Normal tension glaucoma: from the brain to the eye or the inverse?

Glaucoma is a chronic, progressive optic neuropathy characterized by the loss of peripheral vision first and then central vision. Clinically, normal tension glaucoma is considered a special subtype of glaucoma, in which the patient’s intraocular pressure is within the normal range, but the patient experiences typical glaucomatous changes. However, increasing evidence has challenged the traditional pathophysiological view of normal tension glaucoma, which is based only on intraocular pressure, and breakthroughs in central nervous system imaging may now greatly increase our knowledge about the mechanisms underlying normal tension glaucoma. In this article, we review the latest progress in understanding the pathogenesis of normal tension glaucoma and in developing imaging techniques to detect it, to strengthen the appreciation for the connection between normal tension glaucoma and the brain.

Use of venous-to-arterial carbon dioxide tension difference to guide resuscitation therapy in septic shock

The mixed venous-to-arterial carbon dioxide(CO_2)tension difference[P(v-a) CO_2]is the difference between carbon dioxide tension(PCO_2) in mixed venous blood(sampled from a pulmonary artery catheter) and the PCO_2 in arterial blood.P(v-a) CO_2 depends on the cardiac output and the global CO_2 production,and on the complex relationship between PCO_2 and CO_2 content.Experimental and clinical studies support the evidence that P(v-a) CO_2 cannot serve as an indicator of tissue hypoxia,and should be regarded as an indicator of the adequacy of venous blood to wash out the total CO_2generated by the peripheral tissues.P(v-a) CO_2 can be replaced by the central venous-to-arterial CO_2 difference(△PCO_2),which is calculated from simultaneous sampling of central venous blood from a central vein catheter and arterial blood and,therefore,more easy to obtain at the bedside.Determining the △PCO_2 during the resuscitation of septic shock patients might be useful when deciding when to continue resuscitation despite a central venous oxygen saturation(SCVO_2) > 70%associated with elevated blood lactate levels.Because high blood lactate levels is not a discriminatory factor in determining the source of that stress,an increased △PCO_2(> 6 mmHg)could be used to identify patients who still remain inadequately resuscitated.Monitoring the △PCO_2 from the beginning of the reanimation of septic shock patients might be a valuable means to evaluate the adequacy of cardiac output in tissue perfusion and,thus,guiding the therapy.In this respect,it can aid to titrate inotropes to adjust oxygen delivery to CO_2 production,or to choose between hemoglobin correction or fluid/inotrope infusion in patients with a too low ScvO_2 related to metabolic demand.The combination of P(v-a) CO_2 or △PCO_2 with oxygen-derived parameters through the calculation of the P(v-a) CO_2 or △PCO_2/arteriovenous oxygen content difference ratio can detect the presence of global anaerobic metabolism.

The Tension Cosmology, Largest Cosmic Structures and Explosions of Supernovae from SST

Here, using the Scale-Symmetric Theory (SST) we explain the cosmological tension and the origin of the largest cosmic structures. We show that a change in value of strong coupling constant for cold baryonic matter leads to the disagreement in the galaxy clustering amplitude, quantified by the parameter S8. Within the same model we described the Hubble tension. We described also the mechanism that transforms the gravitational collapse into an explosion—it concerns the dynamics of virtual fields that lead to dark energy. Our calculations concern the Type Ia supernovae and the core-collapse supernovae. We calculated the quantized masses of the progenitors of supernovae, emitted total energy during explosion, and we calculated how much of the released energy was transferred to neutrinos. Value of the speed of sound in the strongly interacting matter measured at the LHC confirms that presented here model is correct. Our calculations show that the Universe is cyclic.

Hubble Tension Explanation from This Cosmological Model AΛΩ (Slow Bang Model, SB)

In this article we present a model of Hubble-Lemaître law using the notions of a transmitter (galaxy) and a receiver (MW) coupled to a model of the universe (Slow Bang Model, SB), based on a quantum approach of the evolution of space-time as well as an equation of state that retains all the infinitesimal terms. We find an explanation of the Hubble tension H0. Indeed, we have seen that this constant depends on the transceiver pair which can vary from the lowest observable value, from photons of the CMB (theoretical [km/s/Mpc]) to increasingly higher values depending on the earlier origin of the formation of the observed galaxy or cluster (ETG ~0.3 [Gy], ~74 [km/s/Mpc]). We have produced a theoretical table of the values of the constant according to the possible pairs of transmitter/receiver in the case where these galaxies follow the Hubble flow without large disturbance. The calculated theoretical values of the constant are in the order of magnitude of all values mentioned in past studies. Subsequently, we applied the models to 9 galaxies and COMA cluster and found that the models predict acceptable values of their distances and Hubble constant since these galaxies mainly follow the Hubble flow rather than the effects of a galaxy cluster or a group of clusters. In conclusion, we affirm that this Hubble tension does not really exist and it is rather the understanding of the meaning of this constant that is questioned.

