期刊文献+
共找到1,733篇文章
< 1 2 87 >
每页显示 20 50 100
Pervasive Attentive Neural Network for Intelligent Image Classification Based on N-CDE’s
1
作者 Anas W.Abulfaraj 《Computers, Materials & Continua》 SCIE EI 2024年第4期1137-1156,共20页
The utilization of visual attention enhances the performance of image classification tasks.Previous attentionbased models have demonstrated notable performance,but many of these models exhibit reduced accuracy when co... The utilization of visual attention enhances the performance of image classification tasks.Previous attentionbased models have demonstrated notable performance,but many of these models exhibit reduced accuracy when confronted with inter-class and intra-class similarities and differences.Neural-Controlled Differential Equations(N-CDE’s)and Neural Ordinary Differential Equations(NODE’s)are extensively utilized within this context.NCDE’s possesses the capacity to effectively illustrate both inter-class and intra-class similarities and differences with enhanced clarity.To this end,an attentive neural network has been proposed to generate attention maps,which uses two different types of N-CDE’s,one for adopting hidden layers and the other to generate attention values.Two distinct attention techniques are implemented including time-wise attention,also referred to as bottom N-CDE’s;and element-wise attention,called topN-CDE’s.Additionally,a trainingmethodology is proposed to guarantee that the training problem is sufficiently presented.Two classification tasks including fine-grained visual classification andmulti-label classification,are utilized to evaluate the proposedmodel.The proposedmethodology is employed on five publicly available datasets,including CUB-200-2011,ImageNet-1K,PASCAL VOC 2007,PASCAL VOC 2012,and MS COCO.The obtained visualizations have demonstrated that N-CDE’s are better appropriate for attention-based activities in comparison to conventional NODE’s. 展开更多
关键词 Differential equations neural-controlled DE image classification attention maps N-CDE’s
下载PDF
A Spectral Convolutional Neural Network Model Based on Adaptive Fick’s Law for Hyperspectral Image Classification
2
作者 Tsu-Yang Wu Haonan Li +1 位作者 Saru Kumari Chien-Ming Chen 《Computers, Materials & Continua》 SCIE EI 2024年第4期19-46,共28页
Hyperspectral image classification stands as a pivotal task within the field of remote sensing,yet achieving highprecision classification remains a significant challenge.In response to this challenge,a Spectral Convol... Hyperspectral image classification stands as a pivotal task within the field of remote sensing,yet achieving highprecision classification remains a significant challenge.In response to this challenge,a Spectral Convolutional Neural Network model based on Adaptive Fick’s Law Algorithm(AFLA-SCNN)is proposed.The Adaptive Fick’s Law Algorithm(AFLA)constitutes a novel metaheuristic algorithm introduced herein,encompassing three new strategies:Adaptive weight factor,Gaussian mutation,and probability update policy.With adaptive weight factor,the algorithmcan adjust theweights according to the change in the number of iterations to improve the performance of the algorithm.Gaussianmutation helps the algorithm avoid falling into local optimal solutions and improves the searchability of the algorithm.The probability update strategy helps to improve the exploitability and adaptability of the algorithm.Within the AFLA-SCNN model,AFLA is employed to optimize two hyperparameters in the SCNN model,namely,“numEpochs”and“miniBatchSize”,to attain their optimal values.AFLA’s performance is initially validated across 28 functions in 10D,30D,and 50D for CEC2013 and 29 functions in 10D,30D,and 50D for CEC2017.Experimental results indicate AFLA’s marked performance superiority over nine other prominent optimization algorithms.Subsequently,the AFLA-SCNN model was compared with the Spectral Convolutional Neural Network model based on Fick’s Law Algorithm(FLA-SCNN),Spectral Convolutional Neural Network model based on Harris Hawks Optimization(HHO-SCNN),Spectral Convolutional Neural Network model based onDifferential Evolution(DE-SCNN),SpectralConvolutionalNeuralNetwork(SCNN)model,and SupportVector Machines(SVM)model using the Indian Pines dataset and PaviaUniversity dataset.The experimental results show that the AFLA-SCNN model outperforms other models in terms of Accuracy,Precision,Recall,and F1-score on Indian Pines and Pavia University.Among them,the Accuracy of the AFLA-SCNN model on Indian Pines reached 99.875%,and the Accuracy on PaviaUniversity reached 98.022%.In conclusion,our proposed AFLA-SCNN model is deemed to significantly enhance the precision of hyperspectral image classification. 展开更多
