Objective:To explore the optimal scheme of Shengmai Injection combined with other drugs for clinical doctors.Methods:Based on the large-scale data warehouse established by the institute of Clinical Basic Medicine,Chin...Objective:To explore the optimal scheme of Shengmai Injection combined with other drugs for clinical doctors.Methods:Based on the large-scale data warehouse established by the institute of Clinical Basic Medicine,Chinese Academy of Traditional Chinese Medicine,the hospital information system of 22 large-scale tertiary hospitals in China was collected and 1751 patients with angina pectoris who were treated with Shengmai Injection were selected.Louvain algorithm and complex network analysis are used to build the model to summarize the rule of Shengmai Injection in the treatment of angina pectoris of coronary heart disease.Results:On the basis of Shengmai Injection,according to the symptom treatment of angina pectoris of coronary heart disease,nitrates or Suxiao Jiuxin Pill was used to dilate coronary artery;for the treatment of risk factors of angina pectoris,a combination of"insulin+acarbose+bisoprolol+nifedipine+captopril+estazolam"was used to control blood glucose and blood pressure;"Ganmao Qingre Granule+levofloxacin"to treat upper respiratory tract infection and other medication regimens were used as well.For the complications of angina pectoris of coronary heart disease,"furosemide+spironolactone+potassium chloride+magnesium sulfate"was used to reduce edema and“isosorbide nitrate+metoprolol+Shenmai injection+Wenxin Granule"was used to improve symptom of heart failure of qi and yin deficiency type.Conclusion:The therapeutic regimen of Shengmai Injection combined with traditional chinese medicine and western medicine is basically consistent with the current guidelines,but more clinical studies are still needed to explore more effective combination therapy.展开更多
Objective:To explore the characteristics and rules of Danshen Ligustrazine Injection in the treatment of coronary heart disease with hypertension.Methods:From the information systems of 12 tertiary tier-one hospitals ...Objective:To explore the characteristics and rules of Danshen Ligustrazine Injection in the treatment of coronary heart disease with hypertension.Methods:From the information systems of 12 tertiary tier-one hospitals across the country,we extracted the medical data of the application of Danshen Ligustrazine Injection in the treatment of patients with coronary heart disease and hypertension.After normalization,the model was established by Apriori algorithm,and the association rules were analyzed by Clementine 12.0 software.Results:Most of the 1928 patients were between 75 and 90 years old(54.26%).There were more males than females,most with type 2 diabetes,cerebral infarction,etc.Each dose was more than 10 mL(52.78%).Aspirin enteric-coated tablets(67.63%),L-carnitine injection(58.77%),and atorvastatin calcium capsules(50.93%)were often used in combination with safflower yellow pigment(22.20%),Shexiang Baoxin Pill(16.55%),Suxiao Jiuxin Pill(15.09%);the most commonly used combination of western medicine was anticoagulant thrombolytic and antiplatelet drugs(85.84%),and the type of Chinese medicine was Huoxuehuayu(72.98%);The most common combination of two western medicines was L-carnitine injection+aspirin enteric-coated tablets,with a support of 41.9%;The most common combination of two Chinese and western medicines is western medicine·anti-anginal medicine+western medicine·anticoagulant thrombolytic and antiplatelet drugs with a support of 67.6%.Conclusion:Danshen Ligustrazine injection is mainly used in elderly patients with coronary heart disease and hypertension,with many comorbidities.The dosage standard needs to be optimized.The combination of drugs and guidelines should coordinate with each other,which provide clues for clinical diagnosis and treatment and optimization of medication.展开更多
