气象观测场在汽车试验场中的应用研究

汽车试验场作为汽车开展道路测试的重要场所,用于验证汽车产品的品质以及可靠性。除了场地道路外,气象条件作为汽车道路测试的重要一环,在《GB/T12534-1990汽车道路试验方法通则》中也有明确要求,如:试验时应是无雨无雾天气,相对湿度小于95%,气温0-40℃,风速不大于3m/s。同时气象条件也作为试验场道路管控的重要依据,实时风速、雨量、能见度等信息为场地管理者发布限速、限行、封场等通知提供必要参考依据,直接影响道路测试安全管控的及时性。因此,文章从气象观测场的建设、气象服务、异常天气道路管控等方面开展气象观测场在汽车试验场中的应用研究。

Cyber Resilience through Real-Time Threat Analysis in Information Security

This paper examines how cybersecurity is developing and how it relates to more conventional information security. Although information security and cyber security are sometimes used synonymously, this study contends that they are not the same. The concept of cyber security is explored, which goes beyond protecting information resources to include a wider variety of assets, including people [1]. Protecting information assets is the main goal of traditional information security, with consideration to the human element and how people fit into the security process. On the other hand, cyber security adds a new level of complexity, as people might unintentionally contribute to or become targets of cyberattacks. This aspect presents moral questions since it is becoming more widely accepted that society has a duty to protect weaker members of society, including children [1]. The study emphasizes how important cyber security is on a larger scale, with many countries creating plans and laws to counteract cyberattacks. Nevertheless, a lot of these sources frequently neglect to define the differences or the relationship between information security and cyber security [1]. The paper focus on differentiating between cybersecurity and information security on a larger scale. The study also highlights other areas of cybersecurity which includes defending people, social norms, and vital infrastructure from threats that arise from online in addition to information and technology protection. It contends that ethical issues and the human factor are becoming more and more important in protecting assets in the digital age, and that cyber security is a paradigm shift in this regard [1].

Cyberattack Ramifications, The Hidden Cost of a Security Breach

In this in-depth exploration, I delve into the complex implications and costs of cybersecurity breaches. Venturing beyond just the immediate repercussions, the research unearths both the overt and concealed long-term consequences that businesses encounter. This study integrates findings from various research, including quantitative reports, drawing upon real-world incidents faced by both small and large enterprises. This investigation emphasizes the profound intangible costs, such as trade name devaluation and potential damage to brand reputation, which can persist long after the breach. By collating insights from industry experts and a myriad of research, the study provides a comprehensive perspective on the profound, multi-dimensional impacts of cybersecurity incidents. The overarching aim is to underscore the often-underestimated scope and depth of these breaches, emphasizing the entire timeline post-incident and the urgent need for fortified preventative and reactive measures in the digital domain.

Use of blood-based biomarkers for early diagnosis and surveillance of colorectal cancer

Early screening for colorectal cancer(CRC) holds the key to combat and control the increasing global burden of CRC morbidity and mortality. However, the current available screening modalities are severely inadequate because of their high cost and cumbersome preparatory procedures that ultimately lead to a low participation rate. People simply do not like to have colonoscopies. It would be ideal, therefore, to develop an alternative modality based on blood biomarkers as the first line screening test. This will allow for the differentiation of the general population from high risk individuals. Colonoscopy would then become the secondary test, to further screen the high risk segment of the population. This will encourage participation and therefore help to reach the goal of early detection and thereby reduce the anticipated increasing global CRC incidence rate. A blood-based screening test is anappealing alternative as it is non-invasive and poses minimal risk to patients. It is easy to perform, can be repeated at shorter intervals, and therefore would likely lead to a much higher participation rate. This review surveys various blood-based test strategies currently under investigation, discusses the potency of what is available, and assesses how new technology may contribute to future test design.

