Longitudinal changes in body weight of breastfeeding mothers in the first year after delivery and its relationship with human milk composition:a combined longitudinal and cross-sectional cohort study

Objective:Postpartum weight retention(PPWR)is a common problem among women after childbirth.The main objectives of this study are to understand the changes in body weight of breastfeeding mothers during long-term follow-up and preliminarily explore the relationship between maternal body weight and human milk composition,including macronutrients,leptin,and adiponectin.Methods:The study included a longitudinal cohort(122 mothers),and a cross-sectional cohort(37 mothers).The human milk,maternal weight,and dietary surveys were collected in the longitudinal cohort at different follow-up time points(1-14 days postpartum,2-4 months postpartum,5-7 months postpartum,and 12-17 months postpartum).The maternal body weight was analyzed using the responses in the survey questionnaires.A milk analyzer based on the mid-infrared spectroscopy(MIRS)was used to determine milk composition,and nutrition analysis software evaluated dietary intakes.In the cross-sectional cohort,participating mothers were asked to provide blood and human milk samples and pertinent information related to maternal body composition.Maternal body composition was measured by bioelectrical impedance analysis(BIA),while ELISA analyzed leptin and adiponectin in milk and serum.Results:At 5-7 months postpartum,the PPWR of breastfeeding mothers was(2.46±3.59)kg.At 12-17 months postpartum,the PPWR was(0.98±4.06)kg.PPWR was found to be negatively correlated with milk fat content within 14 days postpartum and positively correlated at 2-4 months postpartum.In addition,the maternal weight and body muscle mass were positively correlated with leptin and adiponectin in milk.Plasma leptin was positively correlated with the mother’s body weight,body mass index(BMI),FAT percentage,and body fat mass,while plasma adiponectin did not correlate with any parameter.The results also indicate that the PPWR did not correlate with leptin and adiponectin in plasma or milk.Conclusions:Breastfeeding mothers may retain considerable weight gain one year after delivery.Human milk composition may be related to changes in maternal body weight.Leptin and adiponectin in breast milk and leptin in plasma are associated with the maternal body composition.This study supports the notion that maternal nutritional status may affect offspring health through lactation,and future research should focus on exploring weight management of postpartum mothers.

Postoperative body weight change and its influencing factors in patients with gastric cancer

BACKGROUND The high incidence and mortality of gastric cancer(GC)pose a significant threat to human life and health,and it has become an important public health challenge in China.Body weight loss is a common complication after surgical treatment in patients with GC and is associated with poor prognosis and GC recurrence.However,current attention to postoperative weight change in GC patients remains insufficient,and the descriptions of postoperative weight change and its influencing factors are also different.AIM To investigate body weight changes in patients with GC within 6 mo after gastrectomy and identify factors that influence dynamic body weight changes.METHODS We conducted a prospective longitudinal study of 121 patients with GC and collected data before(T0)and 1(T1),3(T2),and 6(T3)mo after gastrectomy using a general data questionnaire,psychological distress thermometer,and body weight measurements.The general estimation equation(GEE)was used to analyze the dynamic trends of body weight changes and factors that influence body weight changes in patients with GC within 6 mo of gastrectomy.RESULTS The median weight loss at T1,T2,and T3 was 7.29%(2.84%,9.40%),11.11%(7.64%,14.91%),and 14.75%(8.80%,19.84%),respectively.The GEE results showed that preoperative body mass index(BMI),significant psychological distress,religious beliefs,and sex were risk factors for weight loss in patients with GC within 6 mo after gastrectomy(P<0.05).Compared with preoperative low-weight patients,preoperative obese patients were more likely to have weight loss(β=14.685,P<0.001).Furthermore,patients with significant psychological distress were more likely to lose weight than those without(β=2.490,P<0.001),and religious patients were less likely to lose weight 6 mo after gastrectomy than those without religious beliefs(β=-6.844,P=0.001).Compared to female patients,male patients were more likely to experience weight loss 6 mo after gastrectomy(β=4.262,P=0.038).CONCLUSION Male patients with GC with high preoperative BMI,significant psychological distress,and no religious beliefs are more likely to lose weight after gastrectomy.

