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Wavelength-Tunable Single Frequency Ytterbium-Doped Fiber Laser with Loop Mirror Filter 被引量:1
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作者 陆宝乐 黄圣鸿 +3 位作者 尹默娟 陈浩伟 任兆玉 白晋涛 《Chinese Physics Letters》 SCIE CAS CSCD 2015年第4期54-57,共4页
By using a loop mirror filter, a novel wavelength-tunable single-frequency ytterbium-doped fiber laser is developed to select single longitudinal modes in a linear cavity. The output wavelength could be tuned 2.4 nm i... By using a loop mirror filter, a novel wavelength-tunable single-frequency ytterbium-doped fiber laser is developed to select single longitudinal modes in a linear cavity. The output wavelength could be tuned 2.4 nm intervals range from 1063.3 to 1065.Tnrn with the temperature change of the fiber Bragg grating. The maximum output power could reach 32 m W while the pump power increases to 120 m W. The corresponding optical-to-optical conversion efficiency is 26.7% and the slope efficiency is 33.9%, respectively. The output power fluctuation is below 2%, and its highest signal-to-noise ratio is 60 dB. 展开更多
关键词 Wavelength-Tunable Single Frequency ytterbium-doped fiber Laser with Loop Mirror Filter FBG FSR
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Q-Switched Ytterbium-Doped Fiber Laser Using Black Phosphorus as Saturable Absorber
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作者 A.H.H.Al-Masoodi M.H.M.Ahmed +2 位作者 A.A.Latiff H.Arof S.W.Harun 《Chinese Physics Letters》 SCIE CAS CSCD 2016年第5期54-57,共4页
We demonstrate a Q-switched ytterbium-doped fiber laser (YDFL) using a newly developed multi-layer black phosphorous (BP) saturable absorber (SA). The BP SA is prepared by mechanically exfoliating a BP crystal a... We demonstrate a Q-switched ytterbium-doped fiber laser (YDFL) using a newly developed multi-layer black phosphorous (BP) saturable absorber (SA). The BP SA is prepared by mechanically exfoliating a BP crystal and sticking the acquired BP flakes onto a scotch tape. A small piece of the tape is then placed between two ferrules and incorporated in a YDFL cavity to achieve a stable Q-switched operation in a 1.0 μm region. The laser has a pump threshold of 55.1 mW, a pulse repetition rate that is tunable from 8.2 to 32.9 kHz, and the narrowest pulse width of 10.8 μs. The highest pulse energy of 328 nJ is achieved at the pump power of 97.6 mW. Our results show that multi-layer BP is a promising SA for Q-switching laser operation. 展开更多
关键词 of SA Q-Switched ytterbium-doped fiber Laser Using Black Phosphorus as Saturable Absorber in is for BP that Figure kHz mode
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Dual-Wavelength Passively Q-Switched Ytterbium-Doped Fiber Laser Based on Aluminum Oxide Nanoparticle Saturable Absorbers
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作者 S.K.M.Al-Hayali S.Selleri A.H.Al-Janabi 《Chinese Physics Letters》 SCIE CAS CSCD 2017年第11期24-27,共4页
We report on generation of a dual-wavelength, all-fiber, passively Q-switched ytterbium-doped fiber laser using aluminum oxide nanoparticle (Al2O3-NP) thin film. A thin film of Al2O3 was prepared by embedding Al2O3-... We report on generation of a dual-wavelength, all-fiber, passively Q-switched ytterbium-doped fiber laser using aluminum oxide nanoparticle (Al2O3-NP) thin film. A thin film of Al2O3 was prepared by embedding Al2O3-NPs into a polyvinyl alcohol (PVA) as a host polymer, and then inserted between two fiber ferrules to act as a saturable absorber (SA). By incorporating the Al2O3-PVA SA into the laser cavity, a stable dual-wavelength pulse output centered at 1050 and 1060.7nm is observed at threshold pump power of 80mW. As the pump power is gradually increased from 80 to 300mW, the repetition rate of the generated pulse increases from 16.23 to 59 kHz, while the pulse width decreases from 19 to 6μs. To the best of our knowledge, this is the first demonstration for this type of SA operating in the 1 μm region. 展开更多
关键词 SA Dual-Wavelength Passively Q-Switched ytterbium-doped fiber Laser Based on Aluminum Oxide Nanoparticle Saturable Absorbers
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Low-Threshold Broadband Spectrum Generation by Amplification of Cascaded Stimulated Raman Scattering in an Ytterbium-Doped Fiber Amplifier
