Lithium-bearing Pegmatite Exploration in Western Altun,Xinjiang,using Remote-Sensing Technology

Western Altun in Xinjiang is an important area,where lithium(Li)-bearing pegmatites have been found in recent years.However,the complex terrain and harsh environment of western Altun exacerbates in prospecting for Li-bearing pegmatites.Therefore,remote-sensing techniques can be an effective means for prospecting Li-bearing pegmatites.In this study,the fault information and lithologyical information in the region were obtained using the median-resolution remotesensing image Landsat-8,the radar image Sentinel-1 and hyperspectral data GF-5.Using Landsat-8 data,the hydroxyl alteration information closely related to pegmatite in the region was extracted by principal component analysis,pseudoanomaly processing and other methods.The high spatial resolution remote-sensing data WorldView-2 and WorldView-3 short-wave infrared images were used and analyzed by principal component analysis(PCA),the band ratio method and multi-class machine learning(ML),combined with conventional thresholds specified the algorithms used to automatically extract Li-bearing pegmatite information.Finally,the Li-bearing pegmatite exploration area was determined,based on a comprehensive analysis of the faults,hydroxyl alteration lithology and Li-bearing pegmatite information.Field investigations have verified that the distribution of pegmatites in the central part of the study area is consistent with that of Li-bearing pegmatites extracted in this study.This study provides a new technique for prospecting Li-bearing pegmatites,which shows that remote-sensing technology possesses great potential for identifying lithium-bearing pegmatites,especially in areas that are not readily accessible.

Effect of Panax notoginseng saponins on the expression of beta-amyloid protein in the cortex of the parietal lobe and hippocampus, and spatial learning and memory in a mouse model of senile dementia

BACKGROUND： The pharmacological actions of Panax notoginseng saponins （PNS） lie in removing free radicals, anti-inflammation and anti-oxygenation. It can also improve memory and behavior in rat models of Alzheimer＇s disease. OBJECTIVE： Using the Morris water maze, immunohistochemistry, real-time PCR and RT-PCR, this study aimed to measure improvement in spatial learning, memory, expression of amyloid precursor protein （App） and β -amyloid （A β ）, to investigate the mechanism of action of PNS in the treatment of AD in the senescence accelerated mouse-prone 8 （SAMP8） and compare the effects with huperzine A. DESIGN, TIME AND SETTING： A completely randomized grouping design, controlled animal experiment was performed in the Center for Research ＆ Development of New Drugs, Guangxi Traditional Chinese Medical University from July 2005 to April 2007. MATERIALS： Sixty male SAMP8 mice, aged 3 months, purchased from Tianjin Chinese Traditional Medical University of China, were divided into four groups： PNS high-dosage group, PNS low-dosage group, huperzine A group and control group. PNS was provided by Weihe Pharmaceutical Co., Ltd. （batch No.： Z53021485, Yuxi, Yunan Province, China）. Huperzine A was provided by Zhenyuan Pharmaceutical Co., Ltd. （batch No.： 20040801, Zhejiang, China）. METHODS： The high-dosage group and low-dosage group were treated with 93.50 and 23.38 mg/kg PNS respectively per day and the huperzine A group was treated with 0.038 6 mg/kg huperzine A per day, all by intragastric administration, for 8 consecutive weeks. The same volume of double distilled water was given to the control group. MAIN OUTCOME MEASURES： After drug administration, learning and memory abilities were assessed by place navigation and spatial probe tests. The recording indices consisted of escape latency （time-to-platform）, and the percentage of swimming time spent in each quadrant. The number of A β 1-40, A β 1-42 and App immunopositive neurons in the brains of SAMP8 mice was analyzed by immunohistochemistry. The mRNA content ofApp, tau, acetylcholinesterase, and synaptophysin （Syp） was tested by real time PCR and RT-PCR. RESULTS： The PCR results show that PNS can downregulate the expression of the App gene and upregulate the expression of the Syp gene in the parietal cortex and hippocampus of SAMP8 mice. The therapeutic effects of the PNS high-dosage group were greater than those of the PNS low-dosage group and the huperzine A group （P 〈 0.05）. The results of the Morris water maze and immunohistochemistry indicated that PNS can improve the capacity for spatial learning and memory in SAMP8 mice, and reduce the content of A β 1-40, A β 1-42 and expression of App in the brains of SAMP8 mice. The therapeutic effects of the PNS high-dosage group were greater than that of the PNS low-dosage group and the huperzine A group （P 〈 0.05）. CONCLUSION： These results support the hypothesis that PNS plays a therapeutic and protective role on the pathological lesions and learning dysfunction of Alzheimer＇s disease. The therapeutic effects of PNS for Alzheimer＇s disease are possibly achieved through downregulating the expression of the App gene and upregulating the expression of the Syp gene. The therapeutic effects of PNS are dose-dependent and are greater than the effect of huperzine A.

