The paper, with the backdrop of web-based autonomous learning put forward by the recent college English teaching reform, aims to explore teachers' roles in this learning process in students' perception through the m...The paper, with the backdrop of web-based autonomous learning put forward by the recent college English teaching reform, aims to explore teachers' roles in this learning process in students' perception through the means of questionnaires and interviews. It further analyzes the possible reasons why students perceive their teachers' roles in such a way, in the hope of providing some implications for web-based college English autonomous learning.展开更多
The thesis introduces a comparative study of students'autonomous listening practice in a web-based autonomous learning center and the traditional teacher-dominated listening practice in a traditional language lab....The thesis introduces a comparative study of students'autonomous listening practice in a web-based autonomous learning center and the traditional teacher-dominated listening practice in a traditional language lab.The purpose of the study is to find how students'listening strategies differ in these two approaches and thereby to find which one better facilitates students'listening proficiency.展开更多
Artificial neural networks are capable of machine learning by simulating the hiera rchical structure of the human brain.To enable learning by brain and machine,it is essential to accurately identify and correct the pr...Artificial neural networks are capable of machine learning by simulating the hiera rchical structure of the human brain.To enable learning by brain and machine,it is essential to accurately identify and correct the prediction errors,referred to as credit assignment(Lillicrap et al.,2020).It is critical to develop artificial intelligence by understanding how the brain deals with credit assignment in neuroscience.展开更多
Early identification and treatment of stroke can greatly improve patient outcomes and quality of life.Although clinical tests such as the Cincinnati Pre-hospital Stroke Scale(CPSS)and the Face Arm Speech Test(FAST)are...Early identification and treatment of stroke can greatly improve patient outcomes and quality of life.Although clinical tests such as the Cincinnati Pre-hospital Stroke Scale(CPSS)and the Face Arm Speech Test(FAST)are commonly used for stroke screening,accurate administration is dependent on specialized training.In this study,we proposed a novel multimodal deep learning approach,based on the FAST,for assessing suspected stroke patients exhibiting symptoms such as limb weakness,facial paresis,and speech disorders in acute settings.We collected a dataset comprising videos and audio recordings of emergency room patients performing designated limb movements,facial expressions,and speech tests based on the FAST.We compared the constructed deep learning model,which was designed to process multi-modal datasets,with six prior models that achieved good action classification performance,including the I3D,SlowFast,X3D,TPN,TimeSformer,and MViT.We found that the findings of our deep learning model had a higher clinical value compared with the other approaches.Moreover,the multi-modal model outperformed its single-module variants,highlighting the benefit of utilizing multiple types of patient data,such as action videos and speech audio.These results indicate that a multi-modal deep learning model combined with the FAST could greatly improve the accuracy and sensitivity of early stroke identification of stroke,thus providing a practical and powerful tool for assessing stroke patients in an emergency clinical setting.展开更多
The paper is a literature review, aiming to examine the effectiveness of web-based college English learning which mainly focuses on learners' autonomous learning. Previous studies indicate that the web-based learn...The paper is a literature review, aiming to examine the effectiveness of web-based college English learning which mainly focuses on learners' autonomous learning. Previous studies indicate that the web-based learning can improve learners' autonomous learning, as well as some problems found in their findings. Therefore, this paper first gives a summary and critique of research studies on the web-based autonomous learning and some factors influencing learners' autonomous learning ability;then, areas that deserve further study are also indicated.展开更多
Machine learning(ML)is a type of artificial intelligence that assists computers in the acquisition of knowledge through data analysis,thus creating machines that can complete tasks otherwise requiring human intelligen...Machine learning(ML)is a type of artificial intelligence that assists computers in the acquisition of knowledge through data analysis,thus creating machines that can complete tasks otherwise requiring human intelligence.Among its various applications,it has proven groundbreaking in healthcare as well,both in clinical practice and research.In this editorial,we succinctly introduce ML applications and present a study,featured in the latest issue of the World Journal of Clinical Cases.The authors of this study conducted an analysis using both multiple linear regression(MLR)and ML methods to investigate the significant factors that may impact the estimated glomerular filtration rate in healthy women with and without non-alcoholic fatty liver disease(NAFLD).Their results implicated age as the most important determining factor in both groups,followed by lactic dehydrogenase,uric acid,forced expiratory volume in one second,and albumin.In addition,for the NAFLD-group,the 5th and 6th most important impact factors were thyroid-stimulating hormone and systolic blood pressure,as compared to plasma calcium and body fat for the NAFLD+group.However,the study's distinctive contribution lies in its adoption of ML methodologies,showcasing their superiority over traditional statistical approaches(herein MLR),thereby highlighting the potential of ML to represent an invaluable advanced adjunct tool in clinical practice and research.展开更多
Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life ...Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of patients.To date,there are no viable treatment options for postoperative cognitive dysfunction.The identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future research.To identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial fracture.The dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub gene.Therefore,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re surgery.Mice were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning tests.In addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western blotting.Treatment with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expression compared with vehicle treatment.Intraperitoneal administration of the specific ERK inhibitor PD98059 diminished the effects of recombinant chitinase-3-like protein 1.Collectively,our findings suggest that recombinant chitinase-3-like protein 1 ameliorates surgery-induced cognitive decline by attenuating neuroinflammation via M2 microglial polarization in the hippocampus.Therefore,recombinant chitinase-3-like protein1 may have therapeutic potential fo r postoperative cognitive dysfunction.展开更多
Metacognitive strategies are regarded as advanced strategies in all the learning strategies.This study focuses on the application of metacognitive strategies in English listening in the web-based self-access learning ...Metacognitive strategies are regarded as advanced strategies in all the learning strategies.This study focuses on the application of metacognitive strategies in English listening in the web-based self-access learning environment(WSLE) and tries to provide some references for those students and teachers in the vocational colleges.展开更多
Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s disease.Adult hippocampal neurogenesis is reduced in patients with Alzheimer’s disease.Exercise stimulates adult hippocampal neurogenesis in rode...Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s disease.Adult hippocampal neurogenesis is reduced in patients with Alzheimer’s disease.Exercise stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s disease.However,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly understood.Recently,regulator of G protein signaling 6(RGS6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in mice.Here,we generated novel RGS6fl/fl;APP_(SWE) mice and used retroviral approaches to examine the impact of RGS6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse model.We found that voluntary running in APP_(SWE) mice restored their hippocampal cognitive impairments to that of control mice.This cognitive rescue was abolished by RGS6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal neurogenesis.Adult hippocampal neurogenesis was reduced in sedentary APP_(SWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGS6 deletion in dentate gyrus neural precursor cells.RGS6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGS6-expressing neurons.Thus,RGS6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(SWE) mice,identifying RGS6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.展开更多
There have been numerous attempts recently to promote technology based education (Shrestha, 1997) in the poorer third world countries, but so far all these have not provided a sustainable solution as they are either c...There have been numerous attempts recently to promote technology based education (Shrestha, 1997) in the poorer third world countries, but so far all these have not provided a sustainable solution as they are either centered and controlled from abroad and relying solely on foreign donors for their sustenance or they are not web-based, which make distribution problematic, and some are not affordable by most of the local population in these places. In this paper we discuss an application, the Local College Learning Management System (LoColms) , which we are developing, that is both sustainable and economical to suit the situation inthese countries. The application is a web-based system, and aims at improving the traditional form of education by empowering the local universities. Its economicability comes from the fact that it is supported by traditional communication technology, the public switching telephone network system, PSTN, which eliminates the need for packet switched or dedicated private virtual networks (PVN) usually required in similar situations. At a later stage, we shall incorporate ontology and paging tools to improve resource sharability and storage optimization in the Proxy Caches (ProCa) and LoColms servers. The system is based on the client/server paradigm and its infrastructure consists of the PSTN, ProCa, with the learning centers accessing the universities by means of point-to-point protocol (PPP) .展开更多