关键词 Adaptive Fick’s law algorithm spectral convolutional neural network metaheuristic algorithm intelligent optimization algorithm hyperspectral image classification
下载PDF
Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism
3
作者 Yujie Yang Xinyi Li +7 位作者 Jiaying Lu Jingjie Ge Mingjia Chen Ruixin Yao Mei Tian Jian Wang Fengtao Liu Chuantao Zuo 《Neural Regeneration Research》 SCIE CAS 2025年第1期93-106,共14页
Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of parkinsonism.... Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of parkinsonism.This review provides a comprehensive summary of the latest developments in the application of presynaptic dopaminergic positron emission tomography imaging in disorders that manifest parkinsonism.We conducted a thorough literature search using reputable databases such as PubMed and Web of Science.Selection criteria involved identifying peer-reviewed articles published within the last 5 years,with emphasis on their relevance to clinical applications.The findings from these studies highlight that presynaptic dopaminergic positron emission tomography has demonstrated potential not only in diagnosing and differentiating various Parkinsonian conditions but also in assessing disease severity and predicting prognosis.Moreover,when employed in conjunction with other imaging modalities and advanced analytical methods,presynaptic dopaminergic positron emission tomography has been validated as a reliable in vivo biomarker.This validation extends to screening and exploring potential neuropathological mechanisms associated with dopaminergic depletion.In summary,the insights gained from interpreting these studies are crucial for enhancing the effectiveness of preclinical investigations and clinical trials,ultimately advancing toward the goals of neuroregeneration in parkinsonian disorders. 展开更多
关键词 aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease PARKINsONIsM positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2
下载PDF
The Shaping of Woman's Language and Its Therapeutic Function through Images in "The Yellow Wallpaper"
4
作者 袁芳 《科技信息》 2011年第27期194-194,共1页
In Perkins' "The Yellow Wallpaper",the wallpaper acts as woman's language.Through this interaction between the wallpaper and the heroine in in this story,Gilman displays to us women's embarrassin... In Perkins' "The Yellow Wallpaper",the wallpaper acts as woman's language.Through this interaction between the wallpaper and the heroine in in this story,Gilman displays to us women's embarrassing status in family and society,and leaves the reader to think of woman's future. 展开更多
关键词 英语教学 教学方法 阅读教学 翻译教学
下载PDF
Heroic Woman Images Against Male Power in Tar Baby
5
作者 唐婷 《海外英语》 2011年第8X期8-9,共2页
Ecofeminism is a theory that combines women's unfair condition with nature's overuse by human.It "argues that a strong parallel exists between the oppression and subordination of women in families and soc... Ecofeminism is a theory that combines women's unfair condition with nature's overuse by human.It "argues that a strong parallel exists between the oppression and subordination of women in families and society and the degradation of nature through the construction of differences into conceptual binaries and ideological hierarchies that allow a systematic justification of domination by subjects classed into higher-ranking categories over objects classed into lower-ranking categories" (Miao 184). Tar Baby is the fourth work of Tony Morrison which explores African-Americans' poor status, especially black women's. From ecofeminism's perspective, women and nature share same destiny. Being fed up with the bad condition, women has struggling against male world and tried to win their own happiness and identity, appealing to mutual respect and understanding. 展开更多
