Serum neuronal pentraxin 2 is related to cognitive dysfunction and electroencephalogram slow wave/fast wave frequency ratio in epilepsy

BACKGROUND Cognitive dysfunction in epileptic patients is a high-incidence complication.Its mechanism is related to nervous system damage during seizures,but there is no effective diagnostic biomarker.Neuronal pentraxin 2(NPTX2)is thought to play a vital role in neurotransmission and the maintenance of synaptic plasticity.This study explored how serum NPTX2 and electroencephalogram(EEG)slow wave/fast wave frequency ratio relate to cognitive dysfunction in patients with epilepsy.AIM To determine if serum NPTX2 could serve as a potential biomarker for diagnosing cognitive impairment in epilepsy patients.METHODS The participants of this study,conducted from January 2020 to December 2021,comprised 74 epilepsy patients with normal cognitive function(normal group),37 epilepsy patients with cognitive dysfunction[epilepsy patients with cognitive dysfunction(ECD)group]and 30 healthy people(control group).The minimental state examination(MMSE)scale was used to evaluate cognitive function.We determined serum NPTX2 levels using an enzyme-linked immunosorbent kit and calculated the signal value of EEG regions according to the EEG recording.Pearson correlation coefficient was used to analyze the correlation between serum NPTX2 and the MMSE score.RESULTS The serum NPTX2 level in the control group,normal group and ECD group were 240.00±35.06 pg/mL,235.80±38.01 pg/mL and 193.80±42.72 pg/mL,respectively.The MMSE score was lowest in the ECD group among the three,while no significant difference was observed between the control and normal groups.In epilepsy patients with cognitive dysfunction,NPTX2 level had a positive correlation with the MMSE score(r=0.367,P=0.0253)and a negative correlation with epilepsy duration(r=−0.443,P=0.0061)and the EEG slow wave/fast wave frequency ratio value in the temporal region(r=−0.339,P=0.039).CONCLUSION Serum NPTX2 was found to be related to cognitive dysfunction and the EEG slow wave/fast wave frequency ratio in patients with epilepsy.It is thus a potential biomarker for the diagnosis of cognitive impairment in patients with epilepsy.

Improved form of wind wave frequency spectrum

The lower frequency part of the theoretical wind wave spectrum proposed by the authors (Wen et al. , 1988a, b,c) has been improved and the form of spectrum is appreciably simplified. In addition to the field data collected in the Bohai Sea region and used in the previous papers, those obtained in the Huanghai Sea, the East China Sea and the South China Sea have been employed so that the improved spectra can be verified on a more extensive observational basis. Computed results agree with the observations well. Further comparisons have been made between the proposed spectra and the JONSWAP spectrum. Though the two types of spectrum are close to each other in form, the former shows, as a whole, better agreement with the observation than the latter. By introducing an improved relation between the peak-ness factor and significant wave steepness, the spectrum contains only significant wave height and period as parameters. For spectra given in this form, the computed peak frequencies coincide approximately with observed values and the computed peak magnitudes of spectra agree basically with observations, but, because of the statistic variability inherent in the measurements of significant wave heights and periods, there are certain discrepancies between computed and measured spectrum peak magnitudes.

The equilibrium range of wind wave frequency spectrum

-Theoretical form of equilibrium range is given on the basis of the wind wave frequency spectra proposed by Wenel al. (1988a,b,c, 1989a,b). The effects of peakness factor and water depth are discussed. In the case of deep water the e-quilibrium range is reduced to the form first proposed by Toba (1973) and the coefficient of the formula is shown to be the function of nondimensional fetch or peak frequency. Results of the present paper have been verified through field data.

