Squeezed Coherent States in Non-Unitary Approach and Relation to Sub- and Super-Poissonian Statistics

After developing the concept of displaced squeezed vacuum states in the non-unitary approach and establishing the connection to the unitary approach we calculate their quasiprobabilities and expectation values in general form. Then we consider the displacement of the squeezed vacuum states and calculate their photon statistics and their quasiprobabilities. The expectation values of the displaced states are related to the expectation values of the undisplaced states and are calculated for some simplest cases which are sufficient to discuss their categorization as sub-Poissonian and super-Poissonian statistics. A large set of these states do not belong to sub- or to super-Poissonian states but are also not Poissonian states. We illustrate in examples their photon distributions. This shows that the notions of sub- and of super-Poissonian statistics and their use for the definition of nonclassicality of states are problematic. In Appendix A we present the most important relations for SU (1,1) treatment of squeezing and the disentanglement of their operators. Some initial members of sequences of expectation values for squeezed vacuum states are collected in Appendix E.

Exploring Ester Prodrugs: A Comprehensive Review of Approaches, Applications, and Methods

The review provides an overview of the approaches, applications, and methods for ester prodrugs. Ester prodrugs are pharmacologically inactive compounds in their original form but become active drugs on biotransformation within the body, which offers advantages concerning the solubility, stability, and targeted delivery of the active drug. Several approaches of ester prodrugs have been reviewed in this review, including simple ester prodrugs, amino acid ester prodrugs, sugar ester prodrugs, lipid ester prodrugs, and polymeric ester prodrugs. This review incorporates in vitro and in vivo methods as well as the characterization of physical and chemical properties for ester prodrugs, cell culture systems, enzymatic assays, and animal models—all of these having a very important bearing on the evaluation of stability, bioavailability, and efficacy for ester prodrugs. While the benefits of using ester prodrugs are significant, there are also disadvantages like instability, poor or variable enzymatic hydrolysis, and toxicity from released promoieties or by-products. This review discusses solutions to the various limitations that include enhancing stability with ionizable promoieties and using physiologically-based pharmacokinetic modeling. The review also highlights the application of ester prodrugs in neurological disorders, such as Parkinson’s disease, and the ongoing efforts to address the critical limitations in treatment efficacy. Future prodrug strategies are poised to advance significantly by harnessing diverse transport mechanisms across the blood-brain barrier and integrating nanotechnology.

Sequential Approach with Matrix Framework for Various Types of Economic Thermal Power Dispatch Problems

This paper presents a sequential approach with matrix framework for solving various kinds of economic dispatch problems. The objective of the economic dispatch problems of electrical power generation is to schedule the committed generating units output so as to meet the required load demand while satisfying the system equality and inequality constraints. This is a maiden approach developed to obtain the optimal dispatches of generating units for all possible load demands of power system in a single execution. The feasibility of the proposed method is demonstrated by solving economic load dispatch problem, combined economic and emission dispatch problem, multiarea economic dispatch problem and economic dispatch problem with multiple fuel options. The proposed methodology is tested with different scale of power systems. The generating unit operational constraints are also considered. The simulation results obtained by proposed methodology for various economic dispatch problems are compared with previous literatures in terms of solution quality. Numerical simulation results indicate an improvement in total cost saving and hence the superiority of the proposed method is also revealed for economic dispatch problems.

Exploring the Effects of Gap-Penalties in Sequence-Alignment Approach to Polymorphic Virus Detection

Antiviral software systems (AVSs) have problems in identifying polymorphic variants of viruses without explicit signatures for such variants. Alignment-based techniques from bioinformatics may provide a novel way to generate signatures from consensuses found in polymorphic variant code. We demonstrate how multiple sequence alignment supplemented with gap penalties leads to viral code signatures that generalize successfully to previously known polymorphic variants of JS. Cassandra virus and previously unknown polymorphic variants of W32.CTX/W32.Cholera and W32.Kitti viruses. The implications are that future smart AVSs may be able to generate effective signatures automatically from actual viral code by varying gap penalties to cover for both known and unknown polymorphic variants.

