Working toward an efficient duration and timeline for the preconstruction phase should be one of the main objectives for project owners.Failing to plan for and coordinate preconstruction decisions in order to control ...Working toward an efficient duration and timeline for the preconstruction phase should be one of the main objectives for project owners.Failing to plan for and coordinate preconstruction decisions in order to control preconstruction duration and manage time variances can lead to financial insecurities,incomplete contract documents,permitting issues,and unrealistic schedules and resource allocation during this phase.To minimize time variances and ensure a productive decision-making process,project owners should be familiar with critical elements in a project that cause variances in the preconstruction phase timeline.In this study,the impacts of eleven critical preconstruction elements on time variances were analyzed.These eleven preconstruction elements are considered critical in how they impact time variances during the preconstruction phase.They were determined to be critical based either on significantly impacting time variance during the preconstruction phase or believed to be critical from findings from previous studies,however,the findings from this study showed no significant impact on the time variances.In most previous studies focusing on the elements impacting project schedules,data were collected by surveying construction professionals.In this study,objective and quantitative data related to project preconstruction elements were used as opposed to self-reported data.Using the results of this study,project owners and stakeholders will be able to evaluate the critical preconstruction elements impacting the timing of their projects and prioritize decisions related to the critical elements early on during the preconstruction phase.展开更多
The type 2 modified augmented design(MAD2) is an efficient unreplicated experimental design used for evaluating large numbers of lines in plant breeding and for assessing genetic variation in a population. Statistical...The type 2 modified augmented design(MAD2) is an efficient unreplicated experimental design used for evaluating large numbers of lines in plant breeding and for assessing genetic variation in a population. Statistical methods and data adjustment for soil heterogeneity have been previously described for this design. In the absence of replicated test genotypes in MAD2, their total variance cannot be partitioned into genetic and error components as required to estimate heritability and genetic correlation of quantitative traits, the two conventional genetic parameters used for breeding selection. We propose a method of estimating the error variance of unreplicated genotypes that uses replicated controls, and then of estimating the genetic parameters. Using the Delta method, we also derived formulas for estimating the sampling variances of the genetic parameters.Computer simulations indicated that the proposed method for estimating genetic parameters and their sampling variances was feasible and the reliability of the estimates was positively associated with the level of heritability of the trait. A case study of estimating the genetic parameters of three quantitative traits, iodine value, oil content, and linolenic acid content, in a biparental recombinant inbred line population of flax with 243 individuals, was conducted using our statistical models. A joint analysis of data over multiple years and sites was suggested for genetic parameter estimation. A pipeline module using SAS and Perl was developed to facilitate data analysis and appended to the previously developed MAD data analysis pipeline(http://probes.pw.usda.gov/bioinformatics_ tools/MADPipeline/index.html).展开更多
This paper aims to the debate on the nexus between informal economies and the environment by investigating the long-term dynamic impacts of China’s informal economies on pollution and considering regional differences...This paper aims to the debate on the nexus between informal economies and the environment by investigating the long-term dynamic impacts of China’s informal economies on pollution and considering regional differences in informal economies’ pollution.This paper uses the Multiple Indicators Multiple Causes(MIMIC) model to estimate the size of informal economies and employs econometric models to examine their relationships to pollution based on provincial-level panel data from 2000 to 2017. The results indicate that informal economies’ effects on environmental pollution are not purely positive or negative. Rather, our model indicates that there is an inverted U-shaped relationship between informal economies and pollution in the long run in China;this means that the level of environmental pollution increases at first and then decreases with the growth of informal economies. Further analysis shows that while this inverted, U-shaped relationship is significant in different regions of China, it is affected by different environmental impact factors. The paper concludes by discussing the policy implications for environmental protection and sustainable development.展开更多
