The effect of high frequency oscillatory ventilation（HFOV） at early stage on hemodynamic parameters, extravascular lung water（EVLW）, lung capillary permeability, CC16 and s ICAM-1 in piglets with pulmonary or extr...The effect of high frequency oscillatory ventilation（HFOV） at early stage on hemodynamic parameters, extravascular lung water（EVLW）, lung capillary permeability, CC16 and s ICAM-1 in piglets with pulmonary or extrapulmonary acute respiratory distress syndrome（ARDS） was explored. Central vein pressure（CVP） and pulse indicator continuous cardiac output（Pi CCO） were monitored in 12 anesthetized and intubated healthy piglets. Pulmonary ARDS（ARDSp） and extrapulmonary ARDS（ARDSexp） models were respectively established by lung lavage of saline solution and intravenous injection of oleic acid. Then the piglets received HFOV for 4 h. EVLW index（EVLWI）, EVLW/intratroracic blood volume（ITBV） and pulmonary vascular permeability index（PVPI） were measured before and after modeling（T0 and T1）, and T2（1 h）, T3（2 h）, T4（3 h） and T5（4 h） after HFOV. CC16 and s ICAM-1 were also detected at T1 and T5. Results showed at T1, T3, T4 and T5, EVLWI was increased more significantly in ARDSp group than in ARDSexp group（P〈0.05）. The EVLWI in ARDSp group was increased at T1（P=0.008）, and sustained continuously within 2 h（P=0.679, P=0.216）, but decreased at T4（P=0.007） and T5（P=0.037）. The EVLWI in ARDSexp group was also increased at T1（P=0.003）, but significantly decreased at T3（P=0.002） and T4（P=0.019）. PVPI was increased after modeling in both two groups（P=0.004, P=0.012）, but there was no significant change within 4 h（T5） under HFOV in ARDSp group, while PVPI showed the increasing trends at first, then decreased in ARDSexp group after HFOV. The changes of EVLW/ITBV were similar to those of PVPI. No significant differences were found in ΔEVLWI（P=0.13）, ΔPVPI（P=0.28） and ΔEVLW/ITBV between the two groups（P=0.63）. The significant decreases in both CC16 and s ICAM-1 were found in both two groups 4 h after HFOV, but there was no significant difference between the two groups. It was concluded that EVLWI and lung capillary permeability were markedly increased in ARDSp and ARDSexp groups. EVLW could be decreased 4 h after the HFOV treatment. HFOV, EVLW/ITBV and PVPI were increased slightly at first, and then decreased in ARDSexp group, while in ARDSp group no significant difference was found after modeling. No significant differences were found in the decreases in EVLW and lung capillary permeability 4 h after HFOV.展开更多
Objective:To evaluate the potential effect of human Wharton’s jelly mesenchymal stem cells(hWJMSCs)on acute respiratory distress syndrome in lipopolysaccharide(LPS)-induced rats.Methods:The hWJMSCs(5×10^(4)/mL,5...Objective:To evaluate the potential effect of human Wharton’s jelly mesenchymal stem cells(hWJMSCs)on acute respiratory distress syndrome in lipopolysaccharide(LPS)-induced rats.Methods:The hWJMSCs(5×10^(4)/mL,5×10^(5)/mL,5×10^(6)/mL)were administered to rats on day 1 and day 8 after being induced by LPS(5 mg/kg body weight).TNF-αlevels in the lung and IL-18 and IL-1βlevels in the serum were measured using ELISA.In addition,caspase-1 expression in lung tissues was quantified using qRT-PCR,and NF-κB and IL-6 expressions were assessed using immunohistochemistry.Results:The hWJMSCs decreased TNF-αlevels in the lung and plasma IL-18 and IL-1βlevels.Moreover,the hWJMSCs downregulated the expressions of caspase-1,IL-6,and NF-κB in lung tissues.Conclusions:The hWJMSCs can decrease inflammatory markers of acute respiratory distress syndrome in a rat model and may be further investigated for the treatment of acute respiratory distress syndrome.展开更多
Nearly half of the world’s population comprise youths. However, addressing their Sexual and Reproductive Health (SRH) remains a challenge. Globally countries are mandated to continually provide Youth Friendly Sexual ...Nearly half of the world’s population comprise youths. However, addressing their Sexual and Reproductive Health (SRH) remains a challenge. Globally countries are mandated to continually provide Youth Friendly Sexual and Reproductive Health services (YFSRHs) to the youth. The objective of this study was to assess and describe youth’s perspectives on a sustainable model for the provision of YFSRHs in Kenya. Data was collected among 400 youths aged 18 - 24 years in Embu and Kirinyaga counties, Kenya. A structured questionnaire was utilized as the data collection tool. Collected data was analyzed using SAS statistical software version 9.4. Statistical threshold of P ≤ 0.05 was used. Overall the mean age of the study participants was ±standard deviation (SD) 21.2 ± 1.86 years. Majority of the