Tracking direct and indirect impact on technology and policy of transformative research via ego citation network

Purpose:The disseminating of academic knowledge to nonacademic audiences partly relies on the transition of subsequent citing papers.This study aims to investigate direct and indirect impact on technology and policy originating from transformative research based on ego citation network.Design/methodology/approach:Key Nobel Prize-winning publications(NPs)in fields of gene engineering and astrophysics are regarded as a proxy for transformative research.In this contribution,we introduce a network-structural indicator of citing patents to measure technological impact of a target article and use policy citations as a preliminary tool for policy impact.Findings:The results show that the impact on technology and policy of NPs are higher than that of their subsequent citation generations in gene engineering but not in astrophysics.Research limitations:The selection of Nobel Prizes is not balanced and the database used in this study,Dimensions,suffers from incompleteness and inaccuracy of citation links.Practical implications:Our findings provide useful clues to better understand the characteristics of transformative research in technological and policy impact.Originality/value:This study proposes a new framework to explore the direct and indirect impact on technology and policy originating from transformative research.

Degradation of FAK-targeting by proteolytic targeting chimera technology to inhibit the metastasis of hepatocellular carcinoma

Liver cancer is a prevalent malignant cancer,ranking third in terms of mortality rate.Metastasis and recurrence primarily contribute to the high mortality rate of liver cancer.Hepatocellular carcinoma(HCC)has low expression of focal adhesion kinase(FAK),which increases the risk of metastasis and recurrence.Nevertheless,the efficacy of FAK phosphorylation inhibitors is currently limited.Thus,investigating the mechanisms by which FAK affects HCC metastasis to develop targeted therapies for FAK may present a novel strategy to inhibit HCC metastasis.This study examined the correlation between FAK expression and the prognosis of HCC.Additionally,we explored the impact of FAK degradation on HCC metastasis through wound healing experiments,transwell invasion experiments,and a xenograft tumor model.The expression of proteins related to epithelial-mesenchymal transition(EMT)was measured to elucidate the underlying mechanisms.The results showed that FAK PROTAC can degrade FAK,inhibit the migration and invasion of HCC cells in vitro,and notably decrease the lung metastasis of HCC in vivo.Increased expression of E-cadherin and decreased expression of vimentin indicated that EMT was inhibited.Consequently,degradation of FAK through FAK PROTAC effectively suppressed liver cancer metastasis,holding significant clinical implications for treating liver cancer and developing innovative anti-neoplastic drugs.

Revolutionizing Healthcare—The Integration of Virtual Worlds, AR, and Metaverse Technology

This paper explores the transformative impact of virtual worlds, augmented reality (AR), and the metaverse in the healthcare sector. It delves into the ways these technologies are reshaping patient care, medical education, and research, while also addressing the challenges and opportunities they present. The paper highlights the potential benefits of these technologies and emphasizes the need for comprehensive regulatory frameworks and ethical guidelines to ensure responsible integration. Finally it outlines their transformative impact and discusses the challenges and opportunities they present for the future of healthcare provision.

A Deep Dive into the Trajectory and Transformation of Fintech in Colombia Through the Case of PTM Colombia-A Secondary Publication

This research focuses on analyzing and understanding the evolution and impact of fintech companies in Colombia,using PTM Colombia as a case study,a company that has undergone a significant transformation from its beginnings as a provider of physical recharges to its current position.as a comprehensive platform for digital financial services.The current research uses a qualitative descriptive approach and emphasizes understanding the perceptions and experiences in the field of Fintech in Colombia,particularly in the case of PTM Colombia.The study revealed that adaptability and customer orientation have been fundamental in the evolution of PTM,allowing the company to expand its range of services by actively listening to the needs of its users and adjusting its strategies accordingly.In addition,an accelerated and diversified growth of Fintech will be observed in Colombia,particularly in sectors such as credit and payments,driven by a constantly advancing technological environment and a regulatory framework that,although it presents challenges,also offers opportunities for financial innovation.This growth has impacted the traditional banking sector,which,instead of being replaced by Fintech,is finding new forms of collaboration and coexistence that benefit both parties and,above all,the end consumer.In conclusion,the study highlights how Fintech in Colombia,represented by cases such as PTM,is redefining the financial landscape through the adoption of advanced technologies,collaboration with traditional banking,and strong customer orientation.