The Mediating Effect of Body Dissatisfaction in Association between Obesity and Dietary Behavior Changes for Weight Loss in Chinese Children

Objective The aim of this study was to analyze the mediating effect of body dissatisfaction in correlation between obesity and dietary behavior changes for weight loss(DBCWL).Methods A total of 680 primary and middle school students were included in this study. Their body height, weight, and waistline were effectively measured, and they were also evaluated to assess their body dissatisfaction, perception of dietary behaviors, and DBCWL. The correlation among these factors was analyzed using mediating effect models.Results The prevalence of overweight/obesity and abdominal obesity was significantly higher in males than in females(P < 0.05). Overweight/obesity, abdominal obesity, and body dissatisfaction significantly increased the risk for DBCWL(OR = 2.57, 2.77, and 1.95, respectively). Overweight/obesity and abdominal obesity significantly increased the risk for body dissatisfaction(OR = 6.00 and 4.70,respectively). Significant mediating effects of body dissatisfaction were observed in correlation between overweight/obesity and DBCWL and between abdominal obesity and DBCWL(OR = 2.20 and 1.92,respectively;P < 0.05), and the proportions of mediating effects among the total effects were 48.89% and 46.60%, respectively.Conclusion Body dissatisfaction might play an important mediating effect in association between DBCWL and obesity, which indicates that guiding children to correctly recognize their body might be more conducive than promoting obese children toward weight loss through dietary behavior changes.

Analysis of influencing factors and interaction of body weight and disease outcome in patients with prediabetes

BACKGROUND The trend of prediabetes progressing to type 2 diabetes mellitus(T2DM)is prominent,and effective intervention can lead to a return to prediabetes.Exploring the factors influencing the outcome of prediabetes is helpful to guide clinical intervention.The weight change in patients with prediabetes has not attracted much attention.AIM To explore the interaction between body weight and the factors affecting the progression of prediabetes to T2DM.METHODS We performed a retrospective analysis of 236 patients with prediabetes and 50 with normal glucose tolerance(NGT),and collected clinical data and follow-up results of all patients.Based on natural blood glucose outcomes,we classified 66 patients with progression to T2DM into the disease progression(DP)group,and 170 patients without progression to T2DM into the disease outcome(DO)group.We analyzed the factors that influenced prediabetes outcome and the influence of body weight on prediabetes blood glucose outcome by unconditional logistic regression.A general linear model(univariate)was used to analyze the interaction between body weight and independent influencing factors.RESULTS There were 98 cases of impaired fasting glucose(IFG),90 cases of impaired glucose tolerance(IGT),and 48 cases of coexistent IFG and IGT.The body weight,waist circumference,body mass index,fasting blood glucose,and 2 h plasma glucose of patients with IFG,IGT,and coexistent IFG and IGT were higher than those in patients with NGT(P<0.05).Logistic regression analysis showed that body weight,glycosylated hemoglobin,uric acid,fasting insulin,and homeostatic model assessment for insulin resistance were independent factors affecting progression of prediabetes to T2DM(P<0.05).Receiver operating characteristic curve analysis showed that the area under the curve predicted by the above indicators combined was 0.905[95%confidence interval(CI):0.863-0.948],which was greater than that predicted by each indicator alone.Logistic regression analysis with baseline body weight as an independent variable showed that compared with body weight 1,the odds ratio(95%CI)of body weight 3 was 1.399(1.142-2.126)(P=0.033).There was a multiplicative interaction between body weight and uric acid(β=1.953,P=0.005).CONCLUSION High body weight in patients with prediabetes is an independent risk factor for progression to T2DM,and the risk of progression is increased when coexisting with high uric acid level.