Regional Brand and High-quality Development of Fruits in Ethnic Areas of the Yangtze River Economic Belt under the Greater Food Approach

Establishing the Greater Food Approach and promoting the Yangtze River Economic Belt s national major regional development strategy can better support and serve the agricultural power and Chinese-style modernization.This paper introduces the characteristics of fruit industry in 16 autonomous prefectures and 47 autonomous counties under the jurisdiction of the Yangtze River Economic Belt.It studies the intellectual property resources of brand marks from the aspects of geographical indications,collective trademarks,certification trademarks,well-known trademarks in China and national design patents,and analyzes the main problems of brand and high-quality development of fruit industry in these ethnic autonomous areas.Finally,it puts forward some strategies,such as improving the protection of intellectual property rights of geographical indications,using intellectual property rights of brand signs,building modern seed industry upgrading project,drawing lessons from the experience of thousand villages demonstration project,ensuring that large-scale poverty does not occur,and building a diversified food supply system.

Enhancing perianal disease management with integrated physical and psychological approaches

This article provides a comprehensive analysis of the study by Hou et al,focusing on the complex interplay between psychological and physical factors in the postoperative recovery(POR)of patients with perianal diseases.The study sheds light on how illness perception,anxiety,and depression significantly influence recovery outcomes.Hou et al developed a predictive model that demonstrated high accuracy in identifying patients at risk of poor recovery.The article explores the critical role of pre-operative psychological assessment,highlighting the need for mental health support and personalized recovery plans in enhancing POR quality.A multidisciplinary approach,integrating mental health professionals with surgeons,anesthesiologists,and other specialists,is emphasized to ensure comprehensive care for patients.The study’s findings serve as a call to integrate psychological care into surgical practice to optimize outcomes for patients with perianal diseases.

An Overview of the Multi-Band and the Generalized BCS Equations-Based Approaches to Deal with Hetero-Structured Superconductors

We trace the conceptual basis of the Multi-Band Approach (MBA) and recall the reasons for its wide following for composite superconductors (SCs). Attention is then drawn to a feature that MBA ignores: the possibility that electrons in such an SC may also be bound via simultaneous exchanges of quanta with more than one ion-species—a lacuna which is addressed by the Generalized BCS Equations (GBCSEs). Based on several papers, we give a concise account of how this approach: 1) despite employing a single band, meets the criteria satisfied by MBA because a) GBCSEs are derived from a temperature-incorporated Bethe-Salpeter Equation the kernel of which is taken to be a “superpropagator” for a composite SC-each ion-species of which is distinguished by its own Debye temperature and interaction parameter and b) the band overlapping the Fermi surface is allowed to be of variable width. GBCSEs so-obtained reduce to the usual equations for the Tc and Δ of an elemental SC in the limit superpropagator → 1-phonon propagator;2) accommodates moving Cooper pairs and thereby extends the scope of the original BCS theory which restricts the Hamiltonian at the outset to terms that correspond to pairs having zero centre-of-mass momentum. One can now derive an equation for the critical current density (j0) of a composite SC at T = 0 in terms of the Debye temperatures of its ions and their interaction parameters— parameters that also determine its Tc and Δs;3) transforms the problem of optimizing j0 of a composite SC, and hence its Tc, into a problem of chemical engineering;4) provides a common canopy for most composite SCs, including those that are usually regarded as outside the purview of the BCS theory and have therefore been called “exceptional”, e.g., the heavy-fermion SCs;5) incorporates s±-wave superconductivity as an in-built feature and can therefore deal with the iron-based SCs, and 6) leads to presumably verifiable predictions for the values of some relevant parameters, e.g., the effective mass of electrons, for the SCs for which it has been employed.

Wide-Area Delay-Dependent Adaptive Supervisory Control of Multi-machine Power System Based on Improve Free Weighting Matrix Approach

The paper demonstrates the possibility to enhance the damping of inter-area oscillations using Wide Area Measurement (WAM) based adaptive supervisory controller (ASC) which considers the wide-area signal transmission delays. The paper uses an LMI-based iterative nonlinear optimization algorithm to establish a method of designing state-feedback controllers for power systems with a time-varying delay. This method is based on the delay-dependent stabilization conditions obtained by the improved free weighting matrix (IFWM) approach. In the stabilization conditions, the upper bound of feedback signal’s transmission delays is taken into consideration. Combining theoriesof state feedback control and state observer, the ASC is designed and time-delay output feedback robust controller is realized for power system. The ASC uses the input information from Phase Measurement Units (PMUs) in the system and dispatches supplementary control signals to the available local controllers. The design of the ASC is explained in detail and its performance validated by time domain simulations on a New England test power system (NETPS).