Science and Technology Backyard: A novel model for technology innovation and agriculture transformation towards sustainable intensification

Science and Technology Backyard(STB) is an integrated platform for technology innovation, knowledge transfer, people training and agricultural transformation towards sustainable intensification. STB professors, graduate students and extension workers lived and worked together with smallholder farmers in rural areas.

Research Progress of On-line Monitoring Technology for Electromagnetic Environment of Power Transmission and Transformation Projects

Based on the collection of relevant literature and cases,the research and application status of on-line monitoring technology for electromagnetic environment of power transmission and transformation projects at home and abroad were introduced.Moreover,the problems existing in the on-line monitoring of electromagnetic environment were expounded,and the development prospect was forecasted.

Tetracycline-Based Binary Ti Vectors pLSU with Efficient Cloning by the Gateway Technology for <i>Agrobacterium tumefaciens</i>-Mediated Transformation of Higher Plants

We constructed small high-yielding binary Ti vectors with a bacterial tetracycline resistance gene to facilitate efficient cloning afforded by the Gateway Technology (Invitrogen) for Agrobacterium tumefaciens-mediated transformation of higher plants. The Gateway Technology vectors are kanamycin-based, thus tetracycline-based destination and expression vectors are easily selected for the antibiotic resistance in the Escherichia coli media. We reduced the size of the tetracycline resistance gene TetC from pBR322 to 1468 bp containing 1191 bp of the coding region, 93 bp of 5’-upstream, and 184 bp 3’-downstream region. The final size of binary Ti vector skeleton pLSU11 is 5034 bp. pLSU12 and 13 have the kanamycin resistance NPTII gene as a plant-selectable marker. pLSU13?and 15 contain the hygromycin resistance HPH gene as a selection marker. pLSU13 and 15 also have the β-glucuronidase (GUS) reporter gene in addition to the plant selection marker. We also constructed a mobilizable version of tetracycline-based binary Ti vector pLSU16 in which the mob function of ColE1 replicon was maintained for mobilization of the binary vector from E. coli to A. tumefaciens by tri-parental mating. The final size of binary Ti vector skeleton pLSU16 is 5580 bp. New tetracycline- based binary Ti vectors pLSU12 were found as effective as kanamycin-based vector pLSU2 in promoting a 10-fold increase in fresh weight yield of kanamycin-resistant calli after A. tumefaciens-mediated transformation of tobacco leaf discs. Using the Gateway Technology we introduced the plant-expressible GUSgene to the T-DNA of binary Ti vector pLSU12. Expression of the β-glucuronidase enzyme activity was demonstrated by histochemical staining of the GUS activity in transformed tobacco leaf discs.

What Drives China’s Transformational Growth:Technology,Efficiency or Factor Cost?

With rising costs of capital, labor and energy, cost efficiency and cost management have become important questions confronting the next stage of China＇s economic growth. By building a parametric cost frontier model using panel data, this paper investigates the drivers of economic growth transformation from a cost perspective. According to our research, among various effects triggering corporate cost variations and in addition to the expansion of production scale, the largest effect is from technological progress, followed by the effect of factor price adjustment and the effect of efficiency gains. Within the decomposition of factor price adjustment effect, the energy factor effect is the most significant. Furthermore, energy price fluctuations are likely to become major factors restricting saving-based growth. Further study reveals that both the ownership reform and opening up of SOEs are favorable to reducing the costs generated by inefficiency. This paper provides empirical evidence for the driving mechanism of saving-based growth transformation as well as empirical evidence to support to the further deepening of property rights and market-oriented reforms.

Transformation of Modern Chinese Architectural Form and Its Influence on the Protection of Contemporary Chinese Architectural Heritage

Architecture is a fascinating and complex mixture of cultural practices.Different cultures are intertwined to form a new system.The relationship between Chinese native architecture and Western construction methods in the development of Chinese construction from 1840 to 1937 is inspected.Based on Chinese and British sources,special attention is paid to building materials and different aspects of the building process.The research shows that the complex interaction in shaping Chinese architecture has led to a new style and a new construction method,which combines the characteristics of two systems in material supply and use,construction technology,builder organization,tools used and the education received.In the construction and protection related to integration and conflict,the development of contemporary China's emerging construction protection industry is similar to the history of modern Chinese architecture.