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作者 雷成敏 宋锐 +1 位作者 靳爱军 侯静 《Chinese Physics Letters》 SCIE CAS CSCD 2015年第7期59-62,共4页
We present an experimental study on low-threshold broadband spectrum generation mainly due to the amplirfication of the cascaded stimulated Raman scattering (SRS) effect in a four-stage fiber master oscillator power... We present an experimental study on low-threshold broadband spectrum generation mainly due to the amplirfication of the cascaded stimulated Raman scattering (SRS) effect in a four-stage fiber master oscillator power amplifier system. The cascaded SRS is achieved by using a long passive fiber pumped by a pulsed fiber laser cen: tered at wavelength 1064 nm. The amplified spontaneous emission during the amplification process is efficiently suppressed by cutting the length of the passive fiber and by using a double-clad ytterbium-doped fiber amplifier. The generated broadband spectrum spans from 960nm to 1700nm with maximum average output 13.6 W and average spectral power density approximately 17. 7 mW/nm. 展开更多
关键词 Low-Threshold Broadband Spectrum Generation by Amplification of Cascaded Stimulated Raman Scattering in an ytterbium-doped fiber Amplifier SRS
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Nonlinear polarization rotation-induced pulse shaping in a stretched-pulse ytterbium-doped fiber laser
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作者 白东碧 李文雪 +3 位作者 杨康文 沈旭玲 陈修亮 曾和平 《Chinese Physics B》 SCIE EI CAS CSCD 2014年第10期155-161,共7页
We report on controllable pulse shaping in a Yb-doped stretched-pulse fiber laser followed by a high-power chirped pulse amplifier. We demonstrate that the pulses after an extra-cavity grating pair change their intens... We report on controllable pulse shaping in a Yb-doped stretched-pulse fiber laser followed by a high-power chirped pulse amplifier. We demonstrate that the pulses after an extra-cavity grating pair change their intensity profile from Lorentz to Gaussian and then to sech2 shapes by adjusting the intra-cavity polarization through a quarter-wave plate inside the fiber laser cavity. The laser pulses with different pulse shapes exhibit pulse-to-pulse amplitude fluctuation of -- 1.02%, while the sech2-shaped pulse train is provided with a more stable free-running repetition rate as a result of the stronger self-phase modulation in the fiber laser cavity than Lorentz- and Gaussian-shaped pulse trains. 展开更多
关键词 fiber lasers nonlinear optics mode locking pulse generators
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Novel constant-cladding tapered-core ytterbium-doped fiber for high-power fiber laser oscillator 被引量:5
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作者 Yun Ye Xianfeng Lin +6 位作者 Xiaoming Xi Chen Shi Baolai Yang Hanwei Zhang Xiaolin Wang Jinyan Li Xiaojun Xu 《High Power Laser Science and Engineering》 SCIE CAS CSCD 2021年第2期142-148,共7页
Power scaling based on traditional ytterbium-doped fibers(YDFs)is limited by optical nonlinear effects and transverse mode instability(TMI)in high-power fiber lasers.Here,we propose a novel long tapered fiber with a c... Power scaling based on traditional ytterbium-doped fibers(YDFs)is limited by optical nonlinear effects and transverse mode instability(TMI)in high-power fiber lasers.Here,we propose a novel long tapered fiber with a constant cladding and tapered core(CCTC)along its axis direction.The tapered-core region of the fiber is designed to enhance the stimulated Raman scattering(SRS)threshold and suppress higher-order mode resonance in the laser cavity.The CCTC YDF was fabricated successfully with a modified chemical vapor deposition(MCVD)method combined with solution doping technology,which has a cladding diameter of 400µm and a varying core with a diameter of~24μm at both ends and~31μm in the middle.To test the performance of the CCTC fiber during high-power operation,an all-fiber laser oscillator based on a CCTC YDF was investigated experimentally.As a result,a maximum output power of 3.42 kW was achieved with an optical-to-optical efficiency of 55.2%,although the TMI effect was observed at an output power of~3.12 kW.The measured beam quality(M^(2)factor)was~1.7,and no sign of the Raman component was observed in the spectrum.We believe that CCTC YDF has great potential to simultaneously mitigate the SRS and TMI effects,and further power scaling is promising by optimizing the structure of the YDF. 展开更多