Research purpose:This study implemented somatosensory music therapy on patients with depressive disorders,and explored the effects of somatosensory music therapy on the degree of depression,positive and negative emoti...Research purpose:This study implemented somatosensory music therapy on patients with depressive disorders,and explored the effects of somatosensory music therapy on the degree of depression,positive and negative emotions,intuitive stress and autonomic nervous function of patients.Research method:We collected 66 patients diagnosed with depression from the Department of Psychological Medicine of Henan Provincial People’s Hospital,and divided them into a control group and an intervention group according to the random number table,with 33 people in each group.The control group received routine psychiatric treatment and nursing.On the basis of the control group,the intervention group received somatosensory music therapy 3 times a week,30 min each time,for 4 consecutive weeks.The Hamilton Depression Scale,Positive and Negative Emotion Scale,Perceived Stress Scale,and Heart Rate Variability Index were collected and analyzed at baseline(T0),2 weeks after treatment(T1)and 4 weeks after treatment(T2).Research results:After 4 weeks of treatment,the HAMD scores of the two groups decreased to varying degrees,and the difference between the groups was statistically significant(p<0.05).After 4 weeks of treatment,the scores of positive emotions in both groups increased to varying degrees,and the scores of negative emotions increased to varying degrees.The scores decreased to varying degrees,and there were statistically significant differences between the positive and negative emotion groups(p<0.05).After 4 weeks of treatment,the CPSS scores of the two groups decreased to varying degrees,and the difference between the two groups was statistically significant(p<0.05).Analyzing the main effect of intervention factors alone,after 4 weeks of treatment,SDNN and RMSSD indexes all increased to varying degrees,and the degree of increase in the intervention group was greater than that in the control group,and the difference between the groups was statistically significant(p<0.05).Research conclusion:assisting somatosensory music therapy for patients with depressive disorders can improve depressive symptoms,increase positive emotions,reduce negative emotions,and reduce perceived stress.These are beneficial to restore the balance of autonomic nervous system,and are effective for the treatment of depression.展开更多
This article reviews the current status of cardiovascular disease(CVD) on the international scale.Presently viewed as an epidemic that has migrated from westernized societies to developing countries,several important ...This article reviews the current status of cardiovascular disease(CVD) on the international scale.Presently viewed as an epidemic that has migrated from westernized societies to developing countries,several important issues are elaborated upon.They include the basis for the increasing prevalence of CVD and the associated societal implications.The challenges related to lack of resources and infrastructure support may also impede successful implementation of proven strategies to reduce CVD.In addition to traditional risk factors such as cigarette smoking,hypertension,obesity,hyperlipidemia,diabetes mellitus and insulin resistance,many developing countries must also contend with other risk biomarkers.Included in this grouping are human immunodeficiency virus/acquired immunodeficiency syndrome and other infectious/inflammatory processes as well as nutritional and vitamin deficiencies that make preventive measures more difficult to prioritize.Taken together,greater partnering between local governments,affiliated hospitals and international societies is needed to enhance and facilitate efforts aimed at optimizing standard of care measures in developing countries in order to reduce cardiovascular risk.展开更多
Based on the survey data for 2120 inbound and domestic tourists at the Shanghai World Expo,a structural equation model was constructed for the relationship among tourists' perceived value dimensions,behavioral int...Based on the survey data for 2120 inbound and domestic tourists at the Shanghai World Expo,a structural equation model was constructed for the relationship among tourists' perceived value dimensions,behavioral intention and revisit intention.Additionally,the influence of tourists' perceived value dimensions on the behavioral intention and revisit intention was explored.The results show that the utilitarian value and enjoyment value significantly affect the inbound and domestic tourists' behavioral intention,while the convenience value and aesthetic value have no significant influence.The service value only significantly affects the domestic tourists' behavioral intention,and the aesthetic value only significantly affects the inbound tourists' behavioral intention.The utilitarian value,service value