Parameter Self - Learning of Generalized Predictive Control Using BP Neural Network

This paper describes the self—adjustment of some tuning-knobs of the generalized predictive controller(GPC).A three feedforward neural network was utilized to on line learn two key tuning-knobs of GPC,and BP algorithm was used for the training of the linking-weights of the neural network.Hence it gets rid of the difficulty of choosing these tuning-knobs manually and provides easier condition for the wide applications of GPC on industrial plants.Simulation results illustrated the effectiveness of the method.

Imperatorin alleviates Aβ-induced spatial learning memory impairment and neuroinflam⁃mation in model mice of Alzheimer disease

OBJECTIVE To investigate the effects of imperatorin on the spatial learning memory impairment and neuroinflammation in model mice of Alzheimer disease(AD)induced by intracerebroventricular injection of Aβ1-42.METHODS Mouse model of AD was established by injection of Aβ1-42 into the lateral ventricles.Im⁃peratorin(2.5 and 5.0 mg·kg-1,daily)was inject⁃ed by intraperitoneally 1 h after intracerebroven⁃tricular injection for 13 d.The effect of imperato⁃rin on the spatial learning and memory impair⁃ment was assessed by eight arm maze tests.The levels of cytokines TNF-α,IL-1β,IL-6,IL-18 and chemokines MCP-1 in mouse cortex and hip⁃pocampus were detected by ELISA.The protein expression of NF-κB P65,TLR4,MyD88,p-P38,p-ERK,and p-JNK were detected by Western blotting.RESULTS As compared with the AD model group,imperatorin treatment significantly attenuated Aβ1-42-induced spatial learning and memory impairment assessed by eight arm maze tests.In addition,imperatorin significantly reduced the levels of cytokines TNF-α,IL-1β,IL-6,IL-18 and chemokines MCP-1 in the cerebral cortex and hippocampus.Meanwhile,Western blotting results showed that imperatorin treat⁃ment significantly down-regulated the protein expression of NF-κB P65,TLR4,MyD88,p-P38,p-ERK,and p-JNK.CONCLUSION Imperatorin has neuroprotective effects in the Aβ1-42 induced AD model mice and its mechanism may be partially associated with the inhibition of inflam⁃matory response in the cortex and hippocampus.

Co-translation Strategy for Chinese Culture Going-out in View of the West Learning during the Second Translation Climax in Chinese History

Co-translation is a translation model has been thoughout the whole translation history,and a new co-translation modelemerged in the second translation climax of Chinese history—"Oral Interpretation by Foreigners and Written Chinese by ChineseIntellectuals".During this period,the co-translation brought about the"Western Learning"effect,which was a huge driving forceto the development of China at that time.Consequently,concerning the"Chinese Culture’s Going-out Strategy"in current China,the co-translation model can be analogously used as a reference.By investigating related researches and reading relevant litera-ture,it proposed a co-translation strategy that is consistent with"Chinese Culture Going-out"strategy.