Estimation of Wind Wave Frequency Spectra by Use of the Arcsine Law

In the present study, the surface elevation of wind waves observed in laboratory and in the Bohai Sea are adopted for the estimation of the wind wave frequency spectrtm by use of the method of the arcsine law （MAL）. The traditional method uses the surface elevation to calculate the correlation and then estimate the frequency spectrum while the MAL, presented by Yu and l.an （1979）, uses the time sequence of zero-crossing points of surface elevation rather than directly the surface elevation to calculate the correlation. 66 sets of wind wave data obtained in laboratory and 420 sets of data observed in the Bohai Sea are adopted for the examination of the method introduced by Yu and Lan. Results show that the MAL can give reliable estimation of wind wave spectra. Correlation and form of spectra estimated by the MAL are similar to those estimated by the traditional method. The peak frequency and the spectral density in peak frequency by the MAL are close to those obtained by the traditional method.

Detection of Gravitational Waves with Semi Classical Features and Resulting Cosmological Implications

The author argues in this document that initial vacuum state values possibly responsible for GW generation in relic conditions in the initial onset of inflation may have a temporary unsqueezed, possibly even coherent initial value, which would permit in certain models classical coherent initial gravitational wave states. Furthermore, several arguments pro and con as to if or not initial relic GW should be high frequency will be presented, with the reason given why earlier string models did NOT favor low frequency relic GW from the big bang. What is observed is that large higher dimensions above our 4 Dimensional space time, if recipients of matter-energy from collapse and re birth of the universe are enough to insure low relic GW. The existence of higher dimensions, in itself if the additional dimensions are small and compact will have no capacity to lower the frequency limit values of relic GW, as predicted by Giovannini, et al. in 1995.

Wave height measurement in the Taiwan Strait with a portable high frequency surface wave radar

As an important equipment for sea state remote sensing, high frequency surface wave radar （HFSWR） has received more and more attention. The conventional method for wave height inversion is based on the ratio of the integration of the second-order spectral continuum to that of the first-order region, where the strong external noise and the incorrect delineation of the first- and second-order Doppler spectral regions due to spectral aliasing are two major sources of errors in the wave height. To account for these factors, two more indices are introduced to the wave height estimation, i.e., the ratio of the maximum power of the second-or- der continuum to that of the Bragg spectral region （RSCB） and the ratio of the power of the second harmonic peak to that of the Bragg peak （RSHB）. Both indices also have a strong correlation with the underlying wave height. On the basis of all these indices an empirical model is proposed to estimate the wave height. This method has been used in a three-months long experiment of the ocean state measuring and analyzing ra- dar, type S （OSMAR-S）, which is a portable HFSWR with compact cross-loop/monopole receive antennas developed by Wuhan University since 2006. During the experiment in the Taiwan Strait, the significant wave height varied from 0 to 5 m. The significant wave heights estimated by the OSMAR-S correlate well with the data provided by the Oceanweather Inc. for comparison, with a correlation coefficient of 0.74 and a root mean square error （RMSE） of 0.77 m. The proposed method has made an effective improvement to the wave height estimation and thus a further step toward operational use of the OSMAR-S in the wave height extraction.

A Diagnostic Study on the Relationship between the Assembling of Low Frequency Waves in the Pacific Ocean and the Abnormality of the Subtropical High

By use of the filter analysis technique, the Complex Empirical Othogonal Function (CEOF) method and the ECMWF/WMO 2.5°×2.5°grid data of the geopotential heights during the summer months in 1988, an interseasonal process that the western Pacific subtropical high (WPSH) was anomalously far to the north in the first and second ten days of July is studied. It has been found that in the western Pacific subtropical region in the first and second ten days of July,it is the continuous assembly of low frequency geopotential waves (LFGWs) that leads to the abnormality of WPSH. This abnormality emerges with the enhancement of wave assembling and ceases while the wave assembling situation disappears. The structure of the low frequency assembling waves corresponds to the structure of subtropical high in its abnormal period. The effect of the assembling waves on the abnormality of subtropical high can be considered as the accumulation of disturbance energy carried by the low frequency waves from different directions in the western Pacific region.