Predictive value of extravascular lung water indexed to predicted body weight

AIM: To investigate extravascular lung water indexed to predicted body weight(EVLWIp) and actual body weight(EVLWIa) on outcome of patients with severe sepsis.METHODS: Transpulmonary thermodilution was prospectively used to measure cardiovascular hemodynamics, EVLWIp and EVLWIa via an arterial catheter placed in each patient within 48 h of meeting the criteria for severe sepsis from a medical intensive care unit(ICU) at a university affiliated hospital. Survival was the single dependent variable. In order to examine and compare the predictive power of EVLWIp, EVLWIa and other clinically significant factors in predicting the inhospital survival status of severe sepsis patients in the medical ICU, a receiver operating characteristic(ROC) curve method to analyze the significant variables and the area under the ROC curve(AUC) of the variables, P value and 95%CI were calculated.RESULTS: In total, 33 patients were studied. In the ROC curve method analyses, EVLWIp(the AUC: 0.849; P = 0.001, 95%CI: 0.72-0.98) was as predictive for inhospital survival rate as variables with EVLWIa(AUC, 0.829; P = 0.001, 95%CI: 0.68-0.98). The proportion of patients surviving with a low EVLW(EVLWI < 10 m L/kg) was better than that of patients with a higher EVLW, whether indexed by actual(HR = 0.2; P = 0.0002, 95%CI: 0.06-0.42) or predicted body weight(HR = 0.13; P < 0.0001, 95%CI: 0.05-0.35) during their hospital stay with the Kaplan-Meier method(76% vs 12.5%, respectively).CONCLUSION: This investigation proposed that EVLWIp is as good a predictor as EVLWIa to predict inhospital survival rate among severe sepsis patients in the medical ICU.

Body Image Disturbance and Dissatisfaction, Scorn and Stigma in Severely Obese Individuals, a Case-Control Study

Background: The obesity rate is rising. The aims of this study were to elucidate the connection among body image disturbance and dissatisfaction, scorn and stigma in severely obese individuals using a case-control method. Method: The study group consisted of 112 individuals receiving permanent disability pensions primarily for obesity. The controls were selected by random sampling. The controls were matched with the subjects by place of residence, gender, age, the time since the pension was granted and occupation. Psychiatric interviews and psychological assessments were conducted with all participants. The results were analyzed via chi-squared tests (χ2-tests) and percent distributions. The subject and control groups were compared via paired t-tests. Conditional logistic regression analysis was also conducted. Results: In the Draw a Person test, we found disorganization of the body image to some degree in the subject group. Some significant differences were found between the Machover index and the wholeness index. The Rorschach variables obtained some differences in the responses between the subject and control groups. Obesity was a problem in all age groups. In the study group, half of the participants thought that they were obese. Most of the participants had endured scorn and contempt directed at them due to being overweight. Conclusions: We believe that our study provides a novel and necessary overview of the connection among body image disturbance and dissatisfaction, scorn and stigma.

Effects of Incretin-based Therapies on Weight-related Indicators among Patients with Type 2 Diabetes: A Network Meta-analysis

Objective To evaluate the effects of incretin-based therapies on body weight as the primary outcome,as well as on body mass index(BMI)and waist circumference(WC)as secondary outcomes.Methods Databases including Medline,Embase,the Cochrane Library,and clinicaltrials.gov(www.clinicaltrials.gov)were searched for randomized controlled trials(RCTs).Standard pairwise meta-analysis and network meta-analysis(NMA)were both carried out.The risk of bias(ROB)tool recommended by the Cochrane handbook was used to assess the quality of studies.Subgroup analysis,sensitivity analysis,meta-regression,and quality evaluation based on the Grading of Recommendations Assessment,Development,and Evaluation(GRADE)were also performed.Results A total of 292 trials were included in this study.Compared with placebo,dipeptidyl-peptidase IV inhibitors(DPP-4 Is)increased weight slightly by 0.31 kg[95%confidence interval(CI):0.05,0.58]and had negligible effects on BMI and WC.Compared with placebo,glucagon-like peptide-1 receptor agonists(GLP-1 RAs)lowered weight,BMI,and WC by-1.34 kg(95%CI:-1.60,-1.09),-1.10 kg/m2(95%CI:-1.42,-0.78),and-1.28 cm(95%CI:-1.69,-0.86),respectively.Conclusion GLP-1 RAs were more effective than DPP-4 Is in lowering the three indicators.Overall,the effects of GLP-1 RAs on weight,BMI,and WC were favorable.