and enjoyment value significantly affect the inbound and domestic tourists' revisit intention,while the convenience value only significantly affects the domestic tourists' revisit intention.The utilitarian value is the primary factor affecting the inbound tourists' behavioral intention and revisit intention,and the perceived price has no significant effect on either inbound or domestic tourists' behavioral intention or revisit intention.The study explores the relationships between tourists' perceived value,behavioral intention and revisit intention,analyzes the divergence and causation,theoretically enriches the research field of tourism geography and behavioral geography,and has great practical significance to the sustainable development of mega events in China,including the further development of the Shanghai World Expo.展开更多
As the world's authoritative organization on energy information, the International Energy Agency (IEA), which was founded in 1974, releases Key World Energy Statistics every year from 1997 (hereinafter referred to...As the world's authoritative organization on energy information, the International Energy Agency (IEA), which was founded in 1974, releases Key World Energy Statistics every year from 1997 (hereinafter referred to as the "Key Data"). The "Key Data" released in 2007 announced the 2005 statistics, and also provided the 1973 statistics for comparison. From the published data, we can clearly find the development path and trend of the world energy and power industry. Also, China's strong development momentum, high- speed growth of energy consumption and the enormous challenges in the sustainable energy supply are especially noticeable. This paper reviewed the "Key Data" to perceive China's Energy Development. The analysis and interpretation of these data are purely from the author's point of view.展开更多
Aims:We aimed to observe the improvements in cardiac function indexes and the occurrence of adverse events in patients with heart failure with reduced ejection fraction(HFrEF)after dapagliflozin administration in a rea...Aims:We aimed to observe the improvements in cardiac function indexes and the occurrence of adverse events in patients with heart failure with reduced ejection fraction(HFrEF)after dapagliflozin administration in a real-world setting.Methods:We retrospectively included 201 patients with HFrEF who were treated at a tertiary hospital in Zhengzhou and started to take dapagliflozin(10 mg/d)from March 2020 to June 2021.Their New York Heart Association(NYHA)functional class,cardiac ultrasound indexes,laboratory indexes,and vital signs between baseline and the last follow-up visit were compared,and their adverse events during the follow-up period were recorded.Results:The follow-up period was 173(67–210)days.The cardiac function indexes of patients at follow-up,com-pared with baseline,indicated significant improvement(proportion of NYHA functional class I and II:40.8%vs.56.2%;left ventricular ejection fraction:28.4±5.3%vs.34.7±5.9%;left ventricular end-diastolic diameter:70.1±6.4 mm vs.64.7±5.6 mm;N-terminal pro-B-type natriuretic peptide:5421.9±2864.4 pg/mL vs.2842.8±1703.4 pg/mL at baseline vs.at follow-up;all P<0.05).The rates of hypotension,deterioration of renal function,and genital infection during the follow-up period were 6.5%,4.0%,and 3.5%,respectively.Conclusions:We believe that dapagliflozin is safe and effective in patients with HFrEF in the real world.展开更多
OBJECTIVE: To evaluate the effects of Guasha therapy on the rating of perceived exertion(RPE) scale score, and heart rate variability(HRV).METHODS: A randomized controlled trial of Guasha(skin scraping) was compared w...OBJECTIVE: To evaluate the effects of Guasha therapy on the rating of perceived exertion(RPE) scale score, and heart rate variability(HRV).METHODS: A randomized controlled trial of Guasha(skin scraping) was compared with a sham scraping group and control group. Sixteen sessions within an 8-week period were completed. Sixty-five male weightlifters who had undergone normal weightlifting training for a mean of 5 years before study commencement were recruited. The RPEscale score of "snatch", "clean and jerk" maneuvers(85% of one-repetition maximum), and HRV were measured before and after the intervention.RESULTS: The RPE scale score for snatch, clean and jerk were reduced significantly after intervention in the Guasha group and sham group. However, there was a significant difference in the low frequency(LF) domain and LF/high frequency(HF) ratio(P <0.05): the LF domain decreased, and the LF/HF ratio decreased.CONCLUSION: Guasha could be used to reduce the RPE scale score, and increase the response to HRV.Guasha could be considered as an alternative to some types of recovery from sports training.展开更多
