AIM:To evaluate scleral buckling(SB)surgery using a noncontact wide-field viewing system and 23-gauge intraocular illumination for the treatment of rhegmatogenous retinal detachment in silicone oil(SO)-filled eyes.MET...AIM:To evaluate scleral buckling(SB)surgery using a noncontact wide-field viewing system and 23-gauge intraocular illumination for the treatment of rhegmatogenous retinal detachment in silicone oil(SO)-filled eyes.METHODS:Totally 9 patients(9 eyes)with retinal detachment in SO-filled eyes were retrospectively analyzed.All patients underwent non-contact wide-field viewing system-assisted buckling surgery with 23-gauge intraocular illumination.SO was removed at an appropriate time based on recovery.The patients were followed up for at least 3mo after SO removal.Retinal reattachment,complications,visual acuity and intraocular pressure(IOP)before and after surgery were observed.RESULTS:Patients were followed up for a mean of 8.22mo(3-22mo)after SO removal.All patients had retinal reattachment.At the final follow-up,visual acuity showed improvement for 8 patients,and no change for 1 patient.The IOP was high in 3 patients before surgery,but it stabilized after treatment;it was not affected in the other patients.None of the patients had infections,hemorrhage,anterior ischemia,or any other complication.CONCLUSION:This new non-contact wide-field viewing system-assisted SB surgery with 23-gauge intraocular illumination is effective and safe for retinal detachment in SO-filled eyes.展开更多
We propose and implement a wide-field vibrational phase contrast detection to obtain imaging of imaginary components of third-order nonlinear susceptibility in a coherent anti-Stokes Raman scattering （CARS） microsco...We propose and implement a wide-field vibrational phase contrast detection to obtain imaging of imaginary components of third-order nonlinear susceptibility in a coherent anti-Stokes Raman scattering （CARS） microscope with full suppression of the non-resonant background. This technique is based on the unique ability of recovering the phase of the generated CARS signal based on holographic recording. By capturing the phase distributions of the generated CARS field from the sample and from the environment under resonant illumination, we demonstrate the retrieval of imaginary components in the CARS microscope and achieve background free coherent Raman imaging.展开更多
Metasurfaces have demonstrated unprecedented capabilities in manipulating light with ultrathin and flat architectures.Although great progress has been made in the metasurface designs and function demonstrations,most m...Metasurfaces have demonstrated unprecedented capabilities in manipulating light with ultrathin and flat architectures.Although great progress has been made in the metasurface designs and function demonstrations,most metalenses still only work as a substitution of conventional lenses in optical settings,whose integration advantage is rarely manifested.We propose a highly integrated imaging device with silicon metalenses directly mounted on a complementary metal oxide semiconductor image sensor,whose working distance is in hundreds of micrometers.The imaging performances including resolution,signal-to-noise ratio,and field of view(FOV)are investigated.Moreover,we develop a metalens array with polarization-multiplexed dual-phase design for a wide-field microscopic imaging.This approach remarkably expands the FOV without reducing the resolution,which promises a non-limited space-bandwidth product imaging for wide-field microscopy.As a result,we demonstrate a centimeter-scale prototype for microscopic imaging,showing uniqueness of meta-design for compact integration.展开更多
High-speed ophthalmic optical coherence tomography(OCT)systems are of interest because they allow rapid,motion-free,and wide-field retinal imaging.Space-division multiplexing optical coherence tomography(SDMOCT)is a h...High-speed ophthalmic optical coherence tomography(OCT)systems are of interest because they allow rapid,motion-free,and wide-field retinal imaging.Space-division multiplexing optical coherence tomography(SDMOCT)is a high-speed imaging technology that takes advantage of the long coherence length of micro electro mechanical vertical cavity surface emitting laser sources to multiplex multiple images along a single imaging depth.We demonstrate wide-field retinal OCT imaging,acquired at an effective A-scan rate of 800,000 A-scans/s with volumetric images covering up to 12.5 mm×7.4 mm on the retina and captured in less than 1 s.A clinical feasibility study was conducted to compare the ophthalmic SDM-OCT with commercial OCT systems,illustrating the high-speed capability of SDM-OCT in a clinical setting.展开更多
