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Mathematical Wave Functions and 3D Finite Element Modelling of the Electron and Positron
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作者 Declan Traill 《Journal of Applied Mathematics and Physics》 2024年第4期1134-1162,共29页
The wave/particle duality of particles in Physics is well known. Particles have properties that uniquely characterize them from one another, such as mass, charge and spin. Charged particles have associated Electric an... The wave/particle duality of particles in Physics is well known. Particles have properties that uniquely characterize them from one another, such as mass, charge and spin. Charged particles have associated Electric and Magnetic fields. Also, every moving particle has a De Broglie wavelength determined by its mass and velocity. This paper shows that all of these properties of a particle can be derived from a single wave function equation for that particle. Wave functions for the Electron and the Positron are presented and principles are provided that can be used to calculate the wave functions of all the fundamental particles in Physics. Fundamental particles such as electrons and positrons are considered to be point particles in the Standard Model of Physics and are not considered to have a structure. This paper demonstrates that they do indeed have structure and that this structure extends into the space around the particle’s center (in fact, they have infinite extent), but with rapidly diminishing energy density with the distance from that center. The particles are formed from Electromagnetic standing waves, which are stable solutions to the Schrödinger and Classical wave equations. This stable structure therefore accounts for both the wave and particle nature of these particles. In fact, all of their properties such as mass, spin and electric charge, can be accounted for from this structure. These particle properties appear to originate from a single point at the center of the wave function structure, in the same sort of way that the Shell theorem of gravity causes the gravity of a body to appear to all originate from a central point. This paper represents the first two fully characterized fundamental particles, with a complete description of their structure and properties, built up from the underlying Electromagnetic waves that comprise these and all fundamental particles. 展开更多
关键词 ELECTRON POSITRON Wave Function Solution Electromagnetic Spin Mass Charge Proof Fundamental Particle Properties Quantum Mechanics Classical Physics Computer 3D Model Schrödinger Equation RMS KLEIN GORDON Electric Magnetic Lorentz Invariant Hertzian Vector Point Potential Field Density Phase Flow Attraction REPULSION Shell Theorem Ehrenfest VIRIAL Normalization Harmonic Oscillator
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Multi-scale Simulation on Bonding Mechanism of Solid-Liquid Cast-Rolling of Cu/Al Cladding Strip based on FEM and MD 被引量:2
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作者 YAN Meng HUANG Huagui 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2019年第4期830-839,共10页
To explore the complex thermal-mechanical-chemical behavior in the solid-liquid cast-roll bonding(SLCRB) of Cu/Al cladding strip, numerical simulations were conducted from both macro and micro scales. In macro-scale, ... To explore the complex thermal-mechanical-chemical behavior in the solid-liquid cast-roll bonding(SLCRB) of Cu/Al cladding strip, numerical simulations were conducted from both macro and micro scales. In macro-scale, with birth and death element method, a thermo-mechanical coupled finite element model(FEM) was set up to explore the temperature and contact pressure distribution at the Cu/Al bonding interface in the SLCRB process. Taking these macro-scale simulation results as boundary conditions, we simulated the atom diffusion law of the bonding interface by molecular dynamics(MD) in micro-scale. The results indicate that the temperature in Cu/Al bonding interface deceases from 700 to 320 ℃ from the entrance to the exit of caster, and the peak of contact pressure reaches up to 140 MPa. The interfacial diffusion thickness depends on temperature and rolling reduction, higher temperature results in larger thickness, and the rolling reduction below kiss point leads to significant elongation deformation of cladding strip which yields more newborn interface with fresh metal and make the diffusion layer thinner. The surface roughness of Cu strip was found to be benefit to atoms diffusion in the Cu/Al bonding interface. Meanwhile, combined with the SEM-EDS observation on the microstructure and composition in the bonding interface of the experimental samples acquired from the castrolling bite, it is revealed that the rolling reduction and severe elongation deformation in the solid-solid contact zone below kiss point guarantee the satisfactory metallurgical bonding with thin and smooth diffusion layer. The bonding mechanisms of reactive diffusion, mechanical interlocking and crack bonding are proved to coexist in the SLCRB process. 展开更多
关键词 CU/AL cladding strip SOLID-LIQUID cast-roll bonding (SLCRB) bonding mechanism finite element method (FEM) molecular dynamics (MD)
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In situ atomic-scale observation of size-dependent (de) potassiation and reversible phase transformation in tetragonal FeSe anodes
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作者 Ran Cai Lixia Bao +12 位作者 Wenqi Zhang Weiwei Xia Chunhao Sun Weikang Dong Xiaoxue Chang Ze Hua Ruiwen Shao Toshio Fukuda Zhefei Sun Haodong Liu Qiaobao Zhang Feng Xu Lixin Dong 《InfoMat》 SCIE CAS CSCD 2023年第1期161-171,共11页