2024年9月,《欧洲呼吸病学杂志》发表了第七届世界肺动脉高压研讨会(World Symposium on Pulmonary Hypertension,WSPH)的系列论文,该研讨会于2024年6月底在西班牙巴塞罗那举行。这些论文基于2022年8月发布的肺动脉高压(pulmonary hyper...2024年9月,《欧洲呼吸病学杂志》发表了第七届世界肺动脉高压研讨会(World Symposium on Pulmonary Hypertension,WSPH)的系列论文,该研讨会于2024年6月底在西班牙巴塞罗那举行。这些论文基于2022年8月发布的肺动脉高压(pulmonary hypertension,PH)诊断与治疗指南,汇总了近年来肺动脉高压领域的研究进展。本文聚焦于最常见的一类肺动脉高压——左心疾病相关性肺动脉高压(pulmonary hypertension associated with left heart disease,PH-LHD)的最新进展,包括影响左心疾病的相关病种、病理生理学的进展、PH-LHD的细分类及目前的优化治疗结果的解读。展开更多
基金National Key research and Deve lopment Progr am(No.2018YFC1707410)。
文摘Objective:To explore the optimal scheme of Shengmai Injection combined with other drugs for clinical doctors.Methods:Based on the large-scale data warehouse established by the institute of Clinical Basic Medicine,Chinese Academy of Traditional Chinese Medicine,the hospital information system of 22 large-scale tertiary hospitals in China was collected and 1751 patients with angina pectoris who were treated with Shengmai Injection were selected.Louvain algorithm and complex network analysis are used to build the model to summarize the rule of Shengmai Injection in the treatment of angina pectoris of coronary heart disease.Results:On the basis of Shengmai Injection,according to the symptom treatment of angina pectoris of coronary heart disease,nitrates or Suxiao Jiuxin Pill was used to dilate coronary artery;for the treatment of risk factors of angina pectoris,a combination of"insulin+acarbose+bisoprolol+nifedipine+captopril+estazolam"was used to control blood glucose and blood pressure;"Ganmao Qingre Granule+levofloxacin"to treat upper respiratory tract infection and other medication regimens were used as well.For the complications of angina pectoris of coronary heart disease,"furosemide+spironolactone+potassium chloride+magnesium sulfate"was used to reduce edema and“isosorbide nitrate+metoprolol+Shenmai injection+Wenxin Granule"was used to improve symptom of heart failure of qi and yin deficiency type.Conclusion:The therapeutic regimen of Shengmai Injection combined with traditional chinese medicine and western medicine is basically consistent with the current guidelines,but more clinical studies are still needed to explore more effective combination therapy.
基金This study was supported by the Key Research and Development Program(No.2018YFC1707400)。
文摘Objective:To explore the characteristics and rules of Danshen Ligustrazine Injection in the treatment of coronary heart disease with hypertension.Methods:From the information systems of 12 tertiary tier-one hospitals across the country,we extracted the medical data of the application of Danshen Ligustrazine Injection in the treatment of patients with coronary heart disease and hypertension.After normalization,the model was established by Apriori algorithm,and the association rules were analyzed by Clementine 12.0 software.Results:Most of the 1928 patients were between 75 and 90 years old(54.26%).There were more males than females,most with type 2 diabetes,cerebral infarction,etc.Each dose was more than 10 mL(52.78%).Aspirin enteric-coated tablets(67.63%),L-carnitine injection(58.77%),and atorvastatin calcium capsules(50.93%)were often used in combination with safflower yellow pigment(22.20%),Shexiang Baoxin Pill(16.55%),Suxiao Jiuxin Pill(15.09%);the most commonly used combination of western medicine was anticoagulant thrombolytic and antiplatelet drugs(85.84%),and the type of Chinese medicine was Huoxuehuayu(72.98%);The most common combination of two western medicines was L-carnitine injection+aspirin enteric-coated tablets,with a support of 41.9%;The most common combination of two Chinese and western medicines is western medicine·anti-anginal medicine+western medicine·anticoagulant thrombolytic and antiplatelet drugs with a support of 67.6%.Conclusion:Danshen Ligustrazine injection is mainly used in elderly patients with coronary heart disease and hypertension,with many comorbidities.The dosage standard needs to be optimized.The combination of drugs and guidelines should coordinate with each other,which provide clues for clinical diagnosis and treatment and optimization of medication.
