Integrating ideological and political theories teaching into the whole process of classroom teaching construction is a new requirement for implementing the fundamental task of cultivating people by virtue and playing ...Integrating ideological and political theories teaching into the whole process of classroom teaching construction is a new requirement for implementing the fundamental task of cultivating people by virtue and playing the role of collaborative education.In order to realize the seamless integration of inorganic and analytical chemistry courses and ideological and political education,this paper summarizes the current situation of ideological and political research on inorganic and analytical chemistry courses in three major databases in China(VIP,CNKI and Wanfang),and sorts out the knowledge points,ideological and political elements and educational goals according to the content of the course chapters,to provide a basic guarantee for the ideological and political education construction of the course.展开更多
Agile Transformations are challenging processes for organizations that look to extend the benefits of Agile philosophy and methods beyond software engineering.Despite the impact of these transformations on orga-nizati...Agile Transformations are challenging processes for organizations that look to extend the benefits of Agile philosophy and methods beyond software engineering.Despite the impact of these transformations on orga-nizations,they have not been extensively studied in academia.We conducted a study grounded in workshops and interviews with 99 participants from 30 organizations,including organizations undergoing transformations(“final organizations”)and companies supporting these processes(“consultants”).The study aims to understand the motivations,objectives,and factors driving and challenging these transformations.Over 700 responses were collected to the question and categorized into 32 objectives.The findings show that organizations primarily aim to achieve customer centricity and adaptability,both with 8%of the mentions.Other primary important objectives,with above 4%of mentions,include alignment of goals,lean delivery,sustainable processes,and a flatter,more team-based organizational structure.We also detect discrepancies in perspectives between the objectives identified by the two kinds of organizations and the existing agile literature and models.This misalignment highlights the need for practitioners to understand with the practical realities the organizations face.展开更多
Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on society.Extracellular vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent bioc...Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on society.Extracellular vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic stroke.However,the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery efficiency.By utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles,their delivery efficacy may be greatly improved.Furthermore,previous studies have indicated that microvesicles,a subset of large-sized extracellular vesicles,can transport mitochondria to neighboring cells,thereby aiding in the restoration of mitochondrial function post-ischemic stroke.Small extracellular vesicles have also demonstrated the capability to transfer mitochondrial components,such as proteins or deoxyribonucleic acid,or their sub-components,for extracellular vesicle-based ischemic stroke therapy.In this review,we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification methodologies.Given the complex facets of treating ischemic stroke,we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment process.Moreover,given the burgeoning interest in mitochondrial delivery,we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy.展开更多
Prompt engineering, the art of crafting effective prompts for artificial intelligence models, has emerged as a pivotal factor in determining the quality and usefulness of AI (Artificial Intelligence)-generated outputs...Prompt engineering, the art of crafting effective prompts for artificial intelligence models, has emerged as a pivotal factor in determining the quality and usefulness of AI (Artificial Intelligence)-generated outputs. This practice involves strategically designing and structuring prompts to guide AI models toward desired outcomes, ensuring that they generate relevant, informative, and accurate responses. The significance of prompt engineering cannot be overstated. Well-crafted prompts can significantly enhance the capabilities of AI models, enabling them to perform tasks that were once thought to be exclusively human domain. By providing clear and concise instructions, prompts can guide AI models to generate creative text, translate languages, write different kinds of creative content, and answer your questions in an informative way. Moreover, prompt engineering can help mitigate biases and ensure that AI models produce outputs that are fair, equitable, and inclusive. However, prompt engineering is not without its challenges. Crafting effective prompts requires a deep understanding of both the AI model’s capabilities and the specific task at hand. Additionally, the quality of the prompts can be influenced by factors such as the model’s training data [1] and the complexity of the task. As AI models continue to evolve, prompt engineering will likely become even more critical in unlocking their full potential.展开更多
The traditional thermodynamic theory explains the reversible phenomena quite well, except that reversible phenomena are rare or even impossible in practice. Here the purpose is to propose an explanation valid for reve...The traditional thermodynamic theory explains the reversible phenomena quite well, except that reversible phenomena are rare or even impossible in practice. Here the purpose is to propose an explanation valid for reversible and also irreversible phenomena, irreversibility being common or realistic. It previously exposed points tricky to grasp, as the sign of the work exchange, the adiabatic expansion in vacuum (free expansion) or the transfer of heat between two bodies at the same temperature (isothermal transfer). After having slightly modified the concepts of heat transfer (each body produces heat according to its own temperature) and work (distinguishing external pressure from internal pressure), the previous points are more easily explained. At last, an engine efficiency in case of irreversible transfer is proposed. This paper is focused on the form of thermodynamics, on “explanations”;it does not question on “results” (except the irreversible free expansion of 1845...) which remain unchanged.展开更多