Eudragit®-PEG Nanoparticles: Physicochemical Characterization and Interfacial Tension Measurements

The objectives of this study are to understand the mechanisms involved in the stabilization of water/oil interfaces by polymeric nanoparticles (NPs) (Eudragit®). Eudragit L100 NPs of various sizes and Zeta potentials were studied and compared at a water/cyclohexane model interface using a droplet tensiometer (Tracker Teclis, Longessaigne, France). The progressive interfacial adsorption of the NPs in the aqueous phase was monitored by tensiometry. The model interface was maintained and observed in a drop tensiometer, analyzed via axisymmetric drop shape analysis (ADSA), to determine the interfacial properties. Given the direct relationship between the stability of Pickering emulsions (emulsions stabilized by solid nanoparticles) and the interfacial properties of these layers, different nanoparticle systems were compared. Specifically, Eudragit NPs of different sizes were examined. Moreover, the reduction of the Zeta potential with PEG-6000 induces partial aggregation of the NPs (referred to as NP flocs), significantly impacting the stability of the interfacial layer. Dynamic surface tension measurements indicate a significant decrease in interfacial tension with Eudragit® nanoparticles (NPs). This reduction correlates with the size of the NPs, highlighting that this parameter does not operate in isolation. Other factors, such as the contact angle and wettability of the nanoparticles, also play a critical role. Notably, larger NPs further diminished the interfacial tension. This study enhances our understanding of the stability of Pickering emulsions stabilized by Eudragit® L100 polymeric nanoparticles.

Dynamic Simulation and Tension Compensation Research on Subsea Umbilical Cable Laying System

For studying the dynamic performance of subsea umbilical cable laying system and achieving the goal of cable tension and laying speed control,the rigid finite element method is used to discrete and transform the system into a rigid-flexible coupling multi-body system which consists of rigid elements and spring-damping elements.The mathematical model of subsea umbilical cable laying system kinematic chain is presented with the second order Lagrange equation in the joint coordinate system,and dynamic modeling and simulation is performed with ADAMS.The dynamic analysis is conducted assuming the following three statuses:ideal laying,practical laying under wave disturbance,and practical laying with tension compensation.Results show that motion disturbances of the laying budge under sea waves,especially with heaving and pitching,will cause relatively serious fluctuations in cable tension and laying speed.Tension compensation,i.e.,active back tension torque control can restrict continuous tension increasing or decreasing effectively and rapidly,thus avoiding cable breach or buckling.

Modeling bubble column reactor with the volume of fluid approach:Comparison of surface tension models

This work aims at comparing surface tension models in VOF(Volume of Fluid) modeling and investigating the effects of gas distributor and gas velocity. Hydrodynamics of a continuous chain of bubbles inside a bubble column reactor was simulated. The grid independence study was first conducted and a grid size of 1.0 mm was adopted in order to minimize the computing time without compromising the accuracy of the results. The predictions were validated by comparing the experimental studies reported in the literature. It was found that all surface tension models can describe the bubble rise and bubble plume in a column with slight deviations.

Next Frontier in Physics—Space as a Complex Tension Field

We hypothesize that 100% of the energy of our cosmic system is held by a physically real Complex Tension Field (CTF). We are using an old methodology of thinking used by our forefather engineers long before the advent of modern scientific thinking. We call it Interaction Process Mapping Epistemology or IPM-E. We apply this IPM-E on to the prevailing Measurable Data Modeling Epistemology or MDM-E. This approach helped us analyze the “Measurement Problem”, recognized during the rise of quantum mechanics (QM), and helped us recover a universal property of all linear waves, that they do not interact, or interfere, with each other. This Non-Interaction of Waves, or the NIW-property, should be obvious through daily observations and through the Huygens-Fresnel diffraction integral and through critical evaluation of contradictory hypotheses we have been assigning to photons through ages. This implicates that the time-frequency Fourier theorem, although mathematically correct, and is used universally in all branches of science;does not map the real physical interaction processes for most optical phenomena. Accordingly, we present the necessary modifications for a few selected phenomena in classical and quantum optics to validate the NIW-property. In the process we find that accepting photons as non-interacting, but diffractively propagating linear wave packets crossing the entire cosmic space, requires CTF as a physical medium. Then we develop logical arguments in support of stable elementary particles as nonlinear but resonant vortex-like undulations of this same CTF. These vortex-like particles impose various secondary potential gradients around themselves giving rise to the four forces we know. Thus, CTF can serve as the cosmic substrate to develop a unified field theory without the need of dark matter and dark energy. In the process, we demonstrate a path to add ontologic thinking on our biologically successful epistemic thinking.

