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Dynamic response of wind turbine towers in warm permafrost
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作者 Benjamin Still ZhaoHui (Joey) Yang +1 位作者 Simon Evans FuJun Niu 《Research in Cold and Arid Regions》 CSCD 2014年第5期423-427,共5页
Wind is a great source of renewable energy in western Alaska.Consistent winds blow across the barren tundra underlain by warm permafrost in the winter season,when the energy demand is the highest.Foundation engineerin... Wind is a great source of renewable energy in western Alaska.Consistent winds blow across the barren tundra underlain by warm permafrost in the winter season,when the energy demand is the highest.Foundation engineering in warm permafrost has always been a challenge in wind energy development.Degrading warm permafrost poses engineering issues to design,construction,and operation of wind turbines.This paper describes the foundation design of a wind turbine built in western Alaska.It presents a system for response monitoring and load assessment,and data collected from September 2013 to March 2014.The dynamic properties are assessed based on the monitoring data,and seasonal changes in the dynamic properties of the turbine tower-foundation system and likely resonance between the spinning blades and the tower structure are discussed.These analyses of a wind turbine in warm permafrost are valuable for designing or retrofitting of foundations in warm permafrost. 展开更多
关键词 wind turbine vibration field monitoring warm permafrost
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The Heat Balance in the Western Equatorial Pacific Warm Pool during the Westerly Wind Bursts: A Case Study
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作者 刘海龙 张学洪 李薇 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2001年第5期882-896,共15页
The responses of sea surface temperature (SST) in the western equatorial Pacific warm pool to the westerly wind bursts (WWBs) play an important role in the relationship between WWB and ENSO. By using data collected fr... The responses of sea surface temperature (SST) in the western equatorial Pacific warm pool to the westerly wind bursts (WWBs) play an important role in the relationship between WWB and ENSO. By using data collected from eight buoys of TOGA (Tropical Ocean-Global Atmosphere)- COARE (Coupled Ocean-Atmosphere Response Experiment), the heat balances of the upper ocean in the western equatorial Pacific around 0 degrees, 156 degreesE during two WWB events were calculated according to Stevenson and Niiler's (1983) method. In both events, SST increased before and after the WWBs, while decreased within the WWBs. The SST amplitudes approximated to 1 degreesC. Although sometimes the horizontal heat advections may become the biggest term in the heat balance, the variation of SST was dominated by the surface heat flux. On the other aspect, some different features of the two events are also revealed. The two cases have different variation of mixed layer depth. The depth of mixed layer is almost double in the first case (35 in to 70 m), which is caused by Ekman convergence, while only 10m increments due to entrainment in the second one, There are also