participants’ perspective on the health care system sustainability was that the waiting time at the facility should be less than an hour, accessible geographically (less than a kilometre), affordable (≤20 Ksh.), and convenient working hours (weekday and weekends ratio 1:1). Advocacy was on health care provider’s attributes of politeness, welcoming, confidential and non-judgmental. The most preferred locations for the youth friendly centres by the participants were community and school based locations. Similarly, parental and community support was reported to highly contribute to sustained utilization and provision of the YFSRHs (P < 0.001). Unlike popular belief, 99.8% did not see the need for recreational facilities at the youth centres to ensure sustainability of the model. To ensure a sustainable model for the provision of YFSRHs, there is need for a multi-sectoral and stakeholder involvement that is;youth, health care system structure, health care service providers, parents and community. Further research is needed on parents and health care service provider’s perspectives on how to sustain the provision of YFSRH services.展开更多
This paper discusses how consumerism boosted youth lifestyle in the 1960s--mainly through modem magazines （particularly in Britain） and built a territorial symbolic identity through fashion. In the 1960s, the consol...This paper discusses how consumerism boosted youth lifestyle in the 1960s--mainly through modem magazines （particularly in Britain） and built a territorial symbolic identity through fashion. In the 1960s, the consolidation of youth culture becomes an international phenomenon. With the development of ready-to-wear, adolescents begin to be target as a consumer market. The music and fashion industries unite to create and advertise youth lifestyle. The fashion shifts from Paris to London. Magazine articles and publicity set the latest trends. The method applied is research in primary source--the British journal The Drapers＇ Record aiming to recognize fashion transformation and juvenilization in this period of time. The magazine shows ads and fashion editorials （mainly feminine）, articles and news about fashion trend. There is also a brands guide for shoppers and retailers. The magazines used in the research are from 1964 to 1967, July and August issues, when the fall-winter trends are shown. From 1964 on, we notice the orientation towards a juvenile market and style, but these trends will only fully materialize through 1967. It leads to the conclusion that between 1965 and 1967 fashion juvenilization developed, reached its peak and global range.展开更多
On April 18-20, 2012, 13th China＇s Refractories Youth Symposium was held successfully in Zhengzhou, Henan Province. China＇s Refracto-ries Youth Symposium, an important and influencing conference, is held every two y...On April 18-20, 2012, 13th China＇s Refractories Youth Symposium was held successfully in Zhengzhou, Henan Province. China＇s Refracto-ries Youth Symposium, an important and influencing conference, is held every two years. 13^th China＇s Refractories Youth Symposium was co-sponsored by The Refractories Branch of The Chinese Society for Metals and Henan Society for Metals, co-organized by Beijing Society of Metals, Metallurgy Society of Hebei Province, Liaoning Society for Metals, Shandong Society for Metals and Shanxi Society for Metals, and supported by Sinosteel Luoyang Institute of Refractories Research Co., Ltd., Zhejiang Zili Co., Ltd., etc.展开更多
When Chen Duxiu founded New Youth, he attached great importance to the “women’s issue” and established the “women’s issue” section, publishing articles on women’s issues and discussing women’s identity, status...When Chen Duxiu founded New Youth, he attached great importance to the “women’s issue” and established the “women’s issue” section, publishing articles on women’s issues and discussing women’s identity, status, and rights deeply. New Youth provided a forum for women to express their ideas, and its existence was a reflection of its advancement. However, from the discussion and promotion of “virtuous mother”, it’s easy to see that the intellectuals at that time had a biased perception of women’s identity and emphasized the intersection of women’s consciousness with the state’s thinking.展开更多