Potassium-ion batteries(PIBs)are considered promising alternatives to lithium-ion batteries owing to cost-effective potassium resources and a suitable redox potential of-2.93 V(vs.-3.04 V for Li+/Li).However,the explo... Potassium-ion batteries(PIBs)are considered promising alternatives to lithium-ion batteries owing to cost-effective potassium resources and a suitable redox potential of-2.93 V(vs.-3.04 V for Li+/Li).However,the exploration of appro-priate electrode materials with the correct size for reversibly accommodating large K+ions presents a significant challenge.In addition,the reaction mecha-nisms and origins of enhanced performance remain elusive.Here,tetragonal FeSe nanoflakes of different sizes are designed to serve as an anode for PIBs,and their live and atomic-scale potassiation/depotassiation mechanisms are revealed for the first time through in situ high-resolution transmission electron micros-copy.We found that FeSe undergoes two distinct structural evolutions,sequen-tially characterized by intercalation and conversion reactions,and the initial intercalation behavior is size-dependent.Apparent expansion induced by the intercalation of K+ions is observed in small-sized FeSe nanoflakes,whereas unexpected cracks are formed along the direction of ionic diffusion in large-sized nanoflakes.The significant stress generation and crack extension originating from the combined effect of mechanical and electrochemical interactions are elucidated by geometric phase analysis and finite-element analysis.Despite the different intercalation behaviors,the formed products of Fe and K_(2)Se after full potassiation can be converted back into the original FeSe phase upon depotassiation.In particular,small-sized nanoflakes exhibit better cycling perfor-mance with well-maintained structural integrity.This article presents the first successful demonstration of atomic-scale visualization that can reveal size-dependent potassiation dynamics.Moreover,it provides valuable guidelines for optimizing the dimensions of electrode materials for advanced PIBs. 展开更多
关键词 elucidated by geometric phase analysis and finite-element analysis. Despite the different intercalation behaviors the formed products of Fe and K 2 Se after full potassiation can be converted back into the original FESE phase upon depotassiation. In particular small-sized nanoflakes exhibit better cycling perfor- mance with well-maintained structural integrity. This article presents the first successful demonstration of ATOMIC-SCALE visualization that can reveal size- dependent potassiation dynamics. Moreover it provides valuable guidelines for optimizing the dimensions of electrode materials for advanced PIBs. KEYWOR DS in situ transmission electron microscopy potassium-ion batteries potassium-ion storage mechanism SIZE-DEPENDENT effects TETRAGONAL FESE
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Oxidation Kinetics of Aluminum Powders in a Gas Fluidized Bed Reactor in the Potential Application of Surge Arresting Materials
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作者 Hong Shih 《Materials Sciences and Applications》 2019年第3期253-292,共40页
In this technical paper, the oxidation mechanism and kinetics of aluminum powders are discussed in great details. The potential applications of spherical aluminum powders after oxidation to be part of the surging arre... In this technical paper, the oxidation mechanism and kinetics of aluminum powders are discussed in great details. The potential applications of spherical aluminum powders after oxidation to be part of the surging arresting materials are discussed. Theoretical calculations of oxidation of spherical aluminum powders in a typical gas fluidization bed are demonstrated. Computer software written by the author is used to carry out the basic calculations of important parameters of a gas fluidization bed at different temperatures. A mathematical model of the dynamic system in a gas fluidization bed is developed and the analytical solution is obtained. The mathematical model can be used to estimate aluminum oxide thickness at a defined temperature. The mathematical model created in this study is evaluated and confirmed consistently with the experimental results on a gas fluidization bed. Detail technical discussion of the oxidation mechanism of aluminum is carried out. The mathematical deviations of the mathematical modeling have demonstrated in great details. This mathematical model developed in this study and validated with experimental results can bring a great value for the quantitative analysis of a gas fluidization bed in general from a theoretical point of view. It can be applied for the oxidation not only for aluminum spherical powders, but also for other spherical metal powders. The mathematical model developed can further enhance the applications of gas fluidization technology. In addition to the development of mathematical modeling of a gas fluidization bed reactor, the formation of oxide film through diffusion on both planar and spherical aluminum surfaces is analyzed through a thorough mathematical deviation using diffusion theory and Laplace transformation. The dominant defects and their impact to oxidation of aluminum are also discussed in detail. The well-controlled oxidation film on spherical metal powders such as aluminum and other metal spherical powders can potentially become an important part of switch devices of surge arresting materials, in general. 展开更多
关键词 Aluminum Spherical Power GAS FLUIDIZATION Bed Oxidation mechanism Oxide Growth Rate Gibbs Free Energy Ellingham Diagram Mathematical Modeling Dynamic System Plasma DIFFUSION DIFFUSION Coefficient Crystallographic Defect Vacancy Pressure Temperature Flow Laplace Transform Equation Boundary Condition Ficks Second Law Software Experimental Theoretical SURGE ARRESTING MATERIALS Analytical Solution
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Carbon Fiber Breakage Mechanism in Aluminum(Al)/Carbon Fibers(CFs) Composite Sheet during Accumulative Roll Bonding(ARB) Process
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作者 胡淑芬 SUN Zhenzhong +3 位作者 SHEN Fanghua DENG Jun 杨卫平 杨浩坤 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS CSCD 2024年第1期167-173,共7页
