基于意图的网络专利技术现状

2006年SDN的概念在学术界诞生,工业界即迅速跟进,很快发布了开源SDN控制器。至2016年,SDN不仅在理论上蓬勃发展,还进一步在白盒交换机、网络操作系统、数据中心网络虚拟化和SD-WAN四个领域培育出成熟的细分市场,已成为学术界与工业界协同发展的典范。

Effects of traditional Chinese medicine on symptoms of patients with spleen and stomach deficiency-related tinnitus

BACKGROUND Tinnitus affects 10%-30%of the population.Recent evidence suggests that tinnitus is associated with spleen deficiency.However,compared with kidney deficiency-related tinnitus,less research has been conducted on the impact of spleen defi-ciency-related tinnitus.AIM To investigate the clinical efficacy of using Guipi Wan and dietary and lifestyle modification based on traditional Chinese medicine for treatment of patients with spleen and stomach deficiency-related tinnitus.METHODS We enrolled 110 patients with spleen and stomach deficiency-related tinnitus who were distributed into treatment(58 cases)and control(52 cases)groups.Tinnitus severity,sleep quality and emotional state were assessed by questionnaires[Tinnitus Evaluation Questionnaire(TEQ);Pittsburgh Sleep Quality Index(PSQI);Depression-Anxiety-Stress Scale-21(DASS-21)]that were used for analysis in the two groups during the initial and intervention and after.In the treatment group,patients were treated with oral administration of Guipi Wan and consulted for healthy dietary and lifestyle modification.In the control group,patients were only assessed and not treated.RESULTS At the end of the 6-months,TEQ scores decreased significantly in the treatment group(P=0.021)but not in the Control group.Significant effects in the treatment group were noted for PSQI total score(P=0.043)and several PSQI component scores in the treatment group(P<0.05).After treatment,the DASS-21 scores were significantly reduced in the treatment group(P<0.05).CONCLUSION Guipi Wan combined with dietary and lifestyle modification based on regulating the spleen and stomach can be considered core to the treatment of tinnitus related to spleen and stomach deficiency.

Network pharmacology to decipher the mechanism of Danggui Longhui Wan against chronic myeloid leukemia

Chronic myeloid leukemia(CML)is a hematopoietic myeloproliferative disorder.The Chinese prescription Danggui Longhui Wan(DGLHW)has been utilized in CML treatment,but its underlying mechanisms remain unclear.In this study,we gathered 794 constituents,1249 drug targets,1654 disease genes and 129 intersection genes.GO and KEGG were used to analyze the function of these genes.Compatibility of prescription study showed that monarch drug,minister drug,assistant and guide drug played a synergistic role in the treatment of CML.In addition,we obtained 20 hub genes and 12 key components.Molecular docking indicated that the main compounds and core proteins had good binding ability.The results of this study also showed that DGLHW might play a role in the treatment of CML by affecting MAPK,PI3K/AKT,FoxO and p53 signaling pathways.

Network pharmacology and molecular docking analysis reveal insights into the molecular mechanism of Gualou Qumai Wan in clear cell renal cell carcinoma

Background:To initially clarify the potential therapeutic targets and pharmacological mechanism regarding Gualou Qumai Wan(GQW),a kind of traditional Chinese medicine(TCM),in clear cell renal cell carcinoma(ccRCC)by virtue of the network pharmacology analysis and molecular docking analysis.Methods:The screening of bioactive components and targets of GQW was based on the Traditional Chinese Medicine System Pharmacology(TCMSP)and the UniProt platform served for standardizing their targets.Online Mendelian Inheritance in Man(OMIM),PharmGkb,TTD,DrugBank and GeneCards databases were searched to collect the disease targets of ccRCC.Cytoscape assisted in constructing herb-compound-target(H-C-T)networks.The STRING database was searched for constructing the target protein-protein interaction(PPI)networks,while the R programming language served for analyzing GO functional terms and the KEGG pathways related to potential targets.Analyses of core genes related to survival and tumor microenvironment(TME)were conducted respectively based on the GEPIA2 database and TIMER 2.0 database.Human Protein Atlas(HPA)and The Cancer Genome Atlas(TCGA)helped to obtain core genes’protein expression as well as transcriptome expression level.Autodock Vina software validated the molecular docking regarding GQW components and pivotal targets.Results:The constructed H-C-T networks mainly had 33 compounds and 65 targets.A topological analysis of the PPI network identified that ESR1,AKT1,HIF1A,PTGS2,TP53 and VEGFA serve as core targets in the way GQW affects ccRCC.According to the GO and KEGG pathway enrichment analyses,the effects of GQW are mediated by genes related to hypoxia and oxidative stress as well as the Chemical carcinogenesis-receptor activation and PI3K-Akt signaling pathways.AKT1 shows a close relation to the recruitment of various immune cells and can remarkably affect disease prognosis according to reports.Molecular docking and molecular dynamics simulations showed that diosgenin has higher affinity with core targets.Conclusion:The study makes a comprehensive explanation of the biological activity,potential targets,as well as molecular mechanism regarding GQW against ccRCC,which promisingly assists in revealing the action mechanism of TCM formulae in disease treatment and the respective and scientific basis.

