Determination of Carbon and Nitrogen Isotope Fractions in Tartaric Acid, Oxalic Acid, Glucose and Fructose—National Center of High Technologies of Georgia

Tartaric acid, oxalic acid, glucose, and fructose are highly important compounds. A comprehensive study of these substances is fascinating from a scientific perspective. They are key components found in wine, vegetables, and fruits. Understanding the isotopic compositions in organic compounds is crucial for comprehending various biochemical processes and the nature of substances present in different natural products. Tartaric acid, oxalic acid, glucose, and fructose are widely distributed compounds, including in vegetables and fruits. Tartaric acid plays a significant role in determining the quality and taste properties of wine, while oxalic acid is also prevalent but holds great interest for further research, especially in terms of carbon isotopic composition. We can unveil the mechanisms of processes that were previously impossible to study. Glucose and fructose are the most common monosaccharides in the hexose group, and both are found in fruits, with sweeter fruits containing higher amounts of these substances. In addition to fruits, wheat, barley, rye, onions, garlic, lentils, peppers, dried fruits, beans, broccoli, cabbage, tomatoes, and other foods are also rich sources of fructose and glucose. To determine the mass fraction of the carbon-13 isotope in these compounds, it is important to study their changes during natural synthesis. These compounds can be modified with a carbon center. According to the existing isotopic analysis method, these compounds are converted into carbon oxide or dioxide [1]. At this point, the average carbon content in the given compound is determined, but information about isotope-modified centers is lost. Dilution may occur through the transfer of other carbon-containing organic compounds in the sample or by dilution with natural carbon or carbon dioxide during the transfer process. This article discusses the possibility of carbon-13 isotope propagation directly in these compounds, both completely modified and modified with individual carbon centers. The literature provides information on determining carbon-13 substance in organic compounds, both with a general approach and for individual compounds [2] [3].

Performance of risk stratification systems for gastrointestinal stromal tumors: A multicenter study

BACKGROUND Gastrointestinal stromal tumors(GISTs) are the most common mesenchymal tumor type in the gastrointestinal system. Presently, various classification systems to prognosticate GISTs have been proposed.AIM To evaluate the application value of four different risk stratification systems for GISTs.METHODS Patients who were diagnosed with GISTs and underwent surgical resection at four hospitals from 1998 to 2015 were identified from a database. Risk of recurrence was stratified by the modified National Institute of Health(NIH)criteria, the Armed Forces Institute of Pathology(AFIP) criteria, the Memorial Sloan Kettering Cancer Center(MSKCC) prognostic nomogram, and the contour maps. Receiver operating characteristic(ROC) curves were established to compare the four abovementioned risk stratification systems based on the area under the curve(AUC).RESULTS A total of 1303 patients were included in the study. The mean age of the patients was 55.77 ± 13.70 yr; 52.3% of the patients were male. The mean follow-up period was 64.91 ± 35.79 mo. Approximately 67.0% the tumors were located in the stomach, and 59.5% were smaller than 5 cm; 67.3% of the patients had a mitotic count ≤ 5/50 high-power fields(HPFs). Thirty-four tumors ruptured before and during surgery. Univariate analysis demonstrated that tumor size > 5 cm(P <0.05), mitotic count > 5/50 HPFs(P < 0.05), non-gastric location(P < 0.05), and tumor rupture(P < 0.05) were significantly associated with increased recurrence rates. According to the ROC curve, the AFIP criteria showed the largest AUC(0.754).CONCLUSION According to our data, the AFIP criteria were associated with a larger AUC than the NIH modified criteria, the MSKCC nomogram, and the contour maps, which might indicate that the AFIP criteria have better accuracy to support therapeutic decision-making for patients with GISTs.