We put forward a method of fabricating Aluminum(Al)/carbon fibers(CFs) composite sheets by the accumulative roll bonding(ARB) method. The finished Al/CFs composite sheet has CFs and pure Al sheets as sandwich and surf... We put forward a method of fabricating Aluminum(Al)/carbon fibers(CFs) composite sheets by the accumulative roll bonding(ARB) method. The finished Al/CFs composite sheet has CFs and pure Al sheets as sandwich and surface layers. After cross-section observation of the Al/CFs composite sheet, we found that the CFs discretely distributed within the sandwich layer. Besides, the tensile test showed that the contribution of the sandwich CFs layer to tensile strength was less than 11% compared with annealed pure Al sheet. With ex-situ observation of the CFs breakage evolution with-16%,-32%, and-45% rolling reduction during the ARB process, the plastic instability of the Al layer was found to bring shear damages to the CFs. At last, the bridging strengthening mechanism introduced by CFs was sacrificed. We provide new insight into and instruction on Al/CFs composite sheet preparation method and processing parameters. 展开更多
关键词 Al/CFs composite sheet accumulative roll bonding tensile strength plastic instability carbon fiber breakage
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A retrospective view on the history of natural sciences in XX-XXI
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作者 Vladislav Sergeyevich Olkhovsky 《Natural Science》 2010年第3期228-245,共18页
The presented paper is dedicated to a new ret-rospective view on the history of natural sci-ences in XX-XXI cc, partially including the sci-ence philosophy (mainly, the problems of the scientific realism, i.e. the cor... The presented paper is dedicated to a new ret-rospective view on the history of natural sci-ences in XX-XXI cc, partially including the sci-ence philosophy (mainly, the problems of the scientific realism, i.e. the correspondence of science to reality) and also a novel scheme for different classes of sciences with different ob-jects and paradigms. There are analyzed the chosen “great” and “grand” problems of phys-ics (including the comprehension of quantum mechanics, with a recently elaborated new chapter, connected with time as a quantum obs- ervable and time analysis of quantum processes) and also of natural sciences as a whole. The particular attention is paid to the interpretation questions and slightly to the aspects, inevitably connected with the world- views of the res- earchers (which do often constitute a part of the interpretation questions). 展开更多
关键词 SCIENCE history SCIENCE realism paradigm PROBLEM of interpretation and comprehension of QUANTUM mechanics the WAVE-FUNCTION collapse the Einstein-Podolsky-Rosen paradox TIME as a QUANTUM observable canonically conjugated to energy maximal hermitian TIME operator TIME analysis of QUANTUM processes relationship be-tween physics and biology PROBLEM of origin of biologic life REDUCTIONISM cosmologic PROBLEM Big Bang anthropic principle
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Glucagon-like peptide-1 receptor agonists:Exploring the mechanisms from glycemic control to treatment of multisystemic diseases
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作者 Mo-Wei Kong Yang Yu +2 位作者 Ying Wan Yu Gao Chun-Xiang Zhang 《World Journal of Gastroenterology》 SCIE CAS 2024年第36期4036-4043,共8页
This editorial takes a deeper look at the insights provided by Soresi and Giannitrapani,which examined the therapeutic potential of glucagon-like peptide-1 receptor agonists(GLP-1RAs)for metabolic dysfunction-associat... This editorial takes a deeper look at the insights provided by Soresi and Giannitrapani,which examined the therapeutic potential of glucagon-like peptide-1 receptor agonists(GLP-1RAs)for metabolic dysfunction-associated fatty liver disease.We provide supplementary insights to their research,highlighting the broader systemic implications of GLP-1RAs,synthesizing the current understanding of their mechanisms and the trajectory of research in this field.GLP-1RAs are revolutionizing the treatment of type 2 diabetes mellitus and beyond.Beyond glycemic control,GLP-1RAs demonstrate cardiovascular and renal protective effects,offering potential in managing diabetic kidney disease alongside renin–angiotensin–aldosterone system inhibitors.Their role in bone metabolism hints at benefits for diabetic osteoporosis,while the neuroprotective properties of GLP-1RAs show promise in Alzheimer's disease treatment by modulating neuronal insulin signaling.Additionally,they improve hormonal and metabolic profiles in polycystic ovary syndrome.This editorial highlights the multifaceted mechanisms of GLP-1RAs,emphasizing the need for ongoing research to fully realize their therapeutic potential across a range of multisystemic diseases. 展开更多
关键词 Glucagon-like peptide-1 receptor agonists Glycemic control Multisystem diseases mechanism of action Cardiovascular protection Renal disease Bone metabolism Non-alcoholic fatty liver disease NEUROPROTECTION Polycystic ovary syndrome
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Interfacial Morphology and Bonding Mechanism of Explosive Weld Joints 被引量:3
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作者 Tingting Zhang Wenxian Wang +1 位作者 Zhifeng Yan Jie Zhang 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2021年第2期201-212,共12页
