Objective:The aim of this study was to evaluate effect and mechanism of 125I radioactive particles interposed radiotherapy between organizations on lung cancer.Methods:Fourteen cases of patients diagnosed with non-sma...Objective:The aim of this study was to evaluate effect and mechanism of 125I radioactive particles interposed radiotherapy between organizations on lung cancer.Methods:Fourteen cases of patients diagnosed with non-small cell lung cancer(NSCLC),the use of the B-,CT-guided,according to preoperative imaging and treatment planning system(TPS) program for radioactive particles interposed 125I interstitial radiotherapy.Results:All patients were successfully 125I interstitial radioactive particles interposed radiotherapy.Postoperative local complete tumor remission in 9 cases,partial remission in 5 cases,the efficiency of 100%.No case of serious complications.After 3 to 4 weeks of chemotherapy after 11 cases.4 cases of lung cancer with bone metastases,pain completely disappeared after treatment.Up to now,five cases have died due to tumor progression,survival time of 12 to 16 months.Nine cases still under follow-up observation and treatment.Conclusion:125 I radioactive particles interposed radiotherapy between organizations of lung cancer,simple operation,trauma,fewer complications,conformal high,high local tumor dose,efficacy,and is a supplement of modern radiotherapy techniques for the treatment of lung cancer provides a comprehensive line of the method of effective.展开更多
The Yenisei River, one of the largest rivers in the world, is contaminated with artificial radionuclides released by a Russian nuclear facility producing weapon-grade plutonium, which has been in operation for many ye...The Yenisei River, one of the largest rivers in the world, is contaminated with artificial radionuclides released by a Russian nuclear facility producing weapon-grade plutonium, which has been in operation for many years. Examination of Yenisei River sediment samples revealed the presence of artificial radionuclides typical of radioactive discharge from the Mining-and-Chemical- Combine (MCC) nuclear facility: isotopes of europium (152Eu, 154Eu, and 155Eu), cesium (137Cs and 134Cs), 60Co, 90Sr, and transuranium elements. The MCC is also a source of radioactive particles in the Yenisei. New data on radionuclide concentrations in sediments and radioactive particles in the Yenisei River were obtained using a wide range of analytical methods. Sequential extraction performed on samples of sediment cores showed different degrees of potential environmental availability of artificial radionuclides and uranium. In a few samples, 241Am was present in the unextractable form, which may be accounted for by the presence of microparticles of the reactor fuel. These microparticles were investigated using scanning electron microscopy, and their reactor origin was confirmed.展开更多
Objective: To investigate the effects of bronchial arterial chemoembolization combined with radioactive particle implantation on the level of serum tumor markers and T lymphocyte subsets in patients with locally advan...Objective: To investigate the effects of bronchial arterial chemoembolization combined with radioactive particle implantation on the level of serum tumor markers and T lymphocyte subsets in patients with locally advanced non-small cell lung cancer. Methods: A total of 91 cases of locally advanced non-small cell lung cancer patients according to the random data table were divided into the control group (n=45) and observation group (n=46) according to the random data table. Patients in the control group was treated with bronchial arterial chemoembolization, on the basis of the control group, patients in the observation group were treated with radioactive particle implantation, the serum tumor markers and T lymphocyte subsets of the two groups were compared before and after treatment. Results: The levels of CEA, NSE, CA125, CD4+, CD8+, CD4+/CD8+ and NK in the two groups before the treatment were not statistically significant. Compared with the group before treatment, levels of CEA, NSE, CA125and CD8+ of the two groups after treatment were significantly decreased, and after treatment the level of CEA, NSE, CA125and CD8+ in the observation group was significantly lower than those of the control group;The levels of CD4+, CD4+/CD8+ and NK in the two groups after treatment were significantly higher than those in the group before treatment, and the observation group levels were significantly higher than those of the control group. Conclusion: Bronchial artery embolization combined with radioactive particle implantation for locally advanced non-small cell lung cancer, can effectively reduce the serum tumor markers level, improve the level of T cell subsets of patients, has important clinical value.展开更多