关键词 HEROIC woman images MALE POWER TAR Baby
下载PDF
Image of an“Unknown Woman”in the American and Chinese Film Letter from an Unknown Woman
6
作者 LI Lei 《Journal of Literature and Art Studies》 2020年第9期821-828,共8页
Letter from an Unknown Woman is one of the most well-known works of Austrian novelist Stefan Zweig.Since its first publication in 1922,there have been two film adaptations based on this novella.In 1948,Max Ophüls... Letter from an Unknown Woman is one of the most well-known works of Austrian novelist Stefan Zweig.Since its first publication in 1922,there have been two film adaptations based on this novella.In 1948,Max Ophüls,a German-born director,directed a black-and-white drama romance film of the same name based on a script adapted by Howard Koch and released it in American.In 2005,a Chinese film based on this widely spread love story was adapted and directed by the Chinese female director Xu Jinglei.In this paper,two film adaptations released in different cultural contexts and historical backgrounds will be compared.Based on feminist theories,this paper will expound the similarities and differences in the portrayal of the unknown woman,which can imply unique understandings of two films about women’s role ina love relationship. 展开更多
关键词 Letter from an Unknown woman Max Ophüls Xu Jinglei image
下载PDF
On the Women Image in The Woman Warrior — Based on the Theory of Lacan's Symbolic Order
7
作者 桂花 《海外英语》 2016年第1期166-167,共2页
According to the theory of Lacan's symbolic order, gender identity is determined by the culture that people live in.The culture is the chief determinant of women's gender and their destiny. The Woman Warrior i... According to the theory of Lacan's symbolic order, gender identity is determined by the culture that people live in.The culture is the chief determinant of women's gender and their destiny. The Woman Warrior is the autobiographical novel of Maxine Hong Kingston, in which there are different women images who live in different cultures. The this paper focuses on analyzing the tragic fate of"no name woman"who lives in traditional Chinese patriarchy culture and the hard experience of"I"who struggles between Chinese patriarchy culture and American feminism culture. 展开更多
关键词 The theory of Lacan’s sYMBOLIC order Chinese PATRIARCHY CULTURE FEMINIsM CULTURE The woman WARRIOR W
下载PDF
The Influence of Consumer Culture on American New Woman and Their Literary Image in the Early 20th Century
8
作者 章祎 张俊萍 《海外英语》 2018年第9期194-195,共2页
By the study of three great American literary works, The Great Gatsby, Tender is the Night and The Age of Innocence, this paper aims to give a holistic interpretation of"New Woman"and their intrinsic relatio... By the study of three great American literary works, The Great Gatsby, Tender is the Night and The Age of Innocence, this paper aims to give a holistic interpretation of"New Woman"and their intrinsic relationship with consumer culture in the light of Baudrillard's theories about the consumer society and the consumer culture. 展开更多
关键词 BAUDRILLARD consumer culture the early 20th century AMERICA New woman literary image
下载PDF
Analysis of the Tragic Female Images in Eugene O'Neill's Plays 被引量:1
9
作者 李琳 《海外英语》 2011年第8X期287-288,共2页
Ruth and Mary are two heroines in Eugene O'Neill's plays Beyond the Horizon, and Long Day's Journey into Night. They have some similarities: when they are young, they are beautiful, native and full of hope... Ruth and Mary are two heroines in Eugene O'Neill's plays Beyond the Horizon, and Long Day's Journey into Night. They have some similarities: when they are young, they are beautiful, native and full of hope towards the future life, but both make wrong choices; in the following years, both suffer a lot from these wrong choices, and feel regretful. This paper tries to explore these two tragic female images. 展开更多
关键词 female images Beyond the HORIZON Long Day’s JOURNEY into NIGHT
下载PDF
基于MRI影像组学构建PD-1/PD-L1抑制剂治疗dMMR/MSI-H直肠癌疗效的预测模型
10
作者 张岚 周彦汝 +3 位作者 韩鼎盛 张嘉诚 何旭 刘鹏 《中国医学计算机成像杂志》 CSCD 北大核心 2024年第3期343-348,共6页