College English is a compulsory course for all registered online learners in Jiangsu Open University and students have been practicing web-based learning instead of face-to-face classes ever since 2014.Questionnaires ...College English is a compulsory course for all registered online learners in Jiangsu Open University and students have been practicing web-based learning instead of face-to-face classes ever since 2014.Questionnaires and interviews are adopted to look into the 4-year-long practice of web-based learning in College English in JSOU.By analyzing the data obtained from both teachers and students,the findings show:(1)web-based learning caters to online learners in that the online learning materials,particularly micro-lessons,are well-designed and easily accessible.(2)web-based learning helps teachers monitor the learning process of online learners and therefore assures the quality of online learning.(3)web-based learning enhances effective learning since students and teachers can communicate conveniently and instantly via online chat rooms and instant messaging software.展开更多
Since Henry Holec first put forward the term‘Autonomy'in 1980's, autonomous learning has been drawing the universal attention of scholars both at home and abroad. Promoting learners' ability of self-regul...Since Henry Holec first put forward the term‘Autonomy'in 1980's, autonomous learning has been drawing the universal attention of scholars both at home and abroad. Promoting learners' ability of self-regulated learning has been taken as one of the important goals of modern education. College English autonomous learning based on network environment does not mean free study without any restraints or monitoring, but rather involves the self-monitoring and external monitoring. Meanwhile, different learners may have different cognitive styles in their learning processes, which may have an influence on the improvement of the learners' efficiency in the autonomous language learning. Proper monitoring models coordinating with the students' different field cognitive styles.展开更多
In a field rapidly evolving over the past few years, the management of inflammatory bowel diseases(IBD), Crohn's disease and ulcerative colitis, is becoming in-creasingly complex, demanding and challenging. In the...In a field rapidly evolving over the past few years, the management of inflammatory bowel diseases(IBD), Crohn's disease and ulcerative colitis, is becoming in-creasingly complex, demanding and challenging. In the recent years, IBD quality measures aiming to improve patients' care have been developed, multiple new medical therapies have been approved, new treatment goals have been set with the "treat--to--target" concept and drug monitoring has been implemented into IBD clinical management. Moreover, patients are increasingly using Internet resources to obtain information about their health conditions. The healthcare professional with an interest in treating IBD patients should deal with all these challenges in everyday practice by establishing, enhancing and maintaining a strong core of knowledge and skills related to IBD. This is an ongoing process and traditionally these needs are covered with additional reading of textbook or journal articles, attendance at meetings or conferences, or at local rounds. Web--based learning resources expand the options for knowledge acquisition and save time and costs as well. In the new era of communications technology, web-based resources can cover the educational needs of both patients and healthcare professionals and can contribute to improvement of disease management and patient care. Healthcare professionals can individually visit and navigate regularly relevant websites and tailor choices for educational activities according to their existing needs. They can also provide their patients with a few certified suitable internet resources. In this review, we explored the Internet using PubMed and Startpage(Google), for web-based IBD--related educational resources aiming to provide a guide for those interested in obtaining certified knowledge in this subject.展开更多
In web-based learning environment,College English writing has always been a thorny issue.Here both asynchronous and synchronous communications in college English writing mean the new interactive teaching belief. This ...In web-based learning environment,College English writing has always been a thorny issue.Here both asynchronous and synchronous communications in college English writing mean the new interactive teaching belief. This paper attempts to do the blending of two in the traditional writing learning and teaching in college English in order to promote a more flexible,efficient and interactive learning environment in accordance with students' interests and needs.展开更多
<p align="left"> <span style="font-family:Verdana;">Online learning has been on an upward trend for many years and is becoming more and more prevalent every day, consistently presenting...<p align="left"> <span style="font-family:Verdana;">Online learning has been on an upward trend for many years and is becoming more and more prevalent every day, consistently presenting the less privileged parts of our society with an equal opportunity at education. Unfortunately, though, it seldom takes advantage of the new technologies and capabilities offered by the modern World Wide Web. In this article, we present an interactive online platform that provides users with learning activities for students of English as a foreign language. The platform focuses on using audiovisual multimedia content and a user experience (UX) centered approach to provide learners with an enhanced learning experience that aims at improving their knowledge level while at the same time increasing their engagement and motivation to participate in learning. To achieve this, the platform uses advanced techniques, such as interactive vocabulary and pronunciation assistance, mini-games, embedded media, voice recording, and more. In addition, the platform provides educators with analytics about user engagement and performance. In this study, more than 100 young students participated in a preliminary use of the aforementioned platform and provided feedback concerning their experience. Both the platform’s metrics and the user-provided feedback indicated increased engagement and a preference of the participants for interactive audiovisual multimedia-based learning activities.</span> </p>展开更多