Ni_(25)Ti_(50)Cu_(25) shape memory particle/Al matrix composite was prepared by hot pressing and further extrusion.The Ni_(25)Ti_(50)Cu_(25) particles embeded in Al matrix still keep B19 and B19 structure,and have a g...Ni_(25)Ti_(50)Cu_(25) shape memory particle/Al matrix composite was prepared by hot pressing and further extrusion.The Ni_(25)Ti_(50)Cu_(25) particles embeded in Al matrix still keep B19 and B19 structure,and have a good thermal-elastic martensitic transition with 6K thermal hysteresis,the phase transition temperatures remaining constant during cycling. The scratching force of Ni_(25)Ti_(50)Cu_(25) particle is two times that of Al matrix,When the scratching force is larger than 4.2N, the Ni_(25)Ti_(50)Cu_(25) particle is separated from Al matrix.展开更多
In this paper, we describe a possible method for predicting the earthquakes, which is based on simultaneous recording of the intensity of fluxes of neutrons and charged particles by detectors, commonly used in nuclear...In this paper, we describe a possible method for predicting the earthquakes, which is based on simultaneous recording of the intensity of fluxes of neutrons and charged particles by detectors, commonly used in nuclear physics. These low-energy particles originate from radioactive nuclear processes in the Earth＇s crust. The variations in the particle flux intensity can be the precursor of the earth- quake. A description is given of an electronic installation that records the fluxes of charged particles in the radial direction, which are a possible response to the accumulated tectonic stresses in the Earth＇s crust. The obtained results showed an increase in the intensity of the fluxes for 10 or more hours before the occurrence of the earthquake. The previous version of the installation was able to indicate for the possibility of an earthquake （Maksudov et al. in Instrum Exp Tech 58：130-131, 2015）, but did not give information about the direction of the epicenter location. In this regard, the installation was modified by adding eight directional detectors. With the upgraded setup, we have received both the predictive signals, and signals determining the directions of the location of the forthcoming earthquake, starting 2-3 days before its origin.展开更多
Maximum likelihood estimation(MLE)is an effective method for localizing radioactive sources in a given area.However,it requires an exhaustive search for parameter estimation,which is time-consuming.In this study,heuri...Maximum likelihood estimation(MLE)is an effective method for localizing radioactive sources in a given area.However,it requires an exhaustive search for parameter estimation,which is time-consuming.In this study,heuristic techniques were employed to search for radiation source parameters that provide the maximum likelihood by using a network of sensors.Hence,the time consumption of MLE would be effectively reduced.First,the radiation source was detected using the k-sigma method.Subsequently,the MLE was applied for parameter estimation using the readings and positions of the detectors that have detected the radiation source.A comparative study was performed in which the estimation accuracy and time consump-tion of the MLE were evaluated for traditional methods and heuristic techniques.The traditional MLE was performed via a grid search method using fixed and multiple resolutions.Additionally,four commonly used heuristic algorithms were applied:the firefly algorithm(FFA),particle swarm optimization(PSO),ant colony optimization(ACO),and artificial bee colony(ABC).The experiment was conducted using real data collected by the Low Scatter Irradiator facility at the Savannah River National Laboratory as part of the Intelligent Radiation Sensing System program.The comparative study showed that the estimation time was 3.27 s using fixed resolution MLE and 0.59 s using multi-resolution MLE.The time consumption for the heuristic-based MLE was 0.75,0.03,0.02,and 0.059 s for FFA,PSO,ACO,and ABC,respectively.The location estimation error was approximately 0.4 m using either the grid search-based MLE or the heuristic-based MLE.Hence,heuristic-based MLE can provide comparable estimation accuracy through a less time-consuming process than traditional MLE.展开更多