Surface tidal currents in the open sea area to the east of the Zhoushan Islands measured with high frequency surface wave radar

Based on the quasi-harmonic analysis of 11 d vector ocean currents obtained from two high frequency sur- face wave radars located at Zhujiajian Island and Shengshan Island, the spatial distribution characteristics of surface tidal currents in the open sea area to the east of the Zhoushan Islands of Zhejiang Province, China are studied. The following conclusions are drawn from the analysis： the tidal current pattern in the open sea area to the east of Zhoushan Islands is primarily regular semidiurnal, which is significantly affected by the shallow water constituents. The directions of the major axes of tidal current ellipses of M2 lie approx- imately in the NW-SE direction. With the increasing of distance away from the coast, the directions of the tidal current ellipses gradually shift toward the E-W direction. The tidal currents are mainly reversing cur- rents. The spatial distribution of probable maximum current velocities decreases gradually from northeast to southwest which is basically in accordance with the spatial distribution of measured maximum current velocities. The residual currents near the coast are larger than those far away from the coast. The directions of the residual currents are basically north by east, and the angle to the due north increases gradually with the increasing distance away from the coast. The topography shows a certain impact on the spatial distri- bution of shallow water constituents, the rotation of tidal currents, the probable maximum currents and the residual currents.

Instantaneous frequency and wave mode identification in a magnetosheath using few spatial points

Observational data such as those obtained from the magnetosheath in the downstream of Earth＇s bow shock have waveforms that differ from those of sinusoidal signals. In practice, they are not even aggregates of sinusoidal signals. Therefore, the frequency decomposition for the data requires technique that will account for the time-varying features of the data that will lead to deduction of physical meaning of the observations. The combination of empirical mode decompo- sition （EMD） and Hilbert transform has been used for extracting the various contributing oscillatory modes （EMDs） and the instantaneous frequency determination （Hilbert transform） of every physically meaningful mode called intrinsic mode func- tion （IMF）. The resulting instantaneous frequencies are used to determine instantaneous wave vectors. The combination of the instantaneous frequencies and wave vectors is useful in the identification of wave modes based on the characteristics of the waves. The results show that EMD-Hilbert can be more reliable than simple Hilbert transform alone.

Modified Omega-K algorithm for processing helicopter-borne frequency modulated continuous waveform rotating synthetic aperture radar data

With appropriate geometry configuration, helicopter- borne rotating synthetic aperture radar （ROSAR） can break through the limitations of monostatic synthetic aperture radar （SAR） on forward-looking imaging. With this capability, ROSAR has extensive potential applications, such as self-navigation and self-landing. Moreover, it has many advantages if combined with the frequency modulated continuous wave （FMCW） technology. A novel geometric configuration and an imaging algorithm for helicopter-borne FMCW-ROSAR are proposed. Firstly, by per- forming the equivalent phase center principle, the separated trans- mitting and receiving antenna system is equalized to the case of system configuration with antenna for both transmitting and receiving signals. Based on this, the accurate two-dimensional spectrum is obtained and the Doppler frequency shift effect in- duced by the continuous motion of the platform during the long pulse duration is compensated. Next, the impacts of the velocity approximation error on the imaging algorithm are analyzed in de- tail, and the system parameters selection and resolution analysis are presented. The well-focused SAR image is then obtained by using the improved Omega-K algorithm incorporating the accurate compensation method for the velocity approximation error. FJnally, correctness of the analysis and effectiveness of the proposed al- gorithm are demonstrated through simulation results.

Forming of Space Charge Wave with Broad Frequency Spectrum in Helical Relativistic Two-Stream Electron Beams

We elaborate a quadratic nonlinear theory of plural interactions of growing space charge wave （SCW） harmonics during the development of the two-stream instability in helical relativistic electron beams. It is found that in helical two-stream electron beams the growth rate of the two-stream instability increases with the beam entrance angle. An SCW with the broad frequency spectrum, in which higher harmonics have higher amplitudes, forms when the frequency of the first SCW harmonic is much less than the critical frequency of the two-stream instability. For helical electron beams the spectrum expands with the increase of the beam entrance angle. Moreover, we obtain that utilizing helical electron beams in multiharmonic two-stream superheterodyne free-electron lasers leads to the improvement of their amplification characteristics, the frequency spectrum broadening in multiharmonic signal generation mode, and the reduction of the overall system dimensions.

