BACKGROUND Insomnia is a disease where individuals cannot maintain a steady and stable sleep state or fail to fall asleep.Western medicine mainly uses sedatives and hypnotic drugs to treat insomnia,and long-term use i...BACKGROUND Insomnia is a disease where individuals cannot maintain a steady and stable sleep state or fail to fall asleep.Western medicine mainly uses sedatives and hypnotic drugs to treat insomnia,and long-term use is prone to drug resistance and other adverse reactions.Acupuncture has a good curative effect and unique advantages in the treatment of insomnia.AIM To explore the molecular mechanism of acupuncture at Back-Shu point for the treatment of insomnia.METHODS We first prepared a rat model of insomnia,and then carried out acupuncture for 7 consecutive days.After treatment,the sleep time and general behavior of the rats were determined.The Morris water maze test was used to assess the learning ability and spatial memory ability of the rats.The expression levels of inflammatory cytokines in serum and the hippocampus were detected by ELISA.qRTPCR was used to detect the mRNA expression changes in the ERK/NF-κB signaling pathway.Western blot and immunohistochemistry were carried out to evaluate the protein expression levels of RAF-1,MEK-2,ERK1/2 and NF-κB.RESULTS Acupuncture can prolong sleep duration,and improve mental state,activity,diet volume,learning ability and spatial memory.In addition,acupuncture increased the release of 1L-1β,1L-6 and TNF-αin serum and the hippocampus and inhibited the mRNA and protein expression of the ERK/NF-κB signaling pathway.CONCLUSION These findings suggest that acupuncture at Back-Shu point can inhibit the ERK/NF-κB signaling pathway and treat insomnia by increasing the release of inflammatory cytokines in the hippocampus.展开更多
Precise localization techniques for indoor Wi-Fi access points(APs)have important application in the security inspection.However,due to the interference of environment factors such as multipath propagation and NLOS(No...Precise localization techniques for indoor Wi-Fi access points(APs)have important application in the security inspection.However,due to the interference of environment factors such as multipath propagation and NLOS(Non-Line-of-Sight),the existing methods for localization indoor Wi-Fi access points based on RSS ranging tend to have lower accuracy as the RSS(Received Signal Strength)is difficult to accurately measure.Therefore,the localization algorithm of indoor Wi-Fi access points based on the signal strength relative relationship and region division is proposed in this paper.The algorithm hierarchically divide the room where the target Wi-Fi AP is located,on the region division line,a modified signal collection device is used to measure RSS in two directions of each reference point.All RSS values are compared and the region where the RSS value has the relative largest signal strength is located as next candidate region.The location coordinate of the target Wi-Fi AP is obtained when the localization region of the target Wi-Fi AP is successively approximated until the candidate region is smaller than the accuracy threshold.There are 360 experiments carried out in this paper with 8 types of Wi-Fi APs including fixed APs and portable APs.The experimental results show that the average localization error of the proposed localization algorithm is 0.30 meters,and the minimum localization error is 0.16 meters,which is significantly higher than the localization accuracy of the existing typical indoor Wi-Fi access point localization methods.展开更多
This study analyzes the signal quality and the accuracy of BeiDou 3 rd generation Satellite Navigation System(BDS3) Precise Point Positioning(PPP) in the Arctic Ocean. Assessment of signal quality of BDS3 includes sig...This study analyzes the signal quality and the accuracy of BeiDou 3 rd generation Satellite Navigation System(BDS3) Precise Point Positioning(PPP) in the Arctic Ocean. Assessment of signal quality of BDS3 includes signal to noise ratio(SNR), multipath(MP), dilution of precision(DOP), and code-minus-carrier combination(CC). The results show that, 5 to 13 satellites are visible at any time in the Arctic Ocean area as of September 2018, which are sufficient for positioning. In the mid-latitude oceanic region and in the Arctic Ocean, the SNR is 25–52 dB Hz and the MP ranges from-2 m to 2 m. As the latitude increases, the DOP values show large variation, which may be related to the distribution of BDS satellites. The CC values of signals B1 I and BIC range from-5 m to 5 m in the mid-latitude sea area and the Arctic Ocean, which means the effect of pseudorange noise is small. Moreover, as to obtain the external precise reference value for GNSS positioning in the Arctic Ocean region is difficult, it is hard to evaluate the accuracy of positioning results. An improved isotropy-based protection level method based on Receiver Autonomous Integrity Monitoring is proposed in the paper, which adopts median filter to smooth the gross errors to assess the precision and reliability of PPP in the Arctic Ocean. At first, the improved algorithm is verified with the data from the International GNSS Service Station Tixi. Then the accuracy of BDS3 PPP in the Arctic Ocean is calculated based on the improved algorithm. Which shows that the kinematic accuracy of PPP can reach the decimeter level in both the horizontal and vertical directions, and it meets the precision requirements of maritime navigation.展开更多
点云的处理、传输、语义分割等是3维计算机视觉领域重要的分析任务.现如今,图神经网络和图结构在点云研究方面的有效性已被证实,基于图的点云(graph-based point cloud,GPC)研究不断涌现.因此,一种统一的研究角度、框架和方法论亟待形成...点云的处理、传输、语义分割等是3维计算机视觉领域重要的分析任务.现如今,图神经网络和图结构在点云研究方面的有效性已被证实,基于图的点云(graph-based point cloud,GPC)研究不断涌现.因此,一种统一的研究角度、框架和方法论亟待形成.系统性梳理了GPC研究的各种应用场景,包括配准、降噪、压缩、表示学习、分类、分割、检测等任务,概括出GPC研究的一般性框架,提出了一条覆盖当前GPC全域研究的技术路线.具体来说,给出了GPC研究的分层概念范畴,包括底层数据处理、中层表示学习、高层识别任务;综述了各领域中的GPC模型或算法,包括静态和动态点云的处理算法、有监督和无监督的表示学习模型、传统或机器学习的GPC识别算法;总结了其中代表性的成果及其核心思想,譬如动态更新每层特征空间对应的最近邻图、分层以及参数共享的动态点聚合模块,结合图划分和图卷积提高分割精度;对比了模型性能,包括总体精度(overall accuracy,OA)、平均精度(mean accuracy,mAcc)、平均交并比(mean intersection over union,mIoU);在分析比较现有模型和方法的基础上,归纳了GPC目前面临的主要挑战,提出相应的研究问题,并展望未来的研究方向.建立的GPC研究框架具有一般性和通用性,为后续研究者从事GPC这个新型交叉领域研究提供了领域定位、技术总结及宏观视角.点云研究的出现,是探测器硬件技术长足进步后应运而生的结果;点云研究的现状表明在理论和实践之间存在一些挑战,一些关键问题还有待解决.同时,点云研究的发展将推动人工智能进入新的时代.展开更多
目的探讨电针廉泉穴对脑卒中后吞咽困难(PSD)大鼠神经功能缺损的影响及潜在对瞬时受体电位香草酸亚型1(TRPV1)信号通路的调节机制作用。方法选用SPF级SD雄性大鼠60只,随机分为正常组12只(仅浅插栓线,未导致脑内动脉闭塞),余48只制作PSD...目的探讨电针廉泉穴对脑卒中后吞咽困难(PSD)大鼠神经功能缺损的影响及潜在对瞬时受体电位香草酸亚型1(TRPV1)信号通路的调节机制作用。方法选用SPF级SD雄性大鼠60只,随机分为正常组12只(仅浅插栓线,未导致脑内动脉闭塞),余48只制作PSD模型,将造模成功的36只大鼠随机分为模型组、治疗组和治疗+咖啡酸组,每组12只。记录大鼠吞咽潜伏期和吞咽次数,生物信号采集器检测舌下神经放电、舌肌阈强度和收缩幅度,酶联免疫吸附测定血清P物质含量,甲苯胺蓝染色检测舌下神经核尼氏体数目,免疫组织化学检测舌下神经核TRPV1、五羟色胺(5-HT)、磷酸化p38、神经元型一氧化氮合酶(nNOS)蛋白表达水平。结果与正常组比较,模型组大鼠吞咽潜伏期、吞咽次数、舌下神经放电积分面积、舌肌收缩幅度、血清P物质含量、舌下神经核尼氏体数目、TRPV1及5-HT蛋白表达水平下降,舌肌阈强度和舌下神经核磷酸化p38、nNOS蛋白表达水平增加(P<0.05);与模型组比较,治疗组大鼠舌肌单收缩幅度、舌肌强直收缩幅度、血清P物质含量、舌下神经核尼氏体数目、TRPV1及5-HT蛋白表达水平增加[2.36±0.26 vs 1.77±0.22、3.46±0.36 vs 2.15±0.18、(3.92±0.38)ng/ml vs(1.69±0.17)ng/ml、(33.60±3.65)个vs(24.60±2.34)个、(19.85±2.11)%vs(9.79±1.07)%、(22.43±2.34)%vs(10.85±1.13)%,P<0.05]。结论电针廉泉穴可能通过激活TRPV1信号通路改善PSD大鼠神经功能缺损。展开更多
文摘BACKGROUND Insomnia is a disease where individuals cannot maintain a steady and stable sleep state or fail to fall asleep.Western medicine mainly uses sedatives and hypnotic drugs to treat insomnia,and long-term use is prone to drug resistance and other adverse reactions.Acupuncture has a good curative effect and unique advantages in the treatment of insomnia.AIM To explore the molecular mechanism of acupuncture at Back-Shu point for the treatment of insomnia.METHODS We first prepared a rat model of insomnia,and then carried out acupuncture for 7 consecutive days.After treatment,the sleep time and general behavior of the rats were determined.The Morris water maze test was used to assess the learning ability and spatial memory ability of the rats.The expression levels of inflammatory cytokines in serum and the hippocampus were detected by ELISA.qRTPCR was used to detect the mRNA expression changes in the ERK/NF-κB signaling pathway.Western blot and immunohistochemistry were carried out to evaluate the protein expression levels of RAF-1,MEK-2,ERK1/2 and NF-κB.RESULTS Acupuncture can prolong sleep duration,and improve mental state,activity,diet volume,learning ability and spatial memory.In addition,acupuncture increased the release of 1L-1β,1L-6 and TNF-αin serum and the hippocampus and inhibited the mRNA and protein expression of the ERK/NF-κB signaling pathway.CONCLUSION These findings suggest that acupuncture at Back-Shu point can inhibit the ERK/NF-κB signaling pathway and treat insomnia by increasing the release of inflammatory cytokines in the hippocampus.
基金The work presented in this paper is supported by the National Key R&D Program of China(No.2016YFB0801303,2016QY01W0105)the National Natural Science Foundation of China(No.U1636219,61602508,61772549,U1736214,61572052)+1 种基金Plan for Scientific Innovation Talent of Henan Province(No.2018JR0018)the Key Technologies R&D Program of Henan Province(No.162102210032).
文摘Precise localization techniques for indoor Wi-Fi access points(APs)have important application in the security inspection.However,due to the interference of environment factors such as multipath propagation and NLOS(Non-Line-of-Sight),the existing methods for localization indoor Wi-Fi access points based on RSS ranging tend to have lower accuracy as the RSS(Received Signal Strength)is difficult to accurately measure.Therefore,the localization algorithm of indoor Wi-Fi access points based on the signal strength relative relationship and region division is proposed in this paper.The algorithm hierarchically divide the room where the target Wi-Fi AP is located,on the region division line,a modified signal collection device is used to measure RSS in two directions of each reference point.All RSS values are compared and the region where the RSS value has the relative largest signal strength is located as next candidate region.The location coordinate of the target Wi-Fi AP is obtained when the localization region of the target Wi-Fi AP is successively approximated until the candidate region is smaller than the accuracy threshold.There are 360 experiments carried out in this paper with 8 types of Wi-Fi APs including fixed APs and portable APs.The experimental results show that the average localization error of the proposed localization algorithm is 0.30 meters,and the minimum localization error is 0.16 meters,which is significantly higher than the localization accuracy of the existing typical indoor Wi-Fi access point localization methods.
基金The Science and Technology of Henan Province under contract No.212102310029the National Natural Science Founation Cultivation Project of Xuchang University under contract No.2022GJPY007the Educational Teaching Research and Practice Project of Xuchang University under contract No.XCU2021-YB-024.
文摘This study analyzes the signal quality and the accuracy of BeiDou 3 rd generation Satellite Navigation System(BDS3) Precise Point Positioning(PPP) in the Arctic Ocean. Assessment of signal quality of BDS3 includes signal to noise ratio(SNR), multipath(MP), dilution of precision(DOP), and code-minus-carrier combination(CC). The results show that, 5 to 13 satellites are visible at any time in the Arctic Ocean area as of September 2018, which are sufficient for positioning. In the mid-latitude oceanic region and in the Arctic Ocean, the SNR is 25–52 dB Hz and the MP ranges from-2 m to 2 m. As the latitude increases, the DOP values show large variation, which may be related to the distribution of BDS satellites. The CC values of signals B1 I and BIC range from-5 m to 5 m in the mid-latitude sea area and the Arctic Ocean, which means the effect of pseudorange noise is small. Moreover, as to obtain the external precise reference value for GNSS positioning in the Arctic Ocean region is difficult, it is hard to evaluate the accuracy of positioning results. An improved isotropy-based protection level method based on Receiver Autonomous Integrity Monitoring is proposed in the paper, which adopts median filter to smooth the gross errors to assess the precision and reliability of PPP in the Arctic Ocean. At first, the improved algorithm is verified with the data from the International GNSS Service Station Tixi. Then the accuracy of BDS3 PPP in the Arctic Ocean is calculated based on the improved algorithm. Which shows that the kinematic accuracy of PPP can reach the decimeter level in both the horizontal and vertical directions, and it meets the precision requirements of maritime navigation.
文摘点云的处理、传输、语义分割等是3维计算机视觉领域重要的分析任务.现如今,图神经网络和图结构在点云研究方面的有效性已被证实,基于图的点云(graph-based point cloud,GPC)研究不断涌现.因此,一种统一的研究角度、框架和方法论亟待形成.系统性梳理了GPC研究的各种应用场景,包括配准、降噪、压缩、表示学习、分类、分割、检测等任务,概括出GPC研究的一般性框架,提出了一条覆盖当前GPC全域研究的技术路线.具体来说,给出了GPC研究的分层概念范畴,包括底层数据处理、中层表示学习、高层识别任务;综述了各领域中的GPC模型或算法,包括静态和动态点云的处理算法、有监督和无监督的表示学习模型、传统或机器学习的GPC识别算法;总结了其中代表性的成果及其核心思想,譬如动态更新每层特征空间对应的最近邻图、分层以及参数共享的动态点聚合模块,结合图划分和图卷积提高分割精度;对比了模型性能,包括总体精度(overall accuracy,OA)、平均精度(mean accuracy,mAcc)、平均交并比(mean intersection over union,mIoU);在分析比较现有模型和方法的基础上,归纳了GPC目前面临的主要挑战,提出相应的研究问题,并展望未来的研究方向.建立的GPC研究框架具有一般性和通用性,为后续研究者从事GPC这个新型交叉领域研究提供了领域定位、技术总结及宏观视角.点云研究的出现,是探测器硬件技术长足进步后应运而生的结果;点云研究的现状表明在理论和实践之间存在一些挑战,一些关键问题还有待解决.同时,点云研究的发展将推动人工智能进入新的时代.
文摘目的探讨电针廉泉穴对脑卒中后吞咽困难(PSD)大鼠神经功能缺损的影响及潜在对瞬时受体电位香草酸亚型1(TRPV1)信号通路的调节机制作用。方法选用SPF级SD雄性大鼠60只,随机分为正常组12只(仅浅插栓线,未导致脑内动脉闭塞),余48只制作PSD模型,将造模成功的36只大鼠随机分为模型组、治疗组和治疗+咖啡酸组,每组12只。记录大鼠吞咽潜伏期和吞咽次数,生物信号采集器检测舌下神经放电、舌肌阈强度和收缩幅度,酶联免疫吸附测定血清P物质含量,甲苯胺蓝染色检测舌下神经核尼氏体数目,免疫组织化学检测舌下神经核TRPV1、五羟色胺(5-HT)、磷酸化p38、神经元型一氧化氮合酶(nNOS)蛋白表达水平。结果与正常组比较,模型组大鼠吞咽潜伏期、吞咽次数、舌下神经放电积分面积、舌肌收缩幅度、血清P物质含量、舌下神经核尼氏体数目、TRPV1及5-HT蛋白表达水平下降,舌肌阈强度和舌下神经核磷酸化p38、nNOS蛋白表达水平增加(P<0.05);与模型组比较,治疗组大鼠舌肌单收缩幅度、舌肌强直收缩幅度、血清P物质含量、舌下神经核尼氏体数目、TRPV1及5-HT蛋白表达水平增加[2.36±0.26 vs 1.77±0.22、3.46±0.36 vs 2.15±0.18、(3.92±0.38)ng/ml vs(1.69±0.17)ng/ml、(33.60±3.65)个vs(24.60±2.34)个、(19.85±2.11)%vs(9.79±1.07)%、(22.43±2.34)%vs(10.85±1.13)%,P<0.05]。结论电针廉泉穴可能通过激活TRPV1信号通路改善PSD大鼠神经功能缺损。