Interfacial structure greatly affects the mechanical properties of laminated plates.However,the critical material properties that impact the interfacial morphology,appearance,and associated bonding mechanism of explos... Interfacial structure greatly affects the mechanical properties of laminated plates.However,the critical material properties that impact the interfacial morphology,appearance,and associated bonding mechanism of explosive welded plates are still unknown.In this paper,the same base plate(AZ31B alloy)and different flyer metals(aluminum alloy,copper,and stainless steel)were used to investigate interfacial morphology and structure.SEM and TEM results showed that typical sine wave,wave-like,and half-wave-like interfaces were found at the bonding interfaces of Al/Mg,Cu/Mg and SS/Mg clad plates,respectively.The different interfacial morphologies were mainly due to the differences in hardness and yield strength between the flyer and base metals.The results of the microstructural distribution at the bonding interface indicated metallurgical bonding,instead of the commonly believed solid-state bonding,in the explosive welded clad plate.In addition,the shear strength of the bonding interface of the explosive welded Al/Mg,Cu/Mg and SS/Mg clad plates can reach up to 201.2 MPa,147.8 MPa,and 128.4 MPa,respectively.The proposed research provides the design basis for laminated composite metal plates fabrication by explosive welding technology. 展开更多
关键词 Interfacial structure bonding mechanism Explosive welding Metallurgical bonding Magnesium alloy
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Effect of Mechanical Surface Treatment on the Bonding Mechanism and Properties of Cold‑Rolled Cu/Al Clad Plate 被引量:1
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作者 Jianchao Han Hui Niu +5 位作者 Sha Li Zhongkai Ren Yi Jia Tao Wang A.I.Plokhikh Qingxue Huang 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2020年第5期212-224,共13页
In the case of valuable cold-rolled Cu/Al clad plates,billet surface treatment before rolling is a significant process that can affect the bonding efficiency and quality.While the current studies primarily focus on th... In the case of valuable cold-rolled Cu/Al clad plates,billet surface treatment before rolling is a significant process that can affect the bonding efficiency and quality.While the current studies primarily focus on the influence of rolling parameters,insufficient attention has been paid to surface treatment.In this study,the effects of mechanical surface treatment on the bonding mechanism and bonding properties of cold-rolled Cu/Al clad plates were investigated.The results showed that different mechanical surface treatments have significant effects on the surface morphology,roughness,and residual stress.In addition,the effect of surface mechanical treatment on bonding quality was also observed to be critical.When the grinding direction was consistent with the rolling direction(RD),the bonding quality of the Cu/Al clad plates was significantly improved.After surface treatment along the RD for 20 s,the Cu/Al clad plates showed the highest shear strength(78 MPa),approximately four times as high as that of the unpolished samples.Simultaneously,the peel strength of this process was also significantly higher than that achieved via the other processes.Finally,on the basis of the surface morphology,roughness,and residual stress,the effect of surface treatment on the bonding mechanism and bonding properties of Cu/Al clad plates was analyzed.This study proposes a deeper understanding of the bonding behavior and bonding mechanism for cold rolled clad plates processed via mechanical surface treatment. 展开更多
关键词 Cu/Al clad plates Cold rolling bonding Surface treatment bonding mechanism bonding property
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Abnormal interfacial bonding mechanisms of multi-material additive-manufactured tungsten-stainless steel sandwich structure 被引量:4
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作者 Chao Wei Heng Gu +5 位作者 Yuchen Gu Luchao Liu Yihe Huang Dongxu Cheng Zhaoqing Li Lin Li 《International Journal of Extreme Manufacturing》 SCIE EI 2022年第2期113-128,共16页
Tungsten(W)and stainless steel(SS)are well known for the high melting point and good corrosion resistance respectively.Bimetallic W-SS structures would offer potential applications in extreme environments.In this stud... Tungsten(W)and stainless steel(SS)are well known for the high melting point and good corrosion resistance respectively.Bimetallic W-SS structures would offer potential applications in extreme environments.In this study,a SS→W→SS sandwich structure is fabricated via a special laser powder bed fusion(LPBF)method based on an ultrasonic-assisted powder deposition mechanism.Material characterization of the SS→W interface and W→SS interface was conducted,including microstructure,element distribution,phase distribution,and nano-hardness.A coupled modelling method,combining computational fluid dynamics modelling with discrete element method,simulated the melt pool dynamics and solidification at the material interfaces.The study shows that the interface bonding of SS→W(SS printed on W)is the combined effect of solid-state diffusion with different elemental diffusion rates and grain boundary diffusion.The keyhole mode of the melt pool at the W→SS(W printed on SS)interface makes the pre-printed SS layers repeatedly remelted,causing the liquid W to flow into the sub-surface of the pre-printed SS through the keyhole cavities realizing the bonding of the W→SS interface.The above interfacial bonding behaviours are significantly different from the previously reported bonding mechanism based on the melt pool convection during multiple material LPBF.The abnormal material interfacial bonding behaviours are reported for the first time. 展开更多
关键词 multi-material additive manufacturing laser powder bed fusion interfacial bonding element diffusion keyhole mode
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Exploring mechanism of hidden,steep obliquely inclined bedding landslides using a 3DEC model:A case study of the Shanyang landslide in Shaanxi Province,China
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作者 Jia-yun Wang Zi-long Wu +3 位作者 Xiao-ya Shi Long-wei Yang Rui-ping Liu Na Lu 《China Geology》 CAS CSCD 2024年第2期303-314,I0001-I0003,共15页
Catastrophic geological disasters frequently occur on slopes with obliquely inclined bedding structures(also referred to as obliquely inclined bedding slopes),where the apparent dip sliding is not readily visible.This... Catastrophic geological disasters frequently occur on slopes with obliquely inclined bedding structures(also referred to as obliquely inclined bedding slopes),where the apparent dip sliding is not readily visible.This phenomenon has become a focal point in landslide research.Yet,there is a lack of studies on the failure modes and mechanisms of hidden,steep obliquely inclined bedding slopes.This study investigated the Shanyang landslide in Shaanxi Province,China.Using field investigations,laboratory tests of geotechnical parameters,and the 3DEC software,this study developed a numerical model of the landslide to analyze the failure process of such slopes.The findings indicate that the Shanyang landslide primarily crept along a weak interlayer under the action of gravity.The landslide,initially following a dip angle with the support of a stable inclined rock mass,shifted direction under the influence of argillization in the weak interlayer,moving towards the apparent dip angle.The slide resistance effect of the karstic dissolution zone was increasingly significant during this process,with lateral friction being the primary resistance force.A reduction in the lateral friction due to karstic dissolution made the apparent dip sliding characteristics of the Shanyang landslide more pronounced.Notably,deformations such as bending and uplift at the slope’s foot suggest that the main slide resistance shifts from lateral friction within the karstic dissolution zone to the slope foot’s resistance force,leading to the eventual buckling failure of the landslide.This study unveils a novel failure mode of apparent dip creep-buckling in the Shanyang landslide,highlighting the critical role of lateral friction from the karstic dissolution zone in its failure mechanism.These insights offer a valuable reference for mitigating risks and preventing disasters related to obliquely inclined bedding landslides. 展开更多
关键词 LANDSLIDE Steep obliquely inclined bedding slope Failure mode Failure mechanism Apparent dip creep-buckling Lateral friction 3DEC model Landslide numerical model Geological hazards survey engineering
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Hydrocarbon generation and storage mechanisms of deepwater shelf shales of Ordovician Wufeng Formation–Silurian Longmaxi Formation in Sichuan Basin, China 被引量:11
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作者 GUO Xusheng LI Yuping +5 位作者 BORJIGEN Tenger WANG Qiang YUAN Tao SHEN Baojian MA Zhongliang WEI Fubin 《Petroleum Exploration and Development》 2020年第1期204-213,共10页
As the hydrocarbon generation and storage mechanisms of high quality shales of Upper Ordovician Wufeng Formation– Lower Silurian Longmaxi Formation remain unclear, based on geological conditions and experimental mode... As the hydrocarbon generation and storage mechanisms of high quality shales of Upper Ordovician Wufeng Formation– Lower Silurian Longmaxi Formation remain unclear, based on geological conditions and experimental modelling of shale gas formation, the shale gas generation and accumulation mechanisms as well as their coupling relationships of deep-water shelf shales in Wufeng–Longmaxi Formation of Sichuan Basin were analyzed from petrology, mineralogy, and geochemistry. The high quality shales of Wufeng–Longmaxi Formation in Sichuan Basin are characterized by high thermal evolution, high hydrocarbon generation intensity, good material base, and good roof and floor conditions;the high quality deep-water shelf shale not only has high biogenic silicon content and organic carbon content, but also high porosity coupling. It is concluded that:(1) The shales had good preservation conditions and high retainment of crude oil in the early times, and the shale gas was mainly from cracking of crude oil.(2) The biogenic silicon(opal A) turned into crystal quartz in early times of burial diagenesis, lots of micro-size intergranular pores were produced in the same time;moreover, the biogenic silicon frame had high resistance to compaction, thus it provided the conditions not only for oil charge in the early stage, but also for formation and preservation of nanometer cellular-like pores, and was the key factor enabling the preservation of organic pores.(3) The high quality shale of Wufeng–Longmaxi Formation had high brittleness, strong homogeneity, siliceous intergranular micro-pores and nanometer organic pores, which were conducive to the formation of complicated fissure network connecting the siliceous intergranular nano-pores, and thus high and stable production of shale gas. 展开更多
关键词 hydrocarbon generation and STORAGE mechanism Upper ORDOVICIAN Wufeng FORMATION Lower SILURIAN Longmaxi FORMATION deep-water SHELF siliceous shale Sichuan Basin pore preservation
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Genomic Instability in Cancer II: 4N-Skewed (90°) Reductive Division via Fragile Sites to Fitness Increase for Solid and Hematological Cancer Beginnings 被引量:2
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作者 Kirsten H. Walen 《Journal of Cancer Therapy》 2019年第7期537-564,共28页
