KINETICS OF METHANOL SYNTHESIS IN THE PRESENCE OF C301 Cu-BASED CATALYST (Ⅰ) INTRINSIC AND GLOBAL KINETICS*

The intrinsic and global kinetics of methanol synthesis from carbon monoxide, carbon dioxide and hydrogen in the presence of C301 commercial catalyst is studied. The investigation is performed under typical commercial conditions in an isothermal plug-flow integral reactor and

Electromagnetic Radiation Causes Weight Loss and Weight Destabilization of Objects with Presumed Elevated Levels of KELEA (Kinetic Energy Limiting Electrostatic Attraction), Relevance to Human Health and to Global Warming

A natural force has been proposed, which is required to prevent the fusion and disappearance of the discrete electrical charges that are present on electrostatically attached opposing electrical charges. This force may also explain the repulsion between objects with either matching positive or negative electrical charges. The energy of this force is referred to as KELEA (kinetic energy limiting electrostatic attraction). KELEA is especially attracted to dipolar compounds and to other materials with spatially separated opposite electrical charges. These compounds can be used to increase the level of KELEA in water. KELEA activated water can become an added source of KELEA for objects that are placed in close proximity to the water. It is generally held that the weight of an object is solely determined by its mass in relation to that of the earth. Yet, it was previously reported that the measured weight of certain KELEA attracting objects can undergo considerable variability over time. This observation is consistent with the concept that KELEA can contribute to the measured weight of certain objects. The present study strengthens this concept by demonstrating that the weight of cellulose containing materials, including paper, cotton fabrics, and wood, is increased if the materials are placed close to containers of KELEA activated water. It is further shown that electromagnetic radiation can significantly reduce the added weight of the KELEA exposed cellulose containing materials. Moreover, the previously added weight of the materials can be regained by replacing the materials back into the KELEA enhanced environment. It is proposed that the electrical charges that accompany electromagnetic radiation are able to competitively withdraw some of the KELEA from certain KELEA-enhanced objects. This effect can be reliably demonstrated using single sheets of writing paper, which are primarily composed of mechanically-bonded, branched cellulose fibers. There can be considerable fluctuations of the weight of the materials exposed to electromagnetic radiation after having been placed nearby to KELEA activated water. The weight instability is interpreted as being due to the electromagnetic radiation also triggering a dynamic process of rapid additions and removals of significant quantities of KELEA to and from objects. These observations are relevant to the further understanding of KELEA and to the potential health and climate consequences of manmade electromagnetic radiation causing a reduction in the environmental levels of KELEA.

Global trends in diabetic eye disease research from 2012 to 2021

Diabetic eye disease refers to a group of eye complications that occur in diabetic patients and include diabetic retinopathy, diabetic macular edema, diabetic cataracts, and diabetic glaucoma. However, the global epidemiology of these conditions has not been well characterized. In this study, we collected information on diabetic eye disease-related research grants from seven representative countries––the United States, China, Japan, the United Kingdom, Spain, Germany, and France––by searching for all global diabetic eye disease journal articles in the Web of Science and Pub Med databases, all global registered clinical trials in the Clinical Trials database, and new drugs approved by the United States, China, Japan, and EU agencies from 2012 to 2021. During this time period, diabetic retinopathy accounted for the vast majority(89.53%) of the 2288 government research grants that were funded to investigate diabetic eye disease, followed by diabetic macular edema(9.27%). The United States granted the most research funding for diabetic eye disease out of the seven countries assessed. The research objectives of grants focusing on diabetic retinopathy and diabetic macular edema differed by country. Additionally, the United States was dominant in terms of research output, publishing 17.53% of global papers about diabetic eye disease and receiving 22.58% of total citations. The United States and the United Kingdom led international collaborations in research into diabetic eye disease. Of the 415 clinical trials that we identified, diabetic macular edema was the major disease that was targeted for drug development(58.19%). Approximately half of the trials(49.13%) pertained to angiogenesis. However, few drugs were approved for ophthalmic(40 out of 1830;2.19%) and diabetic eye disease(3 out of 1830;0.02%) applications. Our findings show that basic and translational research related to diabetic eye disease in the past decade has not been highly active, and has yielded few new treatment methods and newly approved drugs.