This survey study aims to investigate the perceptions learners have of the character-learning strategies they employ when taking a web-based course in Chinese.The seven Likert-scale statements are included in the ques...This survey study aims to investigate the perceptions learners have of the character-learning strategies they employ when taking a web-based course in Chinese.The seven Likert-scale statements are included in the questionnaire to examine learners’opinions on the three character-learning strategies that are widely used in traditional campus courses.A total of 65 students who completed the beginner level‘Chinese Characters’web-based course at a university in Sweden completed the survey.The results suggest that students in web-based courses consider these three strategies to be just as helpful and effective as campus students;moreover,the more orthodox strategy-rote learning-is found to be the most popular among distance students.Furthermore,findings of this study provide insight into the limitations and advantages associated with a web-based course,and also the possible effect learners’age and gender may have on learning strategy preferences.展开更多
Stroke is a leading cause of disability and mortality worldwide,necessitating the development of advanced technologies to improve its diagnosis,treatment,and patient outcomes.In recent years,machine learning technique...Stroke is a leading cause of disability and mortality worldwide,necessitating the development of advanced technologies to improve its diagnosis,treatment,and patient outcomes.In recent years,machine learning techniques have emerged as promising tools in stroke medicine,enabling efficient analysis of large-scale datasets and facilitating personalized and precision medicine approaches.This abstract provides a comprehensive overview of machine learning’s applications,challenges,and future directions in stroke medicine.Recently introduced machine learning algorithms have been extensively employed in all the fields of stroke medicine.Machine learning models have demonstrated remarkable accuracy in imaging analysis,diagnosing stroke subtypes,risk stratifications,guiding medical treatment,and predicting patient prognosis.Despite the tremendous potential of machine learning in stroke medicine,several challenges must be addressed.These include the need for standardized and interoperable data collection,robust model validation and generalization,and the ethical considerations surrounding privacy and bias.In addition,integrating machine learning models into clinical workflows and establishing regulatory frameworks are critical for ensuring their widespread adoption and impact in routine stroke care.Machine learning promises to revolutionize stroke medicine by enabling precise diagnosis,tailored treatment selection,and improved prognostication.Continued research and collaboration among clinicians,researchers,and technologists are essential for overcoming challenges and realizing the full potential of machine learning in stroke care,ultimately leading to enhanced patient outcomes and quality of life.This review aims to summarize all the current implications of machine learning in stroke diagnosis,treatment,and prognostic evaluation.At the same time,another purpose of this paper is to explore all the future perspectives these techniques can provide in combating this disabling disease.展开更多
文摘The paper, with the backdrop of web-based autonomous learning put forward by the recent college English teaching reform, aims to explore teachers' roles in this learning process in students' perception through the means of questionnaires and interviews. It further analyzes the possible reasons why students perceive their teachers' roles in such a way, in the hope of providing some implications for web-based college English autonomous learning.
文摘The thesis introduces a comparative study of students'autonomous listening practice in a web-based autonomous learning center and the traditional teacher-dominated listening practice in a traditional language lab.The purpose of the study is to find how students'listening strategies differ in these two approaches and thereby to find which one better facilitates students'listening proficiency.
基金supported by the National Natural Science Foundation of China,No.62276089。
文摘Artificial neural networks are capable of machine learning by simulating the hiera rchical structure of the human brain.To enable learning by brain and machine,it is essential to accurately identify and correct the prediction errors,referred to as credit assignment(Lillicrap et al.,2020).It is critical to develop artificial intelligence by understanding how the brain deals with credit assignment in neuroscience.
基金supported by the Ministry of Science and Technology of China,No.2020AAA0109605(to XL)Meizhou Major Scientific and Technological Innovation PlatformsProjects of Guangdong Provincial Science & Technology Plan Projects,No.2019A0102005(to HW).