Traumatic brain injury is a serious medical condition that can be attributed to falls, motor vehicle accidents, sports injuries and acts of violence, causing a series of neural injuries and neuropsychiatric symptoms. ...Traumatic brain injury is a serious medical condition that can be attributed to falls, motor vehicle accidents, sports injuries and acts of violence, causing a series of neural injuries and neuropsychiatric symptoms. However, limited accessibility to the injury sites, complicated histological and anatomical structure, intricate cellular and extracellular milieu, lack of regenerative capacity in the native cells, vast variety of damage routes, and the insufficient time available for treatment have restricted the widespread application of several therapeutic methods in cases of central nervous system injury. Tissue engineering and regenerative medicine have emerged as innovative approaches in the field of nerve regeneration. By combining biomaterials, stem cells, and growth factors, these approaches have provided a platform for developing effective treatments for neural injuries, which can offer the potential to restore neural function, improve patient outcomes, and reduce the need for drugs and invasive surgical procedures. Biomaterials have shown advantages in promoting neural development, inhibiting glial scar formation, and providing a suitable biomimetic neural microenvironment, which makes their application promising in the field of neural regeneration. For instance, bioactive scaffolds loaded with stem cells can provide a biocompatible and biodegradable milieu. Furthermore, stem cells-derived exosomes combine the advantages of stem cells, avoid the risk of immune rejection, cooperate with biomaterials to enhance their biological functions, and exert stable functions, thereby inducing angiogenesis and neural regeneration in patients with traumatic brain injury and promoting the recovery of brain function. Unfortunately, biomaterials have shown positive effects in the laboratory, but when similar materials are used in clinical studies of human central nervous system regeneration, their efficacy is unsatisfactory. Here, we review the characteristics and properties of various bioactive materials, followed by the introduction of applications based on biochemistry and cell molecules, and discuss the emerging role of biomaterials in promoting neural regeneration. Further, we summarize the adaptive biomaterials infused with exosomes produced from stem cells and stem cells themselves for the treatment of traumatic brain injury. Finally, we present the main limitations of biomaterials for the treatment of traumatic brain injury and offer insights into their future potential.展开更多
This research presents a novel nature-inspired metaheuristic algorithm called Frilled Lizard Optimization(FLO),which emulates the unique hunting behavior of frilled lizards in their natural habitat.FLO draws its inspi...This research presents a novel nature-inspired metaheuristic algorithm called Frilled Lizard Optimization(FLO),which emulates the unique hunting behavior of frilled lizards in their natural habitat.FLO draws its inspiration from the sit-and-wait hunting strategy of these lizards.The algorithm’s core principles are meticulously detailed and mathematically structured into two distinct phases:(i)an exploration phase,which mimics the lizard’s sudden attack on its prey,and(ii)an exploitation phase,which simulates the lizard’s retreat to the treetops after feeding.To assess FLO’s efficacy in addressing optimization problems,its performance is rigorously tested on fifty-two standard benchmark functions.These functions include unimodal,high-dimensional multimodal,and fixed-dimensional multimodal functions,as well as the challenging CEC 2017 test suite.FLO’s performance is benchmarked against twelve established metaheuristic algorithms,providing a comprehensive comparative analysis.The simulation results demonstrate that FLO excels in both exploration and exploitation,effectively balancing these two critical aspects throughout the search process.This balanced approach enables FLO to outperform several competing algorithms in numerous test cases.Additionally,FLO is applied to twenty-two constrained optimization problems from the CEC 2011 test suite and four complex engineering design problems,further validating its robustness and versatility in solving real-world optimization challenges.Overall,the study highlights FLO’s superior performance and its potential as a powerful tool for tackling a wide range of optimization problems.展开更多
Twin support vector machine(TWSVM)is a new development of support vector machine(SVM)algorithm.It has the smaller computation scale and the stronger ability to cope with unbalanced problems.In this paper,TWSVM is intr...Twin support vector machine(TWSVM)is a new development of support vector machine(SVM)algorithm.It has the smaller computation scale and the stronger ability to cope with unbalanced problems.In this paper,TWSVM is introduced into aircraft engine gas path fault diagnosis.The generalization capacity of Gauss kernel function usually used in TWSVM is relatively weak.So a mixed kernel function is used to improve performance to ensure that the TWSVM algorithm can better balance a strong generalization ability and a good learning ability.Experimental results prove that the cross validation training accuracy of TWSVM using the mixed kernel function averagely increases 2%.Grid search is usually applied in parameter optimization of TWSVM,but it heavily depends on experience.Therefore,the hybrid particle swarm algorithm is introduced.It can intelligently and rapidly find the global optimum.Experiments prove that its training accuracy is better than that of the classical particle swarm algorithm by 5%.展开更多
