Advances in Wireless,Batteryless,Implantable Electronics for Real‑Time,Continuous Physiological Monitoring

This review summarizes recent progress in developing wireless,batteryless,fully implantable biomedical devices for real-time continuous physiological signal monitoring,focusing on advancing human health care.Design considerations,such as biological constraints,energy sourcing,and wireless communication,are discussed in achieving the desired performance of the devices and enhanced interface with human tissues.In addition,we review the recent achievements in materials used for developing implantable systems,emphasizing their importance in achieving multi-functionalities,biocompatibility,and hemocompatibility.The wireless,batteryless devices offer minimally invasive device insertion to the body,enabling portable health monitoring and advanced disease diagnosis.Lastly,we summarize the most recent practical applications of advanced implantable devices for human health care,highlighting their potential for immediate commercialization and clinical uses.

Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases

Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative diseases.However,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°C.We aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large cohort.Plasma samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline project.These samples were stored at-80°C for up to 6 years before being used in this study.Our results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage time.However,the level of total tau showed a negative correlation with sample storage time.Notably,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage time.This was not observed in individuals with cognitive impairment.Consequently,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage time.Therefore,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's disease.Furthermore,in cohort studies,it is important to consider the impact of storage time on the overall results.

Real-time Threshold Routing Algorithm Based on Wireless Sensor Network

[Objective] This study was to design an intelligent greenhouse real-time monitoring system based on the core technology of Internet of Things in order to meet the needs of agricultural informatization and intellectualization. [Method] Based on the application characteristics of Wireless Sensor Network （WSN）, the intelligent greenhouse monitoring system was designed. And for the incompleteness strategy of load balancing in the Low-Energy Adaptive Clustering Hierarchy （LEACH）, a Real- time Threshold Routing Algorithm （RTRA） was proposed. [Result] The performance of network lifetime and network delay of RTRA were tested in MATLAB and found that, within the same testing environment, RTRA can save nodes energy consumption, prolong network lifetime, and had better real-time performance than LEACH. The al- gorithm satisfies the crops＇ requirements on real-time and energy efficiency in the greenhouse system. [Conclusion] For the good performance on real-time, the de- signed intelligent greenhouse real-time monitoring system laid the foundation for the research and development of agricultural informatization and intellectualization.

Distributed Time Synchronization in Wireless Sensor Networks via Second-Order Consensus Algorithms

This paper proposes a distributed second-order consensus time synchronization, which incorporates the second-order consensus algorithm into wireless sensor networks. Since local clocks may have different skews and offsets, the algorithm is designed to include offset compensation and skew compensation. The local clocks are not directly modified, thus the virtual clocks are built according to the local clocks via the compensation parameters. Each node achieves a virtual consensus clock by periodically updated compensation parameters. Finally, the effectiveness of the proposed algorithm is verified through a number of simulations in a mesh network. It is proved that the proposed algorithm has the advantage of being distributed, asymptotic convergence, and robust to new node joining.

Time Delay Characteristic of Industrial Wireless Networks Based on IEEE 802.15.4a

The IEEE 802.15.4a standard provides a framework for low-data-rate communication systems,typically sensor networks.In this paper,we established a realistic environment for the time delay characteristic of industrial network based on IEEE 802.15.4a.Several sets of practical experiments are conducted to study its various features,including the effects of 1） numeral wireless nodes,2） numeral data packets,3） data transmissions with different upper-layer protocols,4） physical distance between nodes,and 5） adding and reducing the number of the wireless nodes.The results show that IEEE 802.15.4a is suitable for some industrial applications that have more relaxed throughput requirements and time-delay.Some issues that could degrade the network performance are also discussed.