We evaluated the effects of the 2010 revision of the medical payment system on the length of stay (LOS). In this analysis, we assessed not only the average length of stay (ALOS), but also variance of LOS at individual...We evaluated the effects of the 2010 revision of the medical payment system on the length of stay (LOS). In this analysis, we assessed not only the average length of stay (ALOS), but also variance of LOS at individual hospitals. We used a dataset of 18,641 type 2 diabetes patients collected from 51 general hospitals. The variables found to affect LOS were age, comorbidities, complications, acute hospitalization, introduced by other hospitals, winter, one-week hospitalization, specific hospitalization period, and principal diseases coded E11.5, E11.6 and E11.7. Although the effect was marginal, the 2010 revision did reduce ALOS, and the reduction was larger as ALOS became longer. On the other hand, we did not find that the variance of LOS within hospitals became smaller. The results of the study suggest that new incentives and assistance to hospitals to help them make efficient use of medical information are needed.展开更多
A mixed distribution of empirical variances, composed of two distributions the basic and contaminating ones, and referred to as PERG mixed distribution of empirical variances, is considered. In the paper a robust inve...A mixed distribution of empirical variances, composed of two distributions the basic and contaminating ones, and referred to as PERG mixed distribution of empirical variances, is considered. In the paper a robust inverse problem solution is given, namely a (new) robust method for estimation of variances of both distributions—PEROBVC Method, as well as the estimates for the numbers of observations for both distributions and, in this way also the estimate of contamination degree.展开更多
Global variance reduction is a bottleneck in Monte Carlo shielding calculations.The global variance reduction problem requires that the statistical error of the entire space is uniform.This study proposed a grid-AIS m...Global variance reduction is a bottleneck in Monte Carlo shielding calculations.The global variance reduction problem requires that the statistical error of the entire space is uniform.This study proposed a grid-AIS method for the global variance reduction problem based on the AIS method,which was implemented in the Monte Carlo program MCShield.The proposed method was validated using the VENUS-Ⅲ international benchmark problem and a self-shielding calculation example.The results from the VENUS-Ⅲ benchmark problem showed that the grid-AIS method achieved a significant reduction in the variance of the statistical errors of the MESH grids,decreasing from 1.08×10^(-2) to 3.84×10^(-3),representing a 64.00% reduction.This demonstrates that the grid-AIS method is effective in addressing global issues.The results of the selfshielding calculation demonstrate that the grid-AIS method produced accurate computational results.Moreover,the grid-AIS method exhibited a computational efficiency approximately one order of magnitude higher than that of the AIS method and approximately two orders of magnitude higher than that of the conventional Monte Carlo method.展开更多
Most left ventricular(LV)Doppler measurements vary significantly with age and gender,making it necessary to correct them for physiological variances.We aimed to verify the hypothesis that different Doppler measurement...Most left ventricular(LV)Doppler measurements vary significantly with age and gender,making it necessary to correct them for physiological variances.We aimed to verify the hypothesis that different Doppler measurements correlate nonlinearly with different biometric variables raised to different scaling factors and exponents.In this work,a total of 23 LV Doppler parameters were measured in 1224 healthy Chinese adults.An optimized multivariable allometric model(OMAM)and scaling equations were developed in 70%of the subjects(group A),and the reliability of the model and equations was verified using the remaining 30%of the subjects(group B)as well as 183 overweight subjects(group C).The single-variable isometric model(SVIM)with body surface area(BSA)as a scaling variable was used for comparison.Before