Xanthenedione derivatives were prepared through lnCl3·4H2O promoted condensation of aldehydes with 5, 5-dimethyl-1, 3-cyclohexandione in [bmiml[BF4]. The advantages of this method are: simple operation, environme...Xanthenedione derivatives were prepared through lnCl3·4H2O promoted condensation of aldehydes with 5, 5-dimethyl-1, 3-cyclohexandione in [bmiml[BF4]. The advantages of this method are: simple operation, environmental benign and high efficiency. Moreover, the reaction media and the catalyst can be recovered and reused effectively for at least six times.展开更多
The reaction of aromatic aldehydes 1 with 5, 5-dimethyl-1, 3-cyclohexandione 2 was investigated in this paper by using [bmim][BF4] as the reaction medium. It was found that when the reaction was carried out in the pre...The reaction of aromatic aldehydes 1 with 5, 5-dimethyl-1, 3-cyclohexandione 2 was investigated in this paper by using [bmim][BF4] as the reaction medium. It was found that when the reaction was carried out in the presence of catalytic amount of FeCl3·6H2O, xanthenediones 3 was obtained in high yields. On the other hand, when a combination of trimethylchlorosilane (TMSCl) and FeCl3·6H2O was employed as the catalyst, the reaction afforded ring-opening derivatives of xanthenediones 4 with high efficiency.展开更多
Xanthene and Xanthenediones are structural components of several bioactive and semi-synthetic molecules. This work described an expeditious synthesis of novel and hitherto unreported bis-trifluoromethyl xanthene dione...Xanthene and Xanthenediones are structural components of several bioactive and semi-synthetic molecules. This work described an expeditious synthesis of novel and hitherto unreported bis-trifluoromethyl xanthene dione derivatives. The reaction of two equivalents of 5-trifluoromethyl cyclohexane-1,3- dione with substituted aromatic aldehydes in the presence of ethanol containing 1 - 2 drops of HCl was facile under microwave irradiation. Short reaction time (25 min), good to excellent yields (80% - 95%), good atom economy, and simple workup are the major advantages of the above procedure. Moreover, the fluorinated products represent synthetically useful stable intermediates that could find applications in pharmaceutical, agricultural and material industries.展开更多
基金This work was financially supported by the National Natural Science Foundation of China(No.20273019)the Science Foundation of Henan Normal University for Young Scholars(No.0307032).
文摘Xanthenedione derivatives were prepared through lnCl3·4H2O promoted condensation of aldehydes with 5, 5-dimethyl-1, 3-cyclohexandione in [bmiml[BF4]. The advantages of this method are: simple operation, environmental benign and high efficiency. Moreover, the reaction media and the catalyst can be recovered and reused effectively for at least six times.
基金Supported by the National Natural Science Foundation of China (No. 20273019) and the ScienceFoundation of Henan Normal University for Young Scholars (No. 0307032).
基金This work was financially supported by NNSFC(No.20273019)the Science Foundation of Henan Normal University for Young Scholars(No.0307032).
文摘The reaction of aromatic aldehydes 1 with 5, 5-dimethyl-1, 3-cyclohexandione 2 was investigated in this paper by using [bmim][BF4] as the reaction medium. It was found that when the reaction was carried out in the presence of catalytic amount of FeCl3·6H2O, xanthenediones 3 was obtained in high yields. On the other hand, when a combination of trimethylchlorosilane (TMSCl) and FeCl3·6H2O was employed as the catalyst, the reaction afforded ring-opening derivatives of xanthenediones 4 with high efficiency.
文摘Xanthene and Xanthenediones are structural components of several bioactive and semi-synthetic molecules. This work described an expeditious synthesis of novel and hitherto unreported bis-trifluoromethyl xanthene dione derivatives. The reaction of two equivalents of 5-trifluoromethyl cyclohexane-1,3- dione with substituted aromatic aldehydes in the presence of ethanol containing 1 - 2 drops of HCl was facile under microwave irradiation. Short reaction time (25 min), good to excellent yields (80% - 95%), good atom economy, and simple workup are the major advantages of the above procedure. Moreover, the fluorinated products represent synthetically useful stable intermediates that could find applications in pharmaceutical, agricultural and material industries.