Caudal approach to pure laparoscopic posterior sectionectomy under the laparoscopy-specific view

AIM:To study our novel caudal approach laparoscopic posterior-sectionectomy with parenchymal transection prior to mobilization under laparoscopy-specific view.METHODS:Points of the procedure are:(1) Patients are put in left lateral position and posterior sector is not mobilized;(2) Glissonian pedicle of the sector is encircled and clamped extra-hepatically and divided afterward during the transection;(3) Dissection of inferior vena cava(IVC) anterior wall behind the liver is started from caudal.Simultaneously,liver transection is performed to search right hepatic vein(RHV) from caudal;(4) Liver transection proceeds to the bifurcation of the vessels from caudal to cranial,exposing the surfaces of IVC and RHV.Since the remnant liver sinks down,the cutting surface is well-opend;and(5) After the completion of transection,dissection of the resected liver from retroperitoneum is easily performed using the gravity.This approach was performed for a 63 years old woman with liver metastasis close to RHV.RESULTS:RHV exposure is required for R0 resection of the lesion.Although the cutting plane is horizontal in supine position and the gravity obstructs the exposure in the small subphrenic space,the use of specific characteristics of laparoscopic hepatectomy,such as the good vision for the dorsal part of the liver and IVC and facilitated dissection using the gravity with the patient positioning,made the complete RHV exposure during the liver transection easy to perform.The operation time was 341 min and operative blood loss was 1356 mL.Her postoperative hospital stay was uneventfull and she is well without any signs of recurrences 14 mo after surgery.CONCLUSION:The new procedure is feasible and useful for the patients with tumors close to RHV and the need of the exposure of RHV.

Efficient Approach for 3D Stationary Optical Solitons in Dissipative Systems

We feature the stationary solutions of the 3D complex cubic-quintic Ginzburg-Landau equation (CGLE). Our approach is based on collective variables approach which helps to obtain a system of variational equations, giving the evolution of the light pulses parameters as a function of the propagation distance. The collective variables approach permits us to obtain, efficiently, a global mapping of the 3D stationary dissipative solitons. In addition it allows describing the influence of the parameters of the equation on the various physical parameters of the pulse and their dynamics. Thus it helps to show the impact of dispersion and nonlinear gain on the stationary dynamic.

Colorectal liver metastases:An update on multidisciplinary approach

Liver metastasis is the commonest form of distant metastasis in colorectal cancer.Selection criteria for surgery and liver-directed therapies have recently been extended.However,resectability remains poorly defined.Tumour biology is increasingly recognized as an important prognostic factor;hence molecular profiling has a growing role in risk stratification and management planning.Surgical resection is the only treatment modality for curative intent.The most appropriate surgical approach is yet to be established.The primary cancer and the hepatic metastasis can be removed simultaneously or in a two-step approach;these two strategies have comparable long-term outcomes.For patients with a limited future liver remnant,portal vein embolization,combined ablation and resection,and associating liver partition and portal vein ligation for staged hepatectomy have been advocated,and each has their pros and cons.The role of neoadjuvant and adjuvant chemotherapy is still debated.Targeted biological agents and loco-regional therapies(thermal ablation,intra-arterial chemo-or radio-embolization,and stereotactic radiotherapy) further improve the already favourable results.The recent debate about offering liver transplantation to highly selected patients needs validation from large clinical trials.Evidencebased protocols are missing,and therefore optimal management of hepatic metastasis should be personalized and determined by a multi-disciplinary team.

Effects of hurricane forward speed and approach angle on storm surges: an idealized numerical experiment

The effects of hurricane forward speed(V)and approach angle(θ)on storm surge are important and a systematic investigation covering possible and continuous ranges of these parameters has not been done before.Here we present such a study with a numerical experiment using the Finite Volume Community Ocean Model(FVCOM).The hurricane track is simplified as a straight line,such that V andθfully define the motion of the hurricane.The maximum surge is contributed by both free waves and a forced storm surge wave moving with the hurricane.Among the free waves,Kelvin-type waves can only propagate in the down-coast direction.Simulations show that those waves can only have a significant positive storm surge when the hurricane velocity has a down-coast component.The optimal values of V andθthat maximize the storm surge in an idealized semi-circular ocean basin are functions of the bathymetry.For a constant bathymetry,the maximum surge occurs when the hurricane approaches the coast from the normal direction when the free wave generation is minimal;for a stepped bathymetry,the maximum surge occurs at a certain acute approach angle which maximizes the duration of persistent wind forcing;a step-like bathymetry with a sloped shelf is similar to the stepped bathymetry,with the added possibility of landfall resonance when the free and forced waves are moving at about the same velocity.For other cases,the storm surge is smaller,given other parameters(hurricane size,maximum wind speed,etc.)unchanged.