目的:探讨MRI影像组学模型在程序性细胞死亡蛋白-1(PD-1)/程序性细胞死亡-配体1(PD-L1)抑制剂联合全程新辅助治疗(TNT)局部进展期直肠癌(LARC)的疗效预测价值。方法:收集河南中医药大学第一附属医院PD-1/PD-L1抑制剂联合TNT治疗的80例... 目的:探讨MRI影像组学模型在程序性细胞死亡蛋白-1(PD-1)/程序性细胞死亡-配体1(PD-L1)抑制剂联合全程新辅助治疗(TNT)局部进展期直肠癌(LARC)的疗效预测价值。方法:收集河南中医药大学第一附属医院PD-1/PD-L1抑制剂联合TNT治疗的80例错配修复基因缺陷(dMMR)/微卫星高度不稳定(MSI-H)基因型中低位LARC患者的临床和影像资料。将入组患者按7∶3比例分为训练集和测试集,提取影像组学特征,从中筛选并构建影像组学模型。描绘影像组学模型的Rad-score与病理金标准之间的受试者工作特征(ROC)曲线,计算曲线下面积(AUC),并评价模型的诊断效能。采用决策曲线分析(DCA)计算风险阈值的范围,并评估临床获益情况。收集湖南省人民医院25例dMMR/MSI-H基因型LARC患者的影像资料作为外部验证集。结果:训练集、测试集及外部验证集三者之间的临床特征无统计学差异(P>0.05)。经过降维处理、t检验及一致性检验以及LASSO交叉验证后,筛选出一阶偏度特征和体积2个特征构建影像组学模型。训练集、测试集和外部验证集的影像组学预测模型ROC曲线的AUC、灵敏度、特异度、阳性预测值和阴性预测值分别为0.920、97.1%、85.7%、91.9%、94.7%;0.885、80.0%、88.9%、92.3%、72.7%;0.875、87.5%、88.9%、93.3%、80.0%。DCA曲线显示,当风险阈值范围为0%~82%时,采用影像组学模型预测LARC患者为病理完全缓解(pCR)的获益大于将所有患者都视为pCR或者无病理完全缓解(npCR)。结论:基于MRI影像组学构建的dMMR/MSI-H型局部进展期直肠癌PD-1/PD-L1抑制剂联合全程新辅助放化疗疗效预测模型,有较大潜力为不同基因分型的直肠癌患者制定个体化治疗策略提供量化依据。 展开更多
关键词 磁共振成像 影像组学 直肠肿瘤 局部进展期 程序性细胞死亡蛋白-1/程序性细胞死亡-配体1 全程新辅助放化疗
下载PDF
Detection of Alzheimer’s disease onset using MRI and PET neuroimaging:longitudinal data analysis and machine learning 被引量:2
11
作者 Iroshan Aberathne Don Kulasiri Sandhya Samarasinghe 《Neural Regeneration Research》 SCIE CAS CSCD 2023年第10期2134-2140,共7页
The scientists are dedicated to studying the detection of Alzheimer’s disease onset to find a cure, or at the very least, medication that can slow the progression of the disease. This article explores the effectivene... The scientists are dedicated to studying the detection of Alzheimer’s disease onset to find a cure, or at the very least, medication that can slow the progression of the disease. This article explores the effectiveness of longitudinal data analysis, artificial intelligence, and machine learning approaches based on magnetic resonance imaging and positron emission tomography neuroimaging modalities for progression estimation and the detection of Alzheimer’s disease onset. The significance of feature extraction in highly complex neuroimaging data, identification of vulnerable brain regions, and the determination of the threshold values for plaques, tangles, and neurodegeneration of these regions will extensively be evaluated. Developing automated methods to improve the aforementioned research areas would enable specialists to determine the progression of the disease and find the link between the biomarkers and more accurate detection of Alzheimer’s disease onset. 展开更多
关键词 deep learning image processing linear mixed effect model NEUROimagING neuroimaging data sources onset of Alzheimer’s disease detection pattern recognition
下载PDF
Image Segmentation of Brain MR Images Using Otsu’s Based Hybrid WCMFO Algorithm 被引量:6
12
作者 A.Renugambal K.Selva Bhuvaneswari 《Computers, Materials & Continua》 SCIE EI 2020年第8期681-700,共20页
In this study,a novel hybrid Water Cycle Moth-Flame Optimization(WCMFO)algorithm is proposed for multilevel thresholding brain image segmentation in Magnetic Resonance(MR)image slices.WCMFO constitutes a hybrid betwee... In this study,a novel hybrid Water Cycle Moth-Flame Optimization(WCMFO)algorithm is proposed for multilevel thresholding brain image segmentation in Magnetic Resonance(MR)image slices.WCMFO constitutes a hybrid between the two techniques,comprising the water cycle and moth-flame optimization algorithms.The optimal thresholds are obtained by maximizing the between class variance(Otsu’s function)of the image.To test the performance of threshold searching process,the proposed algorithm has been evaluated on standard benchmark of ten axial T2-weighted brain MR images for image segmentation.The experimental outcomes infer that it produces better optimal threshold values at a greater and quicker convergence rate.In contrast to other state-of-the-art methods,namely Adaptive Wind Driven Optimization(AWDO),Adaptive Bacterial Foraging(ABF)and Particle Swarm Optimization(PSO),the proposed algorithm has been found to be better at producing the best objective function,Peak Signal-to-Noise Ratio(PSNR),Standard Deviation(STD)and lower computational time values.Further,it was observed thatthe segmented image gives greater detail when the threshold level increases.Moreover,the statistical test result confirms that the best and mean values are almost zero and the average difference between best and mean value 1.86 is obtained through the 30 executions of the proposed algorithm.Thus,these images will lead to better segments of gray,white and cerebrospinal fluid that enable better clinical choices and diagnoses using a proposed algorithm. 展开更多