Adolescent Exposure of JWH-018 “Spice” Produces Subtle Effects on Learning and Memory Performance in Adulthood

The active components associated with the bio-designer drugs known variously as “Spice” or “K2” have rapidly gained in popularity among recreational users, forcing the United States Drug Enforcement Administration to classify these compounds as Schedule I drugs in the Spring of 2011. However, although there is some information about many of the synthetic cannabinoids used in Spice products, little is known about the consequences of the main constituent, (1-pentyl-3-(1-naphthoyl)indole;JWH-018), on neuropsychological development or behavior. In the present experiment, adolescent rats were given repeated injections of either saline or 100 μg/kg of JWH-018. Once the animals were 75 days of age, they were trained using tasks with spatial components of various levels of difficulty and a spatial learning set task. On early trials with water maze tasks of varying difficulty, the JWH-018 treated rats were impaired relative to controls. However, by the end of each phase of testing, drug and control animals were comparable, although on probe trials the drug-treated animals spent significantly less time in the target quadrant. In addition, the performance of the drug-treated rats was inferior to that of the control animals on a learning set task, suggesting some difficulty in adapting their responses to changing task demands. The results suggest that chronic exposure to this potent cannabinoid CB1 receptor agonist during adolescence is capable of producing a variety of subtle changes affecting spatial learning and memory performance in adulthood, well after the drug exposure period.

平台项目双引领及促进“科-产-教”深度融合

依托广州华立科技职业学院电力工业自动化研究院平台和广东省科技创新战略专项资金立项项目,创建平台、项目双引领。对接增城本地制造企业,提出构建Solid Learning(形塑学习)培养模式,该模式将数据库、企业、学校联系在一起,以解决企业难点、提升学生STEAM综合能力为目标,探索出一条具有区域特色的“科-产-教”深度融合发展之路。

NP-14 Effects of Osthole on the Improvement of Learning and Memory Impairment in A Mouse Model Injected with Aβ25-35

Objective:We aimed to investigate the effects of osthole on learning and memory impairment of AD mice induced by injection of Aβ25-35 and the content of Ca2+、GLU、Ab1-42 in the brain tissue and peripheral blood.Methods:Mice were randomly assigned to sham operation,Aβ25-35,Aβ25-35+Ost-L,Aβ25-35+Ost-M,and Aβ25-35+Ost-H group.Water maze test was performed to assessing spatial learning ability of mice.It is determined that the MDA level and the activity of SOD in the brain tissue of mice in each group by colorimetry.The GLU kit and Ca2+kit were used to detect the GLU,Ca2+in tissue and serum.Elisa was used to detect the expression of Aβ1-42 in the hippocampus and serum of mice.HE staining and silver staining were used to detect neuron apoptosis and pathological changes in brain slices.Results:①Effects of osthole on learning and memory:With the increase of training day,the escape latencies continuously reduced in each experimental group,the escape latencies of the model group was longer on the 1st,2nd,3rd,and 5th days than the normal group,the difference was statistically significant(day 3,4:P<0.05,day 5:P<0.01);compared with the model group,the escaping latency on the fifth day of the OST low-medium high-dose group was significantly shortened,which was statistically significant(P<0.05).②Effects on oxidative stresspathway:the SOD activity of AD mice in the hippocampus model group was lower than that in the normal group,which was statistically significant(P<0.05);The SOD activity in the OST group was higher than that in the model group,which was statistically significant(P<0.05).The MDA content in the model group was significantly higher than that in the normal group(P<0.05).The MDA content in the OST high-dose group was lower than that in the model group,which was statistically significant(P<0.05).③Effects of GLU levels on neurotransmitters:the results of the detection of GLU in cortical area and GLU in serum of AD mice in OST dose groups showed that serum GLU levels in the model group were significantly lower than those in the sham group,which was statistically significant(P<0.05).GLU levels in the cortical area were also significantly higher than those in the sham group,which was statistically significant(P<0.05).Compared with the model group,GLU levels in the OST administration group were significantly downregulated.Among the serum,the effect of medium dose group was obvious.Although there was a trend of down-regulation in the cortical administration group,there was no statistical significance.④Changes in Ca2+concentration in the brain;Detection of intracellular Ca ion concentration in AD mice by OST doses showed that,compared with the sham group,the model group was significantly upregulated in cortical Ca2+levels.There was no statistical difference in the administration group.Compared with the model group,the concentration of Ca2+in the OST-H group significantly decreased.⑤Effect on levels of Ab1-42 in hippocampus and serum:model group had significantly higher Ab1-42 levels in hippocampus than in sham operation group,which was statistically significant(P<0.05).Ab1-42 in serum was also significantly upregulated compared to the sham group,which was statistically significant(P<0.05).Compared with the model group,the levels of Aβ1-42 in the OST administration group were significantly down-regulated,with the lower and middle doses in the hippocampus being more significant,while the serum was more pronounced at lower doses.⑥Silver staining to detect the tangles of hippocampal neurons:Neuron tangles in the hippocampal CA1 region showed a dark brown-yellow granule distribution in the nuclei of the model group(positive expression).Nerve cell body and dendrites,axons are black or black red,background light yellow.Compared with the model group,the administration group has improved significantly.Conclusion:OST improves spatial learning and memory of dementia model mice injected with Ab25-35 in both hippocampus.Experimental studies have shown that OST has different degrees of regulation on neuronal apoptosis,Ca2+/GLU/oxidative stress and other pathways,and it plays a role in improving multiple AD pathological changes and delaying the pathogenesis of neurodegenerative diseases.

