Representation of Family in the Narratives of Smiling Flower(Gol-e Khandān)

The development of a childs personality is profoundly influenced by the environmental stimuli after their formation.Within this context,lullabies and childhood stories assume significant roles in this formative process.The familial environment serves as the primary locus from which individuals acquire their beliefs and personalities.This research investigates the portrayal of family dynamics within the narrative framework of the Persian story Smiling Flower(Gol-e Khandn).In the majority of narratives of this story,featuring the Laughing Flower,a magical agency is bestowed upon an infant girl,thereby shaping her future.The analysis of this narratives themes prioritizes the familial element,particularly the central figures of parents,who play pivotal roles in the cultivation of the childs personality.Examination of parental representation within this narrative elucidates the prominence of the maternal figure,albeit acknowledging the undeniable influence exerted by the fathers demeanor and character on the childs trajectory.

Tanshinone ⅡA improves Alzheimer’s disease via RNA nuclearenriched abundant transcript 1/microRNA-291a-3p/member RAS oncogene family Rab22a axis

BACKGROUND Alzheimer’s disease(AD)is a neurodegenerative condition characterized by oxidative stress and neuroinflammation.Tanshinone ⅡA(Tan-ⅡA),a bioactive compound isolated from Salvia miltiorrhiza plants,has shown potential neuroprotective effects;however,the mechanisms underlying such a function remain unclear.AIM To investigate potential Tan-ⅡA neuroprotective effects in AD and to elucidate their underlying mechanisms.METHODS Hematoxylin and eosin staining was utilized to analyze structural brain tissue morphology.To assess changes in oxidative stress and neuroinflammation,we performed enzyme-linked immunosorbent assay and western blotting.Additionally,the effect of Tan-ⅡA on AD cell models was evaluated in vitro using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.Genetic changes related to the long non-coding RNA(lncRNA)nuclear-enriched abundant transcript 1(NEAT1)/microRNA(miRNA,miR)-291a-3p/member RAS oncogene family Rab22a axis were assessed through reverse transcription quantitative polymerase chain reaction.RESULTS In vivo,Tan-ⅡA treatment improved neuronal morphology and attenuated oxidative stress and neuroinflammation in the brain tissue of AD mice.In vitro experiments showed that Tan-ⅡA dose-dependently ameliorated the amyloid-beta 1-42-induced reduction of neural stem cell viability,apoptosis,oxidative stress,and neuroinflammation.In this process,the lncRNA NEAT1-a potential therapeutic target-is highly expressed in AD mice and downregulated via Tan-ⅡA treatment.Mechanistically,NEAT1 promotes the transcription and translation of Rab22a via miR-291a-3p,which activates nuclear factor kappa-B(NF-κB)signaling,leading to activation of the pro-apoptotic B-cell lymphoma 2-associated X protein and inhibition of the anti-apoptotic B-cell lymphoma 2 protein,which exacerbates AD.Tan-ⅡA intervention effectively blocked this process by inhibiting the NEAT1/miR-291a-3p/Rab22a axis and NF-κB signaling.CONCLUSION This study demonstrates that Tan-ⅡA exerts neuroprotective effects in AD by modulating the NEAT1/miR-291a-3p/Rab22a/NF-κB signaling pathway,serving as a foundation for the development of innovative approaches for AD therapy.

On Multimodal Criticism of The Kitchen God’s Wife

Studying the covers of the three editions of The Kitchen God’s Wife by Amy Tan,a famous female Chinese American writer,the author finds Chinese cultural elements stood out in publishers’earliest recommendations,but later were replaced by immigrant mother-daughter relationship,and then were overwhelmed by the concern for human beings.It is interesting that this change fits the changing focuses of Chinese American writers in the 21st century.