In Advances in Pure Mathematics (www.scirp.org/journal/apm), Vol. 1, No. 4 (July 2011), pp. 136-154, the mathematical structure of the much discussed problem of probability known as the Monty Hall problem was mapped i...In Advances in Pure Mathematics (www.scirp.org/journal/apm), Vol. 1, No. 4 (July 2011), pp. 136-154, the mathematical structure of the much discussed problem of probability known as the Monty Hall problem was mapped in detail. It is styled here as Monty Hall 1.0. The proposed analysis was then generalized to related cases involving any number of doors (d), cars (c), and opened doors (o) (Monty Hall 2.0) and 1 specific case involving more than 1 picked door (p) (Monty Hall 3.0). In cognitive terms, this analysis was interpreted in function of the presumed digital nature of rational thought and language. In the present paper, Monty Hall 1.0 and 2.0 are briefly reviewed (§§2-3). Additional generalizations of the problem are then presented in §§4-7. They concern expansions of the problem to the following items: (1) to any number of picked doors, with p denoting the number of doors initially picked and q the number of doors picked when switching doors after doors have been opened to reveal goats (Monty Hall 3.0;see §4);(3) to the precise conditions under which one’s chances increase or decrease in instances of Monty Hall 3.0 (Monty Hall 3.2;see §6);and (4) to any number of switches of doors (s) (Monty Hall 4.0;see §7). The afore-mentioned article in APM, Vol. 1, No. 4 may serve as a useful introduction to the analysis of the higher variations of the Monty Hall problem offered in the present article. The body of the article is by Leo Depuydt. An appendix by Richard D. Gill (see §8) provides additional context by building a bridge to modern probability theory in its conventional notation and by pointing to the benefits of certain interesting and relevant tools of computation now available on the Internet. The cognitive component of the earlier investigation is extended in §9 by reflections on the foundations of mathematics. It will be proposed, in the footsteps of George Boole, that the phenomenon of mathematics needs to be defined in empirical terms as something that happens to the brain or something that the brain does. It is generally assumed that mathematics is a property of nature or reality or whatever one may call it. There is not the slightest intention in this paper to falsify this assumption because it cannot be falsified, just as it cannot be empirically or positively proven. But there is no way that this assumption can be a factual observation. It can be no more than an altogether reasonable, yet fully secondary, inference derived mainly from the fact that mathematics appears to work, even if some may deem the fact of this match to constitute proof. On the deepest empirical level, mathematics can only be directly observed and therefore directly analyzed as an activity of the brain. The study of mathematics therefore becomes an essential part of the study of cognition and human intelligence. The reflections on mathematics as a phenomenon offered in the present article will serve as a prelude to planned articles on how to redefine the foundations of probability as one type of mathematics in cognitive fashion and on how exactly Boole’s theory of probability subsumes, supersedes, and completes classical probability theory. §§2-7 combined, on the one hand, and §9, on the other hand, are both self-sufficient units and can be read independently from one another. The ultimate design of the larger project of which this paper is part remains the increase of digitalization of the analysis of rational thought and language, that is, of (rational, not emotional) human intelligence. To reach out to other disciplines, an effort is made to describe the mathematics more explicitly than is usual.展开更多
In this work,we open an avenue toward rational design of potential efficient catalysts for sustainable ammonia synthesis through composition engineering strategy by exploiting the synergistic effects among the active ...In this work,we open an avenue toward rational design of potential efficient catalysts for sustainable ammonia synthesis through composition engineering strategy by exploiting the synergistic effects among the active sites as exemplified by diatomic metals anchored graphdiyne via the combination of hierarchical high-throughput screening,first-principles calculations,and molecular dynamics simulations.Totally 43 highly efficient catalysts feature ultralow onset potentials(|U_(onset)|≤0.40 V)with Rh-Hf and Rh-Ta showing negligible onset potentials of 0 and-0.04 V,respectively.Extremely high catalytic activities of Rh-Hf and Rh-Ta can be ascribed to the synergistic effects.When forming heteronuclears,the combinations of relatively weak(such as Rh)and relatively strong(such as Hf or Ta)components usually lead to the optimal strengths of adsorption Gibbs free energies of reaction intermediates.The origin can be ascribed to the mediate d-band centers of Rh-Hf and Rh-Ta,which lead to the optimal adsorption strengths of intermediates,thereby bringing the high catalytic activities.Our work provides a new and general strategy toward the architecture of highly efficient catalysts not only for electrocatalytic nitrogen reduction reaction(eNRR)but also for other important reactions.We expect that our work will boost both experimental and theoretical efforts in this direction.展开更多
There are costs for doing the right thing,but regret is not one of those costs.I learned this lesson the hard way throughout a 42-year engineering career.As a young engineer,raising a family,I was more adaptable to ma...There are costs for doing the right thing,but regret is not one of those costs.I learned this lesson the hard way throughout a 42-year engineering career.As a young engineer,raising a family,I was more adaptable to management mandates,i.e.,I was more willing to be unethical to keep my job to make money and have health insurance for my family.As I grew in age,experience,and stamina,I was less adaptable,i.e.,I was more ethical.This article tells this story through events at various times in my engineering career1.Ethics define how we do the right thing.展开更多
Sodium alginate(SA)/chitosan(CH)polyelectrolyte scaffold is a suitable substrate for tissue-engineering application.The present study deals with further improvement in the tensile strength and biological properties of...Sodium alginate(SA)/chitosan(CH)polyelectrolyte scaffold is a suitable substrate for tissue-engineering application.The present study deals with further improvement in the tensile strength and biological properties of this type of scaffold to make it a potential template for bone-tissue regeneration.We experimented with adding 0%–15%(volume fraction)gelatin(GE),a protein-based biopolymer known to promote cell adhesion,proliferation,and differentiation.The resulting tri-polymer complex was used as bioink to fabricate SA/CH/GEmatrices by three-dimensional(3D)printing.Morphological studies using scanning electron microscopy revealed the microfibrous porous architecture of all the structures,which had a pore size range of 383–419μm.X-ray diffraction and Fourier-transform infrared spectroscopy analyses revealed the amorphous nature of the scaffold and the strong electrostatic interactions among the functional groups of the polymers,thereby forming polyelectrolyte complexes which were found to improve mechanical properties and structural stability.The scaffolds exhibited a desirable degradation rate,controlled swelling,and hydrophilic characteristics which are favorable for bone-tissue engineering.The tensile strength improved from(386±15)to(693±15)kPa due to the increased stiffness of SA/CH scaffolds upon addition of gelatin.The enhanced protein adsorption and in vitro bioactivity(forming an apatite layer)confirmed the ability of the SA/CH/GE scaffold to offer higher cellular adhesion and a bone-like environment to cells during the process of tissue regeneration.In vitro biological evaluation including the MTT assay,confocal microscopy analysis,and alizarin red S assay showed a significant increase in cell attachment,cell viability,and cell proliferation,which further improved biomineralization over the scaffold surface.In addition,SA/CH containing 15%gelatin designated as SA/CH/GE15 showed superior performance to the other fabricated 3D structures,demonstrating its potential for use in bone-tissue engineering.展开更多
Sentiment analysis is becoming increasingly important in today’s digital age, with social media being a significantsource of user-generated content. The development of sentiment lexicons that can support languages ot...Sentiment analysis is becoming increasingly important in today’s digital age, with social media being a significantsource of user-generated content. The development of sentiment lexicons that can support languages other thanEnglish is a challenging task, especially for analyzing sentiment analysis in social media reviews. Most existingsentiment analysis systems focus on English, leaving a significant research gap in other languages due to limitedresources and tools. This research aims to address this gap by building a sentiment lexicon for local languages,which is then used with a machine learning algorithm for efficient sentiment analysis. In the first step, a lexiconis developed that includes five languages: Urdu, Roman Urdu, Pashto, Roman Pashto, and English. The sentimentscores from SentiWordNet are associated with each word in the lexicon to produce an effective sentiment score. Inthe second step, a naive Bayesian algorithm is applied to the developed lexicon for efficient sentiment analysis ofRoman Pashto. Both the sentiment lexicon and sentiment analysis steps were evaluated using information retrievalmetrics, with an accuracy score of 0.89 for the sentiment lexicon and 0.83 for the sentiment analysis. The resultsshowcase the potential for improving software engineering tasks related to user feedback analysis and productdevelopment.展开更多
The recent increase in blast/bombing incidents all over the world has pushed the development of effective strengthening approaches to enhance the blast resistance of existing civil infrastructures.Engineered geopolyme...The recent increase in blast/bombing incidents all over the world has pushed the development of effective strengthening approaches to enhance the blast resistance of existing civil infrastructures.Engineered geopolymer composite(EGC)is a promising material featured by eco-friendly,fast-setting and strain-hardening characteristics for emergent strengthening and construction.However,the fiber optimization for preparing EGC and its protective effect on structural elements under blast scenarios are uncertain.In this study,laboratory tests were firstly conducted to evaluate the effects of fiber types on the properties of EGC in terms of workability,dry shrinkage,and mechanical properties in compression,tension and flexure.The experimental results showed that EGC containing PE fiber exhibited suitable workability,acceptable dry shrinkage and superior mechanical properties compared with other types of fibers.After that,a series of field tests were carried out to evaluate the effectiveness of EGC retrofitting layer on the enhancement of blast performance of typical elements.The tests include autoclaved aerated concrete(AAC)masonry walls subjected to vented gas explosion,reinforced AAC panels subjected to TNT explosion and plain concrete slabs subjected to contact explosion.It was found that EGC could effectively enhance the blast resistance of structural elements in different scenarios.For AAC masonry walls and panels,with the existence of EGC,the integrity of specimens could be maintained,and their deflections and damage were significantly reduced.For plain concrete slabs,the EGC overlay could reduce the diameter and depth of the crater and spallation of specimens.展开更多
The use of drones in construction engineering has gained increasing attention in recent years due to its potential to revolutionize the industry. Drones, offer the ability to capture high-resolution aerial imagery and...The use of drones in construction engineering has gained increasing attention in recent years due to its potential to revolutionize the industry. Drones, offer the ability to capture high-resolution aerial imagery and collect data that was previously difficult or impossible to obtain. The integration drones in construction engineering presents opportunities for accurate data collection, analysis and visualization, which can improve decision-making processes and improve project outcomes. For example, drones equipped with GIS technology can be used to capture high-resolution aerial images of construction sites, allowing engineers to monitor progress, identify potential issues, and make informed adjustments as needed. By harnessing drones, civil engineers in the civil engineering field can potentially optimize project planning, design and execution while minimizing risks and costs. The work of this topic examines the case of the use of Drones combined with GIS in construction engineering. During this study, aerial photography of a certain segment of the Pristina-Gjilan Highway was taken. The results generated by the processing of aerial photos have been compared with the project. However, further research is needed to fully understand the capabilities and limitations of these technologies in this specific context, as well as to explore any potential challenges and barriers to their widespread adoption.展开更多
基金Supported by 2020 Teaching Reform Research Project of Pingdingshan University(2020-JY05)School-level Ideological and Political Demonstration Course of Pingdingshan University in 2023-Ecological Engineering+1 种基金Science and Technology Research Project of Henan Provincial Department of Science and Technology(212102110189)High-level Talent Start-up Fund Project of Pingdingshan University(PXY-BSQD-202001).