Microscopy is very important in research and industry,yet traditional optical microscopy suffers from the limited field-of-view(FOV)and depth-of-field(DOF)in high-resolution imaging.We demonstrate a simultaneous large...Microscopy is very important in research and industry,yet traditional optical microscopy suffers from the limited field-of-view(FOV)and depth-of-field(DOF)in high-resolution imaging.We demonstrate a simultaneous large FOV and DOF microscope imaging technology based on a chip-scale metalens device that is implemented by a SiNxmetalens array with a co-and cross-polarization multiplexed dual-phase design and dispersive spectrum zoom effect.A 4-mm×4-mm FOV is obtained with a resolution of 1.74μm and DOF of200μm within a wavelength range of 450 to 510 nm,which definitely exceeds the performance of traditional microscopes with the same resolution.Moreover,it is realized in a miniaturized compact prototype,showing an overall advantage for portable and convenient microscope technology.展开更多
Detecting and tracking multiple targets simultaneously for space-based surveillance requires multiple cameras,which leads to a large system volume and weight. To address this problem, we propose a wide-field detection...Detecting and tracking multiple targets simultaneously for space-based surveillance requires multiple cameras,which leads to a large system volume and weight. To address this problem, we propose a wide-field detection and tracking system using the segmented planar imaging detector for electro-optical reconnaissance. This study realizes two operating modes by changing the working paired lenslets and corresponding waveguide arrays： a detection mode and a tracking mode. A model system was simulated and evaluated using the peak signal-to-noise ratio method. The simulation results indicate that the detection and tracking system can realize wide-field detection and narrow-field, multi-target, high-resolution tracking without moving parts.展开更多
基金Supported by National Natural Science Foundation of China(No.81700884)Scientific Research Foundation of National Health and Health Commission(No.WKJ-ZJ-2037)+1 种基金Zhejiang Public Welfare Technology Application Project(No.LGF21H120005)Science and Technology Project of Wenzhou(No.Y20190649).
文摘AIM:To evaluate scleral buckling(SB)surgery using a noncontact wide-field viewing system and 23-gauge intraocular illumination for the treatment of rhegmatogenous retinal detachment in silicone oil(SO)-filled eyes.METHODS:Totally 9 patients(9 eyes)with retinal detachment in SO-filled eyes were retrospectively analyzed.All patients underwent non-contact wide-field viewing system-assisted buckling surgery with 23-gauge intraocular illumination.SO was removed at an appropriate time based on recovery.The patients were followed up for at least 3mo after SO removal.Retinal reattachment,complications,visual acuity and intraocular pressure(IOP)before and after surgery were observed.RESULTS:Patients were followed up for a mean of 8.22mo(3-22mo)after SO removal.All patients had retinal reattachment.At the final follow-up,visual acuity showed improvement for 8 patients,and no change for 1 patient.The IOP was high in 3 patients before surgery,but it stabilized after treatment;it was not affected in the other patients.None of the patients had infections,hemorrhage,anterior ischemia,or any other complication.CONCLUSION:This new non-contact wide-field viewing system-assisted SB surgery with 23-gauge intraocular illumination is effective and safe for retinal detachment in SO-filled eyes.
基金Supported by the National Natural Science Foundation of China under Grant Nos 11174019,61322509 and 11121091the National Basic Research Program of China under Grant No 2013CB921904
文摘We propose and implement a wide-field vibrational phase contrast detection to obtain imaging of imaginary components of third-order nonlinear susceptibility in a coherent anti-Stokes Raman scattering （CARS） microscope with full suppression of the non-resonant background. This technique is based on the unique ability of recovering the phase of the generated CARS signal based on holographic recording. By capturing the phase distributions of the generated CARS field from the sample and from the environment under resonant illumination, we demonstrate the retrieval of imaginary components in the CARS microscope and achieve background free coherent Raman imaging.