基于SD-WAN组网的中小企业数智化应用研究

引言中小企业在经济体系中占据核心地位,其数字化转型对于提升企业竞争力和促进经济创新至关重要。本文探讨了SD-WAN(软件定义广域网)技术在企业数智化转型升级中的应用,分析了企业数智化组网存在的问题,介绍了SD-WAN的总体架构及其特性。以F集团为例,其数智化实践结果表明,SD-WAN组网技术可满足AGV多基地的网络全覆盖,有效提升了网络效率与安全性,并降低了企业的整体建设成本,为企业数智化发展提供了积极的探索与实践。

面向运营商的SD-WAN演进思考

SD-WAN(Software Defined Wide Area Network,软件定义广域网)自2012年问世以来迅速发展。2019年8月,MEF发布了MEF70,推出了SD-WAN的第一个标准化定义。SDWAN凭借敏捷性、安全性、灵活性、多样性等特点在全球备受推崇,尤其是在疫情的影响下,众多企业加速数字化转型,SD-WAN服务将成为产业数字化时代融合通信的必然发展趋势。

Zuo Gui Wan Promotes Osteogenesis via PI3K/AKT Signaling Pathway:Network Pharmacology Analysis and Experimental Validation

Objective Osteogenesis is vitally important for bone defect repair,and Zuo Gui Wan(ZGW)is a classic prescription in traditional Chinese medicine(TCM)for strengthening bones.However,the specific mechanism by which ZGW regulates osteogenesis is still unclear.The current study is based on a network pharmacology analysis to explore the potential mechanism of ZGW in promoting osteogenesis.Methods A network pharmacology analysis followed by experimental validation was applied to explore the potential mechanisms of ZGW in promoting the osteogenesis of bone marrow mesenchymal stem cells(BMSCs).Results In total,487 no-repeat targets corresponding to the bioactive components of ZGW were screened,and 175 target genes in the intersection of ZGW and osteogenesis were obtained.And 28 core target genes were then obtained from a PPI network analysis.A GO functional enrichment analysis showed that the relevant biological processes mainly involve the cellular response to chemical stress,metal ions,and lipopolysaccharide.Additionally,KEGG pathway enrichment analysis revealed that multiple signaling pathways,including the phosphatidylinositol-3-kinase/protein kinase B(PI3K/AKT)signaling pathway,were associated with ZGW-promoted osteogensis.Further experimental validation showed that ZGW could increase alkaline phosphatase(ALP)activity as well as the mRNA and protein levels of ALP,osteocalcin(OCN),and runt related transcription factor 2(Runx 2).What’s more,Western blot analysis results showed that ZGW significantly increased the protein levels of p-PI3K and p-AKT,and the increases of these protein levels significantly receded after the addition of the PI3K inhibitor LY294002.Finally,the upregulated osteogenic-related indicators were also suppressed by the addition of LY294002.Conclusion ZGW promotes the osteogenesis of BMSCs via PI3K/AKT signaling pathway.