文摘Integrating ideological and political theories teaching into the whole process of classroom teaching construction is a new requirement for implementing the fundamental task of cultivating people by virtue and playing the role of collaborative education.In order to realize the seamless integration of inorganic and analytical chemistry courses and ideological and political education,this paper summarizes the current situation of ideological and political research on inorganic and analytical chemistry courses in three major databases in China(VIP,CNKI and Wanfang),and sorts out the knowledge points,ideological and political elements and educational goals according to the content of the course chapters,to provide a basic guarantee for the ideological and political education construction of the course.
基金funding from the European Commission for the Ruralities Project(grant agreement no.101060876).
文摘Agile Transformations are challenging processes for organizations that look to extend the benefits of Agile philosophy and methods beyond software engineering.Despite the impact of these transformations on orga-nizations,they have not been extensively studied in academia.We conducted a study grounded in workshops and interviews with 99 participants from 30 organizations,including organizations undergoing transformations(“final organizations”)and companies supporting these processes(“consultants”).The study aims to understand the motivations,objectives,and factors driving and challenging these transformations.Over 700 responses were collected to the question and categorized into 32 objectives.The findings show that organizations primarily aim to achieve customer centricity and adaptability,both with 8%of the mentions.Other primary important objectives,with above 4%of mentions,include alignment of goals,lean delivery,sustainable processes,and a flatter,more team-based organizational structure.We also detect discrepancies in perspectives between the objectives identified by the two kinds of organizations and the existing agile literature and models.This misalignment highlights the need for practitioners to understand with the practical realities the organizations face.
基金supported by the grants from University of Macao,China,Nos.MYRG2022-00221-ICMS(to YZ)and MYRG-CRG2022-00011-ICMS(to RW)the Natural Science Foundation of Guangdong Province,No.2023A1515010034(to YZ)。
文摘Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on society.Extracellular vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic stroke.However,the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery efficiency.By utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles,their delivery efficacy may be greatly improved.Furthermore,previous studies have indicated that microvesicles,a subset of large-sized extracellular vesicles,can transport mitochondria to neighboring cells,thereby aiding in the restoration of mitochondrial function post-ischemic stroke.Small extracellular vesicles have also demonstrated the capability to transfer mitochondrial components,such as proteins or deoxyribonucleic acid,or their sub-components,for extracellular vesicle-based ischemic stroke therapy.In this review,we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification methodologies.Given the complex facets of treating ischemic stroke,we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment process.Moreover,given the burgeoning interest in mitochondrial delivery,we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy.
文摘Prompt engineering, the art of crafting effective prompts for artificial intelligence models, has emerged as a pivotal factor in determining the quality and usefulness of AI (Artificial Intelligence)-generated outputs. This practice involves strategically designing and structuring prompts to guide AI models toward desired outcomes, ensuring that they generate relevant, informative, and accurate responses. The significance of prompt engineering cannot be overstated. Well-crafted prompts can significantly enhance the capabilities of AI models, enabling them to perform tasks that were once thought to be exclusively human domain. By providing clear and concise instructions, prompts can guide AI models to generate creative text, translate languages, write different kinds of creative content, and answer your questions in an informative way. Moreover, prompt engineering can help mitigate biases and ensure that AI models produce outputs that are fair, equitable, and inclusive. However, prompt engineering is not without its challenges. Crafting effective prompts requires a deep understanding of both the AI model’s capabilities and the specific task at hand. Additionally, the quality of the prompts can be influenced by factors such as the model’s training data [1] and the complexity of the task. As AI models continue to evolve, prompt engineering will likely become even more critical in unlocking their full potential.
文摘The traditional thermodynamic theory explains the reversible phenomena quite well, except that reversible phenomena are rare or even impossible in practice. Here the purpose is to propose an explanation valid for reversible and also irreversible phenomena, irreversibility being common or realistic. It previously exposed points tricky to grasp, as the sign of the work exchange, the adiabatic expansion in vacuum (free expansion) or the transfer of heat between two bodies at the same temperature (isothermal transfer). After having slightly modified the concepts of heat transfer (each body produces heat according to its own temperature) and work (distinguishing external pressure from internal pressure), the previous points are more easily explained. At last, an engine efficiency in case of irreversible transfer is proposed. This paper is focused on the form of thermodynamics, on “explanations”;it does not question on “results” (except the irreversible free expansion of 1845...) which remain unchanged.