Power and Cross-Spectra for the Turbulent Atmospheric Motion and Transports in the Domain of Wave Number Frequency Space: Theoretical Aspects

The study of large-scale atmospheric turbulence and transport processes is of vital importance in the general circulation of the atmosphere. The governing equations of the power and cross-spectra for the atmospheric motion and transports in the domain of wave number frequency space have been derived. The contributions of the nonlinear interactions of the atmospheric waves in velocity and temperature fields to the conversion of kinetic and potential energies and to the meridional transports of angular momentum and sensible heat in the atmosphere have been discussed.

Electromagnetic Resonance of Astigmatic Gaussian Beam to the High Frequency Gravitational Waves

The high frequency gravitational waves （around lOS-lO12 Hz） could interact with a specially designed electro- magnetic resonance system. It is found that the power of transverse perturbative photon flux （PPF） of an electromagnetic resonance system can be improved significantly by virtue of an astigmatic Caussian beam. Cor- respondingly the signal-to-noise ratio （SNR） would also be improved. When the eccentric ratio of waist satisfying w0x ： w0y 〉 1, the peak value of signal photon flux could be raised by 2-4 times with typical systematic parameters, while the background photon flux would be depressed. Therefore, the ratio of transverse PPF to background photon flux （i.e., SNR） can be further improved 3-8 times with dimensionless amplitude of relic gravitational wave ht = 10-36.

Noise in a coupling electromagnetic detecting system for high frequency gravitational waves

This paper discusses the basic categories of noise in detecting high frequency gravitational waves in the microwave band （-0.1-10GHz）, which contain shot noise from the laser and the thermal radiation photons, thermal noise from statistical fluctuation of the thermal photons and fluctuation of the temperature, radiation press noise on the fractal membrane, the noise caused by the scattering of the Gaussian Beam （GB） in the detecting tube and noise in the microwave radiometers. The analysis shows that a reasonable signal-to-noise ratio may be achieved for a detecting device with the fixed power of GB （105 W）, only when the temperature of the environment is no more than T=I K, and the optimal length of the microwave radiometers is about 0.3 m.

Radiation of Ultra Low Frequency Electromagnetic Waves from Atmosphere under the Influence of Strong Shock Waves

We present preliminary results from the experimental investigation of the response of the atmosphere due to the impact of powerful shock waves. The response is evidenced as ultra low frequency electromagnetic wave radiation at frequency of 2-5 kHz and in duration of 3 7s. We hypothesize that this radiation appears due to the following process： the shock wave ionizes the neutral particles in the air and these charged and neutral particles continue their vertical motion, which forms in the trail of the shock wave. Such motion can cause the cyclotron-like radiation measured.

Reduced Soil Moisture Contributes to More Intense and More Frequent Heat Waves in Northern China

Heat waves have attracted increasing attention in recent years due to their frequent occurrence.The present study investigates the heat wave intensity and duration in China using daily maximum temperature from 753 weather stations from 1960 to 2010.In addition,its relationships with soil moisture local forcing on the ten-day period and monthly scales in spring and summer are analyzed using soil moisture data from weather stations and ERA40 reanalysis data.And finally,a mechanistic analysis is carried out using CAM5.1（Community Atmosphere Model,version 5.1） coupled with CLM2（Community Land Model,version 2）.It is found that the heat wave frequency and duration show a sandwich distribution across China,with high occurrence rates in Southeast China and Northwest China,where the maximum frequency and duration exceeded 2.1 times and 9 days per year,respectively.The increasing trends in both duration and intensity occurred to the north of 35°N.The relationships between heat wave frequency in northern China in July（having peak distribution） and soil moisture in the earlier stage（from March to June） and corresponding period（July） are further analyzed,revealing a strong negative correlation in March,June and July,and thus showing that soil moisture in spring and early summer could be an important contributor to heat waves in July via positive subtropical high anomalies.However,the time scales of influence were relatively short in the semi-humid and humid regions,and longer in the arid region.The contribution in the corresponding period took place via positive subtropical high anomalies and positive surface skin temperature and sensible heat flux anomalies.