关键词 Hybrid WCMFO algorithm Otsu’s function multilevel thresholding image segmentation brain MR image
下载PDF
A hybrid quantum encoding algorithm of vector quantization for image compression 被引量:4
13
作者 庞朝阳 周正威 郭光灿 《Chinese Physics B》 SCIE EI CAS CSCD 2006年第12期3039-3043,共5页
Many classical encoding algorithms of vector quantization (VQ) of image compression that can obtain global optimal solution have computational complexity O(N). A pure quantum VQ encoding algorithm with probability... Many classical encoding algorithms of vector quantization (VQ) of image compression that can obtain global optimal solution have computational complexity O(N). A pure quantum VQ encoding algorithm with probability of success near 100% has been proposed, that performs operations 45√N times approximately. In this paper, a hybrid quantum VQ encoding algorithm between the classical method and the quantum algorithm is presented. The number of its operations is less than √N for most images, and it is more efficient than the pure quantum algorithm. 展开更多
关键词 vector quantization Grover's algorithm image compression quantum algorithm
下载PDF
Range anomaly suppression based on neighborhood pixels detection in ladar range images 被引量:2
14
作者 Mingbo Zhao Jun He +1 位作者 Zaiqi Lu Qiang Fu 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2013年第1期68-75,共8页
Research on the range anomaly suppression algorithm in laser radar (ladar) range images is significant in the application and development of ladar. But most of existing algorithms cannot protect the edge and linear ... Research on the range anomaly suppression algorithm in laser radar (ladar) range images is significant in the application and development of ladar. But most of existing algorithms cannot protect the edge and linear target well while suppressing the range anomaly. Aiming at this problem, the differences among the edge, linear target, and range anomaly are analyzed and a novel algo- rithm based on neighborhood pixels detection is proposed. Firstly, the range differences between current pixel and its neighborhood pixels are calculated. Then, the number of neighborhood pixels is detected by the range difference threshold. Finally, whether the current pixel is a range anomaly is distinguished by the neighbor- hood pixel number threshold. Experimental results show that the new algorithm not only has a better range anomaly suppression performance and higher efficiency, but also protects the edge and linear target preferably compared with other algorithms. 展开更多
关键词 image processing range anomaly suppression neigh-borhood p xe s detection linear target laser radar (ladar).
下载PDF
Impact of cognition-related single nucleotide polymorphisms on brain imaging phenotype in Parkinson’s disease
15
作者 Ting Shen Jia-Li Pu +7 位作者 Ya-Si Jiang Yu-Mei Yue Ting-Ting He Bo-Yi Qu Shuai Zhao Ya-Ping Yan Hsin-Yi Lai Bao-Rong Zhang 《Neural Regeneration Research》 SCIE CAS CSCD 2023年第5期1154-1160,共7页
Multiple single nucleotide polymorphisms may contribute to cognitive decline in Parkinson’s disease. However, the mechanism by which these single nucleotide polymorphisms modify brain imaging phenotype remains unclea... Multiple single nucleotide polymorphisms may contribute to cognitive decline in Parkinson’s disease. However, the mechanism by which these single nucleotide polymorphisms modify brain imaging phenotype remains unclear. The aim of this study was to investigate the potential effects of multiple single nucleotide polymorphisms on brain imaging phenotype in Parkinson’s disease. Forty-eight Parkinson’s disease patients and 39 matched healthy controls underwent genotyping and 7 T magnetic resonance imaging. A cognitive-weighted polygenic risk score model was designed, in which the effect sizes were determined individually for 36 single nucleotide polymorphisms. The correlations between polygenic risk score, neuroimaging features, and clinical data were analyzed. Furthermore, individual single nucleotide polymorphism analysis was performed to explore the main