This study＇s objective is to thoroughly analyze representations of teenage sexuality portrayed in two Chinese youths＇ films, which represent social, cultural, and historical diversities in China's Mainland, as w...This study＇s objective is to thoroughly analyze representations of teenage sexuality portrayed in two Chinese youths＇ films, which represent social, cultural, and historical diversities in China's Mainland, as well, to unfold some particular natures and trends of Chinese youth cinema in the context of globalization and internationalization. Content analysis and methodology of narrative explore the ideological nature of representations of youth as well as the interpretation of trends in Chinese youth cinema. This study argues the particular manners of representations of Chinese youth in the youths＇ films produced in China's Mainland, through distinct elements such as film properties, film discourse, and acting on set It will explain how functional and social category diversity, cultural diversity, and historical diversity derive the actuality in Chinese communities, and center on a series of sex-based issues that revel correlations between Chinese youths＇ ideology, psychology, and social construction. Including a discussion of technical factors, it defines the specific natures of Chinese youth cinema in the region based on fixed parameters of culture or ancestry that convey rhetorical messages to discover the characteristics of genre film so that the interpretation of the term ＂peers groups＂ represents the values and beliefs in modern Chinese society, thus presenting the exchange approaches which construct and validate the relationship among society, global film industry, young audience and film content.展开更多
文摘The effect of high frequency oscillatory ventilation（HFOV） at early stage on hemodynamic parameters, extravascular lung water（EVLW）, lung capillary permeability, CC16 and s ICAM-1 in piglets with pulmonary or extrapulmonary acute respiratory distress syndrome（ARDS） was explored. Central vein pressure（CVP） and pulse indicator continuous cardiac output（Pi CCO） were monitored in 12 anesthetized and intubated healthy piglets. Pulmonary ARDS（ARDSp） and extrapulmonary ARDS（ARDSexp） models were respectively established by lung lavage of saline solution and intravenous injection of oleic acid. Then the piglets received HFOV for 4 h. EVLW index（EVLWI）, EVLW/intratroracic blood volume（ITBV） and pulmonary vascular permeability index（PVPI） were measured before and after modeling（T0 and T1）, and T2（1 h）, T3（2 h）, T4（3 h） and T5（4 h） after HFOV. CC16 and s ICAM-1 were also detected at T1 and T5. Results showed at T1, T3, T4 and T5, EVLWI was increased more significantly in ARDSp group than in ARDSexp group（P〈0.05）. The EVLWI in ARDSp group was increased at T1（P=0.008）, and sustained continuously within 2 h（P=0.679, P=0.216）, but decreased at T4（P=0.007） and T5（P=0.037）. The EVLWI in ARDSexp group was also increased at T1（P=0.003）, but significantly decreased at T3（P=0.002） and T4（P=0.019）. PVPI was increased after modeling in both two groups（P=0.004, P=0.012）, but there was no significant change within 4 h（T5） under HFOV in ARDSp group, while PVPI showed the increasing trends at first, then decreased in ARDSexp group after HFOV. The changes of EVLW/ITBV were similar to those of PVPI. No significant differences were found in ΔEVLWI（P=0.13）, ΔPVPI（P=0.28） and ΔEVLW/ITBV between the two groups（P=0.63）. The significant decreases in both CC16 and s ICAM-1 were found in both two groups 4 h after HFOV, but there was no significant difference between the two groups. It was concluded that EVLWI and lung capillary permeability were markedly increased in ARDSp and ARDSexp groups. EVLW could be decreased 4 h after the HFOV treatment. HFOV, EVLW/ITBV and PVPI were increased slightly at first, and then decreased in ARDSexp group, while in ARDSp group no significant difference was found after modeling. No significant differences were found in the decreases in EVLW and lung capillary permeability 4 h after HFOV.
基金the Ministry of Research,Technology and Higher Education of the Republic of Indonesia(Penelitian Terapan Unggulan Perguruan Tinggi,2022).
文摘Objective:To evaluate the potential effect of human Wharton’s jelly mesenchymal stem cells(hWJMSCs)on acute respiratory distress syndrome in lipopolysaccharide(LPS)-induced rats.Methods:The hWJMSCs(5×10^(4)/mL,5×10^(5)/mL,5×10^(6)/mL)were administered to rats on day 1 and day 8 after being induced by LPS(5 mg/kg body weight).TNF-αlevels in the lung and IL-18 and IL-1βlevels in the serum were measured using ELISA.In addition,caspase-1 expression in lung tissues was quantified using qRT-PCR,and NF-κB and IL-6 expressions were assessed using immunohistochemistry.Results:The hWJMSCs decreased TNF-αlevels in the lung and plasma IL-18 and IL-1βlevels.Moreover,the hWJMSCs downregulated the expressions of caspase-1,IL-6,and NF-κB in lung tissues.Conclusions:The hWJMSCs can decrease inflammatory markers of acute respiratory distress syndrome in a rat model and may be further investigated for the treatment of acute respiratory distress syndrome.