Water-saving Technologies,Solar Green House and Ecological Rehabilitation in Minqin Oasis of Gansu Province,China

Land degradation and desertification have become severe environmental problems in arid areas due to excessive use of water resources. It is urgent to reduce agricultural water use for ecological rehabilitation, which may result in a decrease in agricultural production and farmer＇s welfare. This paper focused on the impacts of some main measures including extensions of watersaving irrigation, expanding solar green house and increasing off-farm employment, which are generally recognized to be important to alleviate water shortage and poverty. A bioconomic model is applied taking Minqin Oasis in Gansu Province as a case study site. Simulation results showed that the effect of expanding solar greenhouse was more positive than other ones so it drew more attention. On the view of the different effects between each irrigation zone, mixed policy patterns suitable for them are suggested. In Baqu, expanding solar greenhouse should be the most important, auxiliary with encouraging pipe irrigation. Inversely, with regard to Quanshan, the major attention should be paid to subsidy for pipe irrigation and it would be better to supply the off-farm employment opportunities to the households in Huqu, where the expanding of solar greenhouse should also be summoned. Finally, it should be noted that farmer＇s income would only resume to 90% of the current level in the short run by putting more effort into local policies. Thus, the ecological compensation is needed to ensure farmer＇s welfare.

Design Index and Empirical Analysis of the Evaluation Index System for the Transformation of Scientific and Technological Achievements of Universities in Beijing, Tianjin and Hebei

Promoting the transformation of scientific and technological achievements of universities and colleges in Beijing, Tianjin, and Hebei is an important measure to enhance the level of scientific and technological development in universities, enhance the scientific and technological synergy of Beijing-Tianjiii-Hebei urban agglomeration, practice the coordinated development strategy of Beijing, Tianjin and Hebei, and promote the construction of Xiong'an New District. Based on the scientific and technological input of colleges and universities, the development of science and technology and the output of science and technology, this paper uses Delphi and AHP to construct a Beijing, Tianjin, Hebei University Science and Technology Achievement Transformation Performance Evaluation System from the perspectives of transformation potentials, scientific research activities and achievements transformation of university scientific and technological achievements. An empirical analysis was carried out to provide reference for the government's efficient decision-making and improvement of strategies for transforming scientific and technological achievements in universities.

Coupling effect on the thermal hazard assessment of hazardous chemical materials via calorimetric technologies and simulation approaches

The coupling effect of heat absorption and release exists in the thermal decomposition of a few chemical materials.However,the impact of the above coupling on thermal hazard assessment is not considered in the literature studies.In this work,nitroguanidine(NQ)and 1,3,5-trinitro-1,3,5-triazine(RDX)are selected as representative materials to explore the influence of the coupling effect on the thermal hazard assessment of chemical materials.The linear heating experiments of NQ and RDX are carried out by a microcalorimeter and synchronous thermal analyser.The thermal decomposition curves are decoupled by advanced thermokinetics software.The thermal decomposition and kinetic parameters before and after decoupling are calculated.The results of TG experiment show that both NQ and RDX began to lose mass during the endothermic stage.The endothermic melting and exothermic decomposition of NQ and RDX are coupled within this stage.The coupling effect has different degrees of influence on its initial decomposition temperature and safety parameters.Compared with the parameters in the coupling state,the initial decomposition temperature and adiabatic induction period after decoupling decrease.The self-accelerating decomposition temperature increases,and internal thermal runaway time decreases.In the thermal hazard assessment of chemical materials with coupling effects,the calculated parameters after decoupling should be taken as an important safety index。

Coupling Relationship Among Technological Innovation,Industrial Transformation and Environmental Efficiency:A Case Study of the Huaihai Economic Zone,China