文摘Early identification and treatment of stroke can greatly improve patient outcomes and quality of life.Although clinical tests such as the Cincinnati Pre-hospital Stroke Scale(CPSS)and the Face Arm Speech Test(FAST)are commonly used for stroke screening,accurate administration is dependent on specialized training.In this study,we proposed a novel multimodal deep learning approach,based on the FAST,for assessing suspected stroke patients exhibiting symptoms such as limb weakness,facial paresis,and speech disorders in acute settings.We collected a dataset comprising videos and audio recordings of emergency room patients performing designated limb movements,facial expressions,and speech tests based on the FAST.We compared the constructed deep learning model,which was designed to process multi-modal datasets,with six prior models that achieved good action classification performance,including the I3D,SlowFast,X3D,TPN,TimeSformer,and MViT.We found that the findings of our deep learning model had a higher clinical value compared with the other approaches.Moreover,the multi-modal model outperformed its single-module variants,highlighting the benefit of utilizing multiple types of patient data,such as action videos and speech audio.These results indicate that a multi-modal deep learning model combined with the FAST could greatly improve the accuracy and sensitivity of early stroke identification of stroke,thus providing a practical and powerful tool for assessing stroke patients in an emergency clinical setting.
文摘The paper is a literature review, aiming to examine the effectiveness of web-based college English learning which mainly focuses on learners' autonomous learning. Previous studies indicate that the web-based learning can improve learners' autonomous learning, as well as some problems found in their findings. Therefore, this paper first gives a summary and critique of research studies on the web-based autonomous learning and some factors influencing learners' autonomous learning ability;then, areas that deserve further study are also indicated.
文摘Machine learning(ML)is a type of artificial intelligence that assists computers in the acquisition of knowledge through data analysis,thus creating machines that can complete tasks otherwise requiring human intelligence.Among its various applications,it has proven groundbreaking in healthcare as well,both in clinical practice and research.In this editorial,we succinctly introduce ML applications and present a study,featured in the latest issue of the World Journal of Clinical Cases.The authors of this study conducted an analysis using both multiple linear regression(MLR)and ML methods to investigate the significant factors that may impact the estimated glomerular filtration rate in healthy women with and without non-alcoholic fatty liver disease(NAFLD).Their results implicated age as the most important determining factor in both groups,followed by lactic dehydrogenase,uric acid,forced expiratory volume in one second,and albumin.In addition,for the NAFLD-group,the 5th and 6th most important impact factors were thyroid-stimulating hormone and systolic blood pressure,as compared to plasma calcium and body fat for the NAFLD+group.However,the study's distinctive contribution lies in its adoption of ML methodologies,showcasing their superiority over traditional statistical approaches(herein MLR),thereby highlighting the potential of ML to represent an invaluable advanced adjunct tool in clinical practice and research.
基金supported by the National Natural Science Foundation of China,Nos.81730033,82171193(to XG)the Key Talent Project for Strengthening Health during the 13^(th)Five-Year Plan Period,No.ZDRCA2016069(to XG)+1 种基金the National Key R&D Program of China,No.2018YFC2001901(to XG)Jiangsu Provincial Medical Key Discipline,No.ZDXK202232(to XG)。
文摘Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of patients.To date,there are no viable treatment options for postoperative cognitive dysfunction.The identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future research.To identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial fracture.The dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub gene.Therefore,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re surgery.Mice were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning tests.In addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western blotting.Treatment with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expression compared with vehicle treatment.Intraperitoneal administration of the specific ERK inhibitor PD98059 diminished the effects of recombinant chitinase-3-like protein 1.Collectively,our findings suggest that recombinant chitinase-3-like protein 1 ameliorates surgery-induced cognitive decline by attenuating neuroinflammation via M2 microglial polarization in the hippocampus.Therefore,recombinant chitinase-3-like protein1 may have therapeutic potential fo r postoperative cognitive dysfunction.