Unveiling Global Human Trafficking Trends: A Comprehensive Analysis

This paper presents a comprehensive analysis of global human trafficking trends over a twenty-year period, leveraging a robust dataset from the Counter Trafficking Data Collaborative (CTDC). The study unfolds in a systematic manner, beginning with a detailed data collection phase, where ethical and legal standards for data usage and privacy are strictly observed. Following collection, the data undergoes a rigorous preprocessing stage, involving cleaning, integration, transformation, and normalization to ensure accuracy and consistency for analysis. The analytical phase employs time-series analysis to delineate historical trends and utilizes predictive modeling to forecast future trajectories of human trafficking using the advanced analytical capabilities of Power BI. A comparative analysis across regions—Africa, the Americas, Asia, and Europe—is conducted to identify and visualize the distribution of human trafficking, dissecting the data by victim demographics, types of exploitation, and duration of victimization. The findings of this study not only offer a descriptive and predictive outlook on trafficking patterns but also provide insights into the regional nuances that influence these trends. The article underscores the prevalence and persistence of human trafficking, identifies factors contributing to its evolution, and discusses the implications for policy and law enforcement. By integrating a methodological approach with quantitative analysis, this research contributes to the strategic planning and resource allocation for combating human trafficking. It highlights the necessity for continued research and international cooperation to effectively address and mitigate this global issue. The implications of this research are significant, offering actionable insights for policymakers, law enforcement, and advocates in the ongoing battle against human trafficking.

More Compactification for Differential Systems

This article is a review and promotion of the study of solutions of differential equations in the “neighborhood of infinity” via a non traditional compactification. We define and compute critical points at infinity of polynomial autonomuos differential systems and develop an explicit formula for the leading asymptotic term of diverging solutions to critical points at infinity. Applications to problems of completeness and incompleteness (the existence and nonexistence respectively of global solutions) of dynamical systems are provided. In particular a quadratic competing species model and the Lorentz equations are being used as arenas where our technique is applied. The study is also relevant to the Painlevé property and to questions of integrability of dynamical systems.

商品房住宅区公共物业自治管理制度分析 以上海市水仙苑小区为例

The reform of the housing system in Shanghai has unexpectedly given rise to a self-governed property owners’ collective supervisory system, primarily in the form of Property Owners’ Supervisory Council (POSC), which has picked up some of the government’s administrative functions. Although this new, institutionalized management model has theoretically made democratic managerial participation at the grassroots level possible, it has brought about endless problems, overt and covert, shortly after its appearance, some of which are even alarming. A comprehensive analysis of the data collected over a long period of time has led to the conclusion that this system is a failure, attributable to the overt factor related to skills in reality and the covert “priori” factor that is masked by the former. The existence of such “priori” factor once again demonstrates the deep-rooted, traditional managerial logic: Positive operations is society need only to depend upon individuals’ unstable self-disciplined morality rather than to build a system. The current paper points out that any change in the socioeconomic structure that has long been subject to the power of politics is to inevitably incur a corresponding global structural accommodation, including politics itself. To respond to the two factors for the failure, system building in the two overlapping areas is a must.

Time-course pattern of neuronal loss and gliosis in gerbil hippocampi following mild, severe, or lethal transient global cerebral ischemia

Transient ischemia in the whole brain leads to neuronal loss/death in vulnerable brain regions. The striatum, neocortex and hippocampus selectively loose specific neurons after transient ischemia. Just 5 minutes of transient ischemia can cause pyramidal neuronal death in the hippocampal cornu ammonis (CA) 1 field at 4 days after transient ischemia. In this study, we investigated the effects of 5-minute (mild), 15-minute (severe), and 20-minute (lethal) transient ischemia by bilateral common carotid artery occlusion (BCCAO) on behavioral change and neuronal death and gliosis (astrocytosis and microgliosis) in gerbil hippocampal subregions (CA1-3 region and dentate gyrus). We performed spontaneous motor activity test to evaluate gerbil locomotor activity, cresyl violet staining to detect cellular distribution, neuronal nuclei immunohistochemistry to detect neuronal distribution, and Fluoro-Jade B histofluorescence to evaluate neuronal death. We also conducted immunohistochemical staining for glial fibrillary acidic protein and ionized calcium-binding adapter molecule 1 (Ibal) to evaluate astrocytosis and microgliosis, respectively. Animals subjected to 20-minute BCCAO died in at least 2 days. BCCAO for 15 minutes led to pyramidal cell death in hippocampal CA1-3 region 2 days later and granule cell death in hippocampal de匚tate gyrus 5 days later. Similar results were not found in animals subjected to 5-minute BCCAO. Gliosis was much more rapidly and severely progressed in animals subjected to 15-minute BCCAO than in those subjected to 5- minute BCCAO. Our results indicate that neuronal loss in the hippocampal formation following transient ischemia is significantly different according to regions and severity of transient ischemia. The experimental protocol was approved by Institutional Animal Care and Use Committee (AICUC) of Kangwon National University (approval No. KW-180124-1) on May 22, 2018.