The 14th Five-Year Plan period is a critical period for China to achieve high-quality development. Based on super-efficiency slacks-based measure(SBM) model, grey-related analysis(GRA) and other models, this paper studies the heterogeneity of the coupling relationship among technological innovation, industrial transformation and environmental efficiency in the Huaihai Economic Zone during the period of 2005-2019. In addition, it analyzes the coupling mechanism of single and binary systems to the ternary system, which is of great significance for the collaborative symbiosis among systems. The findings are as follows. 1) The technological innovation, industrial transformation and environmental efficiency(TIE) systems of the Huaihai Economic Zone had significant spatial-temporal heterogeneity. Although their evaluation value fluctuated, the development trends are all positive. Ultimately, technological innovation is characterized by being high in the northeast and low in the southwest around Xuzhou, while other systems are relatively staggered in space. 2) The coupling of TIE systems is in transition, lack of orderly integration and benign interaction. However, the developing trend of interaction is also upward, and a spatial pattern driven by Xuzhou and Linyi as the dual cores has gradually formed. Moreover, the coupling is mostly manifested as outdated technological innovation and industrial transformation. Except for the final coordination of regenerative cities, the other resource types are all in transition. Cities in all traffic locations are still in transition. The overall system interaction of cities on Longhai Line(Lanzhou-Lianyungang Railway) is relatively optimal, and cities on Xinshi Line(Xinxiang-Rizhao Railway) are accelerating toward synergy. 3) The coupling status of TIE systems depends on the development of the single system and the interaction of the binary(2E) system. The coupling is closely related to technological innovation and Technology-Industry system,and is hindered by the inefficient interaction of Technology-Environment system. Specifically, the synergy of regenerative cities is attributed to the advantage of a single system and the effective integration of 2E systems. Beneficial from the advantages of environmental efficiency, the cities on Xinshi Line promote the synergy of the 2E and TIE systems. Therefore, while the Huaihai Economic Zone stimulates the development potential of the single and 2E systems, it is necessary to amplify the superimposition effect of systems in accordance on the basis of resource and location.

Research on the Mode of ESP Course under the Background of the Application of Technological Transformation

In this paper, we conduct research on the mode of ESP course under the background of the application of technological transformation. To cater to the needs of the development of the college students’ vocational students’ English level high starting point of key university fi rst opened the ESP courses. Applied undergraduate colleges and universities is not to be outdone that after students fi nish college English courses opened a professional English and bilingual courses. However, the current ESP teaching in China is not yet mature that mainly displays in: goal is not clear, backward teaching mode, teaching method of the single insufficient standard, teaching material development. Therefore, this paper proposes the countermeasures and suggestions for systematic optimization.

Theoretical Model on Transformation Factors of Scientific and Technological Achievements under the Belt and Road Initiative

With the continuous deepening of the Belt and Road Initiative,the countries involved are increasingly connected in the field of science and technology.Based on the transformation theory of scientific and technological(S&T)achievements,this study establishes a theoretical model of transformation factors of S&T achievements under the Belt and Road Initiative.Combined with the data analysis from questionnaire,it is found that in S&T achievements transformation process,there is a significant positive correlation between the innovation factors and the transfer factors,between the transfer factors and the diffusion factors,and between the diffusion factors and the transformation results.These conclusions provide reference for the subsequent S&T achievements transformation activities under the Belt and Road Initiative.Therefore,in the process of promoting the transformation of S&T achievements under the Belt and Road Initiative in the future,innovation factors such as information innovation,service innovation,and cooperative innovation should be fully reflected.Relevant agencies should take the transfer factors of S&T achievements as guidance;promote and apply the results of incubation through diffusion media and diffusion channels.

Effects of six years of simulated N deposition on gross soil N transformation rates in an old-growth temperate forest

Elevated atmospheric nitrogen(N) deposition has been detected in many regions of China, but its effects on soil N transformation in temperate forest ecosystems are not well known. We therefore simulated N deposition with four levels of N addition rate(N0, N30, N60, and N120) for6 years in an old-growth temperate forest in Xiaoxing’an Mountains in Northeastern China. We measured gross N transformation rates in the laboratory usingN tracing technology to explore the effects of N deposition on soil gross N transformations taking advantage of N deposition soils. No significant differences in gross soil N transformation rates were observed after 6 years of N deposition with various levels of N addition rate. For all N deposition soils, the gross NH~+ immobilization rates were consistently lower than the gross N mineralization rates,leading to net N mineralization. Nitrate(NO~-) was primarily produced via oxidation of NH~+(i.e., autotrophic nitrification), whereas oxidation of organic N(i.e., heterotrophic nitrification) was negligible. Differences between the quantity of ammonia-oxidizing bacteria and ammonia-oxidizing archaea were not significant for any treatment, which likely explains the lack of a significant effect on gross nitrification rates. Gross nitrification rates were much higher than the total NO~- consumption rates,resulting in a build-up of NO~-, which highlights the high risk of N losses via NO~- leaching or gaseous N emissions from soils. This response is opposite that of typical N-limited temperate forests suffering from N deposition,suggesting that the investigated old-growth temperate forest ecosystem is likely to approach N saturation.

Development Prospect and Strategies of Water-saving and Drought-resistance Rice

Water-saving and drought-resistance upland rice has become a preferable choice for cotton farmlands ready for changing crops or paddy fields with water in short,because simplified and mechanical cultivation can be applied for the rice varieties of drought resistance and high yield.At present,it has been applied with an area of 400 000 hm2 in Hunan Province and the area continues growing.The research bred and introduced the relevant cultivation technology standard applicable to local water-saving and drought-resistance rice varieties in order to improve farmer＇s benefits.