The Determination of Surface Tension of Traditional Chinese Medicine Tablet

In this paper we aimed to determine the surface tension of traditional Chinese medicine (TCM) tablet and tried to provide a key reference parameter to control tablet film coating quality. Using contact angle tester, the Chinese medicine tablet, a famous Fufang Danshen tablet CP as a model example, was determined by Zisman critical surface tension method. Our study showed that the critical surface tension of Fufang Danshen tablet CP was determined to be 18.00 dyne/cm. The Zisman method, hence, can determine successfully the critical surface tension of Chinese medicine tablet and will become an effective manner to control tablet film coating quality.

Effects of Second-Order Sum-and Difference-Frequency Wave Forces on the Motion Response of a Tension-Leg Platform Considering the Set-down Motion

This paper presents a study on the motion response of a tension-leg platform(TLP) under first-and second-order wave forces, including the mean-drift force, difference and sum-frequency forces. The second-order wave force is calculated using the full-field quadratic transfer function(QTF). The coupled effect of the horizontal motions, such as surge, sway and yaw motions, and the set-down motion are taken into consideration by the nonlinear restoring matrix. The time-domain analysis with 50-yr random sea state is performed. A comparison of the results of different case studies is made to assess the influence of second-order wave force on the motions of the platform. The analysis shows that the second-order wave force has a major impact on motions of the TLP. The second-order difference-frequency wave force has an obvious influence on the low-frequency motions of surge and sway, and also will induce a large set-down motion which is an important part of heave motion. Besides, the second-order sum-frequency force will induce a set of high-frequency motions of roll and pitch. However, little influence of second-order wave force is found on the yaw motion.

Highly efficient [C8mim][Cl] ionic liquid accompanied with magnetite nanoparticles and different salts for interfacial tension reduction

The 1-octyl-3-methylimidazolium chloride, [C8 mim][Cl] ionic liquid(IL) was used as a novel surfactant in n-heptane/water system. The interfacial tensions(IFT) were measured and corresponding variations were investigated. An IFT reduction of 80.8% was appropriate under the IL CMC of about 0.1 mol·L^-1 and stronger effects were achieved when magnetite nanoparticles and salts were present profoundly under alkaline p Hs.The equilibrium IFT data were accurately simulated with the Frumkin adsorption model. Hereafter, the saturated surface concentration, equilibrium constant and interaction parameter were obtained and their variations were demonstrated. Further, emulsion stability and contact angle of oil/water interface over quartz surface were studied. The oil/water emulsion stability was hardly changed with nanoparticles;however, the stability of oil/water + IL emulsions was significantly improved. It was also revealed that the presence of sodium and calcium chloride electrolytes fortifies the IL impact, whereas sodium sulfate weakens. From dynamic IFT data and fitting with kinetic models, it was found that the IL migration toward interface follows the mixed diffusion–kinetic control model. Consequently, the IL diffusion coefficient and the appropriate activation energy were determined.

A Simple Weighted Integration Method for Calculating Surface Tension Force to Suppress Parasitic Flow in the Level Set Approach

Parasitic flows may occur in the numerical simulation of incompressible multiphase flow due to errors in the calculation of surface tension terms, specifically for the curvature and unit normal vector. An improved method for calculating the surface tension based on the level set approach is proposed, in which the contribution of not only the center node but also the rest area of a control volume to the calculation of surface tension is considered in a balanced manner. The weighted integration method (WIM) is more consistent with the concept of a banded in- terface in the level set method. It is applied to the temporal evolution of a two-dimensional neutrally buoyant liquid drop and a buoyancy driven deformable bubble in an immiscible fluid for the validation of WIM. The results show that the parasitic flows are evidently suppressed by the weighted integration method. The weight factors for WIM in 3-D cases are also suggested.

Strain Capacities Limits of Wrought Magnesium Alloys: Tension vs. Expansion

Lightening structure is one of the goals of many fields of research. As a result, magnesium alloys are studied due to their low density. However, one drawback of these alloys is their low formability at room temperature due to their hexagonal closed-packed structure. In the present work, the forming capacity of an AZ31 Mg alloys has been studied using a mini deep-drawing device, image correlation techniques and tests (tension and expansion) at temperatures contained between 20°C and 200°C. To investigate formability limits of Mg alloys in expansion, major and minor strains data were generated using hemispherical punch tests and analyzed with 3D digital images correlation techniques. Thanks to images correlation, strains on the surface of the samples were observed by means of a double digitization of the sample in three dimensions before and after deformation by using stereoscopic vision and triangulation. Image correlations have also been used in 2D to measure strains on the surface of the tensile test samples. These tests gave interesting information on the evolution of various parameters such as hardening coefficient, strain rate sensitivity parameter, and Lankford coefficient, which may affect the behavior of the alloys. Finally, the forming limits in both configurations (tension and expansion) were compared and discussed.