correction,all 23 LV Doppler parameters correlated significantly with one or more of the biometric variables.In group B,gender differences were found in 47.8%(11/23)of the parameters and were eliminated in 81.8%(9/11)of the parameters after correction with OMAM.The successful correction rate with OMAM was 100%(23/23)in group B and 82.6%(19/23)in group C.New reference values for corrected Doppler measurements independent of biometric variables were established.The SVIM with BSA successfully corrected none of the 23 parameters.In conclusion,different LV Doppler parameters allometrically correlated with one or more of the biometric variables.The novel OMAM developed in this study successfully corrected the effects of the physiological variances of most biometric variables on Doppler measurements in healthy and overweight subjects,and was found to be far superior to the SVIM.However,whether the OMAM equations can be applied to other ethnicities,obese subjects,and pathological conditions requires further investigation.展开更多
The study aimed to determine the genetic variances of phytic acid (myo-inositol 1,2,3,4,5,6 hexakis-dihydrogen phosphate) (PA) and inorganic phosphorus contents (InP) in grains of tropical maize (Zea mays L.)....The study aimed to determine the genetic variances of phytic acid (myo-inositol 1,2,3,4,5,6 hexakis-dihydrogen phosphate) (PA) and inorganic phosphorus contents (InP) in grains of tropical maize (Zea mays L.). The understanding of genetic variances in PA and InP in tropical maize would be useful for breeding management in tropical region. A total of 16 Ki inbred lines and 26 new inbred lines of tropical maize were planted in Completely Randomized Design (CRD) on the dry season 2008 at lnseechandrastitya Institute for Crops Research and Development, Thailand. The results showed that genotypic differences were highly significant (P 〈 0.01) for InP in both sources of germplasm, but genotype effect only was found significant in new inbred lines for PA content. The values for broad sense heritability (h2b) was generally lower on PA in maize grains compared with InP both in Ki and new inbred lines [h^2b of PA: 2.42 (Ki), 14.18 (commercial hybrid extracted); h^2b of InP: 32 (Ki) and 29.53 (commercial hybrid extracted)].展开更多
Impact of satellite elevation cutoff angle and position dilution of precision(PDOP)mask change on epoch-wise variance components of unmodeled effects that accompany relative Global Positioning System(GPS)positioning i...Impact of satellite elevation cutoff angle and position dilution of precision(PDOP)mask change on epoch-wise variance components of unmodeled effects that accompany relative Global Positioning System(GPS)positioning is presented herein.Data used for this study refer to the winter and summer periods of the years with minimal(2008)and maximal(2013)solar activity.These data were collected every 30 s in static mode,at two permanent GPS stations located in Montenegro,establishing a mediumdistance(116-km-long)baseline with a height difference of approximately 760 m between its endpoints.The study showed that changing satellite elevation cutoff angle,with a fixed PDOP mask,affects epochwise two-way nested ANOVA estimates of variances related to the‘far-field’multipath(considered as the nested factor herein)and the combined unmodeled effect of tropospheric and ionospheric refraction(considered as the nesting factor herein).However,changing of PDOP mask,with a fixed satellite elevation cutoff angle,doesn’t affect epoch-wise two-way nested ANOVA estimate of variance of the combined unmodeled effect of tropospheric and ionospheric refraction,but,generally,affects the estimate of variance of the‘far-field’multipath(possibly mixed with a part of a‘shorter-term’ionospheric refraction),which is especially pronounced for the summer period.It should also be noted that there is a significant influence of satellite elevation cutoff angle change on both epoch-wise horizontal and vertical position accuracy,only for the summer period,especially in the presence of maximal solar activity,while there is no significant impact of PDOP mask change on epoch-wise positional accuracy.展开更多