4种植物源性成分多重real-time PCR检测方法的建立及其在食用淀粉中的应用

建立一种可同时快速检测红薯、木薯、马铃薯、玉米源性成分的多重实时聚合酶链式反应(real-time polymerase chain reaction,real-time PCR)方法。分别以红薯g3pdh基因、木薯g3pdh基因、马铃薯UGPase基因、玉米zSSIIb基因为靶基因设计特异性引物和TaqMan探针,以18S rRNA基因为内参基因,建立多重real-time PCR方法,开展方法学验证,并对不同掺入比例模拟样品和实际淀粉样品进行检测。结果显示,该方法具有高通量、特异性强、灵敏度高等优点。与15种非目标源性均无交叉反应;对目标DNA的检测灵敏度可达到3×10^(-3) ng/μL,且具有良好的线性关系和扩增效率;对淀粉样品的检出限可达0.1%,对50份实际样品进行检测,结果与参比方法一致,说明建立的多重real-time PCR法可用于食用淀粉种类掺假鉴别检测。

Research on Time Synchronization Method Under Arbitrary Network Delay in Wireless Sensor Networks

To cope with the arbitrariness of the network delays,a novel method,referred to as the composite particle filter approach based on variational Bayesian(VB-CPF),is proposed herein to estimate the clock skew and clock offset in wireless sensor networks.VB-CPF is an improvement of the Gaussian mixture kalman particle filter(GMKPF)algorithm.In GMKPF,Expectation-Maximization(EM)algorithm needs to determine the number of mixture components in advance,and it is easy to generate overfitting and underfitting.Variational Bayesian EM(VB-EM)algorithm is introduced in this paper to determine the number of mixture components adaptively according to the observations.Moreover,to solve the problem of data packet loss caused by unreliable links,we propose a robust time synchronization(RTS)method in this paper.RTS establishes an autoregressive model for clock skew,and calculates the clock parameters based on the established autoregressive model in case of packet loss.The final simulation results illustrate that VB-CPF yields much more accurate results relative to GMKPF when the network delays are modeled in terms of an asymmetric Gaussian distribution.Moreover,RTS shows good robustness to the continuous and random dropout of time messages.

Weak node protection to maximize the lifetime of wirelesssensor networks

Wireless sensor networks （WSN） provide an approachto collecting distributed monitoring data and transmiting them tothe sink node. This paper proposes a WSN-based multi-hop networkinfrastructure, to increase network lifetime by optimizing therouting strategy. First, a network model is established, an operatingcontrol strategy is devised, and energy consumption characteristicsare analyzed. Second, a fast route-planning algorithm isproposed to obtain the original path that takes into account the remainingenergy of communicating nodes and the amount of energyconsumed in data transmission. Next, considering the amount ofenergy consumed by an individual node and the entire network,a criterion function is established to describe node performanceand to evaluate data transmission ability. Finally, a route optimizingalgorithm is proposed to increase network lifetime by adjusting thetransmission route in protection of the weak node （the node withlow transmission ability）. Simulation and comparison experimentalresults demonstrate the good performance of the proposed algorithmsto increase network lifetime.

A QoS-Based Multichannel MAC Protocol for Two-Tiered Wireless Multimedia Sensor Networks

Rapid penetration of small customized wireless devices and enormous growth of wireless communication technologies has already set the stage for large-scale deployment of wireless sensor networks. Offering precise quality of service (QoS) for multimedia transmission over sensor networks has not received significant attention. However offering some better QoS for wireless multimedia over sensor networks raises significant challenges. In this paper, we propose an adaptive Cross-Layer multi-channel QoS-MAC protocol to support energy-efficient, high throughput, and reliable data transmission in Wireless Multimedia Sensor Network (WMSNs). Our proposed protocol use benefit of TDMA and CSMA/CA to adaptively assign channels and timeslots to active multimedia sensor nodes in clusters. Simulations show that the proposed system achieves the performance objectives of WMSNs with increased network throughput at the cost of a small control and energy overhead.

A Real Plug-and-Play Fog: Implementation of Service Placement in Wireless Multimedia Networks

Initially as an extension of cloud computing, fog computing has been inspiring new ideas about moving computing tasks to the edge of networks. In fog, we often repeat the procedure of placing services because of the geographical distribution of mobile users. We may not expect a fixed demand and supply relationship between users and service providers since users always prefer nearby service with less time delay and transmission consumption. That is, a plug-and-play service mode is what we need in fog. In this paper, we put forward a dynamic placement strategy for fog service to guarantee the normal service provision and optimize the Quality of Service (QoS). The simulation results show that our strategy can achieve better performance under metrics including energy consumption and end-to-end latency. Moreover, we design a real Plug-and-Play Fog (PnPF) based on Raspberry Pi and OpenWrt to provide fog services for wireless multimedia networks.

