Nowadays,due to excellent biological and polymeric characteristics,DNA has been widely noted as an emerging building block to construct diverse materials for biosensing,in vivo imaging,drug delivery,and disease therap...Nowadays,due to excellent biological and polymeric characteristics,DNA has been widely noted as an emerging building block to construct diverse materials for biosensing,in vivo imaging,drug delivery,and disease therapy.Particularly,relying on programmability,predictability,and stability of DNA,DNA walkers have opened new and exciting opportunities in modern life sciences for target detection and biological analysis,which are constructed by self-assembly of DNA or combining DNA with other nanomaterials(e.g.,quantum dots,gold nanoparticles,magnetic nanoparticles,polymers).Compared with conventional nanomaterials(lanthanide-doped upconversion nanoparticles,magnetic nanomaterials,carbon dots,silicon dots,and so on),DNA walkers showed convenient modification,lower biotoxicity,excellent biocompatibility and high biostability,improving the biological application.Meanwhile,with high-speed operating efficiency and sustainable operation,DNA walkers powered by strand displacement reaction or protein enzyme/DNAzyme reaction,have highly sensitive detection and signal amplification abilities,which are applied in biosensing,material assembly and synthesis,and early cancer diagnosis.Worthily,DNA walkers could be regarded as signal amplifiers,which enhanced the signal transduction and amplified biosensor sensing signals.Herein,we systematically and comprehensively summarized the operating principles of various DNA walkers,categorized rational design of the DNA walker,and outlined the application of DNA walker in biosensors.Furthermore,the challenges and future trends of DNA walkers were discussed.展开更多
我的女儿正在学步,步履蹒跚,却是可爱。在网上读到此文,兴趣也就陡增。孤陋寡闻的我,细读本文,感到不解！从来没有听说过幼儿学步车(babywalker)。幼儿学步,竟然要靠学步车,是否必要?学步车的目的何在?是为了防止幼儿摔倒?根据我的观察...我的女儿正在学步,步履蹒跚,却是可爱。在网上读到此文,兴趣也就陡增。孤陋寡闻的我,细读本文,感到不解！从来没有听说过幼儿学步车(babywalker)。幼儿学步,竟然要靠学步车,是否必要?学步车的目的何在?是为了防止幼儿摔倒?根据我的观察,摔倒在地,也是一种人生必需的经验。摔倒了,再爬起来,这种“技能”和“经验”对幼儿是必不可少的。 细读本文,我又为Roger Burton先生的研究精神所动。他们的研究很有说服力,人们相信,改进的学步车不如原始的学步车,而原始的学步车则不如不用学步车！(颇有幽默意味)细读本文,我又为Roger Burton先生的能言善辩所折服。Roger Burton先生这样说: It is likely that normal infants who use newer-style walkers will catch up totheir no-walker peers when they walk and are no longer restricted by being putinto a walker. Roger Burton先生又这样说: When the danger factor is considered in conjunction with the developmentaldata presented by our study, the risks seem to outweigh any possible benefits ofearly walker exposure. 他所说的the risks决非耸听之言。因为自1984年以来,美国已有11个幼儿因学步车而丧命。唉,美国！展开更多
This work uses cloud-resolving simulations to study mock-Walker cells driven by a specified sea surface temperature(SST).The associated precipitation in the mock-Walker cells exhibits three different modes,including a...This work uses cloud-resolving simulations to study mock-Walker cells driven by a specified sea surface temperature(SST).The associated precipitation in the mock-Walker cells exhibits three different modes,including a single peak of precipitation over the SST maximum(mode 1),symmetric double peaks of precipitation straddling the SST maximum(mode 2),and a single peak of precipitation on one side of the SST maximum(mode 3).The three modes are caused by three distinct convective activity center migration traits.Analyses indicate that the virtual effect of water vapor plays an important role in differentiating the three modes.When the SST gradient is large,the virtual effect may be strong enough to overcome the temperature effect,generating a low-level low-pressure anomaly below the ascending branch of the Walker cell off the center.The results here highlight the importance of the virtual effect of water vapor and its interaction with convection and large-scale circulation in the Walker circulation.展开更多
目的:分析并阐明口腔衰弱的概念内涵。方法:系统检索PubMed、Web of Science、ProQuest、中国知网、万方数据知识服务平台、CBM数据库与口腔衰弱相关的研究,检索时限为2013年1月1日~2024年2月23日,依据纳排标准选取文献,应用Walker and ...目的:分析并阐明口腔衰弱的概念内涵。方法:系统检索PubMed、Web of Science、ProQuest、中国知网、万方数据知识服务平台、CBM数据库与口腔衰弱相关的研究,检索时限为2013年1月1日~2024年2月23日,依据纳排标准选取文献,应用Walker and Avant概念分析法分析文献。结果:共纳入44篇文献,口腔衰弱包括3项定义属性:可逆性、多维性和可预测性。前因包括社会人口学因素、疾病史和多重用药史、不良饮食习惯;后果包括躯体衰弱、不良健康结局风险增加、营养不良、生活质量下降。结论:通过概念分析明确了口腔衰弱的概念属性,为后续开展相关研究提供了参考依据。未来研究可结合口腔衰弱的概念内涵,开发适合我国人群的口腔衰弱评估工具,促进口腔衰弱研究在我国的发展。展开更多