文摘Nearly half of the world’s population comprise youths. However, addressing their Sexual and Reproductive Health (SRH) remains a challenge. Globally countries are mandated to continually provide Youth Friendly Sexual and Reproductive Health services (YFSRHs) to the youth. The objective of this study was to assess and describe youth’s perspectives on a sustainable model for the provision of YFSRHs in Kenya. Data was collected among 400 youths aged 18 - 24 years in Embu and Kirinyaga counties, Kenya. A structured questionnaire was utilized as the data collection tool. Collected data was analyzed using SAS statistical software version 9.4. Statistical threshold of P ≤ 0.05 was used. Overall the mean age of the study participants was ±standard deviation (SD) 21.2 ± 1.86 years. Majority of the participants’ perspective on the health care system sustainability was that the waiting time at the facility should be less than an hour, accessible geographically (less than a kilometre), affordable (≤20 Ksh.), and convenient working hours (weekday and weekends ratio 1:1). Advocacy was on health care provider’s attributes of politeness, welcoming, confidential and non-judgmental. The most preferred locations for the youth friendly centres by the participants were community and school based locations. Similarly, parental and community support was reported to highly contribute to sustained utilization and provision of the YFSRHs (P < 0.001). Unlike popular belief, 99.8% did not see the need for recreational facilities at the youth centres to ensure sustainability of the model. To ensure a sustainable model for the provision of YFSRHs, there is need for a multi-sectoral and stakeholder involvement that is;youth, health care system structure, health care service providers, parents and community. Further research is needed on parents and health care service provider’s perspectives on how to sustain the provision of YFSRH services.
文摘This paper discusses how consumerism boosted youth lifestyle in the 1960s--mainly through modem magazines （particularly in Britain） and built a territorial symbolic identity through fashion. In the 1960s, the consolidation of youth culture becomes an international phenomenon. With the development of ready-to-wear, adolescents begin to be target as a consumer market. The music and fashion industries unite to create and advertise youth lifestyle. The fashion shifts from Paris to London. Magazine articles and publicity set the latest trends. The method applied is research in primary source--the British journal The Drapers＇ Record aiming to recognize fashion transformation and juvenilization in this period of time. The magazine shows ads and fashion editorials （mainly feminine）, articles and news about fashion trend. There is also a brands guide for shoppers and retailers. The magazines used in the research are from 1964 to 1967, July and August issues, when the fall-winter trends are shown. From 1964 on, we notice the orientation towards a juvenile market and style, but these trends will only fully materialize through 1967. It leads to the conclusion that between 1965 and 1967 fashion juvenilization developed, reached its peak and global range.
文摘On April 18-20, 2012, 13th China＇s Refractories Youth Symposium was held successfully in Zhengzhou, Henan Province. China＇s Refracto-ries Youth Symposium, an important and influencing conference, is held every two years. 13^th China＇s Refractories Youth Symposium was co-sponsored by The Refractories Branch of The Chinese Society for Metals and Henan Society for Metals, co-organized by Beijing Society of Metals, Metallurgy Society of Hebei Province, Liaoning Society for Metals, Shandong Society for Metals and Shanxi Society for Metals, and supported by Sinosteel Luoyang Institute of Refractories Research Co., Ltd., Zhejiang Zili Co., Ltd., etc.
基金贵州省2018年度哲学社会科学规划国学单列课题阶段性成果,宋元时期宋人别集的编纂与刊刻研究,Serial Number 18GZGX25《新青年》“译介”类栏目规划与内容判断力研究,Serial Number 22150322016)《点石斋画报》(1884-1898)的图文艺术性、现代性传播与出版研究,Serial Number Eb202008.
文摘When Chen Duxiu founded New Youth, he attached great importance to the “women’s issue” and established the “women’s issue” section, publishing articles on women’s issues and discussing women’s identity, status, and rights deeply. New Youth provided a forum for women to express their ideas, and its existence was a reflection of its advancement. However, from the discussion and promotion of “virtuous mother”, it’s easy to see that the intellectuals at that time had a biased perception of women’s identity and emphasized the intersection of women’s consciousness with the state’s thinking.
文摘This study＇s objective is to thoroughly analyze representations of teenage sexuality portrayed in two Chinese youths＇ films, which represent social, cultural, and historical diversities in China's Mainland, as well, to unfold some particular natures and trends of Chinese youth cinema in the context of globalization and internationalization. Content analysis and methodology of narrative explore the ideological nature of representations of youth as well as the interpretation of trends in Chinese youth cinema. This study argues the particular manners of representations of Chinese youth in the youths＇ films produced in China's Mainland, through distinct elements such as film properties, film discourse, and acting on set It will explain how functional and social category diversity, cultural diversity, and historical diversity derive the actuality in Chinese communities, and center on a series of sex-based issues that revel correlations between Chinese youths＇ ideology, psychology, and social construction. Including a discussion of technical factors, it defines the specific natures of Chinese youth cinema in the region based on fixed parameters of culture or ancestry that convey rhetorical messages to discover the characteristics of genre film so that the interpretation of the term ＂peers groups＂ represents the values and beliefs in modern Chinese society, thus presenting the exchange approaches which construct and validate the relationship among society, global film industry, young audience and film content.