A third-order asymptotic solution of nonlinear standing water waves in Lagrangian coordinates

Asymptotic solutions up to third-order which describe irrotational finite amplitude standing waves are derived in Lagrangian coordinates. The analytical Lagrangian solution that is uniformly valid for large times satisfies the irrotational condition and the pressure p = 0 at the free surface, which is in contrast with the Eulerian solution existing under a residual pressure at the free surface due to Taylor＇s series expansion. In the third-order Lagrangian approximation, the explicit parametric equation and the Lagrangian wave frequency of water particles could be obtained. In particular, the Lagrangian mean level of a particle motion that is a function of vertical label is found as a part of the solution which is different from that in an Eulerian description. The dynamic properties of nonlinear standing waves in water of a finite depth, including particle trajectory, surface profile and wave pressure are investigated. It is also shown that the Lagrangian solution is superior to an Eulerian solution of the same order for describing the wave shape and the kinematics above the mean water level.

The instability of dust acoustic waves in inhomogeneous dusty plasmas with non-adiabatic dust charge fluctuation

This paper investigates the propagation of linear dust acoustic waves in inhomogeneous dusty plasmas due to spatial gradients of dust charge, plasma densities. A linear dispersion relation is obtained with the non-adiabatic dust charge iguctuation and the non-thermally distributed ions. The numerical results show that the inhomogeneity, nonthermal ions and non-adlabatic dust charge iguctuatlon have strong iniguence on the frequency and the damping rate of waves.

Dynamic Stability Analysis of Caisson Breakwater in Lifetime Considering the Annual Frequency of Severe Storm

In the dynamic stability analysis of a caisson breakwater, most of current studies pay attention to the motion characteristics of caisson breakwaters under a single periodical breaking wave excitation. And in the lifetime stability analysis of caisson breakwater, it is assumed that the caisson breakwater suffers storm wave excitation once annually in the design lifetime. However, the number of annual severe storm occurrence is a random variable. In this paper, a series of random waves are generated by the Wen Sheng-chang wave spectrum, and the histories of successive and long-term random wave forces are built up by using the improved Goda wave force model. It is assumed that the number of annual severe storm occurrence is in the Poisson distribution over the 50-year design lifetime, and the history of random wave excitation is generated for each storm by the wave spectrum. The response histories of the caisson breakwater to the random waves over 50-year design lifetime are calculated and taken as a set of samples. On the basis of the Monte Carlo simulation technique, a large number of samples can be obtained, and the probability assessment of the safety of the breakwater during the complete design lifetime is obtained by statistical analysis of a large number of samples. Finally, the procedure of probability assessment of the breakwater safety is illustrated by an example.

The Instability of Terahertz Plasma Waves in Two Dimensional Gated and Ungated Quantum Electron Gas

The instability of terahertz（THz）plasma waves in two-dimensional（2D）quantum electron gas in a nanometer field effect transistor（FET）with asymmetrical boundary conditions has been investigated.We analyze THz plasma waves of two parts of the 2D quantum electron gas：gated and ungated regions.The results show that the radiation frequency and the increment（radiation power）in 2D ungated quantum electron gas are much higher than that in 2D gated quantum electron gas.The quantum effects always enhance the radiation power and enlarge the region of instability in both cases.This allows us to conclude that 2D quantum electron gas in the transistor channel is important for the emission and detection process and both gated and ungated parts take part in that process.