A retrospective view on the history of natural sciences in XX-XXI

The presented paper is dedicated to a new ret-rospective view on the history of natural sci-ences in XX-XXI cc, partially including the sci-ence philosophy (mainly, the problems of the scientific realism, i.e. the correspondence of science to reality) and also a novel scheme for different classes of sciences with different ob-jects and paradigms. There are analyzed the chosen “great” and “grand” problems of phys-ics (including the comprehension of quantum mechanics, with a recently elaborated new chapter, connected with time as a quantum obs- ervable and time analysis of quantum processes) and also of natural sciences as a whole. The particular attention is paid to the interpretation questions and slightly to the aspects, inevitably connected with the world- views of the res- earchers (which do often constitute a part of the interpretation questions).

Analysis of Waste-Rock Transportation Process Performance in an Open-Pit Mine Based on Statistical Analysis of Cycle Times Data

In this paper, the performance of a waste rock transportation process in an open pit mine was assessed by using cycle time data. A computerized truck-excavator dispatch system was used to record the cycle times. The process was broken into seven steps (or components of the total cycle), durations of which were recorded for a period of 1 month, leading to N = 60,690 data points or dispatches. The open pit mine studied consisted of 12 waste types loaded by 14 excavators and hauled by 49 trucks (at a trucks-to-excavator ratio of 3.5:1) in 75 changing locations. The string-type data was coded using integers to allow a FORTRAN code to extract process performance parameters using statistical analysis. The study established a wide range of parameters including: the waste material generation rate (about 1.73 million t/month, 81% comprising waste rock), truck fill factor, f, total cycle time (Tct), production capacity, theoretical cycle time, non-productive cycle time Tnp, and cycle time performance ratio (CTPR), denoted as Tpr. The factors affecting the process performance include: truck model, excavator model, location (haul distance and road conditions) and material type. For a fixed material type and tonnage, the PDFs of the cycle time components were logarithmic in nature, capable of differentiating performance variations under different factors. It was concluded that the performance of the waste material transportation system in this mine was determined to be acceptable due to mean value of Tpr = 2.432 being closer to unity. Reduction measures were suggested to minimize the cycle time for the process bottlenecks determined from Pareto analysis (that is, full haul, empty haul and loading processes).

Delayed diagnosis in inflammatory bowel disease:Time to consider solutions

In this editorial,we discuss a recently published manuscript by Blüthner et al in the World Journal of Gastroenterology,with a specific focus on the delayed diagnosis of inflammatory bowel disease(IBD).IBD,which includes Crohn's disease and ulcerative colitis,is a chronic intestinal disorder.A time lag may exist between the onset of inflammation and the appearance of signs and symptoms,potentially leading to an incorrect or delayed diagnosis,a situation referred to as the delayed diagnosis of IBD.Early diagnosis is crucial for effective patient treatment and prognosis,yet delayed diagnosis remains common.The reasons for delayed diagnosis of IBD are numerous and not yet fully understood.One key factor is the nonspecific nature of IBD symptoms,which can easily be mistaken for other conditions.Additionally,the lack of specific diagnostic methods for IBD contributes to these delays.Delayed diagnosis of IBD can result in numerous adverse consequences,including increased intestinal damage,fibrosis,a higher risk of colorectal cancer,and a decrease in the quality of life of the patient.Therefore,it is essential to diagnose IBD promptly by raising physician awareness,enhancing patient education,and developing new diagnostic methods.

Everything Is Timelessly Connected: Metaphysics, Physics, Consciousness, Spacetime Travel, DNA, and the Dry Bones Prophesy (Ezekiel Ch. 37)

This paper provides a perception that all things are connected. Starting with the perception of Metaphysics and how matter exists out of total void, complementary matter, or dark matter, the incompleteness of Einstein relativistic theory. Multi spacetime universes and the jump drive for jumping within and between spacetime universes. Warp drive for space travel. DNA as sequence of momentary frequencies and how it related to Ezekiel’s dry bones prophecy. The outcome of neural patterns as cords of consciousness, consciousness as the collection of all cords of consciousness and the lack of uniqueness of individual consciousness. Finally, all things are cords of consciousness.