Analysis of the Effects of Maternal Body Mass Index and Gestational Weight Gain on Maternal and Neonatal Outcomes in Twin Pregnancy

Objective:To investigate the effects of maternal body mass index(BMI)and gestational weight gain on maternal and neonatal outcomes in twin pregnancies.Methods:Five hundred cases of twin pregnancies were divided into a low body weight group(68 cases),a normal weight group(355 cases),an overweight group(65 cases),and an obesity group(12 cases)according to the World Health Organization(WHO)Body Mass Index(BMI)classification guidelines Results:Comparison of weight gain during different pregnancies revealed that pregnant women were mainly of low weight and average weight.The higher the BMI before pregnancy,the higher the incidence of excessive weight gain during pregnancy.The incidences of gestational diabetes mellitus(GDM)and premature rupture of membranes in women with low weight gain were significantly higher than those in women with average weight gain and high weight gain(P<0.05).The incidences of gestational hypertension,preeclampsia,and anemia in women with high weight gain were significantly higher than those in women with low weight gain and average weight gain(P<0.05).The incidence of neonatal birth weight,fetal distress,and macrosomia in the high weight gain group was significantly higher than those in the low weight gain and average weight gain groups(P<0.05).The birth weight of newborns in low-weight gain mothers was significantly lower than that of normal-weight gain mothers(P<0.05).Conclusion:Poor maternal and infant outcomes were common in women with insufficient or excessive weight gain during pregnancy.Therefore,for women with twin pregnancies,weight management is crucial to ensure maternal and infant health.

A pilot study in relationship among changes in visceral fat area, waist circumference and body weight in Japanese freshmen students

We investigated the relationship among delta (delta represents changes in parameters) visceral fat area, waist circumference and body weight in Japanese freshmen students. Visceral fat was measured at the umbilical level using computerized tomography scanning at baseline study and 6 months later. Body weight and height, as well as waist circumference were also measured. We found that visceral fat area, waist circumference, and body weight significantly correlated with each other at baseline, and 6 months later, delta visceral fat area and changes in % visceral fat area significantly correlated with delta waist circumference and delta body weight in female and in total subjects. In addition, based on the predictive linear equations from the regression analysis, we found that 1kg of delta body weight corresponded to 0.83 cm of delta waist circumference, and 1kg of delta body weight and 1cm of delta waist circumference corresponded to 9.41% and 7.80% of changes in visceral fat area, respectively, in total subjects. The present results suggest that delta visceral fat area is closely related to delta body weight and delta waist circumference in Japanese freshmen students.

Relationships between body weight and other morphological traits in young sea cucumbers Apostichopus japonicas