Global trends in hepatitis C-related hepatocellular carcinoma mortality:A public database analysis(1999-2019)

BACKGROUND Hepatitis C is the leading cause of chronic liver disease worldwide and it significantly contributes to the burden of hepatocellular carcinoma(HCC).However,there are marked variations in the incidence and mortality rates of HCC across different geographical regions.With the advent of new widely available treatment modalities,such as direct-acting antivirals,it is becoming increasingly imperative to understand the temporal and geographical trends in HCC mortality associated with Hepatitis C.Furthermore,gender disparities in HCC mortality related to Hepatitis C are a crucial,yet underexplored aspect that adds to the disease's global impact.While some studies shed light on gender-specific trends,there is a lack of comprehensive data on global and regional mortality rates,particularly those highlighting gender disparities.This gap in knowledge hinders the development of targeted interventions and resource allocation strategies.DISCUSSION The results of our study show an overall decline in the mortality rates of patients with hepatitis C-related HCC over the last two decades.Notably,females exhibited a remarkable decrease in mortality compared to males.Regionally,East Asia and the Pacific displayed a significant decline in mortality,while Europe and Central Asia witnessed an upward trend.Latin America and the Caribbean also experienced an increase in mortality rates.However,no significant difference was observed in the Middle East and North Africa.North America exhibited a notable upward trend.South Asia and Sub-Saharan Africa significantly declined throughout the study period.This raises the hope of identifying areas for implementing more targeted resources.Despite some progress,multiple challenges remain in meeting the WHO 2030 goal of eliminating viral hepatitis[24].

AN INTEGRATION METHOD WITH FITTING CUBIC SPLINE FUNCTIONS TO A NUMERICAL MODEL OF 2ND-ORDER SPACE-TIME DIFFERENTIAL REMAINDER——FOR AN IDEAL GLOBAL SIMULATION CASE WITH PRIMITIVE ATMOSPHERIC EQUATIONS

In this paper,the forecasting equations of a 2nd-order space-time differential remainder are deduced from the Navier-Stokes primitive equations and Eulerian operator by Taylor-series expansion.Here we introduce a cubic spline numerical model(Spline Model for short),which is with a quasi-Lagrangian time-split integration scheme of fitting cubic spline/bicubic surface to all physical variable fields in the atmospheric equations on spherical discrete latitude-longitude mesh.A new algorithm of"fitting cubic spline—time step integration—fitting cubic spline—……"is developed to determine their first-and2nd-order derivatives and their upstream points for time discrete integral to the governing equations in Spline Model.And the cubic spline function and its mathematical polarities are also discussed to understand the Spline Model’s mathematical foundation of numerical analysis.It is pointed out that the Spline Model has mathematical laws of"convergence"of the cubic spline functions contracting to the original functions as well as its 1st-order and 2nd-order derivatives.The"optimality"of the 2nd-order derivative of the cubic spline functions is optimal approximation to that of the original functions.In addition,a Hermite bicubic patch is equivalent to operate on a grid for a 2nd-order derivative variable field.Besides,the slopes and curvatures of a central difference are identified respectively,with a smoothing coefficient of 1/3,three-point smoothing of that of a cubic spline.Then the slopes and curvatures of a central difference are calculated from the smoothing coefficient 1/3 and three-point smoothing of that of a cubic spline,respectively.Furthermore,a global simulation case of adiabatic,non-frictional and"incompressible"model atmosphere is shown with the quasi-Lagrangian time integration by using a global Spline Model,whose initial condition comes from the NCEP reanalysis data,along with quasi-uniform latitude-longitude grids and the so-called"shallow atmosphere"Navier-Stokes primitive equations in the spherical coordinates.The Spline Model,which adopted the Navier-Stokes primitive equations and quasi-Lagrangian time-split integration scheme,provides an initial ideal case of global atmospheric circulation.In addition,considering the essentially non-linear atmospheric motions,the Spline Model could judge reasonably well simple points of any smoothed variable field according to its fitting spline curvatures that must conform to its physical interpretation.