Could Sequential Residual Centering Resolve Low Sensitivity in Moderated Regression? Simulations and Cancer Symptom Clusters

Multicollinearity constitutes shared variation among predictors that inflates standard errors of regression coefficients. Several years ago, it was proven that the common practice of mean centering in moderated regression cannot alleviate multicollinearity among variables comprising an interaction, but merely masks it. Residual centering (orthogonalizing) is unacceptable because it biases parameters for predictors from which the interaction derives, thus precluding interpretation of moderator effects. I propose and validate residual centering in sequential re-estimations of a moderated regression—sequential residual centering (SRC)—by revealing unbiased multicollinearity conditioning across the interaction and its related terms. Across simulations, SRC reduces variance inflation factors (VIF) regardless of distribution shape or pattern of regression coefficients across predictors. For any predictor, the reduced VIF is used to derive a lower standard error of its regression coefficient. A cancer sample illustrates SRC, which allows unbiased interpretations of symptom clusters. SRC can be applied efficiently to alleviate multicollinearity after data collection and shows promise for advancing synergistic frontiers of research.

Coherency Evaluation of Spatiotemporal Neural Activities in the Molluscan Olfactory Center Applying Extracellular Recording with Wavelet Analysis

The procerebrum (PC) of the land slug Limax is the olfactory center involved in olfactory discrimination and learning. In the PC, an oscillation of local field potential (LFP) with 0.5 - 1 Hz is observed by electrophysiological extracellular recording. Additionally, spatiotemporal neural activities in the PC have been examined using optical recordings. However, extracellular recording is preferable to measure neural activities for a long time with a high speed, while it is not abundant in spatial information. In this study, we therefore attempted to elicit spatial information from extracellular recording. For this purpose, we evaluated spatial information included in the LFP compared with the spatiotemporal neural activities measured by the fluorescent voltage imaging. As a result, aversive odors induced the coherent spatiotemporal neural activities in the PC, and the increase in coherency was observed as a change in the LFP waveform. It was also evaluated as a decrease in entropy by analyzing the LFP oscillation patterns and wavelet analysis. Thus, although the LFP provides only one series of signals, the coherency of the spatiotemporal neural activities in the PC can be evaluated by applying extracellular recording with wavelet analysis.

Tectonic Movement and Global Climate Change

Glaciation between northern hemisphere and southern hemisphere were synchronous, the ice age occurred not in high but in low value of the eccentricity of the earth’s orbit. Such facts went against the precession principle of the astronomical theory of ice age. The inhomogeneous distribution of climate consisted with the inhomogeneous distribution of ocean and continent. The north/south antisymmetry may be attributed to southward deviation of the thermal center and northward deviation of the mass center within the mantle demonstrated by seismic tomography. The core - mantle angular momentum makes rotational energy into thermal energy and mantle plumes erupt in the ocean bottom. The earth’s deformation by tidal force makes the eruption of mantle plumes strong. They are the reason that glaciation between the Northern Hemisphere and Southern Hemisphere are synchronotis and the ice age occurred in low value of the eccentricity of the earth’s orbit. The tectonic movement is playing a most important part in global climate change.

Spatiotemporal Neural Activity Changes in the Molluscan Olfactory Center Specifically Induced by Innately Aversive and <i>In Vitro</i>Aversively Conditioned Odors

In the procerebrum (PC), the olfactory center, of the land slug Limax, an oscillation of local field potential (LFP) with 0.5 - 1 Hz is observed by electrophysiological extracellular recording. The oscillation has a phase delay along the distal-proximal axis, resulting in the propagation of waves from the distal to proximal region. One important advantage of nervous systems of mollusks such as Limax is that their nervous systems in vitro retain several types of computational properties found in vivo (e.g. learning and memory). A previous study showed that the LFP frequency in the PC of Limax increased specifically in response to innately aversive and in vitro aversively conditioned odors. In the present study, we examined spatiotemporal neural activity changes induced in the PC by those odors using the fluorescent voltage imaging technique. The results showed that innately aversive (onion and hexanol) and in vitro aversively conditioned (carrot, which is innately attractive) odors specifically induced an increase in propagation speed of the neural activity in the PC, while innately attractive odors did not induce it. The results also suggested that the avoidance behavior by those odors might be induced by the increase of propagation speed and the following increases in the discharges of the partial nerve that transmits the motor output.