Western印迹检测人肾细胞癌中NF-κB信号通路分子蛋白的表达水平

目的应用Western印迹方法检测人肾细胞癌组织及癌旁组织中NF-κB信号通路蛋白表达,探究NF-κB信号通路与人肾细胞癌之间的可能关系。方法手术获得3对人肾细胞癌组织标本以及相应的癌旁组织标本,利用Western印迹方法检测人肾细胞组织以及相应癌旁组织中NF-κB信号通路蛋白p-IκB、NF-κB P65以及NF-κB P50表达水平。结果与相应癌旁组织比较,人肾细胞癌组织中NF-κB信号通路蛋白IκBa表达水平明显下降,而NF-κB信号通路蛋白NF-κB P65和NF-κB P50表达水平明显升高。结论人肾细胞癌的发生可能与NF-κB信号通路存在一定的相关性。

Plasma microRNA-15a/16-1-based machine learning for early detection of hepatitis B virus-related hepatocellular carcinoma

Background and aims:Hepatocellular carcinoma(HCC),which is prevalent worldwide and has a high mortality rate,needs to be effectively diagnosed.We aimed to evaluate the significance of plasma microRNA-15a/16-1(miR-15a/16)as a biomarker of hepatitis B virus-related HCC(HBV-HCC)using the machine learning model.This study was the first large-scale investigation of these two miRNAs in HCC plasma samples.Methods:Using quantitative polymerase chain reaction,we measured the plasma miR-15a/16 levels in a total of 766 participants,including 74 healthy controls,335 with chronic hepatitis B(CHB),47 with compensated liver cirrhosis,and 310 with HBV-HCC.The diagnostic performance of miR-15a/16 was examined using a machine learning model and compared with that of alpha-fetoprotein(AFP).Lastly,to validate the diagnostic efficiency of miR-15a/16,we performed pseudotemporal sorting of the samples to simulate progression from CHB to HCC.Results:Plasma miR-15a/16 was significantly decreased in HCC than in all control groups(P<0.05 for all).In the training cohort,the area under the receiver operating characteristic curve(AUC),sensitivity,and average precision(AP)for the detection of HCC were higher for miR-15a(AUC=0.80,67.3%,AP=0.80)and miR-16(AUC=0.83,79.0%,AP=0.83)than for AFP(AUC=0.74,61.7%,AP=0.72).Combining miR-15a/16 with AFP increased the AUC to 0.86(sensitivity 85.9%)and the AP to 0.85 and was significantly superior to the other markers in this study(P<0.05 for all),as further demonstrated by the detection error tradeoff curves.Moreover,miR-15a/16 impressively showed potent diagnostic power in early-stage,small-tumor,and AFP-negative HCC.A validation cohort confirmed these results.Lastly,the simulated follow-up of patients further validated the diagnostic efficiency of miR-15a/16.Conclusions:We developed and validated a plasma miR-15a/16-based machine learning model,which exhibited better diagnostic performance for the early diagnosis of HCC compared to that of AFP.

