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Protective Effect of Zengye Decoction(增液汤)on Submandibular Glands in Nonobese Diabetic Mice 被引量:10
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作者 LI Cheng-yin WU Su-ling +2 位作者 SUN Li-xia YAN Ting-ting WANG Yue 《Chinese Journal of Integrative Medicine》 SCIE CAS CSCD 2019年第1期45-50,共6页
Objective: To investigate the protective effect of Zengye Decoction(增液汤, ZYD) on the submandibular glands(SMGs) in nonobese diabetic(NOD) mice. Methods: Twenty-seven female NOD mice were randomly equally divided in... Objective: To investigate the protective effect of Zengye Decoction(增液汤, ZYD) on the submandibular glands(SMGs) in nonobese diabetic(NOD) mice. Methods: Twenty-seven female NOD mice were randomly equally divided into 3 groups: the model group, the hydroxychloroquine(HCQ) group, and the ZYD group. Nine C57/B6 mice served as the normal group. After 1-week acclimation, the HCQ and ZYD groups were intragastrically administered with HCQ and ZYD, respectively, and the normal and model groups were administered with normal saline. Changes in the salivary flow rate were observed. Mice from all 4 groups were sacrificed at the age of 20 weeks. The serum and SMGs were collected. Serum cytokines gamma-interferon(IFN-γ), interleukin-10(IL-10) were detected by enzyme-linked immunosorbent assay. Histological changes in the submandibular glands were examined by hematoxylin and eosin staining. The mRNA expression of IFN-γ, IL-10 and vasoactive intestinal peptide(VIP) in the submandibular glands were measured by realtime polymerase chain reaction. Results: Compared with the model group, the salivary flow of the ZYD group significantly increased(P<0.05), the extent of the histological changes was ameliorated(P<0.05), and the Th1/Th2 cytokine imbalance was remedied(P<0.05). In the ZYD-treated mice, the VIP mRNA was up-regulated(P<0.05). Conclusions: ZYD is beneficial in protecting structure and function of SMGs in NOD mice. The mechanism may be associated with the correction of the Th1/Th2 cytokine imbalance, and with the prevention of a progressive decline of the VIP level. 展开更多
关键词 Sjogren's syndrome TH1/TH2 vasoactive intestinal peptide zengye decoction Chinese medicine
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Coronary Heart Disease Complicating With Impaired Glucose Tolerance and Constipation:A Case Report Cured by Integrated Chinese-Western Medicine
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作者 林坚 刘惠霞 +3 位作者 谭宁 叶安娜 余细勇 邓春玉 《South China Journal of Cardiology》 CAS 2009年第4期240-243,共4页
Complications are more frequent in elderly patients with coronary heart disease (CHD), such as impaired glucose tolerance and constipations. It is always difficult to cure these complications in clinical practice. I... Complications are more frequent in elderly patients with coronary heart disease (CHD), such as impaired glucose tolerance and constipations. It is always difficult to cure these complications in clinical practice. In this case we had successfully cured an eighty-three years old man with CHD complicating impaired glucose tolerance and constipation by integrated Chinese-Western medicine. 展开更多
关键词 coronary heart disease impaired glucose tolerance CONSTIPATION integrated Chinese-Western medicine zengye Tang decoction for Increasing Body Fluid) Tao Hong Siwu Tang Four-ingredient decoction with Semen Persicae and Flos Carthamus)
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