背景急性缺血性卒中(AIS)高发,及时恢复脑血流是治疗的关键,超时间窗就诊患者无更多促进脑血流恢复的治疗手段。研究远隔缺血后适应(RIPostC)治疗对AIS超时间窗就诊患者的临床疗效、并发症和预后,具有重要的临床意义。目的探究RIPostC...背景急性缺血性卒中(AIS)高发,及时恢复脑血流是治疗的关键,超时间窗就诊患者无更多促进脑血流恢复的治疗手段。研究远隔缺血后适应(RIPostC)治疗对AIS超时间窗就诊患者的临床疗效、并发症和预后,具有重要的临床意义。目的探究RIPostC治疗对AIS超时间窗患者干预的影响,为超时间窗就诊的AIS患者寻求安全、有效的脑血流恢复治疗方式。方法本研究采用随机、分组、安慰剂对照法进行试验。选取2021-09-02—2022-08-31于北京航天总医院神经内科病房住院治疗的超溶栓时间窗(发病时间>6 h)的AIS患者为研究对象。依据随机数字表法将患者分为对照组和试验组。试验期+随访期共90 d,均使用同等的一般治疗、脑血管病常规治疗,试验组在此基础上给予RIPostC治疗14 d(28次),对照组给予模拟的RIPostC治疗14 d(28次)。在干预前和干预后30 d、干预后90 d,采用改良Rankin量表(mRS)、美国国立卫生研究院卒中量表(NIHSS)评估两组患者神经功能,简易精神状态检查量表(MMSE)、蒙特利尔认知评估量表(MoCA)评估患者认知功能,工具性日常生活能力量表(IADL)评估日常生活能力,焦虑自评量表(SAS)、抑郁自评量表(SDS)评估精神状态,经颅多普勒超声(TCD)评估脑血流速度,以白介素(IL)-6反映炎症情况。结果122例患者中,最终完成试验及随访99例,其中试验组49例,对照组50例。两组患者性别、年龄、基础疾病(高血压、糖尿病、冠心病)及基线NIHSS评分比较,差异无统计学意义(P>0.05)。重复测量方差分析结果示,时间与组别对MMSE、MoCA、mRS、NIHSS、脑血流速度、IL-6存在交互作用(P<0.05),时间和组别对MMSE、MoCA、NIHSS、脑血流速度、IL-6主效应显著(P<0.05),时间对mRS、SAS、SDS、IADL主效应显著(P<0.05)。试验组干预后30、90 d MMSE、MoCA评分及脑血流速度均高于对照组,mRS、NIHSS评分均低于对照组(P<0.05);试验组干预后30、90 d SDS、IADL评分低于对照组(P<0.05);试验组干预后30 d SAS评分高于对照组,IL-6低于对照组(P<0.05)。99例患者中共有23例患者发生不良反应,其中试验组17例,对照组6例,两组皮肤瘀点、头晕、心慌、胸闷发生率比较,差异无统计学意义(P>0.05);对照组患者皮肤瘀斑发生率[4.00%(2/50)与12.24%(6/49)]、总不良反应发生率[12.00%(6/50)与34.69%(17/49)]低于试验组(P<0.05)。结论RIPostC治疗可降低AIS患者的炎症反应,对神经功能、认知功能抑郁情绪及颅内血流速度可起到积极的改善效果。展开更多
[ Objective] The aim was to study variance type of capsule morphological characters in Platycodon grandiflorum population, and provide some theoretical basis for seeking to genetic markers which can differentiate diff...[ Objective] The aim was to study variance type of capsule morphological characters in Platycodon grandiflorum population, and provide some theoretical basis for seeking to genetic markers which can differentiate different P. grandiflorum and breeding new varieties. [ Method] According to shape morphological characters of capsule from the same population of perennial purple P. gandiflorum, seven types of distinct di- versity capsule were selected, variance analysis and multiple comparison on the length, diameter, length/diameter of the different types of capsule were carried out. [ Result] There is unicolor and bicolor, even trichrome, among main color was brown and purple. Capsule shape was main cone, furthermore, containing long roller type, spheroidicity and sphericity. [ Conclusion] P. gandiflorum capsule was divided into long form, short form and middle type from length/diameter size in perennial culture P. gandiflorum population.展开更多
背景:膝骨关节炎是一种常见的关节软骨及周围组织损伤的慢性炎症性疾病,而免疫细胞在膝骨关节炎免疫炎症反应中起到重要作用,但其中的具体机制仍有待深入研究。目的:采用孟德尔随机化方法来评估731种免疫细胞表型与膝骨关节炎风险之间...背景:膝骨关节炎是一种常见的关节软骨及周围组织损伤的慢性炎症性疾病,而免疫细胞在膝骨关节炎免疫炎症反应中起到重要作用,但其中的具体机制仍有待深入研究。目的:采用孟德尔随机化方法来评估731种免疫细胞表型与膝骨关节炎风险之间的潜在因果关系。方法:使用全基因组关联分析(GWAS)目录中公开获取731种免疫细胞表型的全基因组关联分析统计数据(从GCST0001391到GCST0002121)和IEUGWAS数据库中膝骨关节炎的全基因组关联分析数据(ebi-a-GCST007090)。采用逆方差加权法、MR-Egger回归法、加权中位数法、加权模型法和简单模型法来研究免疫细胞与膝骨关节炎之间的因果关系。敏感性分析用于检验孟德尔随机化分析结果是否可靠,然后以同样方法进行反向孟德尔随机化分析。结果与结论:①正向分析结果表明,共有4种免疫细胞表型与膝骨关节炎有显著的因果关系(FDR<0.20),其中B细胞中的CD27 on CD24+CD27+(OR=1.026,P=0.00026,Pfdr=0.18)、髓系细胞中的CD33 on CD33dim HLA DR-(OR=1.014,P=0.00050,Pfdr=0.18)以及Treg细胞中的CD45RA+CD28-CD8br%CD8br(OR=1.001,P=0.00078,Pfdr=0.18)与膝骨关节炎风险呈直接的正向因果关联;单核细胞中PDL-1 on monocyte(OR=0.952,P=0.00098,Pfdr=0.18)与膝骨关节炎风险呈直接的负向因果关联。②反向分析结果表明,当膝骨关节炎作为暴露数据时,与731种免疫细胞表型均不具有显著因果关系(FDR<0.20)。③敏感性分析结果显示:双向孟德尔随机化的Cochran’s Q检验和MR-Egger回归法结果P值均大于0.05,表明免疫细胞表型与膝骨关节炎之间的因果效应分析不存在显著的异质性和多效性。④上述结果证实,CD27 on CD24+CD27+,CD33 on CD33dim HLA DR-,CD45RA+CD28-CD8br%CD8br以及PDL-1 on monocyte免疫细胞表型与膝骨关节炎之间可能具有较为显著的潜在因果关系,这为研究膝骨关节炎的生物学机制及探索膝骨关节炎的早期防治提供有价值的线索,也为干预性药物的开发提供了新的方向。展开更多
Matrix principal component analysis (MatPCA), as an effective feature extraction method, can deal with the matrix pattern and the vector pattern. However, like PCA, MatPCA does not use the class information of sampl...Matrix principal component analysis (MatPCA), as an effective feature extraction method, can deal with the matrix pattern and the vector pattern. However, like PCA, MatPCA does not use the class information of samples. As a result, the extracted features cannot provide enough useful information for distinguishing pat- tern from one another, and further resulting in degradation of classification performance. To fullly use class in- formation of samples, a novel method, called the fuzzy within-class MatPCA (F-WMatPCA)is proposed. F-WMatPCA utilizes the fuzzy K-nearest neighbor method(FKNN) to fuzzify the class membership degrees of a training sample and then performs fuzzy MatPCA within these patterns having the same class label. Due to more class information is used in feature extraction, F-WMatPCA can intuitively improve the classification perfor- mance. Experimental results in face databases and some benchmark datasets show that F-WMatPCA is effective and competitive than MatPCA. The experimental analysis on face image databases indicates that F-WMatPCA im- proves the recognition accuracy and is more stable and robust in performing classification than the existing method of fuzzy-based F-Fisherfaces.展开更多