An Asynchronous Clustering and Mobile Data Gathering Schema Based on Timer Mechanism in Wireless Sensor Networks

Recently,Wireless sensor networks(WSNs)have become very popular research topics which are applied to many applications.They provide pervasive computing services and techniques in various potential applications for the Internet of Things(IoT).An Asynchronous Clustering and Mobile Data Gathering based on Timer Mechanism(ACMDGTM)algorithm is proposed which would mitigate the problem of“hot spots”among sensors to enhance the lifetime of networks.The clustering process takes sensors’location and residual energy into consideration to elect suitable cluster heads.Furthermore,one mobile sink node is employed to access cluster heads in accordance with the data overflow time and moving time from cluster heads to itself.Related experimental results display that the presented method can avoid long distance communicate between sensor nodes.Furthermore,this algorithm reduces energy consumption effectively and improves package delivery rate.

Linear Pulse-Coupled Oscillators Model¬—A New Approach for Time Synchronization in Wireless Sensor Networks

Mutual synchronization is a ubiquitous phenomenon that exists in various natural systems. The individual participants in this process can be modeled as oscillators, which interact by discrete pulses. In this paper, we analyze the synchronization condition of two- and multi-oscillators system, and propose a linear pulse-coupled oscillators model. We prove that the proposed model can achieve synchronization for almost all conditions. Numerical simulations are also included to investigate how different model parameters affect the synchronization. We also discuss the implementation of the model as a new approach for time synchronization in wireless sensor networks.

Tradeoff between utility and lifetime in energy-constrained wireless sensor networks

We study the tradeoff between network utility and network lifetime using a cross-layer optimization approach. The tradeoff model in this paper is based on the framework of layering as optimization decomposition. Our tradeoff model is the first one that incorporates time slots allocation into this framework. By using Lagrangian dual decomposition method, we decompose the tradeoff model into two subproblems： routing problem at network layer and resource allocation problem at medium access control （MAC） layer. The interfaces between the layers are precisely the dual variables. A partially distributed algorithm is proposed to solve the nonlinear, convex, and separable tradeoff model. Numerical simulation results are presented to support our algorithm.

Fuzzy Based Adaptive Clustering to Improve the Lifetime of Wireless Sensor Network

The objective of the recently proposed fuzzy based hierarchical routing protocol F-SCH is to improve the lifetime of a Wireless Sensor Network. Though the performance of F-SCH is better than LEACH, the randomness in CH selection inhibits it from attaining enhanced lifetime. CBCH ensures maximum network lifetime when CH is close to the centroid of the cluster. However, for a widely distributed network, CBCH results in small sized clusters increasing the inter cluster communication cost. Hence, with an objective to enhance the network lifetime, a fuzzy based two-level hierarchical routing protocol is proposed. The novelty of the proposal lies in identification of appropriate parameters used in Cluster Head and Super Cluster Head selection. Experiments for different network scenarios are performed through both simulation and hardware to validate the proposal. The performance of the network is evaluated in terms of Node Death. The proposal is compared with F-SCH and the results reveal the efficacy of the proposal in enhancing the lifetime of network.

A timeslot assignment scheme for cluster-tree based wireless sensor network

Many efforts have been made to develop time division multiple access （TDMA） slots allocation in a multi-hop converge-cast wireless sensor network （WSN）, however, most of them either use complex algorithm or concern frames only without simultaneous transmission in a single slot. In this paper, we present a timeslot assignment scheme for cluster-tree-based TDMA WSN, co：＇ering three frequently used working modes in practical applications. The shortest frame formed can guarantee real-time conununication and is also facilitated for message and slot integration, since timeslots allocated to a single node are continuous. During allocation processes, the algorithms are distributed and light-weighted. The experiment resulted from a WSN prototype system shows that our scheme can achieve a good reliability.