differences in the currents structure. The different variations of thermal and currents structure in the mixing layers accounted for the different variation of the heat balance during the two events, especially the advection and residue terms. The seasonal variation of SST in this area is also investigated simply. The first WWB event happened just during the seasonal transition. So we considered that it is a normal season transition rather than a so-called anomaly. That also suggested that the seasonal distinction of the WWB is worthy of more attention in the researches of its relationship to ENSO. 展开更多
关键词 westerly wind burst the western equatorial Pacific warm pool heat balance
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Evolution of Surface Sensible Heat over the Tibetan Plateau Under the Recent Global Warming Hiatus 被引量:8
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作者 Lihua ZHU Gang HUANG +3 位作者 Guangzhou FAN Xia QU Guijie ZHAO Wei HUA 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2017年第10期1249-1262,共14页
Based on regular surface meteorological observations and NCEP/DOE reanalysis data, this study investigates the evolution of surface sensible heat(SH) over the central and eastern Tibetan Plateau(CE-TP) under the r... Based on regular surface meteorological observations and NCEP/DOE reanalysis data, this study investigates the evolution of surface sensible heat(SH) over the central and eastern Tibetan Plateau(CE-TP) under the recent global warming hiatus. The results reveal that the SH over the CE-TP presents a recovery since the slowdown of the global warming. The restored surface wind speed together with increased difference in ground-air temperature contribute to the recovery in SH.During the global warming hiatus, the persistent weakening wind speed is alleviated due to the variation of the meridional temperature gradient. Meanwhile, the ground surface temperature and the difference in ground-air temperature show a significant increasing trend in that period caused by the increased total cloud amount, especially at night. At nighttime, the increased total cloud cover reduces the surface effective radiation via a strengthening of atmospheric counter radiation and subsequently brings about a clear upward trend in ground surface temperature and the difference in ground-air temperature.Cloud–radiation feedback plays a significant role in the evolution of the surface temperature and even SH during the global warming hiatus. Consequently, besides the surface wind speed, the difference in ground-air temperature becomes another significant factor for the variation in SH since the slowdown of global warming, particularly at night. 展开更多
关键词 surface sensible heat Tibetan Plateau ground-air temperature difference surface wind speed global warming hiatus
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Changes in Tropical Cyclone Number in the Western North Pacific in a Warming Environment as Implied by Classical Thermodynamics 被引量:1
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作者 Xiaogang Zhou Chongjian Liu +2 位作者 Ying Liu Hui Xu Xiuming Wang 《International Journal of Geosciences》 2011年第1期29-35,共7页