加快市场服务步伐 福瑞杰推出新品IP Contact Center

近日，福瑞杰软件有限公司推出新品IP Contact Center(IPCC)。IP Contact Center是一套安装在普通Server上通讯应用平台。基于SIP协议而设计的IPCC拥有高质量的IP话音、功能强大的IP软电话、突出的软件ACD功能、整合的IVR系统功能以及完全的录音系统功能。由于拥有强大的呼叫处理能力，福瑞杰IP Contact Center可为企业提供高性能可扩展性的系统服务；支持多种媒体的接入，方便集成业务和电力营销电子商务架构。IP Contact Center的高度灵活性、

An Algorithm to Determine RBFNN’s Center Based on the Improved Density Method

It takes more time and is easier to fall into the local minimum value when using the traditional full-supervised learning algorithm to train RBFNN. Therefore, the paper proposes one algorithm to determine the RBFNN’s data center based on the improvement density method. First it uses the improved density method to select RBFNN’s data center, and calculates the expansion constant of each center, then only trains the network weight with the gradient descent method. To compare this method with full-supervised gradient descent method, the time not only has obvious reduction (including to choose data center’s time by density method), but also obtains better classification results when using the data set in UCI to carry on the test to the network.

An Approach to Improve Quality of Life and Sustainability in the Centers of Old Cities

The centers of old cities have a special design with a unique urban fabric to record cultural messages with their current citizens or their visitors from the different regions of the city or from outside. It creates spaces that strongly promote social and cultural behavior. Meanwhile, life developments and the stunning technological acceleration along with high population densities have led to many problems for the old cities and their centers, which were not prepared to address these problems. Most of these problems have caused much visual deterioration and economic recession for the centers of old cities, which raise the importance of finding alternative and flexible solutions to prevent damage in urban performance, environmental pollution and lack of requirements that affect the quality of life. The paper aims to present a vision that opens up prospects for subsequent research contributions that may contribute to improving the quality of life, inspired by sustainability and humanization features. The research relies on an inductive analysis method to develop a framework that contributes to the restoration of the old centers for their role, their aesthetic value and their functional importance, while facilitating movement and supporting their valuable architectural features.

The Precise Methods for the Measurement of Collimator Hole Angulation and Center of Rotation of SPECT by Adaptive Quality Control Phantom

The Adaptive Quality Control Phantom (AQCP) is a computer-controlled phantom which positions and moves a radioactive source in the Field of View (FOV) of an imaging nuclear medicine device on a definite path to produce a spatial distribution of gamma rays to perform QC Tests such as the Collimator Hole Angulation (CHA) and the Center of Rotation (COR) of Single Photon Emission Computer Tomography (SPECT). The collimator hole angulation for six collimators was measured using a point source and a computer-controlled cylindrical positioning system. In this method, the displacement of the image of a point source was examined as the AQCP was moving point source vertically away from the collimator face. The results of the high-accuracy measurement method of CHA show that the measurement accuracy for absolute angulation errors is better than ±0.024°. The Root Mean Square (RMS) of CHA for LEHR, LEHS and LEUHR collimators of SMV dual heads camera and LEGP, MEGP and HEGP of GE Millennium MG were evaluated to be 0.290°, 0.292°, 0.208°, 0.154°, 0.220° and 0.202°, respectively. It is to be added in this connection that the evaluated RMS of CHA for LEHR collimator with the distance variation from the collimator’s surface ±1 mm has been varied ±0.04 degree. A new method for the center of rotation assessment by AQCP is introduced and the results of this proposed method as compared with the routine QC test and their differences are discussed in detail. We defined and measured a new parameter called Dynamic Mechanical Error (DME) for applying the gantry motion correction.