Collaborative Multiple Access And Energy-Efficient Resource Allocation in Distributed Maritime Wireless Networks

With the rapid increasing of maritime activities, maritime wireless networks(MWNs) with high reliability, high energy efficiency, and low delay are required. However, the centralized networking with fixed resource scheduling is not suitable for MWNs due to the special environment. In this paper,we introduce the collaborative relay communication in distributed MWNs to improve the link reliability, and propose an orthogonal time-frequency resource block reservation based multiple access(RRMA) scheme for both one-hop direct link and two-hop collaborative relay link to reduce the interference. To further improve the network performance, we formulate an energy efficiency(EE) maximization resource allocation problem and solve it by an iterative algorithm based on the Dinkelbach method. Finally, numerical results are provided to investigate the proposed RRMA scheme and resource allocation algorithm, showing that the low outage probability and transmission delay can be attained by the proposed RRMA scheme. Moreover,the proposed resource allocation algorithm is capable of achieving high EE in distributed MWNs.

Design of real-time data compression wireless sensor network based on LZW algorithm

A real-time data compression wireless sensor network based on Lempel-Ziv-Welch encoding(LZW)algorithm is designed for the increasing data volume of terminal nodes when using ZigBee for long-distance wireless communication.The system consists of a terminal node,a router,a coordinator,and an upper computer.The terminal node is responsible for storing and sending the collected data after the LZW compression algorithm is compressed;The router is responsible for the relay of data in the wireless network;The coordinator is responsible for sending the received data to the upper computer.In terms of network function realization,the development and configuration of CC2530 chips on terminal nodes,router nodes,and coordinator nodes are completed using the Z-stack protocol stack,and the network is successfully organized.Through the final simulation analysis and test verification,the system realizes the wireless acquisition and storage of remote data,and reduces the network occupancy rate through the data compression,which has a certain practical value and application prospects.

Real-Time Monitoring System for Rotor Temperature of a Large Turbogenerator Based on SmartMesh IP Wireless Network Communication Technology

In this study,a real-time rotor temperature monitoring system for large turbogenerators using SmartMesh IP wireless network communication technology was designed and tested.The system is capable of providing comprehensive,accurate,continuous,and reliable real-time temperature monitoring for turbogenerators.Additionally,it has demonstrated satisfactory results in a real-time monitoring test of the rotor temperature of various famous large-scale turbogenerators and giant nuclear power half-speed turbogenerators designed and manufactured in China.The development and application of this wireless temperature measurement system would aid in improving the intelligent operation quality,safety,and stability of China’s large turbine generators and even the entire power system.

Lifetime Optimization via Network Sectoring in Cooperative Wireless Sensor Networks

Employing cooperative communication in multihop wireless sensor networks provides the network with significant energy efficiency. However, the lifetime of such a network is directly dependant upon the lifetime of each of its individual sections (or clusters). Ignoring the fact that those sections close to sink have to forward more data (their own data plus the data received from the previous sections) and hence die sooner with considering equal section sizes, leads to a sub-optimal lifetime. In this paper, we optimize the section sizes of a multihop cooperative WSN so that it maximizes the network lifetime. Simulation results demonstrate a significant lifetime enhancement for the proposed optimal sectoring.

ICON/MIGHTI与TIMED/SABER探测温度数据的对比

ICON卫星为临近空间环境特性研究、建模和预报提供了新数据.通过对ICON/MIGHTI与TIMED/SABER在90~105 km高度探测温度数据的比较,计算两者的年平均温度偏差和均方根误差,同时分析月平均温度偏差在不同月份中随高度和纬度的分布情况,为MIGHTI和SABER温度探测数据在临近空间大气建模和预报应用提供参考依据.结果表明,MIGHTI和SABER的温度垂直廓线变化趋势基本吻合,数值上有所差异.在12°S-42°N范围内,MIGHTI探测温度与SABER相比,在90~93 km时偏低,偏差最大值约2.5 K,在93~105 km偏高,偏差的绝对值最大约10 K.在不同季节,白天的温度偏差通常高于夜晚.SABER和MIGHTI的月平均温度偏差随季节和纬度的变化显著,夏季时的月平均温度偏差最大,且温度的均方根误差最大.