The objective herein was to connect the ontogeny process of diplochromosomal, amitotic, 4n-skewed division-system, to cytogenetic deficiency lesions in satellite, repetitive DNAs, especially in the chromosomal fragile... The objective herein was to connect the ontogeny process of diplochromosomal, amitotic, 4n-skewed division-system, to cytogenetic deficiency lesions in satellite, repetitive DNAs, especially in the chromosomal fragile sites, some 100 distributed over the genome. These latter studies had shown that chemical induced replication-stress led to un-replicated lesions in these fragile sites, which from inaccurate repair processes caused genomic instability. In the chain of events of the ontogeny process to the special tetraploidy, it was proposed that primary damaged human cells could undergo replication stress from repair-process present during cell replication, a suggestion verified by X-ray damaged cells producing the unstable fragile sites (see text). The cancer-importance for therapy is recognition of cell cycle change for the 4n derivative fitness-gained, diploid progeny cells. An open question is whether RB controlling G1 to S-period is mutated at this suggested tumorigenesis initiating phase, and if so, with what consequences for therapy. The fragile site studies further showed that repair of repetitive DNAs could produce two types of genomic changes: single gene mutations and CNVs, which were here shown to be chromosomally located on “borders” to repairing satellite lesions. This genomic placement was found to correspond to mutations identified in tumor sequencing (p53, Rb, MYC), favoring a bad luck location for their cancer “mutational nature”. The CNVs in cancers, are here seen as molecular expressions of long-known cytogenetic HSRs and DMs also with demonstrated origin from amplifications of single genes. Over-expression of oncogenes was hinted of being from duplications, but Drosophila genetics demonstrated the opposite, gene inactivation. The reduced eye-size from dominant, BAR-Ultra-Bar-eye phenotypes, was caused by duplications, inactivating the genetic system for eye-size. The finding of CNVs showing “evasion” of the immune system suggests, inactivation of immune-determining genetics. Since mutated genes on borders to satellite DNAs are a fact in hematological cancers, the 4n-skewed division-system is suggested to replace debated leukemogenesis with fitness-gain from molecular mutations. For these cancers the question is how normal bone marrow cells attain genomic damage for special tetraploidy, which was referred to studies of cells moving in artificial marrow-like substrate, needing serious attention. 展开更多
关键词 Centrifugal 90° Turn CENTROSOME Absence Mitotic Slippage Process Diplochromosomes Mutator mechanism Satellite DNA MUTATIONS Fragile Site Instability Repair MUTATIONS Copy Number Variants CHROMOSOME Nuclear Domains HEMATOLOGIC TRANSLOCATIONS Density Bone Marrow Substrate Abnormal Laminar Proteins Chromosome/Gene UPD Haplo-Insufficiency
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Kinetics and mechanism of the low-energy β-a phase transition of the second kind in 2,4-dinitroanisole
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作者 Aleksandr V.Stankevich Nikolay A.Rasputin +3 位作者 Anisa KhRudina Gennady L.Rusinov Vera I.Filyakova Valery N.Charushin 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第10期210-224,共15页
In this work, comprehensive studies of 2,4-dinitroanisole(2,4DNAN) were carried out using powder thermorentgenography of the internal standard. The time of the complete polymorphic transition in the solid phase β→a ... In this work, comprehensive studies of 2,4-dinitroanisole(2,4DNAN) were carried out using powder thermorentgenography of the internal standard. The time of the complete polymorphic transition in the solid phase β→a in 2,4DNAN under various combinations of conditions has been determined. It has been established that, regardless of the season of manufacture of the substance, when it is stored for 8-9months, with a change in ambient temperature from minus 30℃ to plus 30℃, a complete polymorphic transition β→a occurs. When stored in conditions below minus 5℃, polymorphic transition does not occur. When stored in conditions above plus 30℃ in a closed container, polymorphic transition occurs within 3 weeks. The polymorphic transition is accompanied by a decrease in density by 1.3%-1.5% and an increase in melting temperature by 10-12℃, depending on the degree of purity of the starting substance. The activation energy of the molecular rearrangement was 68-70 k J/mol(16.5 ± 3 kcal/mol). The mechanism of polymorphic transition has been evaluated, which is presumably based on internal homodiffusion and energy transfer to the surface of the mass of powder particles and the product. The average activation energy of the polymorphic transition process was 110 ± 6.2 k J/mol(26.2 kcal/mol). In an open container, reactions proceed by a homogeneous mechanism, and in a closed container by a heterogeneous mechanism involving the gas phase. 展开更多
关键词 Energetic materials Melt-castable 2 4-Dinitroanisole Polymorphic transition Kinetics mechanism Homodiffusion SUBLIMATION
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Decoding molecular mechanisms:brain aging and Alzheimer's disease
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作者 Mahnoor Hayat Rafay Ali Syed +9 位作者 Hammad Qaiser Mohammad Uzair Khalid Al-Regaiey Roaa Khallaf Lubna Abdullah Mohammed Albassam Imdad Kaleem Xueyi Wang Ran Wang Mehwish SBhatti Shahid Bashir 《Neural Regeneration Research》 SCIE CAS 2025年第8期2279-2299,共21页
The complex morphological,anatomical,physiological,and chemical mechanisms within the aging brain have been the hot topic of research for centuries.The aging process alters the brain structure that affects functions a... The complex morphological,anatomical,physiological,and chemical mechanisms within the aging brain have been the hot topic of research for centuries.The aging process alters the brain structure that affects functions and cognitions,but the worsening of such processes contributes to the pathogenesis of neurodegenerative disorders,such as Alzheimer's disease.Beyond these observable,mild morphological shifts,significant functional modifications in neurotransmission and neuronal activity critically influence the aging brain.Understanding these changes is important for maintaining cognitive health,especially given the increasing prevalence of age-related conditions that affect cognition.This review aims to explore the age-induced changes in brain plasticity and molecular processes,differentiating normal aging from the pathogenesis of Alzheimer's disease,thereby providing insights into predicting the risk of dementia,particularly Alzheimer's disease. 展开更多