关键词 fiber design high power stimulated Raman scattering transverse mode instability ytterbium-doped fiber
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Passively Q-switched ytterbium-doped fiber laser using the evanescent field interaction with bulk-like WTe_2 particles 被引量:2
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作者 高承煥 李珍昊 李周翰 《Chinese Optics Letters》 SCIE EI CAS CSCD 2018年第2期108-112,共5页
The potential of bulk-like WTe2 particles for the realization of a passive Q-switch operating at the 1 μm wavelength was investigated. The WTe2 particles were prepared using a simple mechanical exfoliation method tog... The potential of bulk-like WTe2 particles for the realization of a passive Q-switch operating at the 1 μm wavelength was investigated. The WTe2 particles were prepared using a simple mechanical exfoliation method together with Scotch tape. By attaching bulk-like WTe2 particles, which remained on the top of the sticky surface of a small segment of the Scotch tape, to the flat side of a side-polished fiber, a saturable absorber(SA) was readily implemented. A strong saturable absorption was then readily obtained through an evanescent field interaction with the WTe2 particles. The modulation depth of the prepared SA was measured as ~2.18% at 1.03 μm. By incorporating the proposed SA into an all-fiberized ytterbium-doped fiber ring cavity, stable Qswitched pulses were readily achieved. 展开更多
关键词 LENGTH Passively Q-switched ytterbium-doped fiber laser using the evanescent field interaction with bulk-like WTe2 particles SA
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Tunable passively Q-switched ytterbium-doped fiber laser with mechanically exfoliated GaSe saturable absorber 被引量:1
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作者 H.Ahmad S.N.Aidit +1 位作者 S.I.Ooi Z.C.Tiu 《Chinese Optics Letters》 SCIE EI CAS CSCD 2018年第2期93-97,共5页
A tunable passively Q-switched ytterbium-doped fiber laser using few-layer gallium selenide(GaSe) as a saturable absorber(SA) is demonstrated.The few-layer GaSe SA,which is fabricated by the mechanical exfoliation... A tunable passively Q-switched ytterbium-doped fiber laser using few-layer gallium selenide(GaSe) as a saturable absorber(SA) is demonstrated.The few-layer GaSe SA,which is fabricated by the mechanical exfoliation method,is able to generate a Q-switched fiber laser that has a maximum repetition rate of 92.6 kHz and a minimum pulsed width of 2.3 μs.The highest pulse energy exhibited by the generated pulse is 18.8 nJ with a signal to noise ratio of ~40 dB.The tunability of the proposed laser covers from 1042 to 1082 nm,giving a tuning range of 40 nm. 展开更多
关键词 Tunable passively Q-switched ytterbium-doped fiber laser with mechanically exfoliated GaSe saturable absorber SA
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Mode-locked ytterbium-doped fiber laser with zinc phthalocyanine thin film saturable absorber
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作者 Rawan S.M.Soboh Ahmed H.H.Al-Masoodi +5 位作者 Fuad N.A.Erman Abtisam H.H.Al-Masoodi Bilal Nizamani Hamzah Arof Retna Apsari Sulaiman Wadi Harun 《Frontiers of Optoelectronics》 EI CSCD 2022年第2期181-190,共10页
A stable mode-locked laser was demonstrated using a newly developed zinc phthalocyanine(ZnPc)thin film as passive saturable absorber(SA)in ytterbium-doped fiber laser(YDFL).The ZnPc thin film was obtained using a cast... A stable mode-locked laser was demonstrated using a newly developed zinc phthalocyanine(ZnPc)thin film as passive saturable absorber(SA)in ytterbium-doped fiber laser(YDFL).The ZnPc thin film was obtained using a casting method and then inserted between the two fiber ferrules of a YDFL ring cavity to generate mode-locked pulses.The resulting pulsed laser operated at a wavelength of 1034.5 nm having a repetition rate of 3.3 MHz.At pump power of 277 mW,the maximum output power and pulse energy are achieved at 4.92 mW and 1.36 nJ,respectively.ZnPc has a high chemical and photochemical stability,and its significance for use as a potential SA in a mode-locked laser is reported in this work. 展开更多