Vortex-Induced Vibration of a Tension Leg Platform Tendon:Multi-Mode Limit Cycle Oscillations

This paper studies the application of mathematical models to analyze the vortex-induced vibrations of the tendons of a given TLP along the Indian coastline, by using an analytical approach, using MATLAB. The tendon is subjected to a steady current load, which causes vortex-shedding downstream, leading to cross-flow vibrations. The magnitude of the excitation(lift and drag coefficients) depends on the vortex-shedding frequency. The resulting vibration is studied for possible resonant behavior. The excitation force is quantified empirically, the added mass by potential flow hydrodynamics, and the vibration by normal mode summation method. Non-linear viscous damping of the water is considered. The non-linear oscillations are studied by the phase-plane method, investigating the limit-cycle oscillations. The stable/unstable regions of the dynamic behavior are demarcated. The modal contribution to the total deflection is studied to establish the possibility of resonance of one of the wet modes with the vortex-shedding frequency.

CALCULATION OF SURFACE TENSION OF LIQUIDS BY MONTE CARLO METHOD

In this paper a method has been proposed for the calculation of cohesive work and thus sur-face tension of liquids by the Monte Carlo computer simulation method with the use of Kihara po-tential. The surface tension values calculated for liquid argon, oxygen and nitrogen are in fairagreement with the experimental data.

Impact of Tension-Type Headaches in the Workplace in Brazzaville

Introduction: Tension-type headaches are the most widespread of the primary headache disorders. Due to their high prevalence, tension-type headaches represent a major public health problem with an enormous socio-economic burden. Determining their impact remains a challenge. Objective: To assess the impact of occupational tension-type headache in Brazzaville and identify associated factors. Population and Methods: This was an analytical case-control study conducted in public and private companies in the city of Brazzaville over a period of four (04) months. The case population consisted of cephalalgic employees;the control population was drawn from the same companies and was free of tension-type headaches. Study variables were divided into socio-professional, clinical and individual impact variables. Individual impact variables were represented by: the HIT-6 score, which incorporates a very broad conception of disability, covering several domains, namely: severity of pain during attacks and the restrictive and limiting nature of attacks. Results: Individual impact was severe in 18 (62.1%) men and 11 (37.9%) women. Mean age was 36.3 6.14 years for cases with severe impact. The mean duration of headache was 40.3 32.7 months for cases with severe impact. Tension headache evolved in attacks in 22 (75.9%) cases with severe impact, and continuously in seven (24.1%) cases. The average number of attacks per month was 2.52 1.04 for cases with severe impact. Cases with severe impact included 14 (48.3%) with chronic headache and 15 (51.7%) with episodic headache. Pain of severe intensity present in 48.3% of cases was associated with a severe impact of tension-type headache: OR = 151.66 [2.36 - 44245.95] and p-value = 0.037. At least one days absence from work per year was observed in 47.4% of our cases. The number of days off work per year due to tension-type headache had an interquartile range between 0 and 3 days and extremes from 0 to 14 days. It was the consequence of a severe impact on daily and/or professional activities. Conclusion: The high frequency of tension-type headaches in the workplace and its impact on the condition of workers in Brazzaville represent a real public health problem. It was found that the number of days absent from work per year due to tension headaches was the consequence of a severe impact on daily and/or professional activities. An awareness-raising program in this environment seems necessary, as well as an assessment of working conditions.

Studying of Kinematics and Elements of Tension of Blocks of the Massif According to Field Geological Observations

The description of the received new results of field geological (teсtonophysical) study of massifs of rocks is provided: tectonic jointing, explosive and folded deformations, mirrors of slidings, tectonic motions of blocks of breeds. Reconstruction of fields of tension according to geological data of the certain massif of the Chatkalo-Kurama mountain area (Tien-Shan)—a coastal zone of the Charvak reservoir and the Almalyk mining industrial region is executed. The multidirectional motions of blocks of rocks in the massif of a coastal zone of the Charvak reservoir connected with tectonic and technogenic factors are revealed. The scheme of kinematics and the intense deformed condition of blocks of the Almalyk district is received. Here the regional field of tension with horizontal and submeridional orientation of an axis of the main normal tension of compression at the inclined provision of two other axes are observed. The received results testify to opportