期刊文献+
共找到2篇文章
< 1 >
每页显示 20 50 100
多种药物联合应用对小鼠顺铂肾毒性的拮抗作用 被引量:7
1
作者 廖英俊 金亚平 汤浩 《中国药理学与毒理学杂志》 CAS CSCD 北大核心 2009年第3期219-224,共6页
目的探讨硫酸锌(Zn)、亚硒酸钠(Se)、磷霉素钠(Fos)、乙酰半胱氨酸(NAC)、硫代硫酸钠(STS)、蛋氨酸(Met)和牛磺酸(Tau)等对顺铂肾毒性的联合拮抗作用。方法采用7因素(7个药物)2水平(给药或不给药)的正交设计,共8个实验组。各组小鼠ig给... 目的探讨硫酸锌(Zn)、亚硒酸钠(Se)、磷霉素钠(Fos)、乙酰半胱氨酸(NAC)、硫代硫酸钠(STS)、蛋氨酸(Met)和牛磺酸(Tau)等对顺铂肾毒性的联合拮抗作用。方法采用7因素(7个药物)2水平(给药或不给药)的正交设计,共8个实验组。各组小鼠ig给予不同组合的拮抗药物,每日1次,连续9d。从第3天起,ig给予拮抗药后6h,ip顺铂3.5mg.kg-1,连续5d,分别于给予顺铂前和实验结束前测量小鼠体重。给药结束次日,摘小鼠眼球取血,然后处死。快速取肾组织,并分别测定血清尿素氮(BUN)、肾还原型谷胱甘肽(GSH)含量及谷胱甘肽过氧化物酶(GSH-Px)活性。结果Zn,Fos和Met可显著改善顺铂引起的体重减轻;Fos和Met可显著降低顺铂引起的肾脏系数升高;Fos,STS和Met可显著抑制顺铂引起的血清BUN和肾GSH含量升高;Met可显著抑制顺铂引起的肾GSH-Px活性升高。单独给予Se,NAC和Tau对以上指标未见明显改善作用。结论多种药物联合应用可协同拮抗顺铂的肾毒性作用,以Zn(或Se),Fos(或STS)和Met联合应用的拮抗效果最好。 展开更多
关键词 顺铂 肾/毒性 药物拮抗作用 蛋氨酸 磷霉素 硫酸锌 亚硒酸钠 硫代硫酸钠
下载PDF
Involvement of C2H2 zinc finger proteins in the regulation of epidermal cell fate determination in Arabidopsis 被引量:7
2
作者 An Yan Minjie Wu +4 位作者 Yongqin Zhao Aidong Zhang Bohan Liu John Schiefelbein Yinbo Gan 《Journal of Integrative Plant Biology》 SCIE CAS CSCD 2014年第12期1112-1117,共6页
Cell fate determination is a basic developmental process during the growth of multicellular organisms.Trichomes and root hairs of Arabidopsis are both readily accessible structures originating from the epidermal cells... Cell fate determination is a basic developmental process during the growth of multicellular organisms.Trichomes and root hairs of Arabidopsis are both readily accessible structures originating from the epidermal cells of the aerial tissues and roots respectively, and they serve as excellent models for understanding the molecular mechanisms controlling cell fate determination and cell morphogenesis. The regulation of trichome and root hair formationis a complex program that consists of the integration of hormonal signals with a large number of transcriptional factors, including MYB and b HLH transcriptional factors.Studies during recent years have uncovered an important role of C2H2 type zinc finger proteins in the regulation of epidermal cell fate determination. Here in this minireview we briefly summarize the involvement of C2H2 zinc finger proteins in the control of trichome and root hair formation in Arabidopsis. 展开更多
关键词 C2H2 cell fate determination root hair trichome zinc finger protein
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部