Objective:To clarify the concept of self-management in hypertensive patients by analyzing the definition,attributes,and measurement tools through a literature review.Methods:An Internet-based search of the databases w...Objective:To clarify the concept of self-management in hypertensive patients by analyzing the definition,attributes,and measurement tools through a literature review.Methods:An Internet-based search of the databases was conducted using Academic Search Complete,Medical Line,CINAHL,Health Source:Nursing/Scholarly Edition,and Google Scholar.In the search process,keywords or free text were combined by using Boolean operators,with the search terms“self of management”or“self-management,”“concept*analysis”or“concept*definition,”and Walker and Avant’s concept analysis method was used.Results:Analysis of relevant literature summarized the conceptual attributes of self-management in hypertensive patients as the active participation of patients in the treatment process;the presence of interaction provided by patients and health care providers;the use of certain health management tools;and the aim of maintaining and improving the health status and living capacity of hypertensive patients.Conclusion:The concept of self-management for hypertensive patients was clarified,which helps to promote the application of hypertensive self-management in clinical work and improve outcomes and quality of life for patients with hypertension.展开更多
The present study explored how the Indian Ocean Dipole (IOD) influences October-November-December (OND) rainfall over Tanzania in recent decade following the 2011 abrupt change. The study spans 50 years, from 1973 to ...The present study explored how the Indian Ocean Dipole (IOD) influences October-November-December (OND) rainfall over Tanzania in recent decade following the 2011 abrupt change. The study spans 50 years, from 1973 to 2022. Notable abrupt changes were observed in 1976 and 2011, leading us to divide our study into two periods: 1976-2010 and 2011-2022, allowing for a close investigation into the existing relationship between OND IOD and OND rainfall and their associated large-scale atmospheric circulations. It was found that the relationship between OND IOD and OND rainfall strengthened, with the correlation changed from +0.73 during 1976-2010 to +0.81 during 2011-2022. Further investigation revealed that, during 1976-2010, areas that received above- normal rainfall during positive IOD experienced below-normal during 2011- 2022 and vice versa. The same pattern relationship was observed for negative IOD. Spatial analysis demonstrates that the percentage departure of rainfall across the region mirrors the standardized rainfall anomalies. The study highlights that the changing relationship between OND IOD and OND rainfall corresponds to the east-west shift of Walker circulation, as well as the north-south shift of Hadley circulation. Analysis of sea surface temperature (SST) indicates that both positive and negative IOD events strengthened during 2011-2022 compared to 1976-2010. Close monitoring of this relationship across different timescales could be useful for updating OND rainfall seasonal forecasts in Tanzania, serving as a tool for reducing socio-economic impacts.展开更多
基金Financial support was from Hunan Provincial Natural Science Foundation(Nos.2023JJ40210,2023JJ40211)Hunan Provincial Innovation Training Program for College Students(No.202211342042)+2 种基金Hunan Provincial Natural Science Foundation(No.2021JJ10001)Key Areas Research and Development Plan of Hunan Province(No.2021SK2038)Huxiang High Level Talent Gathering Project(No.2021RC5011)。
文摘Nowadays,due to excellent biological and polymeric characteristics,DNA has been widely noted as an emerging building block to construct diverse materials for biosensing,in vivo imaging,drug delivery,and disease therapy.Particularly,relying on programmability,predictability,and stability of DNA,DNA walkers have opened new and exciting opportunities in modern life sciences for target detection and biological analysis,which are constructed by self-assembly of DNA or combining DNA with other nanomaterials(e.g.,quantum dots,gold nanoparticles,magnetic nanoparticles,polymers).Compared with conventional nanomaterials(lanthanide-doped upconversion nanoparticles,magnetic nanomaterials,carbon dots,silicon dots,and so on),DNA walkers showed convenient modification,lower biotoxicity,excellent biocompatibility and high biostability,improving the biological application.Meanwhile,with high-speed operating efficiency and sustainable operation,DNA walkers powered by strand displacement reaction or protein enzyme/DNAzyme reaction,have highly sensitive detection and signal amplification abilities,which are applied in biosensing,material assembly and synthesis,and early cancer diagnosis.Worthily,DNA walkers could be regarded as signal amplifiers,which enhanced the signal transduction and amplified biosensor sensing signals.Herein,we systematically and comprehensively summarized the operating principles of various DNA walkers,categorized rational design of the DNA walker,and outlined the application of DNA walker in biosensors.Furthermore,the challenges and future trends of DNA walkers were discussed.
文摘我的女儿正在学步,步履蹒跚,却是可爱。在网上读到此文,兴趣也就陡增。孤陋寡闻的我,细读本文,感到不解！从来没有听说过幼儿学步车(babywalker)。幼儿学步,竟然要靠学步车,是否必要?学步车的目的何在?是为了防止幼儿摔倒?根据我的观察,摔倒在地,也是一种人生必需的经验。摔倒了,再爬起来,这种“技能”和“经验”对幼儿是必不可少的。 细读本文,我又为Roger Burton先生的研究精神所动。他们的研究很有说服力,人们相信,改进的学步车不如原始的学步车,而原始的学步车则不如不用学步车！(颇有幽默意味)细读本文,我又为Roger Burton先生的能言善辩所折服。Roger Burton先生这样说: It is likely that normal infants who use newer-style walkers will catch up totheir no-walker peers when they walk and are no longer restricted by being putinto a walker. Roger Burton先生又这样说: When the danger factor is considered in conjunction with the developmentaldata presented by our study, the risks seem to outweigh any possible benefits ofearly walker exposure. 他所说的the risks决非耸听之言。因为自1984年以来,美国已有11个幼儿因学步车而丧命。唉,美国！
基金the National Key R&D Program of China(Grant No.2022YFC3003902)the National Natural Science Foundation of China(Grant No.42075146).
文摘This work uses cloud-resolving simulations to study mock-Walker cells driven by a specified sea surface temperature(SST).The associated precipitation in the mock-Walker cells exhibits three different modes,including a single peak of precipitation over the SST maximum(mode 1),symmetric double peaks of precipitation straddling the SST maximum(mode 2),and a single peak of precipitation on one side of the SST maximum(mode 3).The three modes are caused by three distinct convective activity center migration traits.Analyses indicate that the virtual effect of water vapor plays an important role in differentiating the three modes.When the SST gradient is large,the virtual effect may be strong enough to overcome the temperature effect,generating a low-level low-pressure anomaly below the ascending branch of the Walker cell off the center.The results here highlight the importance of the virtual effect of water vapor and its interaction with convection and large-scale circulation in the Walker circulation.
文摘目的:分析并阐明口腔衰弱的概念内涵。方法:系统检索PubMed、Web of Science、ProQuest、中国知网、万方数据知识服务平台、CBM数据库与口腔衰弱相关的研究,检索时限为2013年1月1日~2024年2月23日,依据纳排标准选取文献,应用Walker and Avant概念分析法分析文献。结果:共纳入44篇文献,口腔衰弱包括3项定义属性:可逆性、多维性和可预测性。前因包括社会人口学因素、疾病史和多重用药史、不良饮食习惯;后果包括躯体衰弱、不良健康结局风险增加、营养不良、生活质量下降。结论:通过概念分析明确了口腔衰弱的概念属性,为后续开展相关研究提供了参考依据。未来研究可结合口腔衰弱的概念内涵,开发适合我国人群的口腔衰弱评估工具,促进口腔衰弱研究在我国的发展。
文摘Objective:To clarify the concept of self-management in hypertensive patients by analyzing the definition,attributes,and measurement tools through a literature review.Methods:An Internet-based search of the databases was conducted using Academic Search Complete,Medical Line,CINAHL,Health Source:Nursing/Scholarly Edition,and Google Scholar.In the search process,keywords or free text were combined by using Boolean operators,with the search terms“self of management”or“self-management,”“concept*analysis”or“concept*definition,”and Walker and Avant’s concept analysis method was used.Results:Analysis of relevant literature summarized the conceptual attributes of self-management in hypertensive patients as the active participation of patients in the treatment process;the presence of interaction provided by patients and health care providers;the use of certain health management tools;and the aim of maintaining and improving the health status and living capacity of hypertensive patients.Conclusion:The concept of self-management for hypertensive patients was clarified,which helps to promote the application of hypertensive self-management in clinical work and improve outcomes and quality of life for patients with hypertension.
文摘The present study explored how the Indian Ocean Dipole (IOD) influences October-November-December (OND) rainfall over Tanzania in recent decade following the 2011 abrupt change. The study spans 50 years, from 1973 to 2022. Notable abrupt changes were observed in 1976 and 2011, leading us to divide our study into two periods: 1976-2010 and 2011-2022, allowing for a close investigation into the existing relationship between OND IOD and OND rainfall and their associated large-scale atmospheric circulations. It was found that the relationship between OND IOD and OND rainfall strengthened, with the correlation changed from +0.73 during 1976-2010 to +0.81 during 2011-2022. Further investigation revealed that, during 1976-2010, areas that received above- normal rainfall during positive IOD experienced below-normal during 2011- 2022 and vice versa. The same pattern relationship was observed for negative IOD. Spatial analysis demonstrates that the percentage departure of rainfall across the region mirrors the standardized rainfall anomalies. The study highlights that the changing relationship between OND IOD and OND rainfall corresponds to the east-west shift of Walker circulation, as well as the north-south shift of Hadley circulation. Analysis of sea surface temperature (SST) indicates that both positive and negative IOD events strengthened during 2011-2022 compared to 1976-2010. Close monitoring of this relationship across different timescales could be useful for updating OND rainfall seasonal forecasts in Tanzania, serving as a tool for reducing socio-economic impacts.