Hierarchical multihead self-attention for time-series-based fault diagnosis

Fault diagnosis is important for maintaining the safety and effectiveness of chemical process.Considering the multivariate,nonlinear,and dynamic characteristic of chemical process,many time-series-based data-driven fault diagnosis methods have been developed in recent years.However,the existing methods have the problem of long-term dependency and are difficult to train due to the sequential way of training.To overcome these problems,a novel fault diagnosis method based on time-series and the hierarchical multihead self-attention(HMSAN)is proposed for chemical process.First,a sliding window strategy is adopted to construct the normalized time-series dataset.Second,the HMSAN is developed to extract the time-relevant features from the time-series process data.It improves the basic self-attention model in both width and depth.With the multihead structure,the HMSAN can pay attention to different aspects of the complicated chemical process and obtain the global dynamic features.However,the multiple heads in parallel lead to redundant information,which cannot improve the diagnosis performance.With the hierarchical structure,the redundant information is reduced and the deep local time-related features are further extracted.Besides,a novel many-to-one training strategy is introduced for HMSAN to simplify the training procedure and capture the long-term dependency.Finally,the effectiveness of the proposed method is demonstrated by two chemical cases.The experimental results show that the proposed method achieves a great performance on time-series industrial data and outperforms the state-of-the-art approaches.

Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

Epilepsy is a severe,relapsing,and multifactorial neurological disorder.Studies regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of epilepsy.The pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota composition.Satisfactory results are lacking for conventional treatments for epilepsy.Surgical resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with epilepsy.Non-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research focus.This review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of epilepsy.It also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current stimulation.Numerous studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic seizures.Additionally,many new technologies for the diagnosis and treatment of epilepsy are being explored.However,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

Investigation of Excavator Performance Factors in an Open-Pit Mine Using Loading Cycle Time

This study presents the effect of excavator model, loading operation location, shift availability and truck-shovel combination on loading cycle time and productivity of an open-pit mine. The loading cycle time was used to assess the material loading system performance which is one of the key components of the total cycle time for material transportation in an open-pit mine. Loading is among the components of cycle time during which material is being handled. The data analyzed?was?collected from a computerized dispatch system at GGM from which 62,000 loading dispatches per month involving several shifts, 14 excavators and 49 trucks were loaded. About 4465 dispatches per excavator and 1276 dispatches per truck were assessed using loading cycle time data for each dispatch for a period of four months (between August and December). Under fixed tonnage loaded and waste type (33 t of non-acid forming waste rock),?it was observed that loading cycle time depends on excavator model, location and truck being loaded. Average cycle times, PDFS?and CDFS of loading cycle time series were used to identify differences in performance under different situations. It was concluded that shift availability for excavators, loading location, excavator model and truck-shovel combinations strongly affect the productivity during loading process in an open-pit mine.

The Unified Field

This is a Unified Field description based on the holographic Time Dilation Cosmology, TDC, model, which is an eternal continuum evolving forward in the forward direction of time, at the speed of light, c, at an invariant 1 s/s rate of time. This is the Fundamental Direction of Evolution, FDE. There is also an evolution down time dilation gradients, the Gravitational Direction of Evolution, GDE. These evolutions are gravity, which is the evolutionary force in time. Gravitational velocities are compensation for the difference in the rate of time, dRt, in a dilation field, and the dRtis equal to the compensatory velocity’s percentage of c, and is a measure of the force in time inducing the velocity. In applied force induced velocities, the dRt is a measure of the resistance in time to the induced velocity, which might be called “anti-gravity” or “negative gravity”. The two effects keep the continuum uniformly evolving forward at c. It is demonstrated that gravity is already a part of the electromagnetic field equations in way of the dRt element contained in the TDC velocity formula. Einstein’s energy formula is defined as a velocity formula and a modified version is used for charged elementary particle solutions. A time dilation-based derivation of the Lorentz force ties gravity directly to the electromagnetic field proving the unified field of gravity and the EMF. It is noted how we could possibly create gravity drives. This is followed by a discussion of black holes, proving supermassive objects, like massive black hole singularities, are impossible, and that black holes are massless Magnetospheric Eternally Collapsing Objects (MECOs) that are vortices in spacetime. .