Observational analyses show that the equatorial trough in the western North Pacific (WNP) is a well-known origin for tropical cyclones (TC) which have tended to weaken in intensity and decrease in number during the la... Observational analyses show that the equatorial trough in the western North Pacific (WNP) is a well-known origin for tropical cyclones (TC) which have tended to weaken in intensity and decrease in number during the last several decades under global warming. A scientific problem then arises as to why higher sea surface temperatures (SSTs), one of the necessary conditions for typhoon genesis, can cause a weakened equatorial trough and a decreased TC number. In this paper, the WNP is taken as an example to illustrate a possible mechanism for the above-mentioned seemingly counterintuitive phenomena and explain the causality between the unusually heterogeneous pattern of SSTs in a warming environment and TC number in the WNP. This mechanism is based substantially on the second law of thermodynamics. 展开更多
关键词 SECOND LAW of THERMODYNAMICS Global warmING Thermal wind Relation Sea Surface Temperature
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UPPER OCEAN RESPONSE TO SURFACE MOMENTUM AND FRESHWATER FLUXES IN THE WESTERN PACIFIC WARM POOL 被引量:4
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作者 Dake Chen 《热带海洋学报》 CAS CSCD 北大核心 2004年第6期1-15,共15页
A series of numerical experiments are carried out to study the tropical upper ocean response to combined momentum and buoyancy forcing, with emphasis on the three-dimensional thermohaline structure in the western Paci... A series of numerical experiments are carried out to study the tropical upper ocean response to combined momentum and buoyancy forcing, with emphasis on the three-dimensional thermohaline structure in the western Pacific warm pool. In response to climatological winds, heat fluxes and freshwater input, the model is able to simulate the salient dynamic and hydrographic features of the tropical Pacific Ocean and their seasonal variability. In response to idealized episodic westerly wind bursts and rainfall, the simulated upper ocean conditions compare favorably with available observations, thus enabling us to identify important physical processes involved. Local forcing, vertical mixing and meridional advection dominate the salt and heat budgets in the warm pool on short time scales, but it is necessary to include the saline water coming from the east with the South Equatorial Current to close the salt budget on seasonal and longer time scales. Strong westerly wind bursts generate a swift eastward equatorial jet and a pair of meridional circulation cells with convergence at the equator. This results in an equatorward advection of relatively fresh water from the north and a depression of the thermocline at the equator. Heavy rainfall reduces the surface mixed layer depth by creating a shallow halocline, thus trapping the momentum and heat inputs near the surface. The remote influences of the episodic momentum and buoyancy fluxes are very different. Westerly wind bursts can generate large downstream disturbances in both dynamic and thermal fields through the propagation of equatorial waves, while the effect of rainfall is mostly confined to the forcing area. 展开更多