effects of genotypes and their interactive effects with Parkinson’s disease diagnosis. We found that, in Parkinson’s disease, the polygenic risk score was correlated with the neural activity of the hippocampus, parahippocampus, and fusiform gyrus, and with hippocampal-prefrontal and fusiform-temporal connectivity, as well as with gray matter alterations in the orbitofrontal cortex. In addition, we found that single nucleotide polymorphisms in α-synuclein(SNCA) were associated with white matter microstructural changes in the superior corona radiata, corpus callosum, and external capsule. A single nucleotide polymorphism in catechol-O-methyltransferase was associated with the neural activities of the lingual, fusiform, and occipital gyri, which are involved in visual cognitive dysfunction. Furthermore, DRD3 was associated with frontal and temporal lobe function and structure. In conclusion, imaging genetics is useful for providing a better understanding of the genetic pathways involved in the pathophysiologic processes underlying Parkinson’s disease. This study provides evidence of an association between genetic factors, cognitive functions, and multi-modality neuroimaging biomarkers in Parkinson’s disease. 展开更多
关键词 COGNITION imaging genetics magnetic resonance imaging MULTI-MODALITY Parkinson’s disease polygenic risk score single nucleotide polymorphism ultra-high field
下载PDF
A Content-Based Parallel Image Retrieval System on Cluster Architectures 被引量:1
16
作者 ZHOUBing SHENJun-yi PENGQin-ke 《Wuhan University Journal of Natural Sciences》 CAS 2004年第5期665-670,共6页
We propose a content-based parallel image retrieval system to achieve high responding ability. Our system is developed on cluster architectures. It has several retrieval. servers to supply the service of content-based... We propose a content-based parallel image retrieval system to achieve high responding ability. Our system is developed on cluster architectures. It has several retrieval. servers to supply the service of content-based image retrieval. It adopts the Browser/Server (B/S) mode. The users could visit our system though web pages. It uses the symmetrical color-spatial features (SCSF) to represent the content of an image. The SCSF is effective and efficient for image matching because it is independent of image distortion such as rotation and flip as well as it increases the matching accuracy. The SCSF was organized by M-tree, which could speedup the searching procedure. Our experiments show that the image matching is quickly and efficiently with the use of SCSF. And with the support of several retrieval servers, the system could respond to many users at mean time. Key words content-based image retrieval - cluster architecture - color-spatial feature - B/S mode - task parallel - WWW - Internet CLC number TP391 Foundation item: Supported by the National Natural Science Foundation of China (60173058)Biography: ZHOU Bing (1975-), male, Ph. D candidate, reseach direction: data mining, content-based image retrieval. 展开更多
关键词 content-based image retrieval cluster architecture color-spatial feature B/s mode task parallel WWW INTERNET
下载PDF
Neural stem cell-derived exosomes promote mitochondrial biogenesis and restore abnormal protein distribution in a mouse model of Alzheimer's disease 被引量:1
17
作者 Bo Li Yujie Chen +10 位作者 Yan Zhou Xuanran Feng Guojun Gu Shuang Han Nianhao Cheng Yawen Sun Yiming Zhang Jiahui Cheng Qi Zhang Wei Zhang Jianhui Liu 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第7期1593-1601,共9页
Mitochondrial dysfunction is a hallmark of Alzheimer’s disease.We previously showed that neural stem cell-derived extracellular vesicles improved mitochondrial function in the cortex of AP P/PS1 mice.Because Alzheime... Mitochondrial dysfunction is a hallmark of Alzheimer’s disease.We previously showed that neural stem cell-derived extracellular vesicles improved mitochondrial function in the cortex of AP P/PS1 mice.Because Alzheimer’s disease affects the entire brain,further research is needed to elucidate alterations in mitochondrial metabolism in the brain as a whole.Here,we investigated the expression of several important mitochondrial biogenesis-related cytokines in multiple brain regions