文摘Working toward an efficient duration and timeline for the preconstruction phase should be one of the main objectives for project owners.Failing to plan for and coordinate preconstruction decisions in order to control preconstruction duration and manage time variances can lead to financial insecurities,incomplete contract documents,permitting issues,and unrealistic schedules and resource allocation during this phase.To minimize time variances and ensure a productive decision-making process,project owners should be familiar with critical elements in a project that cause variances in the preconstruction phase timeline.In this study,the impacts of eleven critical preconstruction elements on time variances were analyzed.These eleven preconstruction elements are considered critical in how they impact time variances during the preconstruction phase.They were determined to be critical based either on significantly impacting time variance during the preconstruction phase or believed to be critical from findings from previous studies,however,the findings from this study showed no significant impact on the time variances.In most previous studies focusing on the elements impacting project schedules,data were collected by surveying construction professionals.In this study,objective and quantitative data related to project preconstruction elements were used as opposed to self-reported data.Using the results of this study,project owners and stakeholders will be able to evaluate the critical preconstruction elements impacting the timing of their projects and prioritize decisions related to the critical elements early on during the preconstruction phase.
基金partly supported by an A-base project funded by Agriculture and Agri-Food Canadathe TUFGEN project funded by Genome Canada and other stakeholdersfunds from the Western Grains Research Foundation
文摘The type 2 modified augmented design(MAD2) is an efficient unreplicated experimental design used for evaluating large numbers of lines in plant breeding and for assessing genetic variation in a population. Statistical methods and data adjustment for soil heterogeneity have been previously described for this design. In the absence of replicated test genotypes in MAD2, their total variance cannot be partitioned into genetic and error components as required to estimate heritability and genetic correlation of quantitative traits, the two conventional genetic parameters used for breeding selection. We propose a method of estimating the error variance of unreplicated genotypes that uses replicated controls, and then of estimating the genetic parameters. Using the Delta method, we also derived formulas for estimating the sampling variances of the genetic parameters.Computer simulations indicated that the proposed method for estimating genetic parameters and their sampling variances was feasible and the reliability of the estimates was positively associated with the level of heritability of the trait. A case study of estimating the genetic parameters of three quantitative traits, iodine value, oil content, and linolenic acid content, in a biparental recombinant inbred line population of flax with 243 individuals, was conducted using our statistical models. A joint analysis of data over multiple years and sites was suggested for genetic parameter estimation. A pipeline module using SAS and Perl was developed to facilitate data analysis and appended to the previously developed MAD data analysis pipeline(http://probes.pw.usda.gov/bioinformatics_ tools/MADPipeline/index.html).
基金Under the auspices of the National Natural Science Foundation of China(No.41930646,41771137)the Guangdong Academy of Sciences(GDAS)Project of Science and Technology Development(No.2019GDASYL-0104004)Fundamental Research Funds for the Central Universities(No.20lgpy31)。
文摘This paper aims to the debate on the nexus between informal economies and the environment by investigating the long-term dynamic impacts of China’s informal economies on pollution and considering regional differences in informal economies’ pollution.This paper uses the Multiple Indicators Multiple Causes(MIMIC) model to estimate the size of informal economies and employs econometric models to examine their relationships to pollution based on provincial-level panel data from 2000 to 2017. The results indicate that informal economies’ effects on environmental pollution are not purely positive or negative. Rather, our model indicates that there is an inverted U-shaped relationship between informal economies and pollution in the long run in China;this means that the level of environmental pollution increases at first and then decreases with the growth of informal economies. Further analysis shows that while this inverted, U-shaped relationship is significant in different regions of China, it is affected by different environmental impact factors. The paper concludes by discussing the policy implications for environmental protection and sustainable development.