A Family of Global Attractors for the Generalized Kirchhoff-Beam Equations

In this paper, we discuss the existence and uniqueness of global solutions, the existence of the family of global attractors and its dimension estimation for generalized Beam-Kirchhoff equation under initial conditions and boundary conditions, using the previous research results for reference. Firstly, the existence of bounded absorption set is proved by using a prior estimation, then the existence and uniqueness of the global solution of the problem is proved by using the classical Galerkin’s method. Finally, Housdorff dimension and fractal dimension of the family of global attractors are estimated by linear variational method and generalized Sobolev-Lieb-Thirring inequality.

The Comparative Analysis of The River-Merchant's Wife:A Letter

"The River-Merchant's Wife:A Letter",written by the great poet Li Bai,is the most prestigious version among the translations of Chinese ancient poetry by Ezra Pound and has been accepted as one of the classics of American literature.The poem exquisitely expresses the changes of the wife's mind at different phases.Martin and Rose's Appraisal Theory provides us with a theoretical framework for the analysis of the different realizations of the sentimental resources of the poem in the original and its English version.

Two Female Characters of Tragic Fate from Different Countries—Tess and Xianglin's Wife

This article mainly deals with the comparison between the main character Xiang Lin’s wife in Lu Xun’s short narrative story Blessing and the main character Tess in the novel Tess of the D'Urbervilles written by the famous critic realistic British writer Hardy in 19th century.This article discusses about the similarities and differences between the two tragic figures from three aspects,namely the background of their times;the origins of their tragedies and the personalities of the two women,so that the readers may have a better understanding of the themes of the two novels.

Love Is Intensified by Absence- Book Review on "The Time Traveler's Wife"

In this paper,a review was finished according to a novel-"The Time Traveler's Wife".It use time travel to explore miscommunication and distance in relationships.A lot of knowledge could be obtained from the passage.

Denial of Sartre's Existentialism in The Time Traveler's Wife

By contrast with Sartre's existentialism,The Time Traveler's Wife depicts another humanistic world.Moreover,such things as meaning,reason,compensation and peace are indispensable in this world.

A Story About Mary's Family

The students were having an English class. "Today you can write a story about your family.I want you to tell me something about your parents and your brothers and sisters, "said Mr Shute. Mary raised her hand."What kind of thing shall I write about my parents? "she asked. "Well,"said Mr Shute. "Write about

Similar clinical characteristics of familial and sporadic inflammatory bowel disease in South Korea

AIM:To investigate differences of clinical characteristics and disease courses between familial and sporadic inflammatory bowel disease(IBD)patients.METHODS:We obtained clinical data on Crohn’s disease(CD)(n=691)and ulcerative colitis(n=1113)from a tertiary referral medical center between 2005and 2012.Seventeen patients(2.5%)with CD and27 patients(2.4%)with ulcerative colitis(UC)were identified as having a familial history of IBD,including the first and second degree relatives.For each control case,three times the number of age-,sex-,and diagnosis year-matched CD and UC patients,without a family history of IBD,were randomly selected in this case control study.RESULTS:There were no significant differences in age or main symptom at diagnosis,extraintestinal manifestation,location/extent,behavior of disease activity,number of hospitalizations,number of operations,operation type,number of relapses,or oral medical treatment between familial and sporadic CD and UC patients.Median(min-max)follow-up periods after diagnosis of familial CD and sporadic CD patients were 84(24-312)and 36(8-240)mo,respectively(P=0.008).Familial CD patients more frequently used anti-tumor necrosis factor(TNF)antibodies compared to sporadic CD patients(17.6%vs 0%,P=0.014).CONCLUSION:In conclusion,a family history of IBD does not seem to be an important predictive factor affecting clinical characteristics or disease course even if there is a more frequent use of anti-TNF antibodies in familial CD patients compared to sporadic CD patients.

