In order to construct the zwitterionic structure of phosphorylcholine onto the surface of biomaterials, five novel phospholanes containing hydroxyl group were synthesized from the corresponding diol and 2-chloro-2-oxo...In order to construct the zwitterionic structure of phosphorylcholine onto the surface of biomaterials, five novel phospholanes containing hydroxyl group were synthesized from the corresponding diol and 2-chloro-2-oxo-1,3,2-dioxaphospholane in the presence of THF. Then, five novel phosphorylcholines containing hydroxyl group were prepared by the corresponding phospholane and anhydrous trimethylamine in the presence of acetonitrile. Their structures were characterized by FTIR, 1H NMR and elemental analysis.展开更多
Lipase from Candida sp.99-125 catalyzed ring-opening polymerization of e-caprolactone in the presence of 6-mercapto-1-hexanol was presented as a new metal-free approach for direct synthesis of welldefined thiol-termin...Lipase from Candida sp.99-125 catalyzed ring-opening polymerization of e-caprolactone in the presence of 6-mercapto-1-hexanol was presented as a new metal-free approach for direct synthesis of welldefined thiol-terminated poly（e-caprolactone）.Remarkably,high chemoselectivity of lipase from Candida sp.99-125 toward hydroxyl and thiol was exhibited and quantitative thiol fidelity over 90% was achieved.The tedious protecting/deprotecting steps for thiol and metal residue were avoided.The polymerizations with around 70% monomer conversion were conducted in bulk and toluene at relative low temperature of 40 ℃.Number–average molecular weight of resulted polymers ranged from 3000 to4700 Da by changing the feed ratio between monomer and initiator.The structures of obtained thiolterminated poly（e-caprolactone） were demonstrated by combining NMR and SEC analyses.展开更多
I. INTRODUCTION In our previous articles, we reported the synthesis of diol monomers such as 1,3-dihydroxy-2-methyl-2-propyl and β, β’-dihydroxyethyl derivatives of thymine and uracil and their polycondensation wit...I. INTRODUCTION In our previous articles, we reported the synthesis of diol monomers such as 1,3-dihydroxy-2-methyl-2-propyl and β, β’-dihydroxyethyl derivatives of thymine and uracil and their polycondensation with the active diamides of benzotriazole such as 1, 1’-(isoph-thaloyl)bisbenzotriazole (IPBBT) and 1, 1’-(sebacoyl)bisbenzotriazole (SeBBT),展开更多
文摘In order to construct the zwitterionic structure of phosphorylcholine onto the surface of biomaterials, five novel phospholanes containing hydroxyl group were synthesized from the corresponding diol and 2-chloro-2-oxo-1,3,2-dioxaphospholane in the presence of THF. Then, five novel phosphorylcholines containing hydroxyl group were prepared by the corresponding phospholane and anhydrous trimethylamine in the presence of acetonitrile. Their structures were characterized by FTIR, 1H NMR and elemental analysis.
基金supported by a grant from the National Basic Research Program of China (Nos.2012CB725204 and 2011CB710803)the National High Technology Research and Development Program of China (No.2014AA021201)+1 种基金Natural Science Foundation of China (No.81302632)the Priority Academic Program Development of Jiangsu Higher Education Institutions and China Postdoctoral Science Foundation (No.2014M551574)
文摘Lipase from Candida sp.99-125 catalyzed ring-opening polymerization of e-caprolactone in the presence of 6-mercapto-1-hexanol was presented as a new metal-free approach for direct synthesis of welldefined thiol-terminated poly（e-caprolactone）.Remarkably,high chemoselectivity of lipase from Candida sp.99-125 toward hydroxyl and thiol was exhibited and quantitative thiol fidelity over 90% was achieved.The tedious protecting/deprotecting steps for thiol and metal residue were avoided.The polymerizations with around 70% monomer conversion were conducted in bulk and toluene at relative low temperature of 40 ℃.Number–average molecular weight of resulted polymers ranged from 3000 to4700 Da by changing the feed ratio between monomer and initiator.The structures of obtained thiolterminated poly（e-caprolactone） were demonstrated by combining NMR and SEC analyses.
文摘I. INTRODUCTION In our previous articles, we reported the synthesis of diol monomers such as 1,3-dihydroxy-2-methyl-2-propyl and β, β’-dihydroxyethyl derivatives of thymine and uracil and their polycondensation with the active diamides of benzotriazole such as 1, 1’-(isoph-thaloyl)bisbenzotriazole (IPBBT) and 1, 1’-(sebacoyl)bisbenzotriazole (SeBBT),