Recognition of Ancient Oceanic Island in Paleo-Tethys,Western Yunnan

A volcano-platform carbonate sequence ,from Carboniferous to Permian , is widely trapped in the deep water deposits in Changning- Menglian belt .Three components can be roughly recognized in ascending order as :the lava .the volcaniclastic and carbonate rocks .In most cases, the sequence is incomplete due to faulting resulted from the strong orogenic compression. But (he stratigraphic succession is continuous except for the two interruptions of paleokarsts . which extended from middle Late Carboniferous to Late Permian and from late Early Permian to Late Permian respectively .A preliminary study indicates that the stratigraphy, petrology , sedimentation , vokanism geochemistry and fossils in the sequence are quite similar to mat in modern and ancient oceanic islands and there may be the relics of ancient oceanic islands in the paleo-Tethys .The differences among these sequences probably suggest a complex configuration of the islands or island chain These islands were formed under infra oceanic environments of the paleo-Tethys ,far from continent and accreted to Simao continental margin in Late Permian .The occurrence of large number of ancient oceanic islands in orogenic belts , including the paleo Tethys, Cordillera , etc ..suggests mat some ancient oceans .such as the paleo Tethys and proto-Pacific ,were full of archipelagoes as their modem counterparts . It is possible that more oceanic islands will be recongnized when sufficient research is done in orogenic belts over the world .

非小细胞肺癌组织MAGE-1蛋白的Western印迹分析

目的检测黑素瘤抗原-1(MAGE-1)蛋白在非小细胞肺癌(NSCLC)中的表达,探讨以该蛋白作为疫苗对NSCLC患者进行免疫治疗的可能性。方法采用Western印迹法对3种人肺癌细胞系和56例NSCLC标本及相邻正常肺组织标本MAGE-1蛋白的表达情况进行研究。结果3种人肺癌细胞系均表达MAGE-1蛋白;56例NSCLC标本中,25例表达MAGE-1蛋白,而相邻正常肺组织均不表达。结论MAGE-1蛋白在NSCLC中呈高频率表达,提示该蛋白有望成为对NSCLC患者进行免疫治疗的适宜靶点。

10-25-Day Intraseasonal Variations of Convection and Circulation Associated with Thermal State of the Western Pacific Warm Pool during Boreal Summer

This study focuses on the characteristics of 10-25-day oscillation associated with the interannual variability of the thermal state in the western Pacific warm pool. The time series of 10-25-day oscillation shows a distinct feature between warm (WARM case) and cold (COLD case) summers over the western Pacific warm pool. The significant negative relationship between the time series of 10-25-day convection anomalies in Warm and Cold cases appears over most of Asian-Pacific region manifesting the interactions between the convection on interannual and 10-25-day intraseasonal time scales. At the peak and trough stages of 10-25-day convection oscillation, a Gill-type low-level atmospheric circulation anomaly, cyclonic or anticyclonic. appears northwest of the convection anomaly. This relationship between the convection and circulation exists both in Warm case and in Cold case. However, at other stages rather than the peak and trough stages, there is no Gill-type circulation response, and the circulation anomaly shows a distinct feature between the Warm and Cold cases, although the convection oscillation exhibits a roughly similar feature.

COMPARISON STUDY ON THE INTRASEASONAL VARIATIONS IN CIRCULATIONS AND PRECIPITATION MODULATED BY THE TROPICAL CYCLOGENESIS OVER SOUTH CHINA SEA-WESTERN PACIFIC DURING GUANGDONG FLOODING PERIOD