文摘We evaluated the effects of the 2010 revision of the medical payment system on the length of stay (LOS). In this analysis, we assessed not only the average length of stay (ALOS), but also variance of LOS at individual hospitals. We used a dataset of 18,641 type 2 diabetes patients collected from 51 general hospitals. The variables found to affect LOS were age, comorbidities, complications, acute hospitalization, introduced by other hospitals, winter, one-week hospitalization, specific hospitalization period, and principal diseases coded E11.5, E11.6 and E11.7. Although the effect was marginal, the 2010 revision did reduce ALOS, and the reduction was larger as ALOS became longer. On the other hand, we did not find that the variance of LOS within hospitals became smaller. The results of the study suggest that new incentives and assistance to hospitals to help them make efficient use of medical information are needed.
文摘A mixed distribution of empirical variances, composed of two distributions the basic and contaminating ones, and referred to as PERG mixed distribution of empirical variances, is considered. In the paper a robust inverse problem solution is given, namely a (new) robust method for estimation of variances of both distributions—PEROBVC Method, as well as the estimates for the numbers of observations for both distributions and, in this way also the estimate of contamination degree.
基金supported by the Platform Development Foundation of the China Institute for Radiation Protection(No.YP21030101)the National Natural Science Foundation of China(General Program)(Nos.12175114,U2167209)+1 种基金the National Key R&D Program of China(No.2021YFF0603600)the Tsinghua University Initiative Scientific Research Program(No.20211080081).
文摘Global variance reduction is a bottleneck in Monte Carlo shielding calculations.The global variance reduction problem requires that the statistical error of the entire space is uniform.This study proposed a grid-AIS method for the global variance reduction problem based on the AIS method,which was implemented in the Monte Carlo program MCShield.The proposed method was validated using the VENUS-Ⅲ international benchmark problem and a self-shielding calculation example.The results from the VENUS-Ⅲ benchmark problem showed that the grid-AIS method achieved a significant reduction in the variance of the statistical errors of the MESH grids,decreasing from 1.08×10^(-2) to 3.84×10^(-3),representing a 64.00% reduction.This demonstrates that the grid-AIS method is effective in addressing global issues.The results of the selfshielding calculation demonstrate that the grid-AIS method produced accurate computational results.Moreover,the grid-AIS method exhibited a computational efficiency approximately one order of magnitude higher than that of the AIS method and approximately two orders of magnitude higher than that of the conventional Monte Carlo method.
基金supported by the Program of Introducing Talents of Discipline to Universities(BP 0719033)the State Key Program of the National Natural Science Foundation of China(82030051)+4 种基金the International Collaboration and Exchange Program of China(81920108003)the National Natural Science Foundation of China(81671703,81770442,and 11771408)the Qingdao Key Health Discipline Development Fund(3311000000073)the People’s Livelihood Science and Technology Project of Qingdao(18-6-1-62-nsh)the Fundamental Research Funds for the Central Universities(201964006)。
文摘Most left ventricular(LV)Doppler measurements vary significantly with age and gender,making it necessary to correct them for physiological variances.We aimed to verify the hypothesis that different Doppler measurements correlate nonlinearly with different biometric variables raised to different scaling factors and exponents.In this work,a total of 23 LV Doppler parameters were measured in 1224 healthy Chinese adults.An optimized multivariable allometric model(OMAM)and scaling equations were developed in 70%of the subjects(group A),and the reliability of the model and equations was verified using the remaining 30%of the subjects(group B)as well as 183 overweight subjects(group C).The single-variable isometric model(SVIM)with body surface area(BSA)as a scaling variable was used for comparison.Before correction,all 23 LV Doppler parameters correlated significantly with one or more of the biometric variables.In group B,gender differences were found in 47.8%(11/23)of the parameters and were eliminated in 81.8%(9/11)of the parameters after correction with OMAM.The successful correction rate with OMAM was 100%(23/23)in group B and 82.6%(19/23)in group C.New reference values for corrected Doppler measurements independent of biometric variables were established.The SVIM with BSA successfully corrected none of the 23 parameters.In conclusion,different LV Doppler parameters allometrically correlated with one or more of the biometric variables.The novel OMAM developed in this study successfully corrected the effects of the physiological variances of most biometric variables on Doppler measurements in healthy and overweight subjects,and was found to be far superior to the SVIM.However,whether the OMAM equations can be applied to other ethnicities,obese subjects,and pathological conditions requires further investigation.
文摘The study aimed to determine the genetic variances of phytic acid (myo-inositol 1,2,3,4,5,6 hexakis-dihydrogen phosphate) (PA) and inorganic phosphorus contents (InP) in grains of tropical maize (Zea mays L.). The understanding of genetic variances in PA and InP in tropical maize would be useful for breeding management in tropical region. A total of 16 Ki inbred lines and 26 new inbred lines of tropical maize were planted in Completely Randomized Design (CRD) on the dry season 2008 at lnseechandrastitya Institute for Crops Research and Development, Thailand. The results showed that genotypic differences were highly significant (P 〈 0.01) for InP in both sources of germplasm, but genotype effect only was found significant in new inbred lines for PA content. The values for broad sense heritability (h2b) was generally lower on PA in maize grains compared with InP both in Ki and new inbred lines [h^2b of PA: 2.42 (Ki), 14.18 (commercial hybrid extracted); h^2b of InP: 32 (Ki) and 29.53 (commercial hybrid extracted)].