基于LoRaWAN的机场跑道警戒灯运行状态监视系统的设计与应用

随着物联网技术的快速发展,为解决无法及时监控反馈跑道警戒灯工作状态的问题,切实提高机场的运行安全裕度,完善跑道安全管理,文章在运用LoRaWAN技术手段实时监控远端警示灯工作状态的同时,通过统筹考虑软硬件设计提出充分利用无线广域网技术的解决方案。

Preparation of Dashanzha Wan by three-dimensional printing

Objective:To use three-dimensional(3D)printing technology to prepare Dashanzha Wan.Methods:The standard formula proportion of Dashanzha Wan was used to prepare printable materials(normally called the ink)for 3D printing,and different doses and shapes of Dashanzha Wan were prepared.Then,the rheological properties,texture characteristics,scanning electron microscopy,and content of ursolic acid were evaluated.Results:Dashanzha Wan ink showed good shear thinning properties,which is very suitable for 3D printing.The printed sample had a beautiful and regular shape with high resolution.Meanwhile,ursolic acid content in 3D-printed Dashanzha Wan aligned with the ursolic acid content shown in the Pharmacopoeia of the People's Republic of China 2020.Conclusion:The 3D-printed Dashanzha Wan has a better texture,and can be shaped into various shapes according to individual needs,which would increase patients’interest when taking medicine.Moreover,3D printing of Dashanzha Wan could be easily integrated into the digital life system,enabling online customization or use at home.This study reveals that 3D printing technology is a promising method for the production of traditional Chinese medicine with personalized appearance,dosage,and texture,which is suitable for a broader population.

A Review of Impacts of Climate Change on Birds:Implications of Long-term Studies

It is generally accepted that climate has changed greatly on a global scale, and that the earth＇s climate has already wanned by some degrees over the past century. Ample evidence shows that there have been apparent changes in avian population dynamics, life-history traits and geographic ranges in response to global climate change. This paper briefly reviews the possible effects of climate change on avian biology and ecology all over the world, with emphasis on new findings from several long-term studies in Europe and North America, which provide unique opportunities to investigate how long-term changes in climate affect birds at both individual and population levels. The implications of such long-term studies for future bird studies in China is discussed with hope that this review can contribute to the preparation and plan for studies of climatic effects on birds in China in the future.

Simiao Wan alleviates obesity-associated insulin resistance via PKCε/IRS-1/PI3K/Akt signaling pathway based on network pharmacology analysis and experimental validation

Background:The purpose of the study was to investigatethe active ingredients and potential biochemicalmechanisms of Simiao Wan(SMW)in obesity-associated insulin resistance.Methods:An integrated network pharmacology method to screen the active compoundsand candidate targets,construct the protein-protein-interaction network,and ingredients-targets-pathways network was constructed for topological analysis to identify core targets and main ingredients.To find the possible signaling pathways,enrichment analysis was performed.Further,a model of insulin resistance in HL-7702 cells was established to verify the impact of SMW and the regulatory processes.Results:An overall of 63 active components and 151 candidate targets were obtained,in which flavonoids were the main ingredients.Enrichment analysis indicated that the PI3K-Akt signaling pathway was the potential pathway regulated by SMW in obesity-associated insulin resistance treatment.The result showed that SMW could significantly ameliorate insulin sensitivity,increase glucose synthesis and glucose utilization and reduce intracellular lipids accumulation in hepatocytes.Also,SMW inhibited diacylglycerols accumulation-induced PKCεactivity and decreased its translocation to the membrane.Conclusion:SMW ameliorated obesity-associated insulin resistance through PKCε/IRS-1/PI3K/Akt signaling axis in hepatocytes,providing a new strategy for metabolic disease treatment.

The Governing Philosophy,Institutional Building and Policy Choice of the Rwanda Patriotic Front

The sound economic and governance performance in Rwanda has attracted wide attention in the international community.A lot of research into its specific policies has been done to look at the reasons behind the success of Rwanda.From the perspective of party politics,its success can be equated with that of the governance model of a party-centered country.

Classification of Villages in Wan’an County under the Background of Rural Revitalization

Rural revitalization strategy is an important strategic layout of rural development in the new era of the CPC Central Committee,and scientific and reasonable determination of village types is an important measure to promote rural revitalization by classification.The villages of Wan’an County were selected as the research object.Firstly,the factors that have a key impact on the development of the villages were extracted and qualitatively analyzed to preliminarily screen and judge their types.Secondly,the evaluation index system of development potential of the villages was constructed to quantitatively evaluate and reasonably classify the villages.Finally,the spatial distribution characteristics and quantity of different villages were revealed,and differentiated development strategies were proposed.