Effect of noise on the auditory center

Adult guinea pigs with normal Preyer’s reflexes were used in this experiment and were di-vided into 3 groups according to the intensity of noise and exposure time.Auditory brainstemevoked response was recorded before and after exposure to noise.Clicks were presented monaurallyat a rate of high (50Hz) as well as low (10Hz).The superior olive and inferior colliculus were ob-served under an electron microscope after the guinea pigs were exposured to 110dB noise for30min.The average shift of wave Ⅳ amplitude-intensity function curve was more than that ofwave Ⅰ after exposure to intensive noise.The difference value of wave \ latency from low(10Hz) to high (50Hz) stimulus click rate decreased and was negatively correlated with the exposuretime.Ⅰ-Ⅴ,Ⅲ-Ⅴ and Ⅳ-Ⅴ interpeak latencies were shorter after exposure to noise.Themitochondria and neurilemma swelling were found in the superior olive and inferior colliculus afterexposure,Some mechanisms of the changes of auditory center were discussed in this paper.

Chemical Bonds between Charged Atoms in the Even-Odd Rule and a Limitation to Eight Covalent Bonds per Atom in Centered-Cubic and Single Face-Centered-Cubic Crystals

A crystal is a highly organized arrangement of atoms in a solid, wherein a unit cell is periodically repeated to form the crystal pattern. A unit cell is composed of atoms that are connected to some of their first neighbors by chemical bonds. A recent rule, entitled the even-odd rule, introduced a new way to calculate the number of covalent bonds around an atom. It states that around an uncharged atom, the number of bonds and the number of electrons have the same parity. In the case of a charged atom on the contrary, both numbers have different parity. The aim of the present paper is to challenge the even-odd rule on chemical bonds in well-known crystal structures. According to the rule, atoms are supposed to be bonded exclusively through single-covalent bonds. A distinctive criterion, only applicable to crystals, states that atoms cannot build more than 8 chemical bonds, as opposed to the classical model, where each atom in a crystal is connected to every first neighbor without limitation. Electrical charges can be assigned to specific atoms in order to compensate for extra or missing bonds. More specifically the article considers di-atomic body-centered-cubic, tetra-atomic and dodeca-atomic single-face-centered-cubic crystals. In body-centered crystals, atoms are interconnected by 8 covalent bonds. In face-centered crystal, the unit cell contains 4 or 12 atoms. For di-element crystals, the total number of bonds for both elements is found to be identical. The neutrality of the unit cell is obtained with an opposite charge on the nearest or second-nearest neighbor. To conclude, the even-odd rule is applicable to a wide number of compounds in known cubic structures and the number of chemical bonds per atom is not related to the valence of the elements in the periodic table.

Significant factors associated with fatal outcome in emergency open surgery for perforated peptic ulcer

AIM:To evaluate the main factors associated with mortality in patients undergoing surgery for perforated peptic ulcer referred to an academic department of general surgery in a large southern Italian city. METHODS:One hundred and forty-nine consecutive patients (M:F ratio=110:39,mean age 52 yrs,range 16-95) with peptic ulcer disease were investigated for clinical history (including age,sex,previous history of peptic ulcer,associated diseases,delayed abdominal surgery,ulcer site,operation type,shock on admission,postoperative general complications, and intra-abdominal and/or wound infections),serum analyses and radiological findings. RESULTS:The overall mortality rate was 4.0%.Among all factors,an age above 65 years,one or more associated diseases,delayed abdominal surgery,shock on admission, postoperative abdominal complications and/or wound infections,were significantly associated (x^2) with increased mortality in patients undergoing surgery (0.0001<P<0.03). CONCLUSION:Factors such as concomitant diseases,shock on admission,delayed surgery,and postoperative abdominal and wound infections are significantly associated with fatal outcomes and need careful evaluation within the general workup of patients admitted for perforated peptic ulcer.