关键词 FRESHWATER flux WESTERLY wind BURST western PACIFIC warm POOL
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Warm water wake off northeast Vietnam in the South China Sea 被引量:2
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作者 YAN Yunwei CHEN Changlin LING Zheng 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2014年第11期55-63,共9页
Due to orographic blockage, a weak wind wake occurs in summer off northeast Vietnam in the South China Sea. Under the wind wake, warm water is observed from both high-resolution satellite data and hydrographic observa... Due to orographic blockage, a weak wind wake occurs in summer off northeast Vietnam in the South China Sea. Under the wind wake, warm water is observed from both high-resolution satellite data and hydrographic observations. The wake of warm water forms in June, continues to mature in July and August, starts to decay in September, and disappears in October. The warm water wake also shows robust diurnal variation – it intensifies during the day and weakens in the night. Warm water wakes can be generated through wind-induced mixing and thermal(latent heat flux) processes. In this paper, a mixed layer model is used to evaluate the relative importance of the two processes on seasonal and diurnal timescales, respectively. The results demonstrate that thermal processes make a greater contribution to the wake than wind-induced mixing processes on a seasonal timescale, while the warm water wake is dominated by wind-induced mixing processes on a diurnal timescale. 展开更多
关键词 warm water wake wind-induced mixing processes thermal processes seasonal timescale diurnal timescale northeast Vietnam South China Sea
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Case analysis of water exchange between the Bohai and Yellow Seas in response to high winds in winter 被引量:1
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作者 JU Xia MA Chao +1 位作者 YAO Zhigang BAO Xianwen 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2020年第1期30-41,共12页
Based on the data from a special project titled China's Offshore Marine Integrated Investigation and Evaluation as well as Regional Ocean Modeling Systems(ROMS)diagnostic numerical model,we studied the influence o... Based on the data from a special project titled China's Offshore Marine Integrated Investigation and Evaluation as well as Regional Ocean Modeling Systems(ROMS)diagnostic numerical model,we studied the influence of high wind processes on the circulation and water exchange between the Bohai and Yellow Seas(BYS)in winter.The results show that the vertical structure of the Yellow Sea Warm Current(YSWC)is relatively uniform under condition of high winds,showing obvious barotropic features.However,this flow is not a stable mean flow,showing strong paroxysmal and reciprocating characteristics.A comparison of the changes in sea level suggests that the intensity of the northwards upwind flow is consistent with the abnormal fluctuations in the sea level.It indicates that the upwind flow is closely related to the water exchange between the BYS.The impact of high wind processes on the water exchange between the BYS is enormous.It can make the flux through the Bohai Strait,as well as that through the mouth of each constituent bay(i.e.,Liaodong Bay,Bohai Bay,and Laizhou Bay)far greater than usual,resulting in a significant increase in the water exchange rate.The exchange capacity,which is about 8%of the total volume of the Bohai Sea,can be completed in a few days.Therefore,the water exchange of the Bohai Sea may be completed by only a few occasional high wind processes in winter. 展开更多