Hemophagocytic lymphohistiocytosis: Recent progress in the pathogenesis, diagnosis and treatment

Hemophagocytic lymphohistiocytosis(HLH) is a hyperinflammatory syndrome that develops as a primary(familial/hereditary) or secondary(non-familial/hereditary) disease characterized in the majority of the cases by hereditary or acquired impaired cytotoxic T-cell(CTL) and natural killer responses. The molecular mechanisms underlying impaired immune homeostasis have been clarified, particularly for primary diseases. Familial HLH(familial hemophagocytic lymphohistiocytosis type 2-5, Chediak-Higashi syndrome, Griscelli syndrome type 2, Hermansky-Pudlak syndrome type 2) develops due to a defect in lytic granule exocytosis, impairment of(signaling lymphocytic activation molecule)-associated protein, which plays a key role in CTL activity [e.g., X-linked lymphoproliferative syndrome(XLP) 1], or impairment of X-linked inhibitor of apoptosis, a potent regulator of lymphocyte homeostasis(e.g., XLP2). The development of primary HLH is often triggered by infections, but not in all. Secondary HLH develops in association with infection, autoimmune diseases/rheumatological conditions and malignancy. The molecular mechanisms involved in secondary HLH cases remain unknown and the pathophysiology is not the same as primary HLH. For either primary or secondary HLH cases, immunosuppressive therapy should be given to control the hypercytokinemia with steroids, cyclosporine A, or intravenous immune globulin, and if primary HLH is diagnosed, immunochemotherapy with a regimen containing etoposide or anti-thymocyte globulin should be started. Thereafter, allogeneic hematopoietic stem-cell transplantation is recommended for primary HLH or secondary refractory disease(especially EBVHLH).

Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases

Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative diseases.However,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°C.We aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large cohort.Plasma samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline project.These samples were stored at-80°C for up to 6 years before being used in this study.Our results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage time.However,the level of total tau showed a negative correlation with sample storage time.Notably,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage time.This was not observed in individuals with cognitive impairment.Consequently,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage time.Therefore,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's disease.Furthermore,in cohort studies,it is important to consider the impact of storage time on the overall results.

Autism spectrum disorder:difficulties in diagnosis and microRNA biomarkers

We performed a PubMed search for microRNAs in autism spectrum disorder that could serve as diagnostic biomarkers in patients and selected 17 articles published from January 2008 to December 2023,of which 4 studies were performed with whole blood,4 with blood plasma,5 with blood serum,1 with serum neural cell adhesion molecule L1-captured extracellular vesicles,1 with blood cells,and 2 with peripheral blood mononuclear cells.Most of the studies involved children and the study cohorts were largely males.Many of the studies had performed microRNA sequencing or quantitative polymerase chain reaction assays to measure microRNA expression.Only five studies had used real-time polymerase chain reaction assay to validate microRNA expression in autism spectrum disorder subjects compared to controls.The microRNAs that were validated in these studies may be considered as potential candidate biomarkers for autism spectrum disorder and include miR-500a-5p,-197-5p,-424-5p,-664a-3p,-365a-3p,-619-5p,-664a-3p,-3135a,-328-3p,and-500a-5p in blood plasma and miR-151a-3p,-181b-5p,-320a,-328,-433,-489,-572,-663a,-101-3p,-106b-5p,-19b-3p,-195-5p,and-130a-3p in blood serum of children,and miR-15b-5p and-6126 in whole blood of adults.Several important limitations were identified in the studies reviewed,and need to be taken into account in future studies.Further studies are warranted with children and adults having different levels of autism spectrum disorder severity and consideration should be given to using animal models of autism spectrum disorder to investigate the effects of suppressing or overexpressing specific microRNAs as a novel therapy.