Bystander effects induced by low-dose or low dose-rate radiation have put a great challenge to the tradi- tional model for radiation protection. In order to get a better assessment of the adverse effects of radiation,...Bystander effects induced by low-dose or low dose-rate radiation have put a great challenge to the tradi- tional model for radiation protection. In order to get a better assessment of the adverse effects of radiation, especially the low-dose radiation risk in environment, a radioactive irradiation facility, by which the dose and dose-rate to the biological targets can be controlled by rotating the sample bracket and changing the space between the radioactive source and the targets, was developed. The energy of our α-radioactive source (241Am) is measured averagely 3.5 MeV at the position of the irradiated sample. The dose rate was measured by using a silicon surface barrier detector and a CR39 particle track detector. A dose rate ranging from 0.045 cGy/s to 1.07 cGy/s can be obtained by changing the space length from the radioactive source to the sample dish.展开更多
目的探讨^(125)I放射性粒子植入治疗腹膜后转移瘤患者的临床疗效。方法选取2020年1月至2023年12月湖北中医药大学附属医院(湖北省中医院)的腹膜后转移瘤患者26例,根据随机数字表法,将患者分为观察组和对照组,每组13例。观察组接受盐酸...目的探讨^(125)I放射性粒子植入治疗腹膜后转移瘤患者的临床疗效。方法选取2020年1月至2023年12月湖北中医药大学附属医院(湖北省中医院)的腹膜后转移瘤患者26例,根据随机数字表法,将患者分为观察组和对照组,每组13例。观察组接受盐酸羟考酮缓释片联合^(125)I粒子植入治疗,其中^(125)I粒子剂量10183.9~13296.1 cGy,平均(12485.7±405.2)cGy;对照组仅接受盐酸羟考酮缓释片镇痛治疗,两组均治疗3个月。分别采用疼痛数字评价量表(numeric rating scale,NRS)和欧洲癌症研究与治疗组织生命质量测量量表核心30项(the European Organization for Re⁃search and Treatment of Cancer Quality of Life Questionnaire-Core 30,EORTCQLQ-C30)评估患者的疼痛情况和生命质量。比较治疗前后两组疼痛情况、每日镇痛药需求量、生活质量以及不良反应的发生率。结果26例患者中男16例、女10例,年龄52~71岁,平均(56.1±5.9)岁。治疗后1个月、2个月、3个月,与对照组相比,观察组NRS评分和每日镇痛药需求量较低;治疗后3个月,与对照组相比,观察组疼痛缓解率较高、不良反应发生率较低,EORTCQLQ-C30总分较高,差异均有统计学意义(P<0.05)。结论^(125)I放射性粒子植入治疗可有效缓解腹膜后转移瘤患者疼痛情况,并改善生活质量,安全性高。展开更多
Background and Aims:125I radioactive particles implantation have demonstrated efficacy in eradicating hepatocellular carcinoma(HCC).However,progressive resistance of HCC to 125I radioactive particles has limited its w...Background and Aims:125I radioactive particles implantation have demonstrated efficacy in eradicating hepatocellular carcinoma(HCC).However,progressive resistance of HCC to 125I radioactive particles has limited its wide clinical application.Methods:We investigated the cellular responses to 125I radioactive particles treatment and autophagy-related 9B(ATG9B)silencing in HCC cell lines and Hep3B xenografted tumor model using Cell Counting Kit-8 reagent,western blotting,immunofluorescence,flow cytometry,transmission electron microscopy and immunohistochemistry.Results:In this study,we demonstrated that 125I radioactive particles induced cell apoptosis and protective autophagy of HCC in vitro and in vivo.Inhibition of autophagy enhanced the radiosensitivity of HCC to 125I radioactive particles.Moreover,125I radioactive particles induced autophagy by upregulating ATG9B,with increased expression level of LC3B and decreased expression level of p62.Furthermore,ATG9B silencing downregulated LC3B expression and upregulated p62 expression and enhanced radiosensitivity of HCC to 125I radioactive particles in vitro and in vivo.Conclusions:Inhibition of ATG9B enhanced the antitumor effects of 125I particle radiation against HCC in vitro and in vivo.Our findings suggest that 125I particle radiation plus chloroquine or/and the ATG9B inhibitor may be a novel therapeutic strategy for HCC.展开更多
文摘Objective:The aim of this study was to evaluate effect and mechanism of 125I radioactive particles interposed radiotherapy between organizations on lung cancer.Methods:Fourteen cases of patients diagnosed with non-small cell lung cancer(NSCLC),the use of the B-,CT-guided,according to preoperative imaging and treatment planning system(TPS) program for radioactive particles interposed 125I interstitial radiotherapy.Results:All patients were successfully 125I interstitial radioactive particles interposed radiotherapy.Postoperative local complete tumor remission in 9 cases,partial remission in 5 cases,the efficiency of 100%.No case of serious complications.After 3 to 4 weeks of chemotherapy after 11 cases.4 cases of lung cancer with bone metastases,pain completely disappeared after treatment.Up to now,five cases have died due to tumor progression,survival time of 12 to 16 months.Nine cases still under follow-up observation and treatment.Conclusion:125 I radioactive particles interposed radiotherapy between organizations of lung cancer,simple operation,trauma,fewer complications,conformal high,high local tumor dose,efficacy,and is a supplement of modern radiotherapy techniques for the treatment of lung cancer provides a comprehensive line of the method of effective.