基金supported by the Sichuan Science and Technology Program,No.2023YFS0164 (to JC)。
文摘Traumatic brain injury is a serious medical condition that can be attributed to falls, motor vehicle accidents, sports injuries and acts of violence, causing a series of neural injuries and neuropsychiatric symptoms. However, limited accessibility to the injury sites, complicated histological and anatomical structure, intricate cellular and extracellular milieu, lack of regenerative capacity in the native cells, vast variety of damage routes, and the insufficient time available for treatment have restricted the widespread application of several therapeutic methods in cases of central nervous system injury. Tissue engineering and regenerative medicine have emerged as innovative approaches in the field of nerve regeneration. By combining biomaterials, stem cells, and growth factors, these approaches have provided a platform for developing effective treatments for neural injuries, which can offer the potential to restore neural function, improve patient outcomes, and reduce the need for drugs and invasive surgical procedures. Biomaterials have shown advantages in promoting neural development, inhibiting glial scar formation, and providing a suitable biomimetic neural microenvironment, which makes their application promising in the field of neural regeneration. For instance, bioactive scaffolds loaded with stem cells can provide a biocompatible and biodegradable milieu. Furthermore, stem cells-derived exosomes combine the advantages of stem cells, avoid the risk of immune rejection, cooperate with biomaterials to enhance their biological functions, and exert stable functions, thereby inducing angiogenesis and neural regeneration in patients with traumatic brain injury and promoting the recovery of brain function. Unfortunately, biomaterials have shown positive effects in the laboratory, but when similar materials are used in clinical studies of human central nervous system regeneration, their efficacy is unsatisfactory. Here, we review the characteristics and properties of various bioactive materials, followed by the introduction of applications based on biochemistry and cell molecules, and discuss the emerging role of biomaterials in promoting neural regeneration. Further, we summarize the adaptive biomaterials infused with exosomes produced from stem cells and stem cells themselves for the treatment of traumatic brain injury. Finally, we present the main limitations of biomaterials for the treatment of traumatic brain injury and offer insights into their future potential.
文摘This research presents a novel nature-inspired metaheuristic algorithm called Frilled Lizard Optimization(FLO),which emulates the unique hunting behavior of frilled lizards in their natural habitat.FLO draws its inspiration from the sit-and-wait hunting strategy of these lizards.The algorithm’s core principles are meticulously detailed and mathematically structured into two distinct phases:(i)an exploration phase,which mimics the lizard’s sudden attack on its prey,and(ii)an exploitation phase,which simulates the lizard’s retreat to the treetops after feeding.To assess FLO’s efficacy in addressing optimization problems,its performance is rigorously tested on fifty-two standard benchmark functions.These functions include unimodal,high-dimensional multimodal,and fixed-dimensional multimodal functions,as well as the challenging CEC 2017 test suite.FLO’s performance is benchmarked against twelve established metaheuristic algorithms,providing a comprehensive comparative analysis.The simulation results demonstrate that FLO excels in both exploration and exploitation,effectively balancing these two critical aspects throughout the search process.This balanced approach enables FLO to outperform several competing algorithms in numerous test cases.Additionally,FLO is applied to twenty-two constrained optimization problems from the CEC 2011 test suite and four complex engineering design problems,further validating its robustness and versatility in solving real-world optimization challenges.Overall,the study highlights FLO’s superior performance and its potential as a powerful tool for tackling a wide range of optimization problems.
基金supported by the Fundamental Research Funds for the Central Universities(No.NS2016027)
文摘Twin support vector machine(TWSVM)is a new development of support vector machine(SVM)algorithm.It has the smaller computation scale and the stronger ability to cope with unbalanced problems.In this paper,TWSVM is introduced into aircraft engine gas path fault diagnosis.The generalization capacity of Gauss kernel function usually used in TWSVM is relatively weak.So a mixed kernel function is used to improve performance to ensure that the TWSVM algorithm can better balance a strong generalization ability and a good learning ability.Experimental results prove that the cross validation training accuracy of TWSVM using the mixed kernel function averagely increases 2%.Grid search is usually applied in parameter optimization of TWSVM,but it heavily depends on experience.Therefore,the hybrid particle swarm algorithm is introduced.It can intelligently and rapidly find the global optimum.Experiments prove that its training accuracy is better than that of the classical particle swarm algorithm by 5%.