关键词 HIGH wind YELLOW SEA warm Current (YSWC) SEA level RISE or drop water exchange
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Anomalous eastward displacement of the tropical western Pacific warm pool and warming of the tropical eastern Pacific
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作者 Long Baosen Li Bocheng and Zou Emei 《Acta Oceanologica Sinica》 SCIE CAS CSCD 1999年第1期49-54,5-58,共10页
Based on the data from the Climate Diagnostics Bulletin, Oceanographic Monthly Summary, UH Sea Level Center and TOGA─COARE IOP, the response of warm pool in the tropical western Pacific and the tropical eastern Pacif... Based on the data from the Climate Diagnostics Bulletin, Oceanographic Monthly Summary, UH Sea Level Center and TOGA─COARE IOP, the response of warm pool in the tropical western Pacific and the tropical eastern Pacific SST to the anomalous wind field during 1992/1993 EI Nino has been analyzed. The results show that the eastward transport of warm water of the tropical western Pacific due to the westerly wind burst leads not only to a drop of sea level but also to a raise of thermocline in the tropical western Pacific. Consequently the heat content in upper layer water decreases especially in the thermocline. Contrary to this, the positive anomalies Of heat content and thermocline depth appear in the tropical eastern Pacific. The positive anomalies in the eastern Pacific lag the negative ones in the western Pacific by two months; The anomalous eastward shift of warm pei (28℃isotherm) is a direct response of ocean current to westerly wind anomalies in low-level atmosphere; quantitative calculations show that the thermal advection caused by anomalous ocean current is the main force of anomalous eastward displacement of the warm pool (28℃isotherm) and the one of main causes for anomalous warming of the tropical eastern Pacific. 展开更多
关键词 warm pool westerly wind burst thermal advection EI Nino
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1980—2016年中国北方风蚀气候侵蚀力的变化
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作者 刘伟 邹学勇 +2 位作者 刘博 王汝幸 王祖正 《地理科学》 CSSCI CSCD 北大核心 2024年第4期703-710,共8页
随着修订风蚀方程(RWEQ)的提出,采用增加了冻结因子的气候因子(WF)表达风蚀气候侵蚀力更具有科学性和必要性。基于中国北方风蚀区157个气象站1980—2016年的观测数据,逐月计算了各站点气候因子,并探讨了气候因子时空分布变化特征及影响... 随着修订风蚀方程(RWEQ)的提出,采用增加了冻结因子的气候因子(WF)表达风蚀气候侵蚀力更具有科学性和必要性。基于中国北方风蚀区157个气象站1980—2016年的观测数据,逐月计算了各站点气候因子,并探讨了气候因子时空分布变化特征及影响因素。结果表明:①1980—1997年,年气候因子值表现为快速下降,从940.46 kg/m下降到273.03 kg/m;而1998—2016年,年气候因子值表现相对稳定,在139.81~398.85 kg/m范围内波动。②春季气候因子值约占全年63%,其变化也显著高于其它季节,这也是土壤风蚀发生在春季的主要原因。③气候因子的高值区分布在新疆东部、青海西部、40°N以北的内蒙古中西部,这与气压中心和高大山体地形分布有关。 展开更多
关键词 气候因子 土壤风蚀 全球变暖 北方风蚀区
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Statistical Examination of Frost Characterization: A Case of Global Warming Impact in Jordan