Structure and function of the contactin-associated protein family in myelinated axons and their relationship with nerve diseases

The contactin-associated protein （Caspr） family participates in nerve excitation and conduction, and neurotransmitter release in myelinated axons. We analyzed the structures and functions of the Caspr family- CNTNAP1 （Casprl）, CNTNAP2 （Caspr2）, CNTNAP3 （Caspr3）, CNTNAP4 （Caspr4） and CNTNAP5 （Caspr5）, Casprl-5 is not only involved in the formation of myelinated axons, but also participates in maintaining the stability of adjacent connections. Casprl participates in the formation, differentiation, and proliferation of neurons and astrocytes, and in motor control and cognitive function. We also analyzed the relationship between the Caspr family and neurodegenerative diseases, multiple sclerosis, and autoimmune encephalitis. However, the effects of Caspr on disease course and prognosis remain poorly understood. The effects of Caspr on disease diagnosis and treatment need further investigation.

Adenomas of the common bile duct in familial adenomatous polyposis

Familial adenomatous polyposis(FAP)or Gardner’s syndrome is often accompanied by adenomas of the stomach and duodenum.We experienced a case of adenomas of the common bile duct in a 40-year-old woman with FAP presenting with acute cholangitis.Only 8 cases of adenomas or adenocarcinoma ofthe common bile duct have been reported in the literature in patients with FAP or Gardner’s syndrome.Those patients presented with acute cholangitis or pancreatitis.Local excision or Whipple procedure may be the reasonable surgical option.

Family history and disease outcomes in patients with Crohn's disease:A comparison between China and the United States

AIM To investigate the differences in family history of inflammatory bowel disease(IBD) and clinical outcomes among individuals with Crohn's disease(CD) residing in China and the United States.METHODS We performed a survey-based cross-sectional study of participants with CD recruited from China and the United States.We compared the prevalence of IBD family history and history of ileal involvement,CD-related surgeries and IBD medications in China and the United States,adjusting for potential confounders.RESULTS We recruited 49 participants from China and 145 from the United States.The prevalence of family history of IBD was significantly lower in China compared with the United States(China:4.1%,United States:39.3%).The three most commonly affected types of relatives were cousin,sibling,and parent in the United States compared with child and sibling in China.Ileal involvement(China:63.3%,United States:63.5%) and surgery for CD(China:51.0%,United States:49.7%) were nearly equivalent in the two countries.CONCLUSION The lower prevalence of familial clustering of IBD in China may suggest that the etiology of CD is less attributed to genetic background or a family-shared environment compared with the United States.Despite the potential difference in etiology,surgery and ileal involvement were similar in the two countries.Examining the changes in family history during the continuing rise in IBD may provide further insight into the etiology of CD.

Research on the effects of family care degree on stigma and psychosocial adaptation among the patients with Parkinson’s disease

Objective:This study aimed to investigate the status quo of family care degree,stigma and psychosocial adaptation of the patients with Parkinson’s disease(PD),and discuss the effects of family care degree on stigma and psychosocial adaptation among the patients with PD.Methods:This study was conducted between September 2018 and April 2019 on patients with PD who were admitted to a Ter tiary Grade A hospital in Dalian city.A total of 246 PD patients were investigated by convenience sampling method using self-designed general information questionnaire,along with family care index(APGAR),24-item Stigma Scale for Chronic Illness(SSCI),and Psychosocial Adjustment Scale(PAS)for PD.And patients were divided into two groups according to the level of family care degree and compared with stigma and psychosocial adaptation.Results:The total score of family care for patients with PD was 6.97±2.46,family function was good in 132 cases(53.7%),moderate barrier in 92 cases(37.4%),and severe barrier in 22 cases(8.9%).The scores of stigma and psychosocial adaptability and their dimensions in the group with high degree family care were higher than the low degree group.Conclusions:The overall level of family care for PD patients was poor.Improving family care degree can help patients with PD to reduce stigma and improve psychosocial adaptation.

A Family of Global Attractors for a Class of Generalized Kirchhoff-Beam Equations

The initial boundary value problem for a class of high-order Beam equations with quasilinear and strongly damped terms is studied. Firstly, the existence and uniqueness of the global solution of the equation are proved by prior estimation and Galerkin finite element method. Then the bounded absorption set is obtained by prior estimation, and the family of global attractors for the high-order Kirchhoff-Beam equation is obtained. The Frechet differentiability of the solution semigroup is proved after the linearization of the equation, and the decay of the volume element of the linearization problem is further proved. Finally, the Hausdorff dimension and Fractal dimension of the family of global attractors are proved to be finite.