Based on tropical cyclone datasets from Shanghai Typhoon Institute of China Meteorological Administration,the National Centers for Environmental Prediction (NCEP,USA) reanalysis data and the rainfall records from 743 stations in China,the impacts of cyclogenesis number over the South China Sea and the western Pacific are studied on the 30-60-day oscillations in the precipitation of Guangdong during the flooding period.The year with more-than-normal (less-than-normal) tropical cyclogenesis is defined as a 'high year' ('low year').In light of the irregular periodic oscillations,the method used to construct the composite life cycle is based on nine consecutive phases in each of the cycles.Phases 1,3,5,and 7 correspond to,respectively,the time when precipitation anomalies reach theminimum,a positive transition (negative-turning-to-positive) phase,the maximum,and a negative transition phase.The results showed that the precipitation of the 30-60-day oscillations is associated with the interaction between a well-organized eastward propagation system from the Arabian Sea/Bay of Bengal and a westward-propagating system (with cyclonic and anticyclonic anomalies in the northwest-southeast direction) from the South China Sea to western Pacific during the high years,whereas the precipitation is affected during a low year by the circulation over the South China Sea and western Pacific (with cyclonic and anticyclonic anomalies in the northeast-southwest direction).During the high year,the warm and wet air mass from the ocean to the west and south are transported to Guangdong by westerly anomalies and an enclosed latitudinal cell,which ascends in the Northern Hemisphere low latitudes and descends in the Southern Hemisphere low latitudes.During the low year,the warm and wet air mass from the ocean to the south is transported to Guangdong by southwesterly wind anomalies and local ascending movements.Because the kinetic energy,westerly,easterly shift,vertical velocity and vapor transportation averaged over (109-119° E,10-20° N) is stronger in high years than those in low years,the precipitation of the 30-60-day oscillations in Guangdong is higher in high years than that in low years.

miR-9-3p对细胞脂代谢调节功能及可能机制

目的 检测microRNA-9-3p (miR-9-3p)对HepG2细胞增殖及脂质代谢的影响,探讨其对细胞沉默信息调节因子(Sirt-1)蛋白表达的影响。方法 以HepG2细胞为体外细胞模型,应用体外细胞培养技术、噻唑蓝(MTT)比色法、转染技术和Western印迹,以miR-9-3p mimic、miR-9-3p inhibitor转染为干预手段,应用MTT比色法、Western印迹检测正常对照组、miR-9-3p mimic组、anti-miR-9-3p组3组HepG2细胞增殖水平、总胆固醇(TC)及三酰甘油(TG)表达水平及Sirt-1蛋白的表达。结果 miR-9-3p mimic组miR-9-3p表达水平显著高于正常对照组(P<0.05);anti-miR-9-3p组miR-9-3p表达水平显著低于正常对照组(P<0.05);与正常对照组相比,miR-9-3p mimic组HepG2细胞增殖显著增加(P<0.05);anti-miR-9-3p组HepG2细胞增殖显著抑制(P<0.05);miR-9-3p mimic组HepG2细胞TC及TG表达水平显著增加(P<0.05);anti-miR-9-3p组HepG2细胞TC及TG表达水平显著降低(P<0.05);miR-9-3p mimic组HepG2细胞Sirt-1蛋白表达水平显著降低(P<0.05);anti-miR-9-3p组HepG2细胞Sirt-1蛋白表达水平显著增加(P<0.05)。结论 miR-9-3p转染能够促进HepG2细胞增殖;miR-9-3p转染显著增加HepG2细胞TG及TC表达;miR-9-3p转染能够显著降低HepG2细胞Sirt-1蛋白表达。miR-9-3p能够影响HepG2细胞增殖及TC及TG代谢,其可能是通过调节Sirt-1蛋白表达发挥作用。