关键词 MODE-LOCKING ytterbium-doped fiber laser(YDFL) Saturable absorber(SA) Zinc phthalocyanine(ZnPc)thin film
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A kW Continuous-Wave Ytterbium-Doped All-Fiber Laser Oscillator with Domestic Fiber Components and Gain Fiber 被引量:1
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作者 廖雷 刘鹏 +6 位作者 邢颍滨 王一礴 彭景刚 戴能利 李进延 何兵 周军 《Chinese Physics Letters》 SCIE CAS CSCD 2015年第6期57-60,共4页
We demonstrate a kW continuous-wave ytterbium-doped all-fiber laser oscillator with M1 domestic fiber compo- nents: a 7× I fused fiber bundle combiner, a fiber Bragg grating and a double-clad gain fiber. The osc... We demonstrate a kW continuous-wave ytterbium-doped all-fiber laser oscillator with M1 domestic fiber compo- nents: a 7× I fused fiber bundle combiner, a fiber Bragg grating and a double-clad gain fiber. The oscillator operates at 1079.48nrn with 80.94% slope efficiency and shows no limit of temperature and nonlinear effects. These indicate that the passive fiber components and the gain fiber are all qualified for the high power environ- ment. No evidence of the signal power roll-over shows that this oscillator possesses the capacity to higher output with available pump power. 展开更多
关键词 A kW Continuous-Wave ytterbium-doped All-fiber Laser Oscillator with Domestic fiber Components and Gain fiber FBG SRS
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Double-pass ytterbium-doped fiber amplifier with high gain coefficient and low noise figure 被引量:5
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作者 王安廷 邢美术 +4 位作者 陈光辉 杨文奎 明海 谢建平 吴云霞 《Chinese Optics Letters》 SCIE EI CAS CSCD 2003年第9期532-534,共3页
We have proposed and demonstrated a double-pass ytterbium-doped fiber amplifier using an optical circulator and a fiber Bragg grating as reflector. When the signal has passed through the ytterbium-doped fiber once, it... We have proposed and demonstrated a double-pass ytterbium-doped fiber amplifier using an optical circulator and a fiber Bragg grating as reflector. When the signal has passed through the ytterbium-doped fiber once, it reflects off a 0.2-nm passive fiber Bragg grating filter. This reduces amplified spontaneous emission (ASE) noise from the first pass. The input signal light is amplified both forward and backward through ytterbium-doped fiber. With this double-pass configuration, 1053.15-nm unsaturated signal gain of 28 dB, gain coefficient of 1.1 dB/mW, and noise figure of less than 4 dB are achieved at 977-nm pump power of 68 mW. It is also found that this double-pass configure provides enhancing gain coefficient and improving noise figure by comparison with single-pass configuration. 展开更多
关键词 Doping (additives) fiber Bragg gratings Wavelength division multiplexing YTTERBIUM
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All-fiber,high power single-frequency linearly polarized ytterbium-doped fiber amplifier 被引量:3
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作者 刘驰 漆云凤 +4 位作者 丁亚茜 周军 董景星 魏运荣 楼祺洪 《Chinese Optics Letters》 SCIE EI CAS CSCD 2011年第3期54-56,共3页
We report an all-fiber high power,single frequency large-mode area (LMA) linearly polarized ytterbiumdoped fiber amplifiers (YDFA) module,which is based on the master oscillator multi-stage power amplifiers (MOPA... We report an all-fiber high power,single frequency large-mode area (LMA) linearly polarized ytterbiumdoped fiber amplifiers (YDFA) module,which is based on the master oscillator multi-stage power amplifiers (MOPA).The maximum output power is 43.8 W at a wavelength of 1064 nm when 60-W launched pump light is coupled,with high slope efficiency of 88%,polarization extinction rate (PER) 17.2 dB and nearly diffraction-limited beam quality (M 2 1.1). 展开更多
关键词 fibers High frequency amplifiers Power amplifiers YTTERBIUM
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High-Power Raman Soliton Generation at 1.7 μm in All-Fiber Polarization-Maintaining Erbium-Doped Amplifier
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作者 徐子鹏 王萱 +2 位作者 姚传飞 杨林京 李平雪 《Chinese Physics Letters》 SCIE EI CAS CSCD 2024年第5期35-39,共5页