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作者 Moshrik R Hamdi Mahmoud Abu Alaban Mohammed Jaber 《Journal of Water Resource and Protection》 2011年第8期620-627,共8页
Radiation and advection frost are common in Jordan as well as other neighboring countries as they face several frost waves each year during the late months of winter. Recently, many frost episodes hit the valley and d... Radiation and advection frost are common in Jordan as well as other neighboring countries as they face several frost waves each year during the late months of winter. Recently, many frost episodes hit the valley and damaged the crops that were compensated by millions of dollars by the Jordanian Government. This manuscript addresses and characterizes frost, and assesses the role of global warming in impacting frost in terms of its frequency, severity, and total number of frost days per year. A comprehensive statistical approach was used. The paper indicates that frost waves will continue to hit in the near future regardless of the fact that Earth is moving towards warmer conditions. Agricultural and financial authorities should be urged to minimize frost damage by considering installing wind fans in Jordan valley as an active method in addition to implementing good farm practices (as a passive methods where deemed necessary). 展开更多
关键词 Global warmING FROST JORDAN MIDDLE East wind Machine JORDAN VALLEY Trend Analysis
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温阳宣肺祛风法辨治白癜风经验 被引量:1
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作者 王远红 李奕辰 +3 位作者 葛连佳 王泽芸 杨锐 王绍莹 《辽宁中医杂志》 CAS 北大核心 2024年第6期23-26,共4页
白癜风是皮肤科较为常见的色素脱失性疾病,易诊难治。作者在总结前人经验的基础上,结合自身多年临床认为,白癜风实为本虚标实之证。于内以“阳虚”体质为发病基础,于外以感受“风邪”为致病关键,提出以“温阳宣肺祛风法”治疗白癜风,并... 白癜风是皮肤科较为常见的色素脱失性疾病,易诊难治。作者在总结前人经验的基础上,结合自身多年临床认为,白癜风实为本虚标实之证。于内以“阳虚”体质为发病基础,于外以感受“风邪”为致病关键,提出以“温阳宣肺祛风法”治疗白癜风,并自拟中药方剂“扫白茴风丸”,在临床中取得满意成效。文章从病因病机、治法方药两方面阐释了温阳宣肺祛风法辨治白癜风的经验,并附验案一则,以期为中医药治疗白癜风拓宽思路。 展开更多
关键词 温阳宣肺祛风法 白癜风 扫白茴风丸 证治经验
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台风右侧暖涡对台风“鲇鱼”的响应
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作者 李晟 宣基亮 黄大吉 《海洋学研究》 CSCD 北大核心 2024年第2期1-14,共14页
基于多源观测数据,分析了台风右侧暖涡对2010年南海台风“鲇鱼”的响应,发现了意料之外的暖涡增强和海水下沉现象。台风“鲇鱼”过境期间,暖涡海面高度距平(SLA)最大值从30 cm增加至36 cm、半径从78 km增大至116 km、涡动能从166 m^(2)s... 基于多源观测数据,分析了台风右侧暖涡对2010年南海台风“鲇鱼”的响应,发现了意料之外的暖涡增强和海水下沉现象。台风“鲇鱼”过境期间,暖涡海面高度距平(SLA)最大值从30 cm增加至36 cm、半径从78 km增大至116 km、涡动能从166 m^(2)s^(2)增加至303 m^(2)s^(2)、振幅从3 cm增大至9 cm,台风右侧暖涡边缘的Argo站位处温跃层海水下沉20~40 m。为此,诊断分析了台风风应力旋度对暖涡的单独作用,结果显示暖涡及暖涡边缘的Argo站位处总体受正风应力旋度作用,正风应力旋度将使暖涡减弱、温跃层抬升,与观测到的暖涡增强和海水下沉结果不符。而基于实际海面流场的诊断分析表明,台风“鲇鱼”过境期间台风路径下方的海水辐散,路径右侧暖涡区域海水辐聚,暖涡SLA最大值、涡旋振幅均与辐聚强度呈正相关,Argo站位处海水下沉29 m,都与观测结果相符。个例分析研究表明,位于台风路径外围的中尺度涡对台风的响应不仅受风应力旋度的作用,还受海洋背景环境条件的调制,存在着需要深入研究的过程和机制。 展开更多
关键词 台风 暖涡 增强 风应力 辐聚
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铜砭循经温刮术治疗风寒瘀阻型颞下颌关节紊乱征的疗效观察
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作者 翁仙明 王舒洁 +1 位作者 黄双英 汪永坚 《浙江临床医学》 2024年第10期1524-1525,1530,共3页
目的探讨铜砭循经温刮术治疗风寒瘀阻型颞下颌关节紊乱征的疗效。方法选取2022年2月至2023年6月期间在本院确诊为颞下颌关节紊乱征且辨证为风寒瘀阻型患者78例,根据随机数字表法分成观察组40例和对照组38例。对照组采用常规护理及热敷... 目的探讨铜砭循经温刮术治疗风寒瘀阻型颞下颌关节紊乱征的疗效。方法选取2022年2月至2023年6月期间在本院确诊为颞下颌关节紊乱征且辨证为风寒瘀阻型患者78例,根据随机数字表法分成观察组40例和对照组38例。对照组采用常规护理及热敷。观察组在对照组基础上采用铜砭循经温刮技术。比较两组患者治疗前后Fricton颞下颌关节指数(CMI)量表评分、视觉模拟评分法(VSA)评分及疗效。结果治疗后,两组CMI评分、VAS评分均较前改善,观察组比对照组改善明显(P<0.05);观察组总有效率为90.00%,对照组总有效率为84.21%,两组比较差异有统计学意义(P<0.05)。结论铜砭循经温刮技术能明显改善风寒瘀阻型颞下颌关节紊乱征疼痛、弹响、下颌运动功能障碍等症状。 展开更多