Expression of miR-9-5p and RHOA in aluminum-induced rat cognitive dysfunction

Objective:To investigate the possible mechanism of microRNA-9-5p(miR-9-5p)and Ras homologous gene family A(RHOA)in aluminum-induced cognitive dysfunction in rats.Methods:According to the principle of randomization,48 Wistar rats were randomly divided into four groups(n=12)of blank control,low dose,medium dose and high dose.The blank control group was gavaged daily saline,and the other three dose groups were given daily gavage AlCl3 aqueous solution at three doses of 25 mg/kg,50 mg/kg,and 100 mg/kg to create a rat model of cognitive impairment for three months.The water maze(MWM)positioning navigation experiment was used to record the time t(s),namely,the incubation period,on the platform of rats,and the incubation period of each group was used to determine whether the rats in the infected group had learning and memory impairment.Hematoxylin-eosin(HE)and Nissl stains observed the pathological changes of nerve cells in the hippocampus of the four groups.Western blot detected the protein expression levels of RHOA and cranial neurotrophic factor(BDNF)in fresh rat hippocampal tissues.RT-qPCR detected the mRNA expression of miR-9-5p,RHOA,and BDNF in rat hippocampal tissues.Results:The results of Morris water maze positioning navigation test showed that the incubation period of each group was calculated on the 1st,3rd and 5th days of the experiment,and the motor incubation period of the infected group was higher than that of the control group.The results of HE staining showed that the rat nerve cells in the control group were morphologically intact,the staining was clear,the nucleus was clearly visible,and the edge of the cell membrane was sharp.The rat neurons in the infected group were damaged to varying degrees,the nucleus gradually dissolved,the cytoplasmic staining became deeper,the edges of the cell membrane were blurred and disordered,and the cells were deformed and arranged disordered.The results of Nissl staining showed that the well-stained Nissl body particles were visible in the nerve cells of rats in the control group,and the dissipation of Nissl bodies in the nerve cells of the infected group was reduced,and the staining was shallow.The results of RT-qPCR showed that compared with the control group,the mRNA expression of miR-9-5p and BDNF was decreased in the infected group,and the mRNA expression of RHOA was increased(P<0.05 or P<0.001).The Western blot results showed that compared with the control group,the relative expression of BDNF in the three infected groups was decreased,and the relative expression of RHOA increased(P<0.05).Conclusion:In aluminum-induced cognitive impairment,miR-9-5p is downregulated and RHOA is upregulatd.

明清之际中国社会对欧洲文明的拒斥与接受

16-18世纪耶稣会传教士来中国传教,同时也带来了部分西方的科学知识。中国的儒家士人和士大夫群体中,有一部分人激烈反对、拒斥接受这些知识,也有一部分人乐于学习传教士带来的科学知识,接受并试图融合而后超越西方文化。拒斥的一方,有出于意识形态立场、政治安全角度考虑的,如《破邪集》的编辑者徐昌治,以及该书中收录的各色人等,如清初布衣杨光先;也有王夫之这样的大儒,从儒家经学中天文、地理知识的固有立场出发,批评利玛窦的地圆说和地球与太阳及诸行星的距离说。接受的一方表现出比较多元的立场,有徐光启的“超胜会通”说、方以智的“坐集千古之智”折衷说,也有以康熙皇帝为代表的“西学中源”说。“西学中源”说虽然最终不利于中国人虚心学习西方的科学知识,但也包含着一定的合理的文明交流互鉴思想,即在学习外来文明中的先进内容时,必须保持民族文化的主体性。

基于项目式教学的“西方文化与交际”课程实证研究

以项目式教学法为理论框架,借助网络平台搭建了“西方文化与交际”课程线上线下混合的项目式教学设计,并辅以定量数据与定性分析相结合的研究方法探讨了该教学设计的有效性。研究结果表明,相比于传统教学法,此教学模式能促进学生积极参与课堂,更有效地提高“西方文化与交际”课程的教学效果和教学质量。学生的主观能动性得到激活,提高学习效率,在自然、真实、有意义的教学活动中获得文化知识与跨文化交际能力。

文明互鉴视野下19世纪后期至20世纪早期西方设计史上的折叠屏风

19世纪后期至20世纪早期,西方很多著名设计师如威廉·莫里斯、阿尔丰斯·穆夏等都曾设计过源自中国的折叠屏风。这一突出的现象,是“中国风”的余波与“日本风”的流行所导致的结果。这固然显现了当时弱势的东方文化对强势的西方文化的影响,实际上不过是因东西文明形态不同而产生的文明互鉴的一个常态表现。当然,强势的西方对处于弱势的东方文化采取的“拿来主义”态度是文明互鉴能够发生的一个前提。由此在设计界产生的折衷主义理念,指导着莫里斯等人将折叠屏风作为异域的设计资源,用为实现其求新求变、施展才华的一个媒介,成功地将其本土化,从而完整地演绎了文明互鉴的过程,也使莫里斯等人的折叠屏风成为其中的一个鲜活案例。