<i>PP</i>and <i>P<span style='text-decoration:overline;'>P</span></i>Multi-Particles Production Investigation Based on CCNN Black-Box Approach

The multiplicity distribution (P(nch)) of charged particles produced in a high energy collision is a key quantity to understand the mechanism of multiparticle production. This paper describes the novel application of an artificial neural network (ANN) black-box modeling approach based on the cascade correlation (CC) algorithm formulated to calculate and predict multiplicity distribution of proton-proton (antiproton) (PP and PP ) inelastic interactions full phase space at a wide range of center-mass of energy . In addition, the formulated cascade correlation neural network (CCNN) model is used to empirically calculate the average multiplicity distribution nch> as a function of . The CCNN model was designed based on available experimental data for = 30.4 GeV, 44.5 GeV, 52.6 GeV, 62.2 GeV, 200 GeV, 300 GeV, 540 GeV, 900 GeV, 1000 GeV, 1800 GeV, and 7 TeV. Our obtained empirical results for P(nch), as well as nch> for (PP and PP) collisions are compared with the corresponding theoretical ones which obtained from other models. This comparison shows a good agreement with the available experimental data (up to 7 TeV) and other theoretical ones. At full large hadron collider (LHC) energy ( = 14 TeV) we have predicted P(nch) and nch> which also, show a good agreement with different theoretical models.

Skeletal dysplasias: A radiographic approach and review of common non-lethal skeletal dysplasias

Skeletal dysplasias are not uncommon entities and a radiologist is likely to encounter a suspected case of dysplasia in his practice. The correct and early diagnosis of dysplasia is important for management of complications and for future genetic counselling. While there is an exhaustive classification system on dysplasias, it is important to be familiar with the radiological features of common dysplasias. In this article, we enumerate a radiographic approach to skeletal dysplasias, describe the essential as well as differentiating features of common non-lethal skeletal dysplasias and conclude by presenting working algorithms to either definitively diagnose a particular dysplasia or suggest the most likely differential diagnoses to the referring clinician and thus direct further workup of the patient.

The New Approach for Risk Regulation in Banks

The purpose of this report is to present the necessity of proceeding to new reforms in bank regulation and to increase the stability and risk sensitivity of the capital base under applying the Standardised Credit Risk Assessment Approach (SCRA) in banks. The dynamics in the bank regulation and supervision of credit risk assessment approaches are explored. In the paper, a thorough theoretical-methodological and historical-logical analysis was made of the evolution of the development and chronology of the global regulatory frameworks for banks—Basel 1, Basel 2, and Basel 3. The contemporary projections and challenges for the banks’ management under the new regulatory and institutional changes are presented. The SCRA is a positive asset in bank capital regulation in contemporary banking. The revisions to the regulatory framework by Basel 3 are a long continuous process influenced by numerous economic, social, and political factors. The preparation of the Bulgarian banking system for a new reform of financial regulation is analyzed. The need for adoption of a new risk-based approach for capital assessment and the importance of transparency in bank financial reporting is proved.

Induced pluripotent stem cell-related approaches to generate dopaminergic neurons for Parkinson's disease

The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative disease.Although the detailed pathogenesis accounting for dopaminergic neuron degeneration in Parkinson's disease is still unclear,the advancement of stem cell approaches has shown promise for Parkinson's disease research and therapy.The induced pluripotent stem cells have been commonly used to generate dopaminergic neurons,which has provided valuable insights to improve our understanding of Parkinson's disease pathogenesis and contributed to anti-Parkinson's disease therapies.The current review discusses the practical approaches and potential applications of induced pluripotent stem cell techniques for generating and differentiating dopaminergic neurons from induced pluripotent stem cells.The benefits of induced pluripotent stem cell-based research are highlighted.Various dopaminergic neuron differentiation protocols from induced pluripotent stem cells are compared.The emerging three-dimension-based brain organoid models compared with conventional two-dimensional cell culture are evaluated.Finally,limitations,challenges,and future directions of induced pluripotent stem cell–based approaches are analyzed and proposed,which will be significant to the future application of induced pluripotent stem cell-related techniques for Parkinson's disease.