Global Electronic Dominance with Spatial Grasp

A high-level control technology will be revealed that can dynamically establish overwhelming dominance over distributed networked systems with embedded electronic devices and any communications between them. It is based on implanting of universal control modules (that may be concealed) into key system points which collectively interpret complex but compact mission scenarios in a special high-level Distributed Scenario language (DSL). Self-evolving and self-spreading in networks, matching them in a super-virus mode, DSL scenarios can analyze their structures and states and set up any behavior needed, including creation of benign or elimination of unwanted infrastructures. The scalable technology allows us to convert any distributed networked systems into a sort of integral spatial brain capable of analyzing and withstanding unpredictable situations in a variety of important domains.

Global Solution of a Nonlinear Conservation Law with Weak Discontinuous Flux in the Half Space

This paper is concerned with the initial-boundary value problem of a nonlinear conservation law in the half space R+= {x |x > 0} where a>0 , u(x,t) is an unknown function of x ∈ R+ and t>0 , u ± , um are three given constants satisfying um=u+≠u- or um=u-≠u+ , and the flux function f is a given continuous function with a weak discontinuous point ud. The main purpose of our present manuscript is devoted to studying the structure of the global weak entropy solution for the above initial-boundary value problem under the condition of f '-(ud) > f '+(ud). By the characteristic method and the truncation method, we construct the global weak entropy solution of this initial-boundary value problem, and investigate the interaction of elementary waves with the boundary and the boundary behavior of the weak entropy solution.

The Belt and Road Initiative and the 2030 Agenda for Sustainable Development:seeking linkages for global environmental governance

Global environmental cooperation serves as an important part in the Chinese ideal of building a Community with a Shared Future for all Human Beings. The report of 19 th CPC National Congress indicates that China is committed to proactive mitigation under the Paris Agreement and further participating in global environmental governance under the 2030 Agenda for Sustainable Development, and both of which are largely integrated to the Belt and Road Initiative(BRI). BRI are also closely linked with South-South environmental and climate cooperation proposed by China from previous UN summits. Based on shared ideas, intersected agendas, and compatible governance approaches, BRI and the 2030 Agenda for Sustainable Development grow increasingly relevant and they might form synergies based on increasingly interactive relations. In sum,seeking and intensifying the linkages between BRI and 2030 sustainable development goals(SDGs) could address global environmental governance deficits and enhance cooperation among nations.

Pretreated Oenan the Javanica extract increases anti-inflammatory cytokines, attenuates gliosis, and protects hippocampal neurons following transient global cerebral ischemia in gerbils

Recently,we have reported that Oenanthe javanica extract(OJE)displays strong neuroprotective effect against ischemic damage after transient global cerebral ischemia.However,neuroprotective mechanisms of OJE have not been fully identified.Thus,this study investigated the neuroprotection of OJE in the hippocampal CA1 area and its anti-inflammatory activity in gerbils subjected to 5 minutes of transient global cerebral ischemia.We treated the animals by intragastrical injection of OJE(100 and 200 mg/kg)once daily for 1 week prior to transient global cerebral ischemia.Neuroprotection of OJE was observed by immunohistochemistry for neuronal nuclear antigen and histofluorescence staining for Fluoro-Jade B.Immunohistochemistry of glial fibrillary acidic protein and ionized calcium-binding adapter molecule 1 was done for astrocytosis and microgliosis,respectively.To investigate the neuroprotective mechanisms of OJE,we performed immunohistochemistry of tumor necrosis factor-alpha and interleukin-2 for pro-inflammatory function and interleukin-4 and interleukin-13 for anti-inflammatory function.When we treated the animals by intragastrical administration of 200 mg/kg of OJE,hippocampal CA1 pyramidal neurons were protected from transient global cerebral ischemia and cerebral ischemia-induced gliosis was inhibited in the ischemic hippocampal CA1 area.We also found that interleukin-4 and-13 immunoreactivities were significantly increased in pyramidal neurons of the ischemic CA1 area after OJE pretreatment,and the increased immunoreactivities were sustained in the CA1 pyramidal neurons after transient global cerebral ischemia.However,OJE pretreatment did not increase interleukin-2 and tumor necrosis factor-alpha immunoreactivities in the CA1 pyramidal neurons.Our findings suggest that pretreatment with OJE can protect neurons and attenuate gliosis from transient global cerebral ischemia via increasing expressions of interleukin-4 and-13.The experimental plan of this study was reviewed and approved by the Institutional Animal Care and Use Committee(IACUC)in Kangwon National University(approval No.KW-160802-1)on August 10,2016.

