In spite of the great progress of wound healing materials,the development of dressing with moisture permeabil-ity,stretchable capability,and adhesive performance remains a huge challenge.In this study,gelatin-dopamine...In spite of the great progress of wound healing materials,the development of dressing with moisture permeabil-ity,stretchable capability,and adhesive performance remains a huge challenge.In this study,gelatin-dopamine(GT-DA)nanofiber membrane was prepared by introducing dopamine(DA)into gelatin(GT)via electrospinning followed by in-situ reaction.The effects of DA dosage,crosslinking condition and crosslinking time on the mechanical properties of the fiber membrane were studied systematically.The resultant GT-DA nanofibrous hydrogels exhibited integrated stress strength of 1.96 MPa,good water absorption of 700%,and water vapor transmission(WVT:4.3 kg m^(-2)d^(-1)),which were superior than those of Mepiform■,a commercial adhesive silicone dressing.In addition,Fe^(3+)were introduced into one side of the nanofiber membrane.A stronger adhesion strength of 2.5 KPa on the porcine skin,which was 1.6 times higher than that of Mepiform■was achieved.Our research showed that the prepared nanofibrous hydrogel has potential as wound dressing and could be used in post-traumatic tissue healing engineering.This work presented a type of breathable,stretchable and adhesive nanofibrous hydrogels,which would ensure the stable attachment on wounds during movement as a wound healing material.展开更多
基金supported by the National Natural Science Foundation of China(81771338 and 52073055)Natural Science Foundation of Shanghai(19ZR1470500)+1 种基金the Fundamental Research Funds for the Central UniversitiesDHU Distinguished Young Professor Program.
文摘In spite of the great progress of wound healing materials,the development of dressing with moisture permeabil-ity,stretchable capability,and adhesive performance remains a huge challenge.In this study,gelatin-dopamine(GT-DA)nanofiber membrane was prepared by introducing dopamine(DA)into gelatin(GT)via electrospinning followed by in-situ reaction.The effects of DA dosage,crosslinking condition and crosslinking time on the mechanical properties of the fiber membrane were studied systematically.The resultant GT-DA nanofibrous hydrogels exhibited integrated stress strength of 1.96 MPa,good water absorption of 700%,and water vapor transmission(WVT:4.3 kg m^(-2)d^(-1)),which were superior than those of Mepiform■,a commercial adhesive silicone dressing.In addition,Fe^(3+)were introduced into one side of the nanofiber membrane.A stronger adhesion strength of 2.5 KPa on the porcine skin,which was 1.6 times higher than that of Mepiform■was achieved.Our research showed that the prepared nanofibrous hydrogel has potential as wound dressing and could be used in post-traumatic tissue healing engineering.This work presented a type of breathable,stretchable and adhesive nanofibrous hydrogels,which would ensure the stable attachment on wounds during movement as a wound healing material.