Correlation, multiple regression, and path analyses were used to investigate the relationships between body weight and three other morphological traits in juvenile Japanese sea cucumbers Apostichopus japonicus . We measured live body weight (BW), body length (BL), numbers of papillae (NP), and numbers of tube feet (NF) at 60, 80, 100, and 130 days post-hatching (dph). We calculated path correlation coefficients, correlation indices ( R 2 ), and coefficients of determination with BW as the dependent variable and the other morphological traits as independent variables. The coefficient of variation for BW was high across all age groups, and all measured morphological traits were significantly correlated ( P < 0.01). BL had the greatest direct eff ect on BW across all age groups (60 dph, 0.526;80 dph, 0.404;100 dph, 0.620;and 130 dph, 0.681), while NF had the greatest indirect eff ect on BW across all age groups (60 dph, 0.528;80 dph, 0.452;100 dph, 0.666;and 130 dph, 0.603). Regression analyses between morphological traits and BW indicated that R 2 was greater than 0.85 only in the 100-dph specimens. The indirect eff ects of the other measured morphological traits on BW were age-dependent. The optimal regression equations, as determined with stepwise regression, were, for 60-dph specimens: BW 60 =10 (-3.04+0.092BL+0.014NP+0.014NF)( R 2 =0.632);for 80-dph specimens: BW 80 =10 (- 3.035+0.056BL+0.017NP+0.02NF)( R 2 =0.686);for 100-dph specimens: BW 100 =10 (- 3.742+0.069BL+0. 633 · lg (NP)+0. 464 · lg (NF))( R 2 =0.893);and for 130-dph specimens: BW 130 =10 (- 2.472+0.065BL+0.012NP)( R 2 =0.774). Our work clarified the correlation between various morphological traits and body weight of a commercially-important sea cucumber species ( A . japonicus ). Our predictive models for body weight might be useful for the aquaculture and selective breeding of A . japonicus . These models might also provide theoretical support for the indirect selection of traits that are difficult to select directly.

Living donor liver transplantation with body-weight more or less than 10 kilograms

AIM: To compare the outcomes of pediatric patients weighing less than or more than 10 kg who underwent liver transplantation.METHODS: Data for 196 pediatric patients who underwent living donor liver transplantation between June 1994 and February 2011 were reviewed retrospectively.The information for each patient was anonymized and de-identified before analysis. The data included information regarding the pre-transplant conditions, intraoperative fluid replacement and outcomes for each patient. The 196 patients were divided into two groups: those with body weights of less than 10 kg were included in group 1(G1; n =101), while those with body weights of more than 10 kg were included in group 2(G2; n = 95). For each group, the patients' ages, body weights, heights,pediatric end stage liver disease scores, anesthesia times, and warm and cold ischemic times were analyzed. In addition, between-group comparisons were also made. Mann-Whitney U tests were used to compare all the variables except for complications and survival rates, which were analyzed using χ 2 tests and Kaplan-Meier tests, respectively.RESULTS: The general medical conditions of the G1patients were worse than those of the G2 patients, as shown by the higher pediatric end stage liver disease scores and poorer Z-scores. In addition, the preoperative Hb and serum albumin levels were all lower for the G1 patients than for the G2 patients. The G1 patients also had significantly more intraoperative blood loss than the G2 patients. In addition, the intraoperative fluid requirements for the G1 patients,including leukocyte poor red blood cell transfusions,5% albumin infusions and crystalloid infusions, were significantly higher than those for the G2 patients. The risk of intraoperative portal vein thrombosis was higher for the patients in G1 than for those in G2. However,the one-year survival rates(95.9% and 96.8% for G1 and G2, respectively) and three-year survival rates(94.9% and 94.6% for G1 and G2, respectively) for both groups were similar.CONCLUSION: Patients weighing less than 10 kg typically have poorer conditions, but their survival rates are comparable to those of children weighing more than 10 kg.

Prediction Equation of Body Weight of Amazonian Manatee (Trichechus inunguis) Calves in Captivity Using Biometry

The objective of the study was to determine a prediction equation of body weight of Amazonian manatee calves in captivity using their biometry. It was conducted out with 7 calves (4 males and 3 females) of approximately 8 months of age and average body weight of 29.94 ± 0.055 kg, arranged in pools of sufficient size. Biometry and weighing were performed periodically, with the following measurements: body weight (BW), total curved length (TCL), total length (TL), circumference (CIR), fin width (FW), tail width (TW) and peduncle (PED). Data were subjected to Pearson correlation analysis and linear regression, using the statistical software IBM SPSS 24.0. The results showed a significant correlation (P R2 = 0.855, R2aj = 0.852). In addition, three linear multiple regression equations of BW were calculated using the predictor variables previously analyzed by Person correlation analysis. The equation that used all biometric measurements (TCL, TL, FW, TW, CIR and PED) had the highest coefficient of determination and the lowest estimation error to predict BW. In conclusion, the biometric measurements of TCL, TL, FW, TW, CIR and PED showed a high correlation with the BW and can be used as predictive variables of BW of manatee calves, as they are easy to be measured.