配位聚合物｛[Zn(CF_3COO)_2(C_5H_5ON)·]H_2O｝_n的合成、晶体结构及表征

new coordination polymer {[Zn(CF3COO)2(C5H5ON)]·H2O}n was synthesized based on the reaction of zinc(Ⅱ) trifluoroacetate and 3-hydroxypyridine(C5H5ON) in methanol medium for the first time. The structure of the coordination polymer was confirmed by IR, 1H NMR, elemental analysis and thermal analysis. The crystal structure of the coordination polymer was also determined by X-ray single crystal diffraction. The crystal belongs to monoclinic system with space group P21/m, and crystallographic data of the coordination polymer are: a= 0.863 1(4) nm, b=0.717 7(3) nm, c=1.116 4(5) nm, α=γ=90°, β=107.542(6)°, V=0.659 4(5) nm3; Dc=2.037 g·cm-3; Z=2; F(000)=400; μ=1.969 mm-1. Zinc(Ⅱ) atom lies at the center of an octahedron formed by the coordination of zinc atom and six O atoms which come from four different trifluoroacetate ions and two different 3-hydroxypyridine molecules where each trifluoroacetate ion and 3-hydroxypyridine are coordinated to two different zinc ions to form coordination polymer. CCDC: 253909.

Analysis on influencing factors of patients experience in community health centers of Shenzhen,China

Objective To investigate the patients experience in community health centers( CHCs) and explore its associated factors. Methods A cross-sectional study was conducted among 330 patients who visited CHCs in Shenzhen,China from January to March 2018. Dependent variable was patient experience. Key descriptive variables were age,gender,marital status,working status groups,visits frequency for the past 6 months,whether patients had signed a family doctor,whether trusted in family doctor,whether had chronic diseases. Results Questionnaires for 300 patients were assessed. In the univariate analysis,patients experience total score was significantly associated with marital status( P < 0. 1),working status groups( P < 0. 1),frequency of visit for the past 6 months( P < 0. 05),whether had signed a family doctor( P < 0. 05),whether trusted in family doctor( P < 0. 05),whether had chronic diseases( P < 0. 05). The multivariate analysis showed that unmarried patients( P = 0. 011,OR = 2. 96,95% CI: 1. 24-5. 43) and had signed a family doctor( P = 0. 023,OR = 0. 44,95% CI: 0. 22-0. 85) were more likely to get a higher score. Conclusions Findings of this study showed a medium-level score of patients experience in the community. Patients had a quite good experience and more interventions should be focused upon the influence factors to improve patients experience.

Design and Study on Management Tools of Land Data Center for Integration of Urban and Rural Areas

The rapid development of urbanization requires land management business should change the former single systematic pattern, and advance to integration of functions and data sharing. In order to meets the requirement, this paper presents a new thinking for land management pattern, and management tools of data center for integration of urban and rural areas. The tools were based on MapGIS, which have made the management of multi-subjects, multi-areas, multi-sources and multi-measurement data possible. The techniques of this system are designed accord with national related standard. Experimental result shows that the tools have obvious technical advantage in land resource business integration management.

Scalability of the DVFS Power Management Technique as Applied to 3-Tier Data Center Architecture in Cloud Computing

The increase in computing capacity caused a rapid and sudden increase in the Operational Expenses (OPEX) of data centers. OPEX reduction is a big concern and a key target in modern data centers. In this study, the scalability of the Dynamic Voltage and Frequency Scaling (DVFS) power management technique is studied under multiple different workloads. The environment of this study is a 3-Tier data center. We conducted multiple experiments to find the impact of using DVFS on energy reduction under two scheduling techniques, namely: Round Robin and Green. We observed that the amount of energy reduction varies according to data center load. When the data center load increases, the energy reduction decreases. Experiments using Green scheduler showed around 83% decrease in power consumption when DVFS is enabled and DC is lightly loaded. In case the DC is fully loaded, in which case the servers’ CPUs are constantly busy with no idle time, the effect of DVFS decreases and stabilizes to less than 10%. Experiments using Round Robin scheduler showed less energy saving by DVFS, specifically, around 25% in light DC load and less than 5% in heavy DC load. In order to find the effect of task weight on energy consumption, a set of experiments were conducted through applying thin and fat tasks. A thin task has much less instructions compared to fat tasks. We observed, through the simulation, that the difference in power reduction between both types of tasks when using DVFS is less than 1%.