after treatment with neural stem cell-derived exosomes and used a combination of whole brain clearing,immunostaining,and lightsheet imaging to clarify their spatial distribution.Additionally,to clarify whether the sirtuin 1(SIRT1)-related pathway plays a regulatory role in neural stem cell-de rived exosomes interfering with mitochondrial functional changes,we generated a novel nervous system-SIRT1 conditional knoc kout AP P/PS1mouse model.Our findings demonstrate that neural stem cell-de rived exosomes significantly increase SIRT1 levels,enhance the production of mitochondrial biogenesis-related fa ctors,and inhibit astrocyte activation,but do not suppress amyloid-βproduction.Thus,neural stem cell-derived exosomes may be a useful therapeutic strategy for Alzheimer’s disease that activates the SIRT1-PGC1αsignaling pathway and increases NRF1 and COXIV synthesis to improve mitochondrial biogenesis.In addition,we showed that the spatial distribution of mitochondrial biogenesis-related factors is disrupted in Alzheimer’s disease,and that neural stem cell-derived exosome treatment can reverse this effect,indicating that neural stem cell-derived exosomes promote mitochondrial biogenesis. 展开更多
关键词 Alzheimer’s disease mitochondrial biogenesis neural stem cell-derived exosome sIRT1-PGC1α regional brain distribution whole brain clearing and imaging
下载PDF
On the Creation Background and the Influence of Wei Zhuang’s Famous Poem:Lament of a Northwestern Woman
18
作者 Liu Huo 《Contemporary Social Sciences》 2023年第4期109-120,共12页
Lament of a Northwestern Woman(Qin Fu Yin),composed by Wei Zhuang after the Huangchao uprising,is a long poem that showcases the sufferings of the civilians and embodies the people’s character of the poem,which is th... Lament of a Northwestern Woman(Qin Fu Yin),composed by Wei Zhuang after the Huangchao uprising,is a long poem that showcases the sufferings of the civilians and embodies the people’s character of the poem,which is the profound empathy and compassion of the poet towards the civilians’plight.The poem was written during the reign of Emperor Xizong of the Tang Dynasty in the year Gengmao(883 AD).2023 is also the year Gengmao,so this poem has existed for a remarkable 1140 years.For over a millennium,this long poem remained submerged in history until the opening of the Dunhuang Grottoes at the turn of the 20th century.The deep compassion and commiseration towards the underprivileged masses conveyed in this long poem are reminiscent of Du Fu’s renowned“Three Poems of Separation.”Moreover,it is widely believed that this poem foretells the decline of the Tang Dynasty. 展开更多
关键词 Lament of a Northwestern woman Wei Zhuang people’s character the decline of the Tang Dynasty
下载PDF
泸定M_(S)6.8地震发震机制研究——来自震前噪声成像和b值分布的共同约束
19
作者 花茜 裴顺平 +5 位作者 杨宜海 薛晓添 李磊 李佳蔚 刘翰林 刘巍 《地球物理学报》 SCIE EI CAS CSCD 北大核心 2024年第5期1767-1780,共14页
2022年9月5日四川省甘孜州泸定县发生了M_(S)6.8地震,打破了鲜水河断裂带东南段的大震"平静期",造成了重大自然灾害.清楚认识泸定地震震源区发震构造、地震活动性和应力状态对研究强震发震机制具有重要作用.本文利用震前在泸... 2022年9月5日四川省甘孜州泸定县发生了M_(S)6.8地震,打破了鲜水河断裂带东南段的大震"平静期",造成了重大自然灾害.清楚认识泸定地震震源区发震构造、地震活动性和应力状态对研究强震发震机制具有重要作用.本文利用震前在泸定地震震源区布设的50台短周期流动地震台阵观测资料及区域地震台网震相走时数据,分别采用背景噪声成像、双差定位和改进的b值成像技术,获得了震前震源区浅层高分辨率S波速度结构、地震空间分布及b值横向变化图像.结果揭示,泸定地震主震初始破裂起始于鲜水河断裂磨西段、具有高速异常和高应力特征的凹凸体内;主震西侧存在一条隐伏的正断型伴生分支断裂,5.0级的最大余震即发生在该断裂上;主震凹凸体的破裂同时造成了东南方向另一个较小高速凹凸体的破裂并形成密集余震群.由此可见,震源区跨断层高速异常"铆钉"结构和震前的高应力积累在整体上控制了泸定地震的发生和强余震活动.通过浅层高分辨率结构成像识别这种特殊的"铆钉"结构,同时通过b值成像识别高应力区,可有效评估断层的发震能力,对重点区域地震危险性研判具有极其重要的意义. 展开更多
关键词 泸定M_(s)6.8地震 s波速度结构 b值成像 高速凹凸体 地震发震机制
下载PDF
Identity Issue and Mysterious Images in the Bonesetter's Daughter
20
作者 张砚 《海外英语》 2013年第11X期226-227,共2页
This paper is going to do a research on the book The Bonesetter's Daughter and will make an analysis of mysterious images appear in the novel which can be considered as symbols that reflect the culture of orient. ... This paper is going to do a research on the book The Bonesetter's Daughter and will make an analysis of mysterious images appear in the novel which can be considered as symbols that reflect the culture of orient. And it also looks into the identity issue of Chinese American women from postcolonial perspective. 展开更多
关键词 IDENTITY IssUE Amy TAN image Bonesetter s Daughte
下载PDF
上一页 1 2 87 下一页 到第
使用帮助 返回顶部