Consideration of Viscoelasticity in Time Step FEM-Based Restraint Analyses of Hardening Concrete

Concrete structures may suffer considerable restraint stresses during their hardening period. This is caused by several deformation impacts, especially temperature field changings due to hydration heat and volume changes due to autogenous shrinkage. Mainly affected are massive concrete members, but also the application of new concrete types or the erection of outstanding constructions requires further investigations in this context. 3D-FEM analyses of hydration heat induced temperature development in combination with the well known shrinkage give sufficient results for the deformation impact. The according elastic restraint stresses can be determined with consideration of the concrete’s rising elastic modulus and the restraint degree of the system. But due to duration of the heat flow process, the height of restraint stresses is strongly dependent from the viscoelasticity of the concrete. The viscoelastic effects consist of many components constituted by changing material properties influencing themselves. In practice, different simplified approaches are available for considering this in calculations. Their implementation in time step analyses is not generally admitted and requires expertise. In contrast, present research develops material models needing specific input parameters for every use case. This contribution focuses on a practicable approach considering the superposition of the viscoelastic behaviour of every stress increment in time step FEM analysis. The differentiation between the pure viscoelastic material behaviour (as it is given in the codes for idealistic conditions like creep or relaxation) and the according viscoelastic system response (addicted to the systems variable restraint degree) allows the transfer of this model into practice. As one application example of this approach, the compatibility check and the FEM-based recalculation of the monitoring program of a massive power plant slab will be presented.

Knowledge Management of Software Productivity and Development Time

In this paper, we identify a set of factors that may be used to forecast software productivity and software development time. Software productivity was measured in function points per person hours, and software development time was measured in number of elapsed days. Using field data on over 130 field software projects from various industries, we empirically test the impact of team size, integrated computer aided software engineering (ICASE) tools, software development type, software development platform, and programming language type on the software development productivity and development time. Our results indicate that team size, software development type, software development platform, and programming language type significantly impact software development productivity. However, only team size significantly impacts software development time. Our results indicate that effective management of software development teams, and using different management strategies for different software development type environments may improve software development productivity.

Attosecond ionization time delays in strong-field physics

Electronic processes within atoms and molecules reside on the timescale of attoseconds. Recent advances in the laserbased pump-probe interrogation techniques have made possible the temporal resolution of ultrafast electronic processes on the attosecond timescale, including photoionization and tunneling ionization. These interrogation techniques include the attosecond streak camera, the reconstruction of attosecond beating by interference of two-photon transitions, and the attoclock. While the former two are usually employed to study photoionization processes, the latter is typically used to investigate tunneling ionization. In this review, we briefly overview these timing techniques towards an attosecond temporal resolution of ionization processes in atoms and molecules under intense laser fields. In particular, we review the backpropagation method, which is a novel hybrid quantum-classical approach towards the full characterization of tunneling ionization dynamics. Continued advances in the interrogation techniques promise to pave the pathway towards the exploration of ever faster dynamical processes on an ever shorter timescale.

A clinical evaluation of serological diagnosis for pancreatic cancer

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Research on Estimation of Time Delay Difference in Passive Locating for Impulse Signal

Analyzed the relation between time delay difference and time delay estimation errors, based on the principles of three-point locating, a reformed threshold method for time delay difference estimation of impulse signals, called as amendment estimation for short, is developed by introducing channel equalization technique to its conventional version, named as direct estimation in this paper, to improve the estimation stability. After inherent relationship between time delay and phase shift of signals is analyzed, an integer period error compensation method utilized the diversities of both contribution share and contribution mode of concerned estimates is proposed under the condition of high precision phase lag estimation. Finally, a cooperative multi-threshold estimation method composed of amendment and direct estimations to process impulse signals with three thresholds is established. In sea trials data tests of passive locating, this method improves the estimation precision of time delay difference efficiently. The experiments verify the theoretical predictions.