文摘Impact of satellite elevation cutoff angle and position dilution of precision(PDOP)mask change on epoch-wise variance components of unmodeled effects that accompany relative Global Positioning System(GPS)positioning is presented herein.Data used for this study refer to the winter and summer periods of the years with minimal(2008)and maximal(2013)solar activity.These data were collected every 30 s in static mode,at two permanent GPS stations located in Montenegro,establishing a mediumdistance(116-km-long)baseline with a height difference of approximately 760 m between its endpoints.The study showed that changing satellite elevation cutoff angle,with a fixed PDOP mask,affects epochwise two-way nested ANOVA estimates of variances related to the‘far-field’multipath(considered as the nested factor herein)and the combined unmodeled effect of tropospheric and ionospheric refraction(considered as the nesting factor herein).However,changing of PDOP mask,with a fixed satellite elevation cutoff angle,doesn’t affect epoch-wise two-way nested ANOVA estimate of variance of the combined unmodeled effect of tropospheric and ionospheric refraction,but,generally,affects the estimate of variance of the‘far-field’multipath(possibly mixed with a part of a‘shorter-term’ionospheric refraction),which is especially pronounced for the summer period.It should also be noted that there is a significant influence of satellite elevation cutoff angle change on both epoch-wise horizontal and vertical position accuracy,only for the summer period,especially in the presence of maximal solar activity,while there is no significant impact of PDOP mask change on epoch-wise positional accuracy.
基金Supported by National Natural Science Foundation of China (60874063) and Innovation and Scientific Research Foundation of Graduate Student of Heilongjiang Province (YJSCX2012-263HLJ)
文摘背景急性缺血性卒中(AIS)高发,及时恢复脑血流是治疗的关键,超时间窗就诊患者无更多促进脑血流恢复的治疗手段。研究远隔缺血后适应(RIPostC)治疗对AIS超时间窗就诊患者的临床疗效、并发症和预后,具有重要的临床意义。目的探究RIPostC治疗对AIS超时间窗患者干预的影响,为超时间窗就诊的AIS患者寻求安全、有效的脑血流恢复治疗方式。方法本研究采用随机、分组、安慰剂对照法进行试验。选取2021-09-02—2022-08-31于北京航天总医院神经内科病房住院治疗的超溶栓时间窗(发病时间>6 h)的AIS患者为研究对象。依据随机数字表法将患者分为对照组和试验组。试验期+随访期共90 d,均使用同等的一般治疗、脑血管病常规治疗,试验组在此基础上给予RIPostC治疗14 d(28次),对照组给予模拟的RIPostC治疗14 d(28次)。在干预前和干预后30 d、干预后90 d,采用改良Rankin量表(mRS)、美国国立卫生研究院卒中量表(NIHSS)评估两组患者神经功能,简易精神状态检查量表(MMSE)、蒙特利尔认知评估量表(MoCA)评估患者认知功能,工具性日常生活能力量表(IADL)评估日常生活能力,焦虑自评量表(SAS)、抑郁自评量表(SDS)评估精神状态,经颅多普勒超声(TCD)评估脑血流速度,以白介素(IL)-6反映炎症情况。结果122例患者中,最终完成试验及随访99例,其中试验组49例,对照组50例。两组患者性别、年龄、基础疾病(高血压、糖尿病、冠心病)及基线NIHSS评分比较,差异无统计学意义(P>0.05)。重复测量方差分析结果示,时间与组别对MMSE、MoCA、mRS、NIHSS、脑血流速度、IL-6存在交互作用(P<0.05),时间和组别对MMSE、MoCA、NIHSS、脑血流速度、IL-6主效应显著(P<0.05),时间对mRS、SAS、SDS、IADL主效应显著(P<0.05)。试验组干预后30、90 d MMSE、MoCA评分及脑血流速度均高于对照组,mRS、NIHSS评分均低于对照组(P<0.05);试验组干预后30、90 d SDS、IADL评分低于对照组(P<0.05);试验组干预后30 d SAS评分高于对照组,IL-6低于对照组(P<0.05)。99例患者中共有23例患者发生不良反应,其中试验组17例,对照组6例,两组皮肤瘀点、头晕、心慌、胸闷发生率比较,差异无统计学意义(P>0.05);对照组患者皮肤瘀斑发生率[4.00%(2/50)与12.24%(6/49)]、总不良反应发生率[12.00%(6/50)与34.69%(17/49)]低于试验组(P<0.05)。结论RIPostC治疗可降低AIS患者的炎症反应,对神经功能、认知功能抑郁情绪及颅内血流速度可起到积极的改善效果。
文摘[ Objective] The aim was to study variance type of capsule morphological characters in Platycodon grandiflorum population, and provide some theoretical basis for seeking to genetic markers which can differentiate different P. grandiflorum and breeding new varieties. [ Method] According to shape morphological characters of capsule from the same population of perennial purple P. gandiflorum, seven types of distinct di- versity capsule were selected, variance analysis and multiple comparison on the length, diameter, length/diameter of the different types of capsule were carried out. [ Result] There is unicolor and bicolor, even trichrome, among main color was brown and purple. Capsule shape was main cone, furthermore, containing long roller type, spheroidicity and sphericity. [ Conclusion] P. gandiflorum capsule was divided into long form, short form and middle type from length/diameter size in perennial culture P. gandiflorum population.