文摘In Advances in Pure Mathematics (www.scirp.org/journal/apm), Vol. 1, No. 4 (July 2011), pp. 136-154, the mathematical structure of the much discussed problem of probability known as the Monty Hall problem was mapped in detail. It is styled here as Monty Hall 1.0. The proposed analysis was then generalized to related cases involving any number of doors (d), cars (c), and opened doors (o) (Monty Hall 2.0) and 1 specific case involving more than 1 picked door (p) (Monty Hall 3.0). In cognitive terms, this analysis was interpreted in function of the presumed digital nature of rational thought and language. In the present paper, Monty Hall 1.0 and 2.0 are briefly reviewed (§§2-3). Additional generalizations of the problem are then presented in §§4-7. They concern expansions of the problem to the following items: (1) to any number of picked doors, with p denoting the number of doors initially picked and q the number of doors picked when switching doors after doors have been opened to reveal goats (Monty Hall 3.0;see §4);(3) to the precise conditions under which one’s chances increase or decrease in instances of Monty Hall 3.0 (Monty Hall 3.2;see §6);and (4) to any number of switches of doors (s) (Monty Hall 4.0;see §7). The afore-mentioned article in APM, Vol. 1, No. 4 may serve as a useful introduction to the analysis of the higher variations of the Monty Hall problem offered in the present article. The body of the article is by Leo Depuydt. An appendix by Richard D. Gill (see §8) provides additional context by building a bridge to modern probability theory in its conventional notation and by pointing to the benefits of certain interesting and relevant tools of computation now available on the Internet. The cognitive component of the earlier investigation is extended in §9 by reflections on the foundations of mathematics. It will be proposed, in the footsteps of George Boole, that the phenomenon of mathematics needs to be defined in empirical terms as something that happens to the brain or something that the brain does. It is generally assumed that mathematics is a property of nature or reality or whatever one may call it. There is not the slightest intention in this paper to falsify this assumption because it cannot be falsified, just as it cannot be empirically or positively proven. But there is no way that this assumption can be a factual observation. It can be no more than an altogether reasonable, yet fully secondary, inference derived mainly from the fact that mathematics appears to work, even if some may deem the fact of this match to constitute proof. On the deepest empirical level, mathematics can only be directly observed and therefore directly analyzed as an activity of the brain. The study of mathematics therefore becomes an essential part of the study of cognition and human intelligence. The reflections on mathematics as a phenomenon offered in the present article will serve as a prelude to planned articles on how to redefine the foundations of probability as one type of mathematics in cognitive fashion and on how exactly Boole’s theory of probability subsumes, supersedes, and completes classical probability theory. §§2-7 combined, on the one hand, and §9, on the other hand, are both self-sufficient units and can be read independently from one another. The ultimate design of the larger project of which this paper is part remains the increase of digitalization of the analysis of rational thought and language, that is, of (rational, not emotional) human intelligence. To reach out to other disciplines, an effort is made to describe the mathematics more explicitly than is usual.
基金support from the National Natural Science Foundation of China(22073033,21873032,21673087,21903032)startup fund(2006013118 and 3004013105)from Huazhong University of Science and Technology+1 种基金the Fundamental Research Funds for the Central Universities(2019kfyRCPY116)the Innovation and Talent Recruitment Base of New Energy Chemistry and Device(B21003)
文摘In this work,we open an avenue toward rational design of potential efficient catalysts for sustainable ammonia synthesis through composition engineering strategy by exploiting the synergistic effects among the active sites as exemplified by diatomic metals anchored graphdiyne via the combination of hierarchical high-throughput screening,first-principles calculations,and molecular dynamics simulations.Totally 43 highly efficient catalysts feature ultralow onset potentials(|U_(onset)|≤0.40 V)with Rh-Hf and Rh-Ta showing negligible onset potentials of 0 and-0.04 V,respectively.Extremely high catalytic activities of Rh-Hf and Rh-Ta can be ascribed to the synergistic effects.When forming heteronuclears,the combinations of relatively weak(such as Rh)and relatively strong(such as Hf or Ta)components usually lead to the optimal strengths of adsorption Gibbs free energies of reaction intermediates.The origin can be ascribed to the mediate d-band centers of Rh-Hf and Rh-Ta,which lead to the optimal adsorption strengths of intermediates,thereby bringing the high catalytic activities.Our work provides a new and general strategy toward the architecture of highly efficient catalysts not only for electrocatalytic nitrogen reduction reaction(eNRR)but also for other important reactions.We expect that our work will boost both experimental and theoretical efforts in this direction.
文摘There are costs for doing the right thing,but regret is not one of those costs.I learned this lesson the hard way throughout a 42-year engineering career.As a young engineer,raising a family,I was more adaptable to management mandates,i.e.,I was more willing to be unethical to keep my job to make money and have health insurance for my family.As I grew in age,experience,and stamina,I was less adaptable,i.e.,I was more ethical.This article tells this story through events at various times in my engineering career1.Ethics define how we do the right thing.
基金The authors are thankful to Ministry of Human Resource Development(presently Ministry of Education),Government of India,New Delhi,for providing research facility by sanctioning Center of Excellence(F.No.5-6/2013-TS VII)in Tissue Engineering and Center of Excellence in Orthopedic Tissue Engineering and Rehabilitation funded by World Bank under TEQIP-II.