An all-fiber polarization maintaining high-power laser system operating at 1.7 μm based on the Ramaninduced soliton self-frequency shifting effect is demonstrated. The entirely fiberized system is built by erbiumdope... An all-fiber polarization maintaining high-power laser system operating at 1.7 μm based on the Ramaninduced soliton self-frequency shifting effect is demonstrated. The entirely fiberized system is built by erbiumdoped oscillator and two-stage amplifiers with polarization maintaining commercial silica fibers and devices, which can provide robust and stable soliton generation. High-power soliton laser with the average power of 0.28 W,the repetition rate of 42.7 MHz, and pulse duration of 515 fs is generated directly from the main amplifier.Our experiment provides a feasible method for high-power all-fiber polarization maintaining femtosecond laser generation working at 1.7 μm. 展开更多
关键词 polarization fiber AMPLIFIER
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Optical Nonlinearity of Violet Phosphorus and Applications in Fiber Lasers
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作者 杨慧苒 齐梦婷 +5 位作者 李旭鹏 薛泽 鲁晨浩 成嘉伟 韩冬冬 李璐 《Chinese Physics Letters》 SCIE EI CAS CSCD 2024年第1期16-20,共5页
A D-shaped fiber is coated with a new two-dimensional nanomaterial,violet phosphorus(VP),to create a saturable absorber(SA)with a modulation depth of 3.68%.Subsequently,the SA is inserted into a fiber laser,enabling s... A D-shaped fiber is coated with a new two-dimensional nanomaterial,violet phosphorus(VP),to create a saturable absorber(SA)with a modulation depth of 3.68%.Subsequently,the SA is inserted into a fiber laser,enabling successful generation of dark solitons and bright–dark soliton pairs through adjustment of the polarization state within the cavity.Through further study,mode-locked pulses are achieved,proving the existence of polarization-locked vector solitons.The results indicate that VP can be used as a polarization-independent SA. 展开更多
关键词 POLARIZATION fiber ABSORBER
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Time Transfer in a 1839-km Telecommunication Fiber Link Demonstrating a Picosecond-Scale Stability
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作者 郭新兴 侯丙安 +5 位作者 刘博) 杨凡 孔维成 刘涛 董瑞芳 张首刚 《Chinese Physics Letters》 SCIE EI CAS CSCD 2024年第6期49-53,共5页
An implementation of high-precision time transfer over a 1839-km field fiber loop back link between two provincial capitals of China,Xi’an and Taiyuan,is reported.Time transfer stabilities of 6.5 ps at averaging time... An implementation of high-precision time transfer over a 1839-km field fiber loop back link between two provincial capitals of China,Xi’an and Taiyuan,is reported.Time transfer stabilities of 6.5 ps at averaging time of 1 s and 4.6 ps at 40000 s were achieved.The uncertainty for the time transfer system was evaluated,showing a budget of 56.2 ps.These results stand for a significant milestone in achieving high-precision time transfer over a field fiber link spanning thousands of kilometers,signifying a record-breaking achievement for the real-field time transfer in both stability and distance,which paves the way for constructing the nationwide high-precision time service via fiber network. 展开更多
关键词 fiber NATIONWIDE LINK
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On the generation of high-quality Nyquist pulses in mode-locked fiber lasers
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作者 任俞宣 葛锦蔓 +2 位作者 李小军 彭俊松 曾和平 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第3期424-427,共4页
Nyquist pulses have wide applications in many areas,from electronics to optics.Mode-locked lasers are ideal platforms to generate such pulses.However,how to generate high-quality Nyquist pulses in mode-locked lasers r... Nyquist pulses have wide applications in many areas,from electronics to optics.Mode-locked lasers are ideal platforms to generate such pulses.However,how to generate high-quality Nyquist pulses in mode-locked lasers remains elusive.We address this problem by managing different physical effects in mode-locked fiber lasers through extensive numerical simulations.We find that net dispersion,linear loss,gain and filter shaping can affect the quality of Nyquist pulses significantly.We also demonstrate that Nyquist pulses experience similariton shaping due to the nonlinear attractor effect in the gain medium.Our work may contribute to the design of Nyquist pulse sources and enrich the understanding of pulse shaping dynamics in mode-locked lasers. 展开更多
