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Susceptibility weighted imaging in the evaluation of hemorrhagic diffuse axonal injury 被引量:6
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作者 Jing-jing Tao Wei-jiang Zhang +5 位作者 Dong Wang Chun-juan Jiang Hua Wang Wei Li Wei-yang Ji Qing Wang 《Neural Regeneration Research》 SCIE CAS CSCD 2015年第11期1879-1881,共3页
Diffuse axonal injury(DAI)is axonal and small vessel injury produced by a sudden acceleration of the head by an external force,and is a major cause of death and severe disability(Paterakis et al.,2000).Prognosis i... Diffuse axonal injury(DAI)is axonal and small vessel injury produced by a sudden acceleration of the head by an external force,and is a major cause of death and severe disability(Paterakis et al.,2000).Prognosis is poorer in patients with apparent hemorrhage than in those without(Paterakis et al.,2000).Therefore,it is important to identify the presence and precise position of hemorrhagic foci for a more accurate diagnosis.CT and magnetic resonance imaging(MRI)have long been applied in the diagnosis of DAI, but they are not sensitive enough for the detection of small hemorrhagic foci, and cannot meet the requirements for early diagnosis. A major advance in MRI has been the development of susceptibility weighted imaging (SWI), which has greatly increased the ability to detect small hemorrhagic foci after DAI (Ashwal et al., 2006). 展开更多
关键词 Susceptibility weighted imaging in the evaluation of hemorrhagic diffuse axonal injury SWI GCS FLAIR DWI
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Necroptosis plays a crucial role in the exacerbation of retinal injury after blunt ocular trauma
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作者 Yu Huan Xiu-Quan Wu +6 位作者 Tao Chen Ya-Nan Dou Bo Jia Xin He Dong-Yu Wei Zhou Fei Fei Fei 《Neural Regeneration Research》 SCIE CAS CSCD 2023年第4期922-928,共7页
Retinal injury after blunt ocular trauma may directly affect prognosis and lead to vision loss.To investigate the pathological changes and molecular mechanisms involved in retinal injury after blunt ocular trauma,we e... Retinal injury after blunt ocular trauma may directly affect prognosis and lead to vision loss.To investigate the pathological changes and molecular mechanisms involved in retinal injury after blunt ocular trauma,we established a weight drop injury model of blunt ocular trauma in male Beagle dogs.Hematoxylin-eosin staining,immunofluorescence staining,western blotting,and TUNEL assays were performed to investigate retinal injury within 14 days after blunt ocular trauma.Compared with the control group,the thicknesses of the inner and outer nuclear layers,as well as the number of retinal ganglion cells,gradually decreased within 14 days after injury.The number of bipolar cells in the inner nuclear layer began to decrease 1 day after injury,while the numbers of cholinergic and amacrine cells in the inner nuclear layer did not decrease until 7 days after injury.Moreover,retinal cell necroptosis increased with time after injury;it progressed from the ganglion cell layer to the outer nuclear layer.Visual electrophysiological findings indicated that visual impairment began on the first day after injury and worsened over time.Additionally,blunt ocular trauma induced nerve regeneration and Müller glial hyperplasia;it also resulted in the recruitment of microglia to the retina and polarization of those microglia to the M1 phenotype.These findings suggest that necroptosis plays an important role in exacerbating retinal injury after blunt ocular trauma via gliosis and neuroinflammation.Such a role has important implications for the development of therapeutic strategies. 展开更多
关键词 Beagle dogs blunt ocular trauma GLIOSIS M1 microglia Müller cells NECROPTOSIS NEUROINFLAMMATION retinal ganglion cells retinal injury weight drop injury
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