis,the NLR,PLR,and SII were significant predictors of DR(P<0.001 for all).The highest area under the curve(AUC)was for the PLR(0.929 for PLR,0.925 for SII,and 0.821 for NLR).Multivariate regression analysis indicated that NLR,PLR,and SII were statistically significantly positive and independent predictors for the DR stages in patients with DM[odds ratio(OR)=1.122,95%confidence interval(CI):0.200–2.043,P<0.05;OR=0.038,95%CI:0.018–0.058,P<0.05;OR=0.007,95%CI:0.001–0.01,P<0.05,respectively).CONCLUSION:The NLR,PLR,and SII may be used as predictors of DR.
基金supported by the National Natural Science Foundation of China[no.81903336,Yi-de Yang]the Health Research Project of Hunan Provincial Health Commission[no.202112031516,Yi-de Yang]+3 种基金Scientific Research Fund of Hunan Provincial Education Department[no.22B0038,Yi-de Yang]the Research Team for Reproduction Health and Translational Medicine of Hunan Normal University[2023JC101]Key Project of Developmental Biology and Breeding from Hunan Province[no.2022XKQ0205]Open Project for Postgraduates of Hunan Normal University[no.KF2022019,Tianli Xiao].
文摘Objective Hypertriglyceridemic waist(HW),hypertriglyceridemic waist-to-height ratio(HWHtR),and waist-to-hip ratio(WHR)have been shown to be indicators of cardiometabolic risk factors.However,it is not clear which indicator is more suitable for children and adolescents.We aimed to investigate the relationship between HW,HWHtR,WHR,and cardiovascular risk factors clustering to determine the best screening tools for cardiometabolic risk in children and adolescents.Methods This was a national cross-sectional study.Anthropometric and biochemical variables were assessed in approximately 70,000 participants aged 6–18 years from seven provinces in China.Demographics,physical activity,dietary intake,and family history of chronic diseases were obtained through questionnaires.ANOVA,χ2 and logistic regression analysis was conducted.Results A significant sex difference was observed for HWHtR and WHR,but not for HW phenotype.The risk of cardiometabolic health risk factor clustering with HW phenotype or the HWHtR phenotype was significantly higher than that with the non-HW or non-HWHtR phenotypes among children and adolescents(HW:OR=12.22,95%CI:9.54-15.67;HWHtR:OR=9.70,95%CI:6.93-13.58).Compared with the HW and HWHtR phenotypes,the association between risk of cardiometabolic health risk factors(CHRF)clustering and high WHR was much weaker and not significant(WHR:OR=1.14,95%CI:0.97-1.34).Conclusion Compared with HWHtR and WHR,the HW phenotype is a more convenient indicator with higher applicability to screen children and adolescents for cardiovascular risk factors.
文摘We conducted a comprehensive review of existing prediction models pertaining to the efficacy of immune-checkpoint inhibitor(ICI)and the occurrence of immune-related adverse events(irAEs).The predictive potential of neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)in determining ICI effectiveness has been extensively investigated,while limited research has been conducted on predicting irAEs.Furthermore,the combined model incor-porating NLR and PLR,either with each other or in conjunction with additional markers such as carcinoembryonic antigen,exhibits superior predictive capabilities compared to individual markers alone.NLR and PLR are promising markers for clinical applications.Forthcoming models ought to incorporate established efficacious models and newly identified ones,thereby constituting a multifactor composite model.Furthermore,efforts should be made to explore effective clinical application approaches that enhance the predictive accuracy and efficiency.
基金Supported by Shanxi Province“136”Revitalization Medical Project Construction Funds,No.2019XY004.
文摘BACKGROUND The neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)are novel inflammatory indicators that can be used to predict the severity and prognosis of various diseases.We categorize acute pancreatitis by etiology into acute biliary pancreatitis(ABP)and hypertriglyceridemia-induced acute pancreatitis(HTGP).AIM To investigate the clinical significance of NLR and PLR in assessing persistent organ failure(POF)in HTGP and ABP.METHODS A total of 1450 patients diagnosed with acute pancreatitis(AP)for the first time at Shanxi Bethune Hospital between January 2012 and January 2023 were enrolled.The patients were categorized into two groups according to the etiology of AP:ABP in 530 patients and HTGP in 241 patients.We collected and compared the clinical data of the patients,including NLR,PLR,and AP prognostic scoring systems,within 48 h of hospital admission.RESULTS The NLR(9.1 vs 6.9,P<0.001)and PLR(203.1 vs 160.5,P<0.001)were significantly higher in the ABP group than in the HTGP group.In the HTGP group,both NLR and PLR were significantly increased in patients with severe AP and those with a SOFA score≥3.Likewise,in the ABP group,NLR and PLR were significantly elevated in patients with severe AP,modified computed tomography severity index score≥4,Japanese Severity Score≥3,and modified Marshall score≥2.Moreover,NLR and PLR showed predictive value for the development of POF in both the ABP and HTGP groups.CONCLUSION NLR and PLR vary between ABP and HTGP,are strongly associated with AP prognostic scoring systems,and have predictive potential for the occurrence of POF in both ABP and HTGP.
基金the National Natural Science Foundation of China(Nos.52368032 and 51808272)the China Postdoctoral Science Foundation(No.2023M741455)+1 种基金the Tianyou Youth Talent Lift Program of Lanzhou Jiaotong UniversityGansu Province Youth Talent Support Project(No.GXH20210611-10)。
文摘The effects of the water-cement ratio and the molding temperature on the hydration heat of cement were investigated with semi-adiabatic calorimetry.The specimens were prepared with water-cement ratios of 0.31,0.38,and 0.45,and the molding temperature was specified at 10 and 20℃.The experimental results show that,as the water-binder ratio increases,the value of the second temperature peak on the temperature curve of the cement paste decreases,and the age at which the peak appears is delayed.The higher the water-cement ratio,the higher the hydration heat release in the early period of cement hydration,but this trend reverses in the late period.There are intersection points of the total hydration heat curve of the cement pastes under the influence of the water-cement ratio,and this law can be observed at both molding temperatures.With the increase in the molding temperature,the age of the second temperature peak on the temperature curve of the cement paste will advance,but the temperature peak will decrease.The higher the molding temperature,the earlier the acceleration period of the cement hydration began,and the larger the hydration heat of the cement in the early stage,but the smaller the total heat in the late period.A subsection function calculation model of the hydration heat,which was based on the existing models,was proposed in order to predict the heat of the hydration of the concrete.