文摘Metacognitive strategies are regarded as advanced strategies in all the learning strategies.This study focuses on the application of metacognitive strategies in English listening in the web-based self-access learning environment(WSLE) and tries to provide some references for those students and teachers in the vocational colleges.
基金supported by the National Institutes of Health,Nos.AA025919,AA025919-03S1,and AA025919-05S1(all to RAF).
文摘Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s disease.Adult hippocampal neurogenesis is reduced in patients with Alzheimer’s disease.Exercise stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s disease.However,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly understood.Recently,regulator of G protein signaling 6(RGS6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in mice.Here,we generated novel RGS6fl/fl;APP_(SWE) mice and used retroviral approaches to examine the impact of RGS6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse model.We found that voluntary running in APP_(SWE) mice restored their hippocampal cognitive impairments to that of control mice.This cognitive rescue was abolished by RGS6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal neurogenesis.Adult hippocampal neurogenesis was reduced in sedentary APP_(SWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGS6 deletion in dentate gyrus neural precursor cells.RGS6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGS6-expressing neurons.Thus,RGS6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(SWE) mice,identifying RGS6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.
文摘There have been numerous attempts recently to promote technology based education (Shrestha, 1997) in the poorer third world countries, but so far all these have not provided a sustainable solution as they are either centered and controlled from abroad and relying solely on foreign donors for their sustenance or they are not web-based, which make distribution problematic, and some are not affordable by most of the local population in these places. In this paper we discuss an application, the Local College Learning Management System (LoColms) , which we are developing, that is both sustainable and economical to suit the situation inthese countries. The application is a web-based system, and aims at improving the traditional form of education by empowering the local universities. Its economicability comes from the fact that it is supported by traditional communication technology, the public switching telephone network system, PSTN, which eliminates the need for packet switched or dedicated private virtual networks (PVN) usually required in similar situations. At a later stage, we shall incorporate ontology and paging tools to improve resource sharability and storage optimization in the Proxy Caches (ProCa) and LoColms servers. The system is based on the client/server paradigm and its infrastructure consists of the PSTN, ProCa, with the learning centers accessing the universities by means of point-to-point protocol (PPP) .
文摘College English is a compulsory course for all registered online learners in Jiangsu Open University and students have been practicing web-based learning instead of face-to-face classes ever since 2014.Questionnaires and interviews are adopted to look into the 4-year-long practice of web-based learning in College English in JSOU.By analyzing the data obtained from both teachers and students,the findings show:(1)web-based learning caters to online learners in that the online learning materials,particularly micro-lessons,are well-designed and easily accessible.(2)web-based learning helps teachers monitor the learning process of online learners and therefore assures the quality of online learning.(3)web-based learning enhances effective learning since students and teachers can communicate conveniently and instantly via online chat rooms and instant messaging software.
文摘Since Henry Holec first put forward the term‘Autonomy'in 1980's, autonomous learning has been drawing the universal attention of scholars both at home and abroad. Promoting learners' ability of self-regulated learning has been taken as one of the important goals of modern education. College English autonomous learning based on network environment does not mean free study without any restraints or monitoring, but rather involves the self-monitoring and external monitoring. Meanwhile, different learners may have different cognitive styles in their learning processes, which may have an influence on the improvement of the learners' efficiency in the autonomous language learning. Proper monitoring models coordinating with the students' different field cognitive styles.
文摘In a field rapidly evolving over the past few years, the management of inflammatory bowel diseases(IBD), Crohn's disease and ulcerative colitis, is becoming in-creasingly complex, demanding and challenging. In the recent years, IBD quality measures aiming to improve patients' care have been developed, multiple new medical therapies have been approved, new treatment goals have been set with the "treat--to--target" concept and drug monitoring has been implemented into IBD clinical management. Moreover, patients are increasingly using Internet resources to obtain information about their health conditions. The healthcare professional with an interest in treating IBD patients should deal with all these challenges in everyday practice by establishing, enhancing and maintaining a strong core of knowledge and skills related to IBD. This is an ongoing process and traditionally these needs are covered with additional reading of textbook or journal articles, attendance at meetings or conferences, or at local rounds. Web--based learning resources expand the options for knowledge acquisition and save time and costs as well. In the new era of communications technology, web-based resources can cover the educational needs of both patients and healthcare professionals and can contribute to improvement of disease management and patient care. Healthcare professionals can individually visit and navigate regularly relevant websites and tailor choices for educational activities according to their existing needs. They can also provide their patients with a few certified suitable internet resources. In this review, we explored the Internet using PubMed and Startpage(Google), for web-based IBD--related educational resources aiming to provide a guide for those interested in obtaining certified knowledge in this subject.