文摘The Yenisei River, one of the largest rivers in the world, is contaminated with artificial radionuclides released by a Russian nuclear facility producing weapon-grade plutonium, which has been in operation for many years. Examination of Yenisei River sediment samples revealed the presence of artificial radionuclides typical of radioactive discharge from the Mining-and-Chemical- Combine (MCC) nuclear facility: isotopes of europium (152Eu, 154Eu, and 155Eu), cesium (137Cs and 134Cs), 60Co, 90Sr, and transuranium elements. The MCC is also a source of radioactive particles in the Yenisei. New data on radionuclide concentrations in sediments and radioactive particles in the Yenisei River were obtained using a wide range of analytical methods. Sequential extraction performed on samples of sediment cores showed different degrees of potential environmental availability of artificial radionuclides and uranium. In a few samples, 241Am was present in the unextractable form, which may be accounted for by the presence of microparticles of the reactor fuel. These microparticles were investigated using scanning electron microscopy, and their reactor origin was confirmed.
基金the National Natural Science Foundation of China(81541061).
文摘Objective: To investigate the effects of bronchial arterial chemoembolization combined with radioactive particle implantation on the level of serum tumor markers and T lymphocyte subsets in patients with locally advanced non-small cell lung cancer. Methods: A total of 91 cases of locally advanced non-small cell lung cancer patients according to the random data table were divided into the control group (n=45) and observation group (n=46) according to the random data table. Patients in the control group was treated with bronchial arterial chemoembolization, on the basis of the control group, patients in the observation group were treated with radioactive particle implantation, the serum tumor markers and T lymphocyte subsets of the two groups were compared before and after treatment. Results: The levels of CEA, NSE, CA125, CD4+, CD8+, CD4+/CD8+ and NK in the two groups before the treatment were not statistically significant. Compared with the group before treatment, levels of CEA, NSE, CA125and CD8+ of the two groups after treatment were significantly decreased, and after treatment the level of CEA, NSE, CA125and CD8+ in the observation group was significantly lower than those of the control group;The levels of CD4+, CD4+/CD8+ and NK in the two groups after treatment were significantly higher than those in the group before treatment, and the observation group levels were significantly higher than those of the control group. Conclusion: Bronchial artery embolization combined with radioactive particle implantation for locally advanced non-small cell lung cancer, can effectively reduce the serum tumor markers level, improve the level of T cell subsets of patients, has important clinical value.
文摘Ni_(25)Ti_(50)Cu_(25) shape memory particle/Al matrix composite was prepared by hot pressing and further extrusion.The Ni_(25)Ti_(50)Cu_(25) particles embeded in Al matrix still keep B19 and B19 structure,and have a good thermal-elastic martensitic transition with 6K thermal hysteresis,the phase transition temperatures remaining constant during cycling. The scratching force of Ni_(25)Ti_(50)Cu_(25) particle is two times that of Al matrix,When the scratching force is larger than 4.2N, the Ni_(25)Ti_(50)Cu_(25) particle is separated from Al matrix.
文摘In this paper, we describe a possible method for predicting the earthquakes, which is based on simultaneous recording of the intensity of fluxes of neutrons and charged particles by detectors, commonly used in nuclear physics. These low-energy particles originate from radioactive nuclear processes in the Earth＇s crust. The variations in the particle flux intensity can be the precursor of the earth- quake. A description is given of an electronic installation that records the fluxes of charged particles in the radial direction, which are a possible response to the accumulated tectonic stresses in the Earth＇s crust. The obtained results showed an increase in the intensity of the fluxes for 10 or more hours before the occurrence of the earthquake. The previous version of the installation was able to indicate for the possibility of an earthquake （Maksudov et al. in Instrum Exp Tech 58：130-131, 2015）, but did not give information about the direction of the epicenter location. In this regard, the installation was modified by adding eight directional detectors. With the upgraded setup, we have received both the predictive signals, and signals determining the directions of the location of the forthcoming earthquake, starting 2-3 days before its origin.
文摘Maximum likelihood estimation(MLE)is an effective method for localizing radioactive sources in a given area.However,it requires an exhaustive search for parameter estimation,which is time-consuming.In this study,heuristic techniques were employed to search for radiation source parameters that provide the maximum likelihood by using a network of sensors.Hence,the time consumption of MLE would be effectively reduced.First,the radiation source was detected using the k-sigma method.Subsequently,the MLE was applied for parameter estimation using the readings and positions of the detectors that have detected the radiation source.A comparative study was performed in which the estimation accuracy and time consump-tion of the MLE were evaluated for traditional methods and heuristic techniques.The traditional MLE was performed via a grid search method using fixed and multiple resolutions.Additionally,four commonly used heuristic algorithms were applied:the firefly algorithm(FFA),particle swarm optimization(PSO),ant colony optimization(ACO),and artificial bee colony(ABC).The experiment was conducted using real data collected by the Low Scatter Irradiator facility at the Savannah River National Laboratory as part of the Intelligent Radiation Sensing System program.The comparative study showed that the estimation time was 3.27 s using fixed resolution MLE and 0.59 s using multi-resolution MLE.The time consumption for the heuristic-based MLE was 0.75,0.03,0.02,and 0.059 s for FFA,PSO,ACO,and ABC,respectively.The location estimation error was approximately 0.4 m using either the grid search-based MLE or the heuristic-based MLE.Hence,heuristic-based MLE can provide comparable estimation accuracy through a less time-consuming process than traditional MLE.