Kinetics and mechanism of the low-energy β-a phase transition of the second kind in 2,4-dinitroanisole

In this work, comprehensive studies of 2,4-dinitroanisole(2,4DNAN) were carried out using powder thermorentgenography of the internal standard. The time of the complete polymorphic transition in the solid phase β→a in 2,4DNAN under various combinations of conditions has been determined. It has been established that, regardless of the season of manufacture of the substance, when it is stored for 8-9months, with a change in ambient temperature from minus 30℃ to plus 30℃, a complete polymorphic transition β→a occurs. When stored in conditions below minus 5℃, polymorphic transition does not occur. When stored in conditions above plus 30℃ in a closed container, polymorphic transition occurs within 3 weeks. The polymorphic transition is accompanied by a decrease in density by 1.3%-1.5% and an increase in melting temperature by 10-12℃, depending on the degree of purity of the starting substance. The activation energy of the molecular rearrangement was 68-70 k J/mol(16.5 ± 3 kcal/mol). The mechanism of polymorphic transition has been evaluated, which is presumably based on internal homodiffusion and energy transfer to the surface of the mass of powder particles and the product. The average activation energy of the polymorphic transition process was 110 ± 6.2 k J/mol(26.2 kcal/mol). In an open container, reactions proceed by a homogeneous mechanism, and in a closed container by a heterogeneous mechanism involving the gas phase.

Global and International Security Under Spatial Grasp Paradigm

Global and international security cannot be provided from a single point or a set of separate points whatever powerful these might be(even with quantum supercomputers!).It should rather be deeply embedded and integrated with bodies of real systems wherever in physical,virtual,or combined spaces they may exist.So global security capabilities should not only be distributed,but rather be really spatial,self-organized,and dynamic,also exhibiting overall integrity,awareness,and consciousness features.The paper describes applicability of the patented and revealed in 10 books Spatial Grasp Model and Technology(SGT)and its basic Spatial Grasp Language(SGL)which conceptually and functionally match security problems of large distributed and heterogeneous systems.It investigates very practical security solutions for finding and tracing distribution of forbidden items,world roaming criminals,recovery from natural and human-made disasters,tracing and elimination of moving dangerous objects in terrestrial and celestial spaces,as well as analysis and restoration of damaged transport networks.It advises how different security infrastructures can be organized and managed,and how to cooperate and integrate within global security systems with higher awareness and consciousness levels over them.The provided security-oriented version of SGL can be quickly implemented and integrated with existing distributed management and security systems.

再论中产阶级:理论、历史与类型学 兼及一种全球化的视野

The emergence of the middle class was closely related to the appearance of industrial society and its consequential constant changes in the social structure. Karl Marx and other theorists in the same camp were among the earliest scholars who discussed that topic. For a quite long period of time, the debate was mainly focused on the characteristics of the “new middle class.” The middle class, however, has undergone a categorical transformation from the old to the new middle-class, and furthermore, this transformation itself has signified the transition in social patterns from industrial to post-industrial society as well as economic globalization, both of which have contributed to the growth and global expansion of the middle class, having thus fundamentally renovated the middle class.

Trends in Global Solar Radiation and Sunshine Duration in Past Two Decades in Japan

Global solar radiation (GSR) is an essential physical quantity for agricultural management and designing infrastructures. Because GSR has often been modeled as a function of sunshine duration (SD) and day length for a given set of locations and calendar days, analyzing interannual trends in GSR and SD is important to evaluate, predict or regulate the cycles of energy and water between geosphere and atmosphere. This study aimed to exemplify interannual trends in GSR and SD, which had been recorded from 2001 to 2022 in 40 meteorological stations in Japan, and validate the applicability of an SD-based model to the evaluation of GSR. Both the measured GSR and SD had increased in many of the stations in the study period with averaged rates of 0.252 [W·m−2·y−1] and 0.015 [h·d−1·y−1], respectively. The offset and the slope of the SD-based model were estimated by fitting the model to the measured data sets and were found to have been almost constant with the averages of 0.201[-] and 0.566[-], respectively, indicating that characteristics of the SD-GSR relation had not varied for the 22-year period and that the model and its parameter set can be stationarily applicable to the analyses and predictions of GSR in recent years. The stable trends in both parameters also implied that the upward trend in SD can be a main explanatory factor for that in the measured GSR. The upward trend in SD had coincided with the increase in the frequency of heavy-shortened rains, suggesting that the time period of each rainfall event had gradually decreased, which may be attributable to the obtained upward trend in SD. Further studies are required to clarify if there is some cause-effect relation between the changes in rainfall patterns and the standard level of solar radiation reaching the land surface.