文摘Research purpose:This study implemented somatosensory music therapy on patients with depressive disorders,and explored the effects of somatosensory music therapy on the degree of depression,positive and negative emotions,intuitive stress and autonomic nervous function of patients.Research method:We collected 66 patients diagnosed with depression from the Department of Psychological Medicine of Henan Provincial People’s Hospital,and divided them into a control group and an intervention group according to the random number table,with 33 people in each group.The control group received routine psychiatric treatment and nursing.On the basis of the control group,the intervention group received somatosensory music therapy 3 times a week,30 min each time,for 4 consecutive weeks.The Hamilton Depression Scale,Positive and Negative Emotion Scale,Perceived Stress Scale,and Heart Rate Variability Index were collected and analyzed at baseline(T0),2 weeks after treatment(T1)and 4 weeks after treatment(T2).Research results:After 4 weeks of treatment,the HAMD scores of the two groups decreased to varying degrees,and the difference between the groups was statistically significant(p<0.05).After 4 weeks of treatment,the scores of positive emotions in both groups increased to varying degrees,and the scores of negative emotions increased to varying degrees.The scores decreased to varying degrees,and there were statistically significant differences between the positive and negative emotion groups(p<0.05).After 4 weeks of treatment,the CPSS scores of the two groups decreased to varying degrees,and the difference between the two groups was statistically significant(p<0.05).Analyzing the main effect of intervention factors alone,after 4 weeks of treatment,SDNN and RMSSD indexes all increased to varying degrees,and the degree of increase in the intervention group was greater than that in the control group,and the difference between the groups was statistically significant(p<0.05).Research conclusion:assisting somatosensory music therapy for patients with depressive disorders can improve depressive symptoms,increase positive emotions,reduce negative emotions,and reduce perceived stress.These are beneficial to restore the balance of autonomic nervous system,and are effective for the treatment of depression.
文摘This article reviews the current status of cardiovascular disease(CVD) on the international scale.Presently viewed as an epidemic that has migrated from westernized societies to developing countries,several important issues are elaborated upon.They include the basis for the increasing prevalence of CVD and the associated societal implications.The challenges related to lack of resources and infrastructure support may also impede successful implementation of proven strategies to reduce CVD.In addition to traditional risk factors such as cigarette smoking,hypertension,obesity,hyperlipidemia,diabetes mellitus and insulin resistance,many developing countries must also contend with other risk biomarkers.Included in this grouping are human immunodeficiency virus/acquired immunodeficiency syndrome and other infectious/inflammatory processes as well as nutritional and vitamin deficiencies that make preventive measures more difficult to prioritize.Taken together,greater partnering between local governments,affiliated hospitals and international societies is needed to enhance and facilitate efforts aimed at optimizing standard of care measures in developing countries in order to reduce cardiovascular risk.
基金Under the auspices of National Natural Science Foundation of China(No.41271171,41230631)
文摘Based on the survey data for 2120 inbound and domestic tourists at the Shanghai World Expo,a structural equation model was constructed for the relationship among tourists' perceived value dimensions,behavioral intention and revisit intention.Additionally,the influence of tourists' perceived value dimensions on the behavioral intention and revisit intention was explored.The results show that the utilitarian value and enjoyment value significantly affect the inbound and domestic tourists' behavioral intention,while the convenience value and aesthetic value have no significant influence.The service value only significantly affects the domestic tourists' behavioral intention,and the aesthetic value only significantly affects the inbound tourists' behavioral intention.The utilitarian value,service value and enjoyment value significantly affect the inbound and domestic tourists' revisit intention,while the convenience value only significantly affects the domestic tourists' revisit intention.The utilitarian value is the primary factor affecting the inbound tourists' behavioral intention and revisit intention,and the perceived price has no significant effect on either inbound or domestic tourists' behavioral intention or revisit intention.The study explores the relationships between tourists' perceived value,behavioral intention and revisit intention,analyzes the divergence and causation,theoretically enriches the research field of tourism geography and behavioral geography,and has great practical significance to the sustainable development of mega events in China,including the further development of the Shanghai World Expo.