基金The authors acknowledge the financial support from the National Key R&D Program of China(Nos.2016YFA0202103 and 2017YFA0303701)the National Natural Science Foundation of China(Nos.91850204 and 11674167)Tao Li thanks the Dengfeng Project B of Nanjing University for the support.The authors declare that they have no conflicts of interest.
文摘Metasurfaces have demonstrated unprecedented capabilities in manipulating light with ultrathin and flat architectures.Although great progress has been made in the metasurface designs and function demonstrations,most metalenses still only work as a substitution of conventional lenses in optical settings,whose integration advantage is rarely manifested.We propose a highly integrated imaging device with silicon metalenses directly mounted on a complementary metal oxide semiconductor image sensor,whose working distance is in hundreds of micrometers.The imaging performances including resolution,signal-to-noise ratio,and field of view(FOV)are investigated.Moreover,we develop a metalens array with polarization-multiplexed dual-phase design for a wide-field microscopic imaging.This approach remarkably expands the FOV without reducing the resolution,which promises a non-limited space-bandwidth product imaging for wide-field microscopy.As a result,we demonstrate a centimeter-scale prototype for microscopic imaging,showing uniqueness of meta-design for compact integration.
基金National Science Foundation(DBI-1455613,IIP-1623823,IIP-1640707)National Institutes of Health(R01-EB025209)。
文摘High-speed ophthalmic optical coherence tomography(OCT)systems are of interest because they allow rapid,motion-free,and wide-field retinal imaging.Space-division multiplexing optical coherence tomography(SDMOCT)is a high-speed imaging technology that takes advantage of the long coherence length of micro electro mechanical vertical cavity surface emitting laser sources to multiplex multiple images along a single imaging depth.We demonstrate wide-field retinal OCT imaging,acquired at an effective A-scan rate of 800,000 A-scans/s with volumetric images covering up to 12.5 mm×7.4 mm on the retina and captured in less than 1 s.A clinical feasibility study was conducted to compare the ophthalmic SDM-OCT with commercial OCT systems,illustrating the high-speed capability of SDM-OCT in a clinical setting.
基金financial support from the National Key R&D Program of China(2017YFA0303701)the National Natural Science Foundation of China(91850204 and 12174186)support from the Dengfeng Project B of Nanjing University。
文摘Microscopy is very important in research and industry,yet traditional optical microscopy suffers from the limited field-of-view(FOV)and depth-of-field(DOF)in high-resolution imaging.We demonstrate a simultaneous large FOV and DOF microscope imaging technology based on a chip-scale metalens device that is implemented by a SiNxmetalens array with a co-and cross-polarization multiplexed dual-phase design and dispersive spectrum zoom effect.A 4-mm×4-mm FOV is obtained with a resolution of 1.74μm and DOF of200μm within a wavelength range of 450 to 510 nm,which definitely exceeds the performance of traditional microscopes with the same resolution.Moreover,it is realized in a miniaturized compact prototype,showing an overall advantage for portable and convenient microscope technology.
基金supported by the Foundation of Youth Innovation Promotion Association,Chinese Academy of Sciences(No.20150192)
文摘Detecting and tracking multiple targets simultaneously for space-based surveillance requires multiple cameras,which leads to a large system volume and weight. To address this problem, we propose a wide-field detection and tracking system using the segmented planar imaging detector for electro-optical reconnaissance. This study realizes two operating modes by changing the working paired lenslets and corresponding waveguide arrays： a detection mode and a tracking mode. A model system was simulated and evaluated using the peak signal-to-noise ratio method. The simulation results indicate that the detection and tracking system can realize wide-field detection and narrow-field, multi-target, high-resolution tracking without moving parts.