Changes in fat but not fruit and vegetable intakes linked with body weight change in Mexican women immigrants in Quebec

The objective of the present study was to identify dietary parameters for predicting body weight change (ΔBW) in Mexican-born women (Mexicans) following immigration to Quebec City, Canada. Methods: Changes in fruit (ΔF), vegetable (ΔV), fruit and vegetable (ΔFV), and fat (ΔFat) intake were assessed according to post-immigration periods (1-5 years, 6-10 years, 11-20 years) using a food frequency questionnaire (FFQ). Anthropometric measures were also conducted in 87 Mexicans (study group) and 88 native-born Quebecers (comparison group) aged 18-65 years. Associations were calculated using full and partial robust regression models adjusting for potential confounders (origin, education, income, age, length of residence in Quebec City). Results: There was no difference in ΔBW between the groups. Body weight (BW) increased significantly in both Mexican (5.5 ± 0.9 kg, P < 0.0001) and Quebec women (4.7 ± 0.8 kg, P < 0.0001). ΔBW was positively correlated with ΔFat (β = 0.03, P = 0.003), but not correlated with origin, ΔF, or ΔV. ΔBW was negatively associated with education (β = –4.33, P = 0.007) and positively associated with length of residence (β = 0.3, P = 0.003). Partial models indicated ΔF (β = –1.35, P β = –1.04, P = 0.0001), and ΔFV (β = –2.27, P < 0.0001) were associated with origin, whereas net annual household income (β = 0.16, P = 0.04) was positively associated with ΔFat. Conclusions: Change in body weight could be predicted by length of residence, education, and change in fat intake in Mexican immigrant women and native-born Quebecers whereas changes in fruit and vegetable intakes could be predicted by Mexican or Quebec origin.

Effects of 17<i>β</i>-Estradiol on Dopamine D2 Receptors in Thiamine-Deficient Female Rats: Consequences on Sucrose, Alcohol, Water Intakes and Body Weight

Our previous studies showed that 17β-estradiol (E2) modulated dopamine D2 receptor in regulating body weight set-point. The aim of this study was to understand whether thiamine deficiency influenced the E2 modulation on dopamine D2 receptors, using bromocriptine mesylate (BR) and sulpiride (SUL) as selective central dopamine-D2 receptors agonist and antagonist respectively. We studied the E2-dopamine D2 receptors interferences in a 10-day thiamine-deficient female rats for which consumptions of water, sugar, alcohol and food were daily-recorded and their consequences on body weights assessed. Our results showed that the volume of water daily ingested doubled in thiamine-deficient female rats (OXT), while sugar and alcohol consumptions collapsed with decreased weight and food consumption. On the one hand, thiamine potentiated D2/BR activity (bromocriptine-activated D2 receptors) to induce sugar intake and inhibited the same D2/BR receptors to induce water intake. On the other hand, thiamine promoted D2/SUL receptors (sulpiride-inhibited D2 receptors) for enhanced alcohol intake, increased food consumption and weight gain. Taking together, thiamine modulated the actions of 17β-estradiol on both D2/BR and D2/SUL receptors activities.