Exploring Global Demands for Integrating Social Aspects into Community Healthcare: A Literature Review

Aging and crises like pandemics and climate change are global concerns that affect community environments. These social and natural changes influence people’s health worldwide. Aging impacts human health, including physical and mental aspects, and increases the need for care. Recent crises have affected not only the elderly but also younger populations, necessitating further efforts to develop a systematic community strategy. The goal of such a strategy is to maintain or enhance people’s well-being. As we face aging and crises like pandemics and climate change, it becomes essential to consider health holistically and globally, taking into account the community environment and social determinants without boundaries. The present study aimed to explore the necessary aspects of incorporating social determinants into clinical practice, enabling healthcare providers to view health from a holistic and planetary perspective. This approach facilitates the development of integrated community strategies. The study reviewed literature from PubMed, MEDLINE, and CINAHL databases, focusing on medicine, health, and welfare. An electronic search for English-language articles in peer-reviewed journals was conducted up to July 2024, using search terms such as “holistic health,” “planetary health,” and “social determinants.” Eight articles were identified through the search. After excluding three based on their titles, abstracts, and full texts, five articles were selected. The research focused on three areas: perceiving health in ecosystems, considering health-related policy in clinical situations, and addressing health in primary care settings. This study emphasizes the need for further research on innovative, integrated community strategies in the context of a globally aging society, focusing on non-medical aspects like pandemics, climate change, and social determinants to achieve a holistic and planetary understanding of people’s health. It suggests that understanding the social aspects of ecosystems in clinical settings, through interdisciplinary collaboration, is crucial for developing systematic community strategies for people’s well-being life in medical, health, and welfare contexts.

HEXAGON GLOBAL REFERENCE活动桥式测量机

GLOBAL REFERENCE具备非常高的扫描效率，可以为具有最复杂几何形状的工件提供测量解决方案。采用LEITZ的TRAX测头技术，具备极高的测量精度，重复性好。配置当今功能最为完善的软件之一：QUINDOS，使得用户在完成箱体类工件测量的同时，还可完成包括多种曲面元素，诸如叶片、齿轮和压缩机螺杆以及轮廓、自由曲面等多种复杂几何形状的测量。独特的TRICISION(精密三角梁)横梁设计，提供了良好的刚性质量比。轻合金桥架，与传统设计相比较刚性提高了25%，

Global Burden of Fungal Infections and Antifungal Resistance from 1961 to 2024: Findings and Future Implications

Background: Antifungal resistance (AFR) is a global public health problem with devastating effects, especially among immunocompromised individuals. Addressing AFR requires a One Health approach including Antifungal Stewardship (AFS). This study aimed to comprehensively review global studies published on fungal infections and AFR and to recommend solutions to address this growing problem. Materials and Methods: This was a narrative review that was conducted using published papers on fungal infections, AFR, and AFS between January 1961 and March 2024. The literature was searched using PubMed, Google Scholar, Web of Science, and EMBASE. Results: This found that there has been an increase in fungal infections globally, especially among immunocompromised patients. Due to this increase in fungal infections, there has been a proportionate increase in the use of antifungal agents to prevent and treat fungal infections. This increased use of antifungal agents has worsened the problem of AFR contributing to increased morbidity and mortality. Globally, fungal infections have contributed to 150 million infections annually and 1.7 million deaths per year. By the year 2023, over 3.8 million people died from fungal infections. Addressing AFR remains a challenge because the treatment of antifungal-resistant infections is difficult. Finally, the treatment of fungal infections is a global challenge exacerbated by the limited number of antifungal agents to treat invasive fungal infections. Conclusion: The results of this study indicated that fungal infections and AFR are prevalent across humans, animals, agriculture, and the environment. Addressing this problem requires the provision of solutions such as improving the awareness of AFR, conducting further research on the discovery of new antifungal agents, and implementing AFS programs. If this global problem is not addressed, the morbidity and mortality associated with AFR will continue to rise in the future.