基金Supported by the National Natural Science Foundation of China(No.30070192)and he National Science Fund for Distinguished Young Scholars(No.10225526).
文摘Bystander effects induced by low-dose or low dose-rate radiation have put a great challenge to the tradi- tional model for radiation protection. In order to get a better assessment of the adverse effects of radiation, especially the low-dose radiation risk in environment, a radioactive irradiation facility, by which the dose and dose-rate to the biological targets can be controlled by rotating the sample bracket and changing the space between the radioactive source and the targets, was developed. The energy of our α-radioactive source (241Am) is measured averagely 3.5 MeV at the position of the irradiated sample. The dose rate was measured by using a silicon surface barrier detector and a CR39 particle track detector. A dose rate ranging from 0.045 cGy/s to 1.07 cGy/s can be obtained by changing the space length from the radioactive source to the sample dish.
文摘目的探讨^(125)I放射性粒子植入治疗腹膜后转移瘤患者的临床疗效。方法选取2020年1月至2023年12月湖北中医药大学附属医院(湖北省中医院)的腹膜后转移瘤患者26例,根据随机数字表法,将患者分为观察组和对照组,每组13例。观察组接受盐酸羟考酮缓释片联合^(125)I粒子植入治疗,其中^(125)I粒子剂量10183.9~13296.1 cGy,平均(12485.7±405.2)cGy;对照组仅接受盐酸羟考酮缓释片镇痛治疗,两组均治疗3个月。分别采用疼痛数字评价量表(numeric rating scale,NRS)和欧洲癌症研究与治疗组织生命质量测量量表核心30项(the European Organization for Re⁃search and Treatment of Cancer Quality of Life Questionnaire-Core 30,EORTCQLQ-C30)评估患者的疼痛情况和生命质量。比较治疗前后两组疼痛情况、每日镇痛药需求量、生活质量以及不良反应的发生率。结果26例患者中男16例、女10例,年龄52~71岁,平均(56.1±5.9)岁。治疗后1个月、2个月、3个月,与对照组相比,观察组NRS评分和每日镇痛药需求量较低;治疗后3个月,与对照组相比,观察组疼痛缓解率较高、不良反应发生率较低,EORTCQLQ-C30总分较高,差异均有统计学意义(P<0.05)。结论^(125)I放射性粒子植入治疗可有效缓解腹膜后转移瘤患者疼痛情况,并改善生活质量,安全性高。
基金supported by the Science and Technology Innovation Project of Social Undertakings and Livelihood Security in Chongqing (No.cstc2016shms-ztzx0045).
文摘Background and Aims:125I radioactive particles implantation have demonstrated efficacy in eradicating hepatocellular carcinoma(HCC).However,progressive resistance of HCC to 125I radioactive particles has limited its wide clinical application.Methods:We investigated the cellular responses to 125I radioactive particles treatment and autophagy-related 9B(ATG9B)silencing in HCC cell lines and Hep3B xenografted tumor model using Cell Counting Kit-8 reagent,western blotting,immunofluorescence,flow cytometry,transmission electron microscopy and immunohistochemistry.Results:In this study,we demonstrated that 125I radioactive particles induced cell apoptosis and protective autophagy of HCC in vitro and in vivo.Inhibition of autophagy enhanced the radiosensitivity of HCC to 125I radioactive particles.Moreover,125I radioactive particles induced autophagy by upregulating ATG9B,with increased expression level of LC3B and decreased expression level of p62.Furthermore,ATG9B silencing downregulated LC3B expression and upregulated p62 expression and enhanced radiosensitivity of HCC to 125I radioactive particles in vitro and in vivo.Conclusions:Inhibition of ATG9B enhanced the antitumor effects of 125I particle radiation against HCC in vitro and in vivo.Our findings suggest that 125I particle radiation plus chloroquine or/and the ATG9B inhibitor may be a novel therapeutic strategy for HCC.
