The important role of atherosclerosis in pathophysiology of Alzheimer's Disease has become evident.Mechanisms such as hyperlipidemia,inflammation,abdominal obesity and insulin resistance are important yet they may...The important role of atherosclerosis in pathophysiology of Alzheimer's Disease has become evident.Mechanisms such as hyperlipidemia,inflammation,abdominal obesity and insulin resistance are important yet they may not fully explain the specific involvement of the Circle of Willis in these pathologies.The Circle of Wills is a complex geometrical structure which has several areas with different curvature as well as various branching angles of vessels composing the circle.The hemodynamics in this region should take into account the Dean number which indicates the influence of curvature on the resistance to blood flow.Thus,areas with various curvature and angles may have different hemodynamics and there are certain areas in the Circle of Willis that are more likely to develop atherosclerotic changes.Therefore,this could suggest the novel pathophysiological pathway resulting from the geometric peculiarities of the Circle of Willis.One of the directions of future research is to examine whether specific areas of the Circle of Willis are more likely to develop atherosclerotic changes compared to other ones.Selective areas of the Circle of Willis affected by atherosclerotic changes could indicate the primary role of atherosclerosis promoting Alzheimer's disease although other pathophysiological mechanisms suggesting the opposite direction should be also examined in prospective studies.展开更多
Based on the discussion of relationships between thinning and wind damage, and published information, a method for estimating risk ratios of wind damage was developed. Estimations of risk-ratio for Pinus thunbergii tr...Based on the discussion of relationships between thinning and wind damage, and published information, a method for estimating risk ratios of wind damage was developed. Estimations of risk-ratio for Pinus thunbergii trees and stands were de-duced from stem bending theory and coefficients characterizing wind profile, distribution of branches and optical stratification po-rosity. The results showed that if the value of constant b in the branch distribution-model equals the attenuation coefficient s in the wind profile model for a single tree crown, then the parameter H/D1.33 (height over stem diameter cubed) can be used to compare and evaluate the risk-ratio of wind damage for individual trees. The same method can be applied to stands using the coefficient of wind profile in a stand, i.e. attenuation coefficient , the coefficient from distributions of optical stratification porosity, i.e. extinction coefficient , and the parameter D1.33. The application of parameter H/D1.33 and the process of determining risk ra-tios of wind damage for stands were also given in the paper.展开更多
文摘The important role of atherosclerosis in pathophysiology of Alzheimer's Disease has become evident.Mechanisms such as hyperlipidemia,inflammation,abdominal obesity and insulin resistance are important yet they may not fully explain the specific involvement of the Circle of Willis in these pathologies.The Circle of Wills is a complex geometrical structure which has several areas with different curvature as well as various branching angles of vessels composing the circle.The hemodynamics in this region should take into account the Dean number which indicates the influence of curvature on the resistance to blood flow.Thus,areas with various curvature and angles may have different hemodynamics and there are certain areas in the Circle of Willis that are more likely to develop atherosclerotic changes.Therefore,this could suggest the novel pathophysiological pathway resulting from the geometric peculiarities of the Circle of Willis.One of the directions of future research is to examine whether specific areas of the Circle of Willis are more likely to develop atherosclerotic changes compared to other ones.Selective areas of the Circle of Willis affected by atherosclerotic changes could indicate the primary role of atherosclerosis promoting Alzheimer's disease although other pathophysiological mechanisms suggesting the opposite direction should be also examined in prospective studies.
基金This study was supported by Innovation Research Project of Chinese Academy of Sciences and the Ministry of Culture and Education Japanese Government.
文摘Based on the discussion of relationships between thinning and wind damage, and published information, a method for estimating risk ratios of wind damage was developed. Estimations of risk-ratio for Pinus thunbergii trees and stands were de-duced from stem bending theory and coefficients characterizing wind profile, distribution of branches and optical stratification po-rosity. The results showed that if the value of constant b in the branch distribution-model equals the attenuation coefficient s in the wind profile model for a single tree crown, then the parameter H/D1.33 (height over stem diameter cubed) can be used to compare and evaluate the risk-ratio of wind damage for individual trees. The same method can be applied to stands using the coefficient of wind profile in a stand, i.e. attenuation coefficient , the coefficient from distributions of optical stratification porosity, i.e. extinction coefficient , and the parameter D1.33. The application of parameter H/D1.33 and the process of determining risk ra-tios of wind damage for stands were also given in the paper.