关键词 Alzheimers disease brain aging cognitive health DEMENTIA molecular mechanisms neuronal activity NEUROPLASTICITY NEUROTRANSMISSION
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Hydrocarbon Generation Potential and Organic Matter Enrichment Mechanism of the Cambrian Marine Shale in the Tadong Low Uplift,Tarim Basin
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作者 MIAO Huan WANG Yanbin +5 位作者 JIANG Zhenxue ZHAO Shihu SHANG Peng GONG Xun TAO Chuanqi ZHANG Yu 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2024年第5期1301-1321,共21页
Cambrian shales in China and elsewhere contain abundant oil and gas resources.However,due to its deep burial and limited outcrop,there has been relatively little research conducted on it.The Cambrian shale of the Tado... Cambrian shales in China and elsewhere contain abundant oil and gas resources.However,due to its deep burial and limited outcrop,there has been relatively little research conducted on it.The Cambrian shale of the Tadong low uplift in the Tarim Basin of western China,specifically the Xidashan-Xishanbulake Formation(Fm.)and overlying Moheershan Fm.provide a case study through the use of organic petrology,mineralogy,organic and elemental geochemistry,with the aim of analyzing and exploring the hydrocarbon generation potential(PG)and organic matter(OM)enrichment mechanisms within these shale formations.The results indicate that:(1)the Cambrian shale of the Tadong low uplift exhibits relatively dispersed OM that consists of vitrinite-like macerals and solid bitumen.These formations have a higher content of quartz and are primarily composed of silica-based lithology;(2)shale samples from the Xidashan-Xishanbulake and Moheershan formations demonstrate high total organic carbon(TOC)and low pyrolytic hydrocarbon content(S_(2))content.The OM is predominantly typeⅠand typeⅡkerogens,indicating a high level of maturation in the wet gas period.These shales have undergone extensive hydrocarbon generation,showing characteristics of relatively poor PG;(3)the sedimentary environments of the Xidashan-Xishanbulake and Moheershan formations in the Tadong low uplift are similar.They were deposited in warm and humid climatic conditions,in oxygen-deficient environments,with stable terrigenous inputs,high paleoproductivity,high paleosalinity,weak water-holding capacity,and no significant hydrothermal activity;and(4)the relationship between TOC and the paleoproductivity parameter(P/Ti)is most significant in the Lower Cambrian Xidashan-Xishanbulake Fm.,whereas correlation with other indicators is not evident.This suggests a productivity-driven OM enrichment model,where input of landderived material was relatively small during the Middle Cambrian,and the ancient water exhibited lower salinity.A comprehensive pattern was formed under the combined control of paleoproductivity and preservation conditions.This study provides valuable guidance for oil and gas exploration in the Tarim Basin. 展开更多
关键词 Conventional resources hydrocarbon generation potential geochemistry sedimentary environment enrichment mechanism organic matter CAMBRIAN Tadong low uplift
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Computational and bioinformatics tools for understanding disease mechanisms
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作者 MOHD ATHAR ANU MANHAS +1 位作者 NISARG RANA AHMAD IRFAN 《BIOCELL》 SCIE 2024年第6期935-944,共10页
Computational methods have significantly transformed biomedical research,offering a comprehensive exploration of disease mechanisms and molecular protein functions.This article reviews a spectrum of computational tools... Computational methods have significantly transformed biomedical research,offering a comprehensive exploration of disease mechanisms and molecular protein functions.This article reviews a spectrum of computational tools and network analysis databases that play a crucial role in identifying potential interactions and signaling networks contributing to the onset of disease states.The utilization of protein/gene interaction and genetic variation databases,coupled with pathway analysis can facilitate the identification of potential drug targets.By bridging the gap between molecular-level information and disease understanding,this review contributes insights into the impactful utilization of computational methods,paving the way for targeted interventions and therapeutic advancements in biomedical research. 展开更多
关键词 Interaction database Disease mechanisms Protein function Network analysis BIOINFORMATICS Genetic variations Protein-protein interactions Signaling pathways
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Pathological mechanism of immune disorders in diabetic kidney disease and intervention strategies
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作者 Tong Zhou Yi-Lin Fang +1 位作者 Tian-Tian Tian Gui-Xia Wang 《World Journal of Diabetes》 SCIE 2024年第6期1111-1121,共11页
Diabetic kidney disease is one of the most severe chronic microvascular complications of diabetes and a primary cause of end-stage renal disease.Clinical studies have shown that renal inflammation is a key factor dete... Diabetic kidney disease is one of the most severe chronic microvascular complications of diabetes and a primary cause of end-stage renal disease.Clinical studies have shown that renal inflammation is a key factor determining kidney damage during diabetes.With the development of immunological technology,many studies have shown that diabetic nephropathy is an immune complex disease,and that most patients have immune dysfunction.However,the immune response associated with diabetic nephropathy and autoimmune kidney disease,or caused by ischemia or infection with acute renal injury,is different,and has a complicated pathological mechanism.In this review,we discuss the pathogenesis of diabetic nephropathy in immune disorders and the intervention mechanism,to provide guidance and advice for early intervention and treatment of diabetic nephropathy. 展开更多