The Problems and Measures for Small Tourism Town Development in China:A Case Study of Wan Town

With the rapid development of tourism and urbanization in China,small tourism towns gradually grow toward prosperity.This paper takes Wan Town as an example to analyze the problem and countermeasures concerning the development of small tourism towns in China.There are a series of issues in the process of development of Wan Town,which includes uncoordinated architectural style,inaccurate market positioning,repeated cultural themes,and vulnerable linkage of the industrial chain.Based on the factor analysis,these development issues were classified into three categories:confusing architectural style,repetitive cultural theme,and weak linkage of industrial chain.To achieve the goal of sustainable development of small tourism towns,some countermeasures must be taken which include promoting the development of small tourism towns with the new rural revitalization,strengthening services improvement in small tourism towns,gathering industrial elements related to the tourism industry,and increasing tourism cultural connotation.

广西沿海西部山心、巫头和澫尾岛植被类型初步研究

本文概述了在广西沿海西部山心、巫头和尾岛特殊环境条件下植被的性质及主要类型，初步分析了岛屿上主要森林植被群落的基本特点，并根据岛屿上主要植被类型组合、分布及与环境之间的关系，从植物生态学的角度上提出了森林植被恢复的途径。

橡椀单宁降解菌的筛选及降解条件

从自然环境中分离、筛选出了降解橡单宁能力较强的菌株 ,并对该菌株降解单宁的培养条件进行分析。结果表明 ,2 8～ 32℃、pH 4.5培养 8d为橡单宁的最适降解条件。在此条件下 ,对该菌株驯化 ,有效提高了该菌株的耐单宁性及单宁降解率。通过研究外加碳源、氮源及碳氮比对该菌株降解单宁的影响 ,发现这 3个因素均明显影响微生物对单宁的降解。在适宜的培养条件下 ,该降解菌在以葡萄糖为外加碳源 ,以硝酸铵为氮源 ,碳氮比为 1 0∶1的条件下 ,单宁的降解率最高 ,并发现在一定范围内 ,碳氮比高有利于菌株降解单宁 ,而碳氮比低则不利于单宁的降解。

基于Linux系统的IPSec-VPN在IPv6中的研究

介绍了虚拟专用网技术(VPN),并以安全性较强的IP安全(IPSec)协议集来实现。在简述IPSec协议集主要组件的基础上,借鉴IPv4网络中实施VPN的成功经验,提出了在IPv6网络中以IPSec与源码开放的操作系统相集成的方式构建VPN。深入探讨了在Linux平台上如何利用FreeS/WAN实施支持IPv6网络的IPSec虚拟专用网,并依据实验提出了一些建议。

改性橡椀栲胶与非铬金属离子结合鞣

将国产橡椀栲胶进行水解、缩合得到渗透性好、收敛性小的栲胶产品 ,用其与金属离子RE3+ 、Al3+ 、Cr3+ 、Ti4 + 、Zr4 + 构成结合鞣。结合鞣革的粒面平细度很好。耐湿热稳定性较各单独作用时有极大增加。实验表明改性栲胶有好的低pH分散性(pH =4 ) ,缓冲区宽 ,使后继金属离子在改性植鞣革内较未改性时有更好的分布均匀性。

橡椀单宁生物降解动力学研究

研究了微生物菌系对橡单宁的生物降解能力。结果表明 ,其过程符合反应动力学方程L =Lmax(1-e-k(t-t0 ) ;并发现温度是影响降解速率的主要因素 ,在 10～ 35℃范围内 ,温度升高 ,橡单宁的生物降解速率相应增大 ,滞后期相应缩短 ;橡单宁浓度对生物降解滞后期的影响 ,在低温时表现较显著 ,随温度的升高 ,这种影响减弱。

橡椀单宁降解酶产生菌发酵条件

对分离到的一株可产生橡单宁降解酶 ,并有较高鞣花酸产率的曲霉发酵条件进行了研究。结果表明 ,该菌产橡单宁降解酶的适宜培养条件为 :培养液的橡单宁浓度为 5 .0 g L、蔗糖 2 0 g L、蛋白胨 6.0 g L ,起始 pH 5 .0 ,2 5 0mL三角瓶培养液装液量为 1 0 0mL ,30℃、1 2 0r min摇床培养 48h。该酶在 pH为 4.0～ 5 .0、温度 30℃时稳定性最好。