关键词 mode locking LASER SOLITON fiber PULSE
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Giving Food a Fiber Boost: Adding High Beta-Glucan Ingredient from Barley to Everyday Foods
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作者 Gongshe Hu Sherry Ellberg +1 位作者 Kathy Satterfield Chris Evans 《Food and Nutrition Sciences》 CAS 2024年第4期277-289,共13页
Lack of dietary fiber contributes to many health issues, particularly chronic vascular diseases. Mixed linkage β-1.3 - 1.4 beta-glucan (beta-glucan, in this paper) is a confirmed beneficial ingredient for the human d... Lack of dietary fiber contributes to many health issues, particularly chronic vascular diseases. Mixed linkage β-1.3 - 1.4 beta-glucan (beta-glucan, in this paper) is a confirmed beneficial ingredient for the human diet through reduction of cholesterol and the glycemic index. Barley contains the highest beta-glucan content of all the grains, and in this study, a percentage of flour from two high beta glucan lines was, each, added to an array of wheat-based food products to measure how it impacted total dietary fiber. Results showed that beta-glucan content was higher in all the products containing the added high beta-glucan flour, along with increased total dietary fiber content. Protein content in the food products is also increased with the higher protein in the barley flours added. Beta-glucan content in the barley-added products increased to 1.2% - 4.0% versus 0.2% - 0.5% in the pure wheat products, while the dietary fibers increased to 3.5% - 24.4% versus 2.1% - 9.1% in pure wheat product controls. This research provided experimental evidence that using a high beta-glucan barley ingredient in food can increase dietary fiber to benefit health. 展开更多
关键词 FOOD High fiber Barley Ingredient BETA-GLUCAN Human Health
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Increasing dietary fiber intake for type 2 diabetes mellitus management: A systematic review
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作者 Douglas Nitzke Juliana Czermainski +3 位作者 Carolina Rosa Chaline Coghetto Sabrina Alves Fernandes Randhall B Carteri 《World Journal of Diabetes》 SCIE 2024年第5期1001-1010,共10页
BACKGROUND Type 2 diabetes is a chronic,non-communicable disease with a substantial global impact,affecting a significant number of individuals.Its etiology is closely tied to imbalanced dietary practices and sedentar... BACKGROUND Type 2 diabetes is a chronic,non-communicable disease with a substantial global impact,affecting a significant number of individuals.Its etiology is closely tied to imbalanced dietary practices and sedentary lifestyles.Conversely,increasing die-tary fiber(DF)intake has consistently demonstrated health benefits in numerous studies,including improvements in glycemic control and weight management.AIM To investigate the efficacy of DF interventions in the management of type 2 diabetes mellitus(T2DM).METHODS A systematic literature review was conducted to explore the association between DF intake and the management of T2DM.Following the inclusion and exclusion criteria,a total of 26 studies were included in this review.RESULTS The main strategies implied to increased DF intake were:High DF diet plus acarbose(2 studies);DF supplements(14 studies);and high DF diets(10 studies).Overall,most studies indicated that increased DF intake resulted in im-provements in glycemic control and weight management in T2DM patients.CONCLUSION DF represents a valuable strategy in the treatment of type 2 diabetes,improving health outcomes.DF intake offers the potential to improve quality of life and reduce complications and mortality associated with diabetes.Likewise,through supplements or enriched foods,DF contributes significantly to the control of several markers such as HbA1c,blood glucose,triglycerides,low-density lipoprotein,and body weight. 展开更多
关键词 Type 2 diabetes mellitus Soluble fibers Insoluble fibers PROBIOTICS Blood glucose NUTRITION