文摘Sodium alginate(SA)/chitosan(CH)polyelectrolyte scaffold is a suitable substrate for tissue-engineering application.The present study deals with further improvement in the tensile strength and biological properties of this type of scaffold to make it a potential template for bone-tissue regeneration.We experimented with adding 0%–15%(volume fraction)gelatin(GE),a protein-based biopolymer known to promote cell adhesion,proliferation,and differentiation.The resulting tri-polymer complex was used as bioink to fabricate SA/CH/GEmatrices by three-dimensional(3D)printing.Morphological studies using scanning electron microscopy revealed the microfibrous porous architecture of all the structures,which had a pore size range of 383–419μm.X-ray diffraction and Fourier-transform infrared spectroscopy analyses revealed the amorphous nature of the scaffold and the strong electrostatic interactions among the functional groups of the polymers,thereby forming polyelectrolyte complexes which were found to improve mechanical properties and structural stability.The scaffolds exhibited a desirable degradation rate,controlled swelling,and hydrophilic characteristics which are favorable for bone-tissue engineering.The tensile strength improved from(386±15)to(693±15)kPa due to the increased stiffness of SA/CH scaffolds upon addition of gelatin.The enhanced protein adsorption and in vitro bioactivity(forming an apatite layer)confirmed the ability of the SA/CH/GE scaffold to offer higher cellular adhesion and a bone-like environment to cells during the process of tissue regeneration.In vitro biological evaluation including the MTT assay,confocal microscopy analysis,and alizarin red S assay showed a significant increase in cell attachment,cell viability,and cell proliferation,which further improved biomineralization over the scaffold surface.In addition,SA/CH containing 15%gelatin designated as SA/CH/GE15 showed superior performance to the other fabricated 3D structures,demonstrating its potential for use in bone-tissue engineering.
基金Researchers supporting Project Number(RSPD2024R576),King Saud University,Riyadh,Saudi Arabia.
文摘Sentiment analysis is becoming increasingly important in today’s digital age, with social media being a significantsource of user-generated content. The development of sentiment lexicons that can support languages other thanEnglish is a challenging task, especially for analyzing sentiment analysis in social media reviews. Most existingsentiment analysis systems focus on English, leaving a significant research gap in other languages due to limitedresources and tools. This research aims to address this gap by building a sentiment lexicon for local languages,which is then used with a machine learning algorithm for efficient sentiment analysis. In the first step, a lexiconis developed that includes five languages: Urdu, Roman Urdu, Pashto, Roman Pashto, and English. The sentimentscores from SentiWordNet are associated with each word in the lexicon to produce an effective sentiment score. Inthe second step, a naive Bayesian algorithm is applied to the developed lexicon for efficient sentiment analysis ofRoman Pashto. Both the sentiment lexicon and sentiment analysis steps were evaluated using information retrievalmetrics, with an accuracy score of 0.89 for the sentiment lexicon and 0.83 for the sentiment analysis. The resultsshowcase the potential for improving software engineering tasks related to user feedback analysis and productdevelopment.
基金National Natural Science Foundation of China(Grant Nos.51908188 and 51938011).
文摘The recent increase in blast/bombing incidents all over the world has pushed the development of effective strengthening approaches to enhance the blast resistance of existing civil infrastructures.Engineered geopolymer composite(EGC)is a promising material featured by eco-friendly,fast-setting and strain-hardening characteristics for emergent strengthening and construction.However,the fiber optimization for preparing EGC and its protective effect on structural elements under blast scenarios are uncertain.In this study,laboratory tests were firstly conducted to evaluate the effects of fiber types on the properties of EGC in terms of workability,dry shrinkage,and mechanical properties in compression,tension and flexure.The experimental results showed that EGC containing PE fiber exhibited suitable workability,acceptable dry shrinkage and superior mechanical properties compared with other types of fibers.After that,a series of field tests were carried out to evaluate the effectiveness of EGC retrofitting layer on the enhancement of blast performance of typical elements.The tests include autoclaved aerated concrete(AAC)masonry walls subjected to vented gas explosion,reinforced AAC panels subjected to TNT explosion and plain concrete slabs subjected to contact explosion.It was found that EGC could effectively enhance the blast resistance of structural elements in different scenarios.For AAC masonry walls and panels,with the existence of EGC,the integrity of specimens could be maintained,and their deflections and damage were significantly reduced.For plain concrete slabs,the EGC overlay could reduce the diameter and depth of the crater and spallation of specimens.
文摘The use of drones in construction engineering has gained increasing attention in recent years due to its potential to revolutionize the industry. Drones, offer the ability to capture high-resolution aerial imagery and collect data that was previously difficult or impossible to obtain. The integration drones in construction engineering presents opportunities for accurate data collection, analysis and visualization, which can improve decision-making processes and improve project outcomes. For example, drones equipped with GIS technology can be used to capture high-resolution aerial images of construction sites, allowing engineers to monitor progress, identify potential issues, and make informed adjustments as needed. By harnessing drones, civil engineers in the civil engineering field can potentially optimize project planning, design and execution while minimizing risks and costs. The work of this topic examines the case of the use of Drones combined with GIS in construction engineering. During this study, aerial photography of a certain segment of the Pristina-Gjilan Highway was taken. The results generated by the processing of aerial photos have been compared with the project. However, further research is needed to fully understand the capabilities and limitations of these technologies in this specific context, as well as to explore any potential challenges and barriers to their widespread adoption.