文摘As the world's authoritative organization on energy information, the International Energy Agency (IEA), which was founded in 1974, releases Key World Energy Statistics every year from 1997 (hereinafter referred to as the "Key Data"). The "Key Data" released in 2007 announced the 2005 statistics, and also provided the 1973 statistics for comparison. From the published data, we can clearly find the development path and trend of the world energy and power industry. Also, China's strong development momentum, high- speed growth of energy consumption and the enormous challenges in the sustainable energy supply are especially noticeable. This paper reviewed the "Key Data" to perceive China's Energy Development. The analysis and interpretation of these data are purely from the author's point of view.
文摘Aims:We aimed to observe the improvements in cardiac function indexes and the occurrence of adverse events in patients with heart failure with reduced ejection fraction(HFrEF)after dapagliflozin administration in a real-world setting.Methods:We retrospectively included 201 patients with HFrEF who were treated at a tertiary hospital in Zhengzhou and started to take dapagliflozin(10 mg/d)from March 2020 to June 2021.Their New York Heart Association(NYHA)functional class,cardiac ultrasound indexes,laboratory indexes,and vital signs between baseline and the last follow-up visit were compared,and their adverse events during the follow-up period were recorded.Results:The follow-up period was 173(67–210)days.The cardiac function indexes of patients at follow-up,com-pared with baseline,indicated significant improvement(proportion of NYHA functional class I and II:40.8%vs.56.2%;left ventricular ejection fraction:28.4±5.3%vs.34.7±5.9%;left ventricular end-diastolic diameter:70.1±6.4 mm vs.64.7±5.6 mm;N-terminal pro-B-type natriuretic peptide:5421.9±2864.4 pg/mL vs.2842.8±1703.4 pg/mL at baseline vs.at follow-up;all P<0.05).The rates of hypotension,deterioration of renal function,and genital infection during the follow-up period were 6.5%,4.0%,and 3.5%,respectively.Conclusions:We believe that dapagliflozin is safe and effective in patients with HFrEF in the real world.
基金the National Natural Science Foundation of China(Research of the Biological Effects and Mechanism of Different Guasha Therapies,No.30672720)the National Natural Science Foundation of China(Comparative Research of Different Acupuncture Stimulation Methods on The Expression of Effects in Acupoint Areas,No.81674079)
文摘OBJECTIVE: To evaluate the effects of Guasha therapy on the rating of perceived exertion(RPE) scale score, and heart rate variability(HRV).METHODS: A randomized controlled trial of Guasha(skin scraping) was compared with a sham scraping group and control group. Sixteen sessions within an 8-week period were completed. Sixty-five male weightlifters who had undergone normal weightlifting training for a mean of 5 years before study commencement were recruited. The RPEscale score of "snatch", "clean and jerk" maneuvers(85% of one-repetition maximum), and HRV were measured before and after the intervention.RESULTS: The RPE scale score for snatch, clean and jerk were reduced significantly after intervention in the Guasha group and sham group. However, there was a significant difference in the low frequency(LF) domain and LF/high frequency(HF) ratio(P <0.05): the LF domain decreased, and the LF/HF ratio decreased.CONCLUSION: Guasha could be used to reduce the RPE scale score, and increase the response to HRV.Guasha could be considered as an alternative to some types of recovery from sports training.
文摘2024年9月,《欧洲呼吸病学杂志》发表了第七届世界肺动脉高压研讨会(World Symposium on Pulmonary Hypertension,WSPH)的系列论文,该研讨会于2024年6月底在西班牙巴塞罗那举行。这些论文基于2022年8月发布的肺动脉高压(pulmonary hypertension,PH)诊断与治疗指南,汇总了近年来肺动脉高压领域的研究进展。本文聚焦于最常见的一类肺动脉高压——左心疾病相关性肺动脉高压(pulmonary hypertension associated with left heart disease,PH-LHD)的最新进展,包括影响左心疾病的相关病种、病理生理学的进展、PH-LHD的细分类及目前的优化治疗结果的解读。