关键词 Diabetic kidney disease Immune disorders Pathological mechanism Intervention strategy Kidney damage Diabetic nephropathy INFLAMMASOME IMMUNOGLOBULIN
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Plasticity of photorespiratory carbon concentration mechanism in Sedobassia sedoides(Pall.)Freitag&G.Kadereit under elevated CO_(2)concentration and salinity
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作者 Zulfira RAKHMANKULOVA Elena SHUYSKAYA +2 位作者 Maria PROKOFIEVA Kristina TODERICH Pavel VORONIN 《Journal of Arid Land》 SCIE CSCD 2024年第7期963-982,共20页
Rising atmospheric CO_(2)(carbon dioxide)concentrations and salinization are manifestations of climate change that affect plant growth and productivity.Species with an intermediate C_(3)-C_(4)type of photosynthesis li... Rising atmospheric CO_(2)(carbon dioxide)concentrations and salinization are manifestations of climate change that affect plant growth and productivity.Species with an intermediate C_(3)-C_(4)type of photosynthesis live in a wide range of precipitation,temperature,and soil quality,but are more often found in warm and dry habitats.One of the intermediate C_(3)-C_(4)photosynthetic type is C_(2)photosynthesis with a carbon concentration mechanism(CCM)that reassimilates CO_(2)released via photorespiration.However,the ecological significance under which C_(2)photosynthesis has advantages over C_(3)and C_(4)plants remains largely unexplored.Salt tolerance and functioning of CCM were studied in plants from two populations(P1 and P2)of Sedobassia sedoides(Pall.)Freitag&G.Kadereit Asch.species with C_(2)photosynthesis exposed to 4 d and 10 d salinity(200 mM NaCl)at ambient(785.7 mg/m^(3),aCO_(2)and elevated(1571.4 mg/m^(3),eCO_(2))CO_(2).On the fourth day of salinity,an increase in Na+content,activity catalase,and superoxide dismutase was observed in both populations.P2 plants showed an increase in proline content and a decrease in photosynthetic enzyme content:rubisco,phosphoenolpyruvate carboxylase(PEPC),and glycine decarboxylase(GDC),which indicated a weakening of C_(2)and C_(4)characteristics under salinity.Treatment under 10 d salinity led to an increased Na^(+)content and activity of cyclic electron flow around photosystem I(PSI CEF),a decreased content of K^(+)and GDC in both populations.P1 plants showed greater salt tolerance,which was assessed by the degree of reduction in photosynthetic enzyme content,PSI CEF activity,and changes in relative growth rate(RGR).Differences between populations were evident under the combination of eCO_(2)and salinity.Under long-term salinity and eCO_(2),more salt-tolerant P1 plants had a higher dry biomass(DW),which was positively correlated with PSI CEF activity.In less salt-tolerant P2 plants,DW correlated with transpiration and dark respiration.Thus,S.sedoides showed a high degree of photosynthetic plasticity under the influence of salinity and eCO_(2)through strengthening(P1 plants)and weakening C_(4)characteristics(P2 plants). 展开更多
关键词 photosystemsand carbon-concentrating mechanism glycine decarboxylase RUBISCO phosphoenolpyruvate carboxylase(PEPC) cyclic electron flow salinity stress DRYLANDS
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Two stages of subsidence and its formation mechanisms in Mid-Late Triassic Ordos Basin,NW China
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作者 DENG Xiuqin CHU Meijuan +2 位作者 WANG Long CHEN Xiu WANG Yanxin 《Petroleum Exploration and Development》 SCIE 2024年第3期576-588,共13页
Based on a large number of newly added deep well data in recent years,the subsidence of the Ordos Basin in the Mid-Late Triassic is systematically studied,and it is proposed that the Ordos Basin experienced two import... Based on a large number of newly added deep well data in recent years,the subsidence of the Ordos Basin in the Mid-Late Triassic is systematically studied,and it is proposed that the Ordos Basin experienced two important subsidence events during this depositional period.Through contrastive analysis of the two stages of tectonic subsidence,including stratigraphic characteristics,lithology combination,location of catchment area and sedimentary evolution,it is proposed that both of them are responses to the Indosinian Qinling tectonic activity on the edge of the craton basin.The early subsidence occurred in the Chang 10 Member was featured by high amplitude,large debris supply and fast deposition rate,with coarse debris filling and rapid subsidence accompanied by rapid accumulation,resulting in strata thickness increasing from northeast to southwest in wedge-shape.The subsidence center was located in Huanxian–Zhenyuan–Qingyang–Zhengning areas of southwestern basin with the strata thickness of 800–1300 m.The subsidence center deviating from the depocenter developed multiple catchment areas,until then,unified lake basin has not been formed yet.Under the combined action of subsidence and Carnian heavy rainfall event during the deposition period of Chang 7 Member,a large deep-water depression was formed with slow deposition rate,and the subsidence center coincided with the depocenter basically in the Mahuangshan–Huachi–Huangling areas.The deep-water sediments were 120–320 m thick in the subsidence center,characterized by fine grain.There are differences in the mechanism between the two stages of subsidence.The early one was the response to the northward subduction of the MianLüe Ocean and intense depression under compression in Qinling during Mid-Triassic.The later subsidence is controlled by the weak extensional tectonic environment of the post-collision stage during Late Triassic. 展开更多
关键词 Ordos Basin Chang 10 Member Chang 7 Member subsidence center depocenter subsidence mechanism Qinling orogenic belt Indosinian movement
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