Towards Attaining Reliable and Efficient Green Cloud Computing Using Micro-Smart Grids to Power Internet Data Center

Energy generation and consumption are the main aspects of social life due to the fact that modern people’s necessity for energy is a crucial ingredient for existence. Therefore, energy efficiency is regarded as the best economical approach to provide safer and affordable energy for both utilities and consumers, through the enhancement of energy security and reduction of energy emissions. One of the problems of cloud computing service providers is the high rise in the cost of energy, efficiency together with carbon emission with regards to the running of their internet data centres (IDCs). In order to mitigate these issues, smart micro-grid was found to be suitable in increasing the energy efficiency, sustainability together with the reliability of electrical services for the IDCs. Therefore, this paper presents idea on how smart micro-grids can bring down the disturbing cost of energy, carbon emission by the IDCs with some level of energy efficiency all in an effort to attain green cloud computing services from the service providers. In specific term, we aim at achieving green information and communication technology (ICT) in the field of cloud computing in relations to energy efficiency, cost-effectiveness and carbon emission reduction from cloud data center’s perspective.

A Single Center Experience in Biological Therapy for the Treatment of Rheumatoid Arthritis in Saudi Arabia

Background: Biological therapy is indicated in the treatment of RA (Rheumatoid Arthritis) after failure of disease-modifying anti-rheumatic drugs (DMARDS) by the ACR/EULAR recommendations. The objective of the study is to describe the characteristics of Saudi patients at the initiation of biological therapy and to evaluate clinical effectiveness of this therapy measured by the disease activity score DAS 28. Methods: This was a retrospective cohort study of RA (rheumatoid arthritis) patients in King Fahad Hospital in Jeddah, Saudi Arabia from January 2005-July 2011. Data were collected from the medical records of all RA patients on biological therapy including: demographics, disease characteristics, comorbid illnesses and DAS 28 score over a period of 1 year. Results: 139 patients were studied (mean age 46 ± 13 years), of which 118 (84%) were females;mean duration of affliction with RA was 7.2 years ranging 1-45 years. Rheumatoid factor (RF) was positive in 88 patients (63.3%) and one or more comorbidities were present in 102 patients (73.3%). First choice of biological drug was ADA (Adalimumab) 44 patients (31.7%) and RTX (Rituximab) was the 2nd frequently prescribed biological drug. Mean DAS 28 activity at baseline was in ADA 41 patients (6.10 ± 1.62), ETA (Etarnercept) 29 patients (6.64 ± 1.42) and RTX 50 patients (6.7 ± 1.32). Moderate to good EULAR response was obtained in 74%, 85.7% and 53.3% at 6 months in ADA, ETA and RTX patients respectively. Moderate to good EULAR response was obtained in 61.8%, 86.6% and 72% in ADA, ETA AND RTX patients respectively at 1 year of treatment. Therapeutic effectiveness was comparable with the response rates in published observational trials. Conclusion: Our data demonstrate daily clinical practice in management of RA. The pattern of prescription is in agreement with the ACR/EULAR recommendations for initiation of biologicals in the treatment of RA.

Hip joint center localisation: A biomechanical application to hip arthroplasty population

AIM: To determine hip joint center(HJC) location on hip arthroplasty population comparing predictive and functional approaches with radiographic measurements.METHODS: The distance between the HJC and the mid-pelvis was calculated and compared between the three approaches. The localisation error between the predictive and functional approach was compared using the radiographic measurements as the reference. The operated leg was compared to the non-operated leg.RESULTS: A significant difference was found for the distance between the HJC and the mid-pelvis when comparing the predictive and functional method. The functional method leads to fewer errors. A statistical difference was found for the localization error between the predictive and functional method. The functional method is twice more precise.CONCLUSION: Although being more individualized, the functional method improves HJC localization and should be used in three-dimensional gait analysis.