文摘背景:膝骨关节炎是一种常见的关节软骨及周围组织损伤的慢性炎症性疾病,而免疫细胞在膝骨关节炎免疫炎症反应中起到重要作用,但其中的具体机制仍有待深入研究。目的:采用孟德尔随机化方法来评估731种免疫细胞表型与膝骨关节炎风险之间的潜在因果关系。方法:使用全基因组关联分析(GWAS)目录中公开获取731种免疫细胞表型的全基因组关联分析统计数据(从GCST0001391到GCST0002121)和IEUGWAS数据库中膝骨关节炎的全基因组关联分析数据(ebi-a-GCST007090)。采用逆方差加权法、MR-Egger回归法、加权中位数法、加权模型法和简单模型法来研究免疫细胞与膝骨关节炎之间的因果关系。敏感性分析用于检验孟德尔随机化分析结果是否可靠,然后以同样方法进行反向孟德尔随机化分析。结果与结论:①正向分析结果表明,共有4种免疫细胞表型与膝骨关节炎有显著的因果关系(FDR<0.20),其中B细胞中的CD27 on CD24+CD27+(OR=1.026,P=0.00026,Pfdr=0.18)、髓系细胞中的CD33 on CD33dim HLA DR-(OR=1.014,P=0.00050,Pfdr=0.18)以及Treg细胞中的CD45RA+CD28-CD8br%CD8br(OR=1.001,P=0.00078,Pfdr=0.18)与膝骨关节炎风险呈直接的正向因果关联;单核细胞中PDL-1 on monocyte(OR=0.952,P=0.00098,Pfdr=0.18)与膝骨关节炎风险呈直接的负向因果关联。②反向分析结果表明,当膝骨关节炎作为暴露数据时,与731种免疫细胞表型均不具有显著因果关系(FDR<0.20)。③敏感性分析结果显示:双向孟德尔随机化的Cochran’s Q检验和MR-Egger回归法结果P值均大于0.05,表明免疫细胞表型与膝骨关节炎之间的因果效应分析不存在显著的异质性和多效性。④上述结果证实,CD27 on CD24+CD27+,CD33 on CD33dim HLA DR-,CD45RA+CD28-CD8br%CD8br以及PDL-1 on monocyte免疫细胞表型与膝骨关节炎之间可能具有较为显著的潜在因果关系,这为研究膝骨关节炎的生物学机制及探索膝骨关节炎的早期防治提供有价值的线索,也为干预性药物的开发提供了新的方向。
文摘Matrix principal component analysis (MatPCA), as an effective feature extraction method, can deal with the matrix pattern and the vector pattern. However, like PCA, MatPCA does not use the class information of samples. As a result, the extracted features cannot provide enough useful information for distinguishing pat- tern from one another, and further resulting in degradation of classification performance. To fullly use class in- formation of samples, a novel method, called the fuzzy within-class MatPCA (F-WMatPCA)is proposed. F-WMatPCA utilizes the fuzzy K-nearest neighbor method(FKNN) to fuzzify the class membership degrees of a training sample and then performs fuzzy MatPCA within these patterns having the same class label. Due to more class information is used in feature extraction, F-WMatPCA can intuitively improve the classification perfor- mance. Experimental results in face databases and some benchmark datasets show that F-WMatPCA is effective and competitive than MatPCA. The experimental analysis on face image databases indicates that F-WMatPCA im- proves the recognition accuracy and is more stable and robust in performing classification than the existing method of fuzzy-based F-Fisherfaces.