沙棘木蠹蛾的人工饲养

采用A、B和C 3种饲料饲养沙棘木蠹蛾Holcocerushippophaecolus,A饲料成分为水、玉米粉、豆粉、蔗糖、琼脂、酵母粉、山梨酸钾、对羟基苯甲酸甲酯 ;B饲料成分为水、玉米粉、豆粉、琼脂、酵母粉、抗坏血酸、苯甲酸钠 ;C饲料成分为大豆粉、沙棘木粉、蔗糖、琼脂、维生素混合液、酵母浸粉、抗坏血酸、防腐剂混合液、无机盐。其中 ,B饲料防腐能力较差 ,饲养 1 2周后放弃。A和C 2种饲料能使沙棘木蠹蛾幼虫体重持续增长 ,饲养前期A饲料平均体重增量是C饲料的 1 6倍 ,A和C 2种饲料化蛹率分别为83. 3 %和 66. 7% ,羽化率分别为 3 0 % ,1. 6 7%。选择在沙土中结茧化蛹 ,能显著提高饲养成功率。

Relationships among body weight,lipids and bone mass in elderly individuals with fractures:A case-control study

BACKGROUND The prevalence of osteoporosis and low bone mass is steadily rising each year.Low body weight is commonly linked to diminished bone mass and serves as a robust predictor of osteoporosis.Nonetheless,the connection between body mass index(BMI),bone mineral density,and lipid profiles among the elderly remains elusive.AIM To examine the association between BMI and bone mass,explore the correlation between lipid profiles and bone mass,and delve into the interplay between lipid metabolism and bone health.METHODS The study included 520 patients aged≥65 years(178 men and 342 women).Age,sex,weight,and height were recorded.Femoral neck bone mineral density and T scores were determined using a dual-energy X-ray absorptiometry scanner.Blood calcium(Ca),phosphorus(P),albumin(ALB),alkaline phosphatase(ALP),aspartate aminotransferase,alanine aminotransferase,triglyceride(TG),total cholesterol(TC),high-density lipoprotein(HDL)and low-density lipoprotein(LDL)levels were measured.Patients were classified by sex(male and female),age(65-79 years and≥80 years),and T score(normal bone mineral density,osteopenia and osteoporosis).RESULTS Age,sex,BMI,and ALP and TG levels were independent risk factors for osteoporosis.For the 65-79-and≥80-yearold groups,females presented lower T scores than males.Ca,P,ALB,ALP,TC,HDL and LDL levels were significantly different between men and women in the 65-79-year-old group.In addition,BMI and TG levels were significantly decreased in osteoporotic patients compared with patients with normal bone mass.TC levels declined in 65-to 79-year-old male and female osteoporosis patients.In the group of women aged≥80 years,osteoporotic patients showed significantly increased ALP levels.Furthermore,we found positive correlations between BMI and TG levels in the male and female patient groups.However,we found no significant differences in ALB,Ca,P,HDL and LDL levels in osteoporotic patients compared to patients with normal bone mass.CONCLUSION Osteoporotic patients showed significantly decreased BMI and TG levels compared with those with normal bone mass.BMI showed positive correlations with TG levels in male and female patients.These results indicate correlations between BMI and bone mass and between lipid profiles and bone mass.

Feeding Behavior, Body Weight and Growth Rate during Post-Deprivation Period in Rats

Deprivation is an environmental experience that organisms are continually exposed to. However, few studies analyze deprivation effects on the consumption pattern during the post-deprivation period systematically. The aim of this study was to evaluate the deprivation effect on feeding pattern, growth rate and body weight during post-deprivation. Sixteen albino rats (3 months old at the beginning of the experiment) were exposed to 72-hour total food deprivation every 15 days. Food and water were freely available during non-deprivation periods. Rats completed three cycles comprised by a free access period followed by food deprivation. Once deprivation was removed, food and water consumption increased and then decreased, while body weight was recovered. Growth rate increased after every deprivation period and reached similar levels to those presented by the control group. Depriving rats from one commodity (i.e., food) cause them to restrain their consumption of the other freely available commodity (i.e., water). Results confirm that food deprivation modifies growth rate, water and food consumption. Additionally, during post-deprivation period, differences between males and females were not registered.