The role of green industrial transformation in mitigating carbon emissions:Exploring the channels of technological innovation and environmental regulation

The industrial sector is vital to economic progress,yet industrial pollution poses environmental and economic concerns.The purpose of the study was to investigate the influence of green industrial transformation in re-ducing Pakistan’s carbon intensity between 1975 and 2020.Carbon emissions are considered an endogenous construct,while foreign direct investment(FDI)inflows,technological innovation,green industrial transforma-tion,environmental legislation,and research and development(R&D)investment are possible mediators.The association between variables is assessed using the robust least-squares approach.Green industrial transforma-tion is connected with lower carbon emissions,yet technical innovation,R&D investment,and inbound FDI raise a country’s carbon emissions.The findings support the pollution haven hypothesis in a country.The causality esti-mates indicate that inward FDI contributes to environmental regulations;green industrial transformation directly relates to inbound FDI and R&D expenditures;and technological innovations correspond to inbound FDI,R&D ex-penditures,industrial ecofriendly progression,and environmental standards.According to the impulse response function,environmental policies are anticipated to have a differential effect on carbon emissions in 2023,2024,2028-2030,while they are likely to decrease in the years 2025-2027 and 2031 forward.Additionally,inward FDI and technology advancements would almost certainly result in a rise in carbon emissions over time.Green industrial transitions are projected to result in a ten-year reduction in carbon emissions.The variance decomposi-tion analysis indicates that eco-friendly industrial adaptations would likely have the largest variance error shock on carbon emissions(11.747%),followed by inbound FDI,technological advancements,and regulatory changes,with R&D spending having a minimal impact over time.Pakistan’s economy should foster a green industrial revolution to avoid pollution and increase environmental sustainability to meet its environmental goals.

Progress and Knowledge Transfer from Science to Technology in the Research Frontier of CRISPR Based on the LDA Model

Purpose:This study explores the underlying research topics regarding CRISPR based on the LDA model and figures out trends in knowledge transfer from science to technology in this area over the latest 10 years.Design/methodology/approach:We collected publications on CRISPR between 2011 and2020 from the Web of Science,and traced all the patents citing them from lens.org.15,904 articles and 18,985 patents in total are downloaded and analyzed.The LDA model was applied to identify underlying research topics in related research.In addition,some indicators were introduced to measure the knowledge transfer from research topics of scientific publications to IPC-4 classes of patents.Findings:The emerging research topics on CRISPR were identified and their evolution over time displayed.Furthermore,a big picture of knowledge transition from research topics to technological classes of patents was presented.We found that for all topics on CRISPR,the average first transition year,the ratio of articles cited by patents,the NPR transition rate are respectively 1.08,15.57%,and 1.19,extremely shorter and more intensive than those of general fields.Moreover,the transition patterns are different among research topics.Research limitations:Our research is limited to publications retrieved from the Web of Science and their citing patents indexed in lens.org.A limitation inherent with LDA analysis is in the manual interpretation and labeling of"topics".Practical implications:Our study provides good references for policy-makers on allocating scientific resources and regulating financial budgets to face challenges related to the transformative technology of CRISPR.Originality/value:The LDA model here is applied to topic identification in the area of transformative researches for the first time,as exemplified on CRISPR.Additionally,the dataset of all citing patents in this area helps to provide a full picture to detect the knowledge transition between S&T.

Five trends of education and technology in a sustainable future

Quality education is one of the pillars in the United Nations 2030 Agenda for Sustainable Development,which aims to ensure inclusive and equitable quality education and promote lifelong learning opportunities for all.This overall goal can be connected to some general trends affecting education in the information age.We argue that education is key to the future quality of human life and the sustainability of the world.Generally,education is being transformed in both formal and informal learning contexts by new digital technologies.Overall,some of these major innovations and how they are changing education can be summarized into the following aspects:1)our educational aims and objectives;2)educational ecologies and contexts of learning;3)the processes of learning;4)the processes of teaching;and 5)educational governance and policy.Meanwhile,we note some of the potential risks and downsides of these technology trends.From the sustainable perspective,our review points to a great potential for educational reform,but it can only be achieved if we are willing to rethink and even abandon some of our traditional ways of doing things in education.