The aim was to evaluate the effects of dietary supplementation of spay-dried whole egg containing antiF4 antibodies(SDWE) against recombinantly produced F4 antigens in enterotoxigenic Escherichia coli K88^+(ETEC)-chal...The aim was to evaluate the effects of dietary supplementation of spay-dried whole egg containing antiF4 antibodies(SDWE) against recombinantly produced F4 antigens in enterotoxigenic Escherichia coli K88^+(ETEC)-challenged piglets. Twenty-seven 21-d-old and individually housed piglets were randomly allotted to 3 treatments consisting of a wheat-soybean meal basal diet containing either 0(control egg powder; CEP), 0.1%(SDWE1) or 0.4%(SDWE2) SDWE. After a 7-d adaptation period, blood samples were collected from all pigs,and pigs were weighed and orally challenged with an ETEC inoculum. Blood was sampled at 24 and 48 h post-challenge, and diarrhea incidences and scores were recorded. On d 14, all pigs were weighed and then euthanized to obtain intestinal tissue samples for histomorphology measurement. During the pre-challenge period, pigs fed the SDWE showed a linear improvement(P < 0.05)in average daily gain(ADG) and gain to feed ratio(G:F), but there were no differences among treatments in growth performance during the post-challenge period. Diarrhea incidences and scores, fecal shedding of ETEC, plasma urea nitrogen content and intestinal histo morphology were similar among treatments.The results show that 0.4% SDWE supported greater piglet performance before challenge although such benefits were not evident during the post-challenge period at either 0.1% or 0.4% supplementation.展开更多
基金funded by Natural Sciences and Engineering Research Council of Canada and Zyme Fast System Inc.
文摘The aim was to evaluate the effects of dietary supplementation of spay-dried whole egg containing antiF4 antibodies(SDWE) against recombinantly produced F4 antigens in enterotoxigenic Escherichia coli K88^+(ETEC)-challenged piglets. Twenty-seven 21-d-old and individually housed piglets were randomly allotted to 3 treatments consisting of a wheat-soybean meal basal diet containing either 0(control egg powder; CEP), 0.1%(SDWE1) or 0.4%(SDWE2) SDWE. After a 7-d adaptation period, blood samples were collected from all pigs,and pigs were weighed and orally challenged with an ETEC inoculum. Blood was sampled at 24 and 48 h post-challenge, and diarrhea incidences and scores were recorded. On d 14, all pigs were weighed and then euthanized to obtain intestinal tissue samples for histomorphology measurement. During the pre-challenge period, pigs fed the SDWE showed a linear improvement(P < 0.05)in average daily gain(ADG) and gain to feed ratio(G:F), but there were no differences among treatments in growth performance during the post-challenge period. Diarrhea incidences and scores, fecal shedding of ETEC, plasma urea nitrogen content and intestinal histo morphology were similar among treatments.The results show that 0.4% SDWE supported greater piglet performance before challenge although such benefits were not evident during the post-challenge period at either 0.1% or 0.4% supplementation.