The relationship between maternal body fat and pre-implantation embryonic weight: Implications for survival and long-term development in an assisted reproductive environment

There can be little argument that embryo quality is one of the most critical factors in the success of assisted reproductive techniques. Yet the current methods of grading embryos are subjective at best. While a number of different groups have described more qualitative means of assessing embryo quality, the current standard remains morphology. Morphology has proven a good standard, but it does not allow for the detection of chromosomal abnormalities nor can it assess the biochemical status of the embryo prior to transfer. This laboratory recently described a method to estimate embryo weight and suggested weight might be a good indicator of biochemical status. The objective of the present study was to determine the relationship between maternal body composition and embryo weight and determine the influence maternal chemistry had on embryo development. The data continue to suggest that maternal body composition, especially body fat, influences the chemical nature of the embryo and may play a critical role in long-term survival.

Effect of dietary energy level on body weight, testicular development and semen quality of local barred chicken of the western highlands of Cameroon

This study was designed to examine the effects of dietary energy levels on some growth and reproductive parameters of local barred chickens in Cameroon. For this purpose, One hundred and forty four day-old barred male chicks, weighing 28.33 g in average were randomly divided into 12 groups of 12 chicks each. Three feeding programs (FP) comprising each a starter diet from day old to 12 weeks (S0: 2800 Kcal/Kg;S1: 2900 Kcal/Kg;S2: 3000 Kcal/Kg) and grower diet from 13 to 20 weeks (G0: 2900 Kcal/Kg;G1: 3000 Kcal/ Kg;G2: 3100 Kcal/Kg) were used and designated FP1, FP2 and FP3 respectively. Each of the FP was randomly allotted of 4 groups of 12 birds in a completely randomized design. Throughout experiment (1 day old to 20 weeks), body weight was recovered every 2 weeks. At 20 weeks of age, roosters were sacrificed;semen characteristic was analyzed and testes were characterized. Between 2 to 10 weeks old, body weight of cocks fed with FP3 was significantly higher (P < 0.05) as compared to others FP. Inversely, from 12 to 20 weeks, body weight of cocks receiving FP1 was significantly higher (P < 0.05) than that of cocks receiving feeding programs 2 and 3. At 20 weeks, 100% of cocks fed on FP3 produced semen versus 66.66% and 16.66% respectively for those on FP1 and FP2. Semen volume and mass motility of cocks fed on FP3 or FP1 were significantly (P < 0.05) higher than FP2. It was concluded that FP1 had more suitable dietary energy levels for growth and reproduction of local barred cocks.

<i>Tephrosia purpurea</i>Fraction Attenuates Lipid Accumulation and Adipogenesis in 3T3-L1 Adipocytes and Reduces Body Weight in High Fat Diet Induced Obese Rats

The anti-adipogenic and anti-obesity activity of chloroform fraction of Tephrosia purpurea (CFTp) on 3T3-L1 adipocytes and high fat diet (HFD)-fed obese rats was evaluated in this study. A substantial and dose dependent inhibition of α-glucosidase (81%) and lipase (75%) activities by CFTp was noticed. Treatment with CFTp (250 μg/mL) significantly inhibited 3T3-L1 adipocytes differentiation and lipid accumulation. A semi-quantitative RT-PCR analysis of 3T3-L1 cells revealed down regulation of mRNA expression of peroxisome proliferator-activated receptor-γ (PPAR-γ), fatty acid synthase (FAS) and acetyl CoA carboxylase-2 (ACC-2), while glucose transporter type-4 (GLUT-4) expression was up-regulated in a dose dependent manner with CFTp. Further, oral administration of CFTp (200 mg/kg.b.wt.) significantly reduced body weight gain, fat mass, blood glucose and leptin levels in high fat diet (HFD)-induced obese rats. Taken together, these findings demonstrate that CFTp possesses potent anti-obesity activities.