A Hybrid Unit Commitment Approach Incorporating Modified Priority List with Charged System Search Methods

This paper presents a new hybrid approach that combines Modified Priority List (MPL) with Charged System Search (CSS), termed MPL-CSS, to solve one of the most crucial power system’s operational optimization problems, known as unit commitment (UC) scheduling. The UC scheduling problem is a mixed-integer nonlinear problem, highly-dimensional and extremely constrained. Existing meta-heuristic UC solution methods have the problems of stopping at a local optimum and slow convergence when applied to large-scale, heavily-constrained UC applications. In the first step of the proposed method, initial hourly optimum solutions of UC are obtained by Modified Priority List (MPL);however, the obtained UC solution may still be possible to be further improved. Therefore, in the second step, the CSS is utilized to achieve higher quality solutions. The UC is formulated as mixed integer linear programming to ensure the tractability of the results. The proposed method is successfully applied to a popular test system up to 100 units generators for both 24-hr and 168-hr system. Computational results show that both solution cost and execution time are superior to those of published methods.

Productivity Growth, Technological Progress, and Efficiency Change in Vietnamese Manufacturing Industries: A Stochastic Frontier Approach

This study applies a stochastic frontier production approach to decompose the sources of total productivity (TFP) growth into technical progress and changes in technical efficiency of 8057 firms in Vietnamese manufacturing industries during 2003-2007. Using both total manufacturing industry and sub-manufacturing industrial regressions, the analysis focuses on the trend of technological progress (TP) and technical efficiency change (TEC), and the role of productivity change in economic growth. According to the estimated results, the annual technical progress for the manufacturing industry and sub-manufacturing industries are calculated directly from the estimated parameters of the translog stochastic frontier production function by taking a partial derivative of output with respect to time t. The average technical changes in manufacturing industry and sub-manufacturing industries are positive, with an average technical change about 5.2%, 5.8%, 5.4%, 11.8%, 4.6%, 4.1%, 7.3%, 4.8%, 4.8% and 4.8% for total sample, food products & beverages, textile & wearing apparel, footwear, paper & products, industrial chemicals, rubber & plastic products, non- metallic mineral, basic & fabricated metal and other sub-industries, respectively. Total TFP in the manufacturing sector has grown at the annual rate of 0.052, although the rate of growth decreased continuously during the sample period. For the sub-industry estimates during the sample period, TFP grew fastest in the footwear sub-industry, with annual average growth rate of 11.8%, followed by the rubber & plastic products with a rate of 7.3%, and the food products & beverages with a rate of 5.8% per annum.

A Theoretical Approach for Estimating Fracture Toughness of Ductile Metals

Fracture toughness is very important when applying Damage Tolerance Design and Assessment Techniques. The traditional testing approach for obtaining fracture toughness values is costly and time consuming. In order to estimate the fracture toughness of ductile metals, the fracture mechanics theory, materials plastic deformation theory and materials constructive relationships are employed here. A series of formulae and a theoretical approach are presented to calculate fracture toughness values of different materials in the plane stress and plane strain conditions. Compared with test results, evaluated values have a good agreement.

Bipolar hemiarthroplasty for femoral neck fracture using the direct anterior approach

AIM: To evaluate whether walking ability recovers early after bipolar hemiarthroplasty(BHA) using a direct anterior approach.METHODS: Between 2008 and 2010, 81 patients with femoral neck fracture underwent BHA using the direct anterior approach(DAA) or the posterior approach(PA). The mean observation period was 36 mo. The age, sex, body mass index(BMI), time from admission to surgery, length of hospitalization, outcome after discharge, walking ability, duration of surgery, blood loss and complications were compared. RESULTS: There was no significant difference in the age, sex, BMI, time from admission to surgery, length of hospitalization, outcome after discharge, duration of surgery and blood loss between the two groups. Two weeks after the operation, assistance was not necessary for walking in the hospital in 65.0% of the patients in the DAA group and in 33.3% in the PA group(P < 0.05). As for complications, fracture of the femoral greater trochanter developed in 1 patient in the DAA group and calcar crack and dislocation in 1 patient each in the PA group.CONCLUSION: DAA is an approach more useful for BHA for femoral neck fracture in elderly patients than total hip arthroplasty in terms of the early acquisition of walking ability.