关键词 铜砭 循经温刮 风寒瘀阻型 颞下颌关节紊乱征
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全球变暖背景下中国海域风速长期变化趋势分析及风资源评估
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作者 徐杰 胡玉植 +2 位作者 李江夏 朱博渊 任宁丹 《海洋科学进展》 CAS CSCD 北大核心 2024年第2期269-280,共12页
采用第六阶段国际耦合模式比较计划(Coupled Model Intercomparison Project Phase 6,CMIP6)数据对未来我国海域风速长期变化趋势进行分析,并评估风能资源分布的变化。研究表明SSP126、SSP245、SSP370和SSP585共四种代表性情景下,2015—... 采用第六阶段国际耦合模式比较计划(Coupled Model Intercomparison Project Phase 6,CMIP6)数据对未来我国海域风速长期变化趋势进行分析,并评估风能资源分布的变化。研究表明SSP126、SSP245、SSP370和SSP585共四种代表性情景下,2015—2100年东海风速呈显著减小趋势;南海海域风速随外辐射强迫的增加呈显著增长趋势;黄海、渤海地区增长趋势较弱。未来南海北部海域风功率密度显著增加,相对历史数据最大增长12%,东海则有所下降,最大降幅为11%。4种代表性情景下,近岸风能总体变化较小,随着人为辐射强迫增加呈现略减小趋势,长江口附近海域风功率密度及年均风能随外辐射强迫增加而出现较为明显下降,黄海、渤海、南海沿岸大多基本维持不变。 展开更多
关键词 全球变暖 CMIP6 ScenarioMIP 风速 风能 趋势分析
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中医药治疗社区获得性肺炎的研究进展
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作者 刘苗 肖顺琼 +2 位作者 张瑞彬 范森稷 毛伟旭 《医学综述》 CAS 2024年第24期3012-3016,共5页
社区获得性肺炎(CAP)是常见的呼吸道感染疾病之一。近年来,随着病原体变迁、混合感染日益增加、耐药菌增加、全球老龄化、合并慢性疾病等相关因素的影响,CAP的发病率逐年上升。目前,西医对于CAP主要采取抗感染治疗,但抗生素滥用导致的... 社区获得性肺炎(CAP)是常见的呼吸道感染疾病之一。近年来,随着病原体变迁、混合感染日益增加、耐药菌增加、全球老龄化、合并慢性疾病等相关因素的影响,CAP的发病率逐年上升。目前,西医对于CAP主要采取抗感染治疗,但抗生素滥用导致的耐药菌增加,菌株变异、多重细菌感染等问题突出,因此正确选择抗菌药物、减少耐药发生、降低非重症肺炎进展为危重症肺炎风险、降低再住院率成为当前临床医师面临的重大挑战。而中医药在应对抗生素滥用和耐药方面有一定优势,临床可选用经方(麻杏石甘汤、清金化痰汤、小青龙汤等)、经验方、中医外治法(如穴位敷贴)等治疗CAP,且均已取得一定进展。未来可挖掘更多用于治疗CAP的经典名方,以为临床治疗CAP提供参考。 展开更多
关键词 社区获得性肺炎 风温肺热病 中医药治疗
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穴位贴敷联合综合护理在风温肺热型肺炎患者中的应用效果分析
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作者 项良 《中国社区医师》 2024年第26期118-120,共3页
目的:分析穴位贴敷联合综合护理在风温肺热型肺炎患者中的应用效果。方法:选择2022年1月—2023年1月泰兴市中医院收治的89例风温肺热型肺炎患者作为研究对象,采用随机数字表法分为综合组(n=45)、参照组(n=44)。参照组采用穴位贴敷联合... 目的:分析穴位贴敷联合综合护理在风温肺热型肺炎患者中的应用效果。方法:选择2022年1月—2023年1月泰兴市中医院收治的89例风温肺热型肺炎患者作为研究对象,采用随机数字表法分为综合组(n=45)、参照组(n=44)。参照组采用穴位贴敷联合常规护理,综合组采用穴位贴敷联合综合护理。对比两组干预效果。结果:综合组护理总有效率高于参照组(P<0.05)。干预前,两组中医症状积分对比,无统计学差异(P>0.05);干预1周后,两组中医症状积分降低,且综合组低于参照组(P<0.05)。综合组咳嗽消失时间、体温恢复正常时间、肺部啰音消失时间早于参照组(P<0.05)。结论:穴位贴敷联合综合护理在风温肺热型肺炎患者中的应用效果显著,可改善护理效果,减轻患者症状,加快患者康复。 展开更多
关键词 肺炎 风温肺热型 穴位贴敷 综合护理
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祛风扶阳汤对支气管哮喘大鼠TGF-β_(1)/Smad信号通路与Th17/Treg失衡的影响
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作者 范彩虹 张豪杰 姚梓平 《现代中西医结合杂志》 CAS 2024年第17期2364-2370,共7页
目的观察祛风扶阳汤对支气管哮喘大鼠气道炎症、气道重塑、转化生长因子-β_(1)(TGF-β_(1))/Smad信号通路及辅助性T细胞17(Th17)/调节性T细胞(Treg)失衡的影响,探究其作用及机制。方法将45只SD大鼠随机分为空白组、哮喘组、地塞米松组... 目的观察祛风扶阳汤对支气管哮喘大鼠气道炎症、气道重塑、转化生长因子-β_(1)(TGF-β_(1))/Smad信号通路及辅助性T细胞17(Th17)/调节性T细胞(Treg)失衡的影响,探究其作用及机制。方法将45只SD大鼠随机分为空白组、哮喘组、地塞米松组、祛风扶阳汤中剂量组、祛风扶阳汤高剂量组,每组9只。除空白组外,其余组大鼠均采用卵蛋白腹腔注射和雾化吸入方法建立支气管哮喘模型。建模成功后,地塞米松组给予地塞米松0.001 g/kg灌胃,祛风扶阳汤中、高剂量组分别给予祛风扶阳汤9.95 g/kg和19.9 g/kg灌胃,空白组和哮喘组灌胃等量生理盐水,均1次/d,连续灌胃4周。记录各组大鼠末次灌胃后咳嗽次数,HE染色观察肺组织病理形态,ELISA法检测肺泡灌洗液中白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、白细胞介素-17A(IL-17A)、TGF-β_(1)水平,Western blot法检测肺组织中TGF-β_(1)、α-平滑肌肌动蛋白(α-SMA)、Smad2/3、p-Smad2/3蛋白表达情况,流式细胞仪检测肺组织中IL-17A^(+)CD4^(+)、CD4^(+)CD25^(+)Foxp3^(+)Treg比例。