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Estimation of cancer cell migration in biomimetic random/oriented collagen fiber microenvironments
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作者 姚静如 李国强 +8 位作者 姚喜耀 周连杰 叶志凯 刘艳平 郑栋天 唐婷 宋克纳 陈果 刘雳宇 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第5期749-756,共8页
Increasing data indicate that cancer cell migration is regulated by extracellular matrixes and their surrounding biochemical microenvironment,playing a crucial role in pathological processes such as tumor invasion and... Increasing data indicate that cancer cell migration is regulated by extracellular matrixes and their surrounding biochemical microenvironment,playing a crucial role in pathological processes such as tumor invasion and metastasis.However,conventional two-dimensional cell culture and animal models have limitations in studying the influence of tumor microenvironment on cancer cell migration.Fortunately,the further development of microfluidic technology has provided solutions for the study of such questions.We utilize microfluidic chip to build a random collagen fiber microenvironment(RFM)model and an oriented collagen fiber microenvironment(OFM)model that resemble early stage and late stage breast cancer microenvironments,respectively.By combining cell culture,biochemical concentration gradient construction,and microscopic imaging techniques,we investigate the impact of different collagen fiber biochemical microenvironments on the migration of breast cancer MDA-MB-231-RFP cells.The results show that MDA-MB-231-RFP cells migrate further in the OFM model compared to the RFM model,with significant differences observed.Furthermore,we establish concentration gradients of the anticancer drug paclitaxel in both the RFM and OFM models and find that paclitaxel significantly inhibits the migration of MDA-MB-231-RFP cells in the RFM model,with stronger inhibition on the high concentration side compared to the low concentration side.However,the inhibitory effect of paclitaxel on the migration of MDA-MB-231-RFP cells in the OFM model is weak.These findings suggest that the oriented collagen fiber microenvironment resembling the late-stage tumor microenvironment is more favorable for cancer cell migration and that the effectiveness of anticancer drugs is diminished.The RFM and OFM models constructed in this study not only provide a platform for studying the mechanism of cancer development,but also serve as a tool for the initial measurement of drug screening. 展开更多
关键词 microfluidic chip random collagen fiber microenvironment(RFM) oriented collagen fiber microenvironment(OFM) cancer cell migration
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Development of a scintillating-fiber-based beam monitor for the coherent muon-to-electron transition experiment
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作者 Yu Xu Yun-Song Ning +7 位作者 Zhi-Zhen Qin Yao Teng Chang-Qing Feng Jian Tang Yu Chen Yoshinori Fukao Satoshi Mihara Kou Oishi 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2024年第4期156-164,共9页
The coherent muon-to-electron transition(COMET)experiment is a leading experiment for the coherent conversion of μ^(-)N→e^(-)N using a high-intensity pulsed muon beamline,produced using innovative slow-extraction te... The coherent muon-to-electron transition(COMET)experiment is a leading experiment for the coherent conversion of μ^(-)N→e^(-)N using a high-intensity pulsed muon beamline,produced using innovative slow-extraction techniques.Therefore,it is critical to measure the muon beam characteristics.We set up a muon beam monitor(MBM),where scintillating fibers woven in a cross shape were coupled to silicon photomultipliers to measure the spatial profile and timing structure of the extracted muon beam for the COMET.The MBM detector was tested successfully with a proton beamline at the China Spallation Neutron Source and took data with good performance in the commissioning run.The development of the MBM,including its mechanical structure,electronic readout,and beam measurement results,are discussed. 展开更多
关键词 Beam instrumentation Profile monitor Scintillating fiber Silicon photomultipliers
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