Several 2-D displacement sensing methods are reviewed. As to the crossdiffraction grating, there is no absolute zero-reference. In regards to the optical fiber method,the output signal is affected greatly by the quali...Several 2-D displacement sensing methods are reviewed. As to the crossdiffraction grating, there is no absolute zero-reference. In regards to the optical fiber method,the output signal is affected greatly by the quality of the reflecting surface and it is hard to gethigh resolution. Considering the concentric-circle gratings, the displacement can only be gainedwith complicated calculating of the experiment data. Compared with the advantages and limitations ofthe methods above, a novel 2-D zero-reference mark is especially proposed and demonstrated. Thiskind of mark has an absolute zero-reference when used in pair, and the experimental result is simpleto dispose. By superimposing a pair of specially coded 2-D marks, the correct alignment position ofthe two marks can be detected by the maximum output of the sharp intensity peak. And each slope ofthe peak is of good linearity which can be used to achieve high resolution in positioning andalignment in two dimensions. Design and fabrication of such 2-D zero-reference marks are introducedin detail. The experiment results are agreed with the theoretical ones.展开更多
An optimized formulation of a sustained release tablet of Gliclazide was developed. The use of Doptimal design with a polynomial statistical model to analyze dissolution data reduced the number of laboratory tests req...An optimized formulation of a sustained release tablet of Gliclazide was developed. The use of Doptimal design with a polynomial statistical model to analyze dissolution data reduced the number of laboratory tests required to obtain an optimal dosage form. The final formulation contained 22 mg of Methocel®E15LV, 16.5 mg Methocel®E15 and 10.0 mg of Dibasic Calcium Phosphate per 30 mg Gliclazide sustained release tablet. Dissolution studies performed on tablets from 5000 tablet test batches released greater than 90 percent of loaded drug in eight hours. Drug release from the optimized tablets followed a pattern more closely similar to zero-order than other mechanisms of drug release tested. Storage of tablets in accelerated and ambient conditions for 6 and 12 months respectively did not alter any of the physico-chemical properties, drug release or the drug release rate compared to initial observations and dissolution data of the prepared tablets. The addition of potassium phosphate and monosodium phosphate to the tablet reduced the effect pH has on Gliclazide dissolution compared to the commercially available product.展开更多
Combined multi-body dynamics with structural dynamics, a new discrete element with flexible connector, which is applicable for 3-D beam structures, is developed in this paper. Both the generalized elastic coefficient ...Combined multi-body dynamics with structural dynamics, a new discrete element with flexible connector, which is applicable for 3-D beam structures, is developed in this paper. Both the generalized elastic coefficient matrix of the flexible connector and the mass matrix of discrete element may be off-diagonal in a general case. The zero-length rigid element is introduced to simulate the node at which multiple elements are jointed together. It may also be effective when the axes of adjacent elements are not in the same line. The examples for eigenvalue calculation show that the model is successful. It can be extended to the geometric nonlinear response analysis.展开更多
基金Supported by National High Technology Research and Development Program of China （863 Program） （2006AA04Z183）, National Natural Science Foundation of China （60621001, 60534010, 60572070, 60774048, 60728307）, Program for Changjiang Scholars and Innovative Research Groups of China （60728307, 4031002）
基金This project is supported by National Natural Science Foundation of China(No.50335050, No.50275140)Specialized Research Foundation for Doctoral Program of Higher Education (SRFDP) of China(No. 20030358020).
文摘Several 2-D displacement sensing methods are reviewed. As to the crossdiffraction grating, there is no absolute zero-reference. In regards to the optical fiber method,the output signal is affected greatly by the quality of the reflecting surface and it is hard to gethigh resolution. Considering the concentric-circle gratings, the displacement can only be gainedwith complicated calculating of the experiment data. Compared with the advantages and limitations ofthe methods above, a novel 2-D zero-reference mark is especially proposed and demonstrated. Thiskind of mark has an absolute zero-reference when used in pair, and the experimental result is simpleto dispose. By superimposing a pair of specially coded 2-D marks, the correct alignment position ofthe two marks can be detected by the maximum output of the sharp intensity peak. And each slope ofthe peak is of good linearity which can be used to achieve high resolution in positioning andalignment in two dimensions. Design and fabrication of such 2-D zero-reference marks are introducedin detail. The experiment results are agreed with the theoretical ones.
文摘An optimized formulation of a sustained release tablet of Gliclazide was developed. The use of Doptimal design with a polynomial statistical model to analyze dissolution data reduced the number of laboratory tests required to obtain an optimal dosage form. The final formulation contained 22 mg of Methocel®E15LV, 16.5 mg Methocel®E15 and 10.0 mg of Dibasic Calcium Phosphate per 30 mg Gliclazide sustained release tablet. Dissolution studies performed on tablets from 5000 tablet test batches released greater than 90 percent of loaded drug in eight hours. Drug release from the optimized tablets followed a pattern more closely similar to zero-order than other mechanisms of drug release tested. Storage of tablets in accelerated and ambient conditions for 6 and 12 months respectively did not alter any of the physico-chemical properties, drug release or the drug release rate compared to initial observations and dissolution data of the prepared tablets. The addition of potassium phosphate and monosodium phosphate to the tablet reduced the effect pH has on Gliclazide dissolution compared to the commercially available product.
基金The project was financially supported by the National Natural Science Foundation of China
文摘Combined multi-body dynamics with structural dynamics, a new discrete element with flexible connector, which is applicable for 3-D beam structures, is developed in this paper. Both the generalized elastic coefficient matrix of the flexible connector and the mass matrix of discrete element may be off-diagonal in a general case. The zero-length rigid element is introduced to simulate the node at which multiple elements are jointed together. It may also be effective when the axes of adjacent elements are not in the same line. The examples for eigenvalue calculation show that the model is successful. It can be extended to the geometric nonlinear response analysis.