结果与空白组比较,哮喘组大鼠咳嗽次数明显增加(P<0.05),肺泡灌洗液中IL-6、IL-17A、TGF-β_(1)水平和肺组织中TGF-β_(1)、α-SMA、p-Smad2/3蛋白相对表达量及IL-17A^(+)CD4^(+)比例均明显升高(P均<0.05),肺泡灌洗液中IL-10水平和肺组织中CD4^(+)CD25^(+)Foxp3^(+)Treg比例均明显降低(P均<0.05);肺组织胶原纤维沉积、炎性细胞浸润明显。与哮喘组比较,各药物组大鼠的咳嗽次数均明显减少(P均<0.05),地塞米松组和祛风扶阳汤高剂量组肺泡灌洗液中IL-6、IL-17A、TGF-β_(1)水平和肺组织中TGF-β_(1)、α-SMA、p-Smad2/3蛋白相对表达量及IL-17A^(+)CD4^(+)比例均明显降低(P均<0.05),地塞米松组和祛风扶阳汤高剂量组肺泡灌洗液中IL-10水平和祛风扶阳汤高剂量组肺组织中CD4^(+)CD25^(+)Foxp3^(+)Treg比例均明显升高(P均<0.05);各药物组肺组织损伤、胶原纤维沉积、炎性细胞浸润均减轻。结论祛风扶阳汤可以通过调节TGF-β_(1)/Smad信号通路以及Th17/Treg细胞平衡,从而减轻支气管哮喘大鼠气道炎症反应与气道重塑。 展开更多
关键词 哮喘 祛风扶阳汤 转化生长因子-β_(1)/Smad信号通路 辅助性T细胞17 调节性T细胞
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温针灸联合西药治疗风寒袭络型周围性面瘫疗效观察及对面神经功能、表情肌弹性的影响
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作者 龚杰 徐密密 +2 位作者 潘宁芳 潘亚英 柴晓萍 《新中医》 CAS 2024年第17期103-108,共6页
目的:观察温针灸联合西药治疗风寒袭络型周围性面瘫的疗效及对面神经功能和表情肌弹性的影响。方法:选取94例周围性面瘫患者,按随机数字表法分为观察组及对照组各47例。对照组予以西药治疗,观察组在对照组基础上实施温针灸治疗。2组疗... 目的:观察温针灸联合西药治疗风寒袭络型周围性面瘫的疗效及对面神经功能和表情肌弹性的影响。方法:选取94例周围性面瘫患者,按随机数字表法分为观察组及对照组各47例。对照组予以西药治疗,观察组在对照组基础上实施温针灸治疗。2组疗程均为2周。比较2组临床疗效,比较2组治疗前后中医证候评分、面肌表面肌电图指标值、面动脉血流动力学指标值[面动脉舒张末期流速(Vd)、收缩期峰值流速(Vs)、阻力指数(RI)]、表情肌弹性模量值、House-Brackmann(H-B)评分、面部残疾指数躯体功能评分(FDIS)的变化。结果:观察组临床疗效总有效率为95.74%,对照组为82.98%,2组临床疗效比较,差异有统计学意义(P<0.05)。治疗后,2组口角歪斜、面肌瘫痪、眼不能闭、鼻唇沟变浅、味觉减退、耳后疼痛中医证候评分均较治疗前下降(P<0.05),观察组上述6项评分均低于对照组(P<0.05)。治疗后,2组额肌、眼轮匝肌、口轮匝肌表面肌电信号潜伏期均较治疗前缩短,波幅均较治疗前增大,差异均有统计学意义(P<0.05);观察组上述3项表面肌电信号潜伏期均短于对照组,波幅均高于对照组,差异均有统计学意义(P<0.05)。治疗后,2组患侧面动脉Vd、Vs指标值均较治疗前升高,RI指标值均较治疗前下降,差异均有统计学意义(P<0.05);观察组Vd、Vs指标值均高于对照组(P<0.05),RI指标值低于对照组(P<0.05)。治疗后,2组额肌、降口角肌、降下唇肌弹性模量值均较治疗前增加(P<0.05),观察组上述3项弹性模量值均高于对照组(P<0.05)。治疗后,2组H-B评分均较治疗前下降,FDIS评分均较治疗前升高,差异均有统计学意义(P<0.05);观察组H-B评分低于对照组,FDIS评分高于对照组,差异均有统计学意义(P<0.05)。结论:温针灸联合西药治疗风寒袭络型周围性面瘫可改善血液循环和面神经功能,恢复表情肌弹性,缓解临床症状。 展开更多
关键词 周围性面瘫 风寒袭络型 温针灸 面神经 面肌 弹性模量值
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麻杏石甘汤加减治疗风温肺热病痰热壅肺证临床分析
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作者 魏金冰 《中国医药指南》 2024年第5期118-120,共3页
目的研究麻杏石甘汤加减治疗风温肺热病痰热壅肺证临床效果。方法选取将乐县中医院于2021年1月至2022年12月收治的风温肺热病痰热壅肺证患者220例,采用随机数字表法将患者分为对照组(110例)和观察组(110例),对照组根据细菌培养药敏试验... 目的研究麻杏石甘汤加减治疗风温肺热病痰热壅肺证临床效果。方法选取将乐县中医院于2021年1月至2022年12月收治的风温肺热病痰热壅肺证患者220例,采用随机数字表法将患者分为对照组(110例)和观察组(110例),对照组根据细菌培养药敏试验结果给予抗生素治疗,观察组联用麻杏石甘汤加减治疗。对比两组治疗效果。结果观察组使用抗生素治疗联合麻杏石甘汤加减治疗患者总有效率、最大呼气压、最大吸气压、呼气峰流量均高于对照组(均P<0.05);观察组患者胸部X线渗出性完全吸收占比高于对照组,吸收70%、吸收50%、吸收30%占比均低于对照组(均P<0.05);观察组患者住院时间、发热退却时间、咳痰消失时间、咳嗽消失时间均短于对照组,每日住院费用低于对照组(均P<0.05);治疗后,观察组患者白细胞计数、血清胱抑素C、超敏C反应蛋白水平等炎症因子水平,发热、咳嗽、咳痰等中医证候积分均低于对照组(均P<0.05)。结论麻杏石甘汤加减治疗风温肺热病痰热壅肺证可缩短治疗时间,改善通气情况,减轻炎性反应,缓解疾病症状,有效率高,临床效果好。 展开更多
关键词 风温肺热病 痰热壅肺证 麻杏石甘汤 中医证候积分
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游走罐疗法在小儿邪在卫分型风温病中的临床效果
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作者 许新连 周晓翠 刘丽荣 《中外医药研究》 2024年第22期87-89,共3页
目的:观察游走罐疗法在小儿邪在卫分型风温病中的临床效果。方法:选取2022年6月—2023年9月惠州市中医医院收治的邪在卫分型风温病患儿60例作为研究对象,采用随机数字表法分为对照组和观察组,各30例。对照组接受标准对症治疗,观察组加... 目的:观察游走罐疗法在小儿邪在卫分型风温病中的临床效果。方法:选取2022年6月—2023年9月惠州市中医医院收治的邪在卫分型风温病患儿60例作为研究对象,采用随机数字表法分为对照组和观察组,各30例。对照组接受标准对症治疗,观察组加用游走罐疗法治疗。比较两组退热时间、治疗总有效率、中医证候评分。结果:观察组退热时间短于对照组,差异有统计学意义(P=0.001)。观察组治疗总有效率高于对照组,差异有统计学意义(P=0.037)。治疗前,两组中医证候评分比较,差异无统计学意义(P>0.05);治疗后,两组中医证候评分均低于治疗前,观察组低于对照组(P<0.001)。结论:游走罐疗法在小儿邪在卫分型风温病中的应用效果较好,可缩短小儿外感发热时间,减轻患儿症状。 展开更多
关键词 游走罐 邪在卫分型 风温病
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