文摘In web-based learning environment,College English writing has always been a thorny issue.Here both asynchronous and synchronous communications in college English writing mean the new interactive teaching belief. This paper attempts to do the blending of two in the traditional writing learning and teaching in college English in order to promote a more flexible,efficient and interactive learning environment in accordance with students' interests and needs.
文摘<p align="left"> <span style="font-family:Verdana;">Online learning has been on an upward trend for many years and is becoming more and more prevalent every day, consistently presenting the less privileged parts of our society with an equal opportunity at education. Unfortunately, though, it seldom takes advantage of the new technologies and capabilities offered by the modern World Wide Web. In this article, we present an interactive online platform that provides users with learning activities for students of English as a foreign language. The platform focuses on using audiovisual multimedia content and a user experience (UX) centered approach to provide learners with an enhanced learning experience that aims at improving their knowledge level while at the same time increasing their engagement and motivation to participate in learning. To achieve this, the platform uses advanced techniques, such as interactive vocabulary and pronunciation assistance, mini-games, embedded media, voice recording, and more. In addition, the platform provides educators with analytics about user engagement and performance. In this study, more than 100 young students participated in a preliminary use of the aforementioned platform and provided feedback concerning their experience. Both the platform’s metrics and the user-provided feedback indicated increased engagement and a preference of the participants for interactive audiovisual multimedia-based learning activities.</span> </p>
文摘This survey study aims to investigate the perceptions learners have of the character-learning strategies they employ when taking a web-based course in Chinese.The seven Likert-scale statements are included in the questionnaire to examine learners’opinions on the three character-learning strategies that are widely used in traditional campus courses.A total of 65 students who completed the beginner level‘Chinese Characters’web-based course at a university in Sweden completed the survey.The results suggest that students in web-based courses consider these three strategies to be just as helpful and effective as campus students;moreover,the more orthodox strategy-rote learning-is found to be the most popular among distance students.Furthermore,findings of this study provide insight into the limitations and advantages associated with a web-based course,and also the possible effect learners’age and gender may have on learning strategy preferences.
文摘Stroke is a leading cause of disability and mortality worldwide,necessitating the development of advanced technologies to improve its diagnosis,treatment,and patient outcomes.In recent years,machine learning techniques have emerged as promising tools in stroke medicine,enabling efficient analysis of large-scale datasets and facilitating personalized and precision medicine approaches.This abstract provides a comprehensive overview of machine learning’s applications,challenges,and future directions in stroke medicine.Recently introduced machine learning algorithms have been extensively employed in all the fields of stroke medicine.Machine learning models have demonstrated remarkable accuracy in imaging analysis,diagnosing stroke subtypes,risk stratifications,guiding medical treatment,and predicting patient prognosis.Despite the tremendous potential of machine learning in stroke medicine,several challenges must be addressed.These include the need for standardized and interoperable data collection,robust model validation and generalization,and the ethical considerations surrounding privacy and bias.In addition,integrating machine learning models into clinical workflows and establishing regulatory frameworks are critical for ensuring their widespread adoption and impact in routine stroke care.Machine learning promises to revolutionize stroke medicine by enabling precise diagnosis,tailored treatment selection,and improved prognostication.Continued research and collaboration among clinicians,researchers,and technologists are essential for overcoming challenges and realizing the full potential of machine learning in stroke care,ultimately leading to enhanced patient outcomes and quality of life.This review aims to summarize all the current implications of machine learning in stroke diagnosis,treatment,and prognostic evaluation.At the same time,another purpose of this paper is to explore all the future perspectives these techniques can provide in combating this disabling disease.