The present study investigated the effect of treatment with methanolic extracts of Yin- and Yang-Chinese tonifying herbs on concanavalin A (Con A)/lipopolysaccharide (LPS)-stimulated splenocyte proliferation (adaptive...The present study investigated the effect of treatment with methanolic extracts of Yin- and Yang-Chinese tonifying herbs on concanavalin A (Con A)/lipopolysaccharide (LPS)-stimulated splenocyte proliferation (adaptive immunity) and natural killer (NK) cell activity (innate immunity) in an ex vivo mouse model. The results indicated that while treatment with most Yin herbal extracts potentiated the Con A/LPS-stimulated splenocyte proliferation, only Yang (but not Yin) herbal extracts stimulated NK cell activity. The differential effects of Yin- and Yang-Chinese tonifying herbs on innate and adaptive immunity are consistent with the Chinese medicine theory which depicts the Yin and Yang functional components of Zheng Qi (vital energy), with the Yang component being responsible for the first line of defense against invading microorganisms (i.e., innate immunity) and the Yin oner serving as a follow-up defensive response (adaptive immunity).展开更多
目的:观察肺气虚证患者和肺阴虚证患者外周血自然杀伤细胞(NK 细胞)表达状况。方法:应用流式细胞仪分别对58例肺气虚证患者、12例肺阴虚证患者和20例健康查体者 CD_(16)/CD_(56)进行测定。结果:肺气虚证患者和肺阴虚证患者 NK 细胞活性...目的:观察肺气虚证患者和肺阴虚证患者外周血自然杀伤细胞(NK 细胞)表达状况。方法:应用流式细胞仪分别对58例肺气虚证患者、12例肺阴虚证患者和20例健康查体者 CD_(16)/CD_(56)进行测定。结果:肺气虚证患者和肺阴虚证患者 NK 细胞活性下降;肺气虚证各组间 NK 细胞活性也存在明显的差异。结论:肺气虚证患者免疫功能由早期的活跃状态逐步发展到不同程度的免疫抑制,然后发展至肺阴虚证,最终导致免疫系统内环境稳定失调。展开更多
文摘The present study investigated the effect of treatment with methanolic extracts of Yin- and Yang-Chinese tonifying herbs on concanavalin A (Con A)/lipopolysaccharide (LPS)-stimulated splenocyte proliferation (adaptive immunity) and natural killer (NK) cell activity (innate immunity) in an ex vivo mouse model. The results indicated that while treatment with most Yin herbal extracts potentiated the Con A/LPS-stimulated splenocyte proliferation, only Yang (but not Yin) herbal extracts stimulated NK cell activity. The differential effects of Yin- and Yang-Chinese tonifying herbs on innate and adaptive immunity are consistent with the Chinese medicine theory which depicts the Yin and Yang functional components of Zheng Qi (vital energy), with the Yang component being responsible for the first line of defense against invading microorganisms (i.e., innate immunity) and the Yin oner serving as a follow-up defensive response (adaptive immunity).
文摘目的:观察肺气虚证患者和肺阴虚证患者外周血自然杀伤细胞(NK 细胞)表达状况。方法:应用流式细胞仪分别对58例肺气虚证患者、12例肺阴虚证患者和20例健康查体者 CD_(16)/CD_(56)进行测定。结果:肺气虚证患者和肺阴虚证患者 NK 细胞活性下降;肺气虚证各组间 NK 细胞活性也存在明显的差异。结论:肺气虚证患者免疫功能由早期的活跃状态逐步发展到不同程度的免疫抑制,然后发展至肺阴虚证,最终导致免疫系统内环境稳定失调。