The role of DJ-1 complexes and catecholamine metabolism： relevance for familial and idiopathic Parkinson＇s disease

Autosomal recessive mutations in the PARK7 gene,which encodes for the protein DJ-1,result in a loss of function and are a cause of familial Parkinson’s disease（PD）,while increased wild-type DJ-1protein levels are associated with some forms of cancer.Several functions of DJ-1 have been described,with the greatest evidence indicating that DJ-1 is a redox-sensitive protein involved in the regulation of oxidative stress and cell survival.

Analysis of the Contradictory Relationship among Family Members in Long Day' s Journey into Night

Long Day' s Journey into Night is one of Eugene O' Neill' s (1888-1953) masterpieces, who is a great American playwright and called the father of modern American drama. This thesis aims at the analysis of the contradictions in family members in the play. The first part analyzes the contradictions between wife and husband. The second part focuses on the contradictory relationship in parents and sons. The contradictions between brothers are discussed in the third part. Through the study of the causes of the contradictory relationship among family members, the tragedy of the characters in the play will be explored to the readers, which is also the tragedy of modern Ameri can people.

Treatment of Crohn's disease and familial Mediterranean fever by leukopheresis:Single shot for two targets

Coexistence of Crohn's disease(CD) and familial Mediterranean fever(FMF) is a rare condition and knowledge about this clinical situation is limited with a few case reports in the literature. The treatment of both diseases depends on their individual therapies. However, it is very hard to deal with this coexistence when CD is refractory to standard therapies. Ongoing activity of CD triggers the clinical attacks of FMF and the symptoms like abdominal pain interfere with both disease presentations which can cause problems about diagnostic and therapeutic approach. The main therapeutic agent for FMF is colchicine and diarrhea is the most common side effect of this drug. This side effect also causes problems about management of these diseases when both of them are clinically active. Here we report probably the first case in the literature with coexisting CD and FMF who was successfully treated by leukopheresis since he was refractory to conventional therapies for CD.

PARK1 gene mutation of autosomal dominant Parkinson's disease family

Studies have shown that PARK1 gene is associated with the autosomal dominant inheritance of Parkinson＇s disease. PARK1 gene contains two mutation sites, namely Ala30Pro and Ala53Thr, which are located on exons 3 and 4, respectively. However, the genetic loci of the pathogenic genes remain unclear. In this study, blood samples were collected from 11 members of a family with high prevalence of Parkinson＇s disease, including four affected cases, five suspected cases and two non-affected cases. Point mutation screening of common mutation sites on PARK1 gene exon 4 was conducted using PCR, to determine the genetic loci of the causative gene for Parkinson＇s disease. Gene identification and sequencing results showed that a T base deletion mutation was observed in the PARK1 gene exon 4 of all 11 collected samples. It was confirmed that the PARK1 gene exon 4 gene mutation is an important pathogenic mutation for Parkinson＇s disease.

割手密GST基因家族的分析及其对阿特拉津的响应

从全基因组的角度分析了割手密谷胱苷肽⁃S⁃转移酶(GST)基因家族成员的特征,共鉴定出129个GST。通过对割手密GST蛋白的系统发育分析,发现这些GST可以划分为4个亚家族,且每个亚家族内的蛋白排列紧凑,说明同亚族内部基因进化关系均比较亲近。此外,对在阿特拉津处理下GST基因家族中10个F亚族基因的表达水平进行检测,结果表明,根中的SpGSTF1、SpGSTF9、SpGSTF14、SpGSTF16、SpGSTF18、SpGSTF31在阿特拉津胁迫下表达显著上调,推测这6个基因可能在响应阿特拉津胁迫的过程中起重要作用。研究结果有助于揭示割手密GST家族的进化和功能演替,并对进一步了解割手密GST对阿特拉津的解毒响应机制提供理论参考,同时也为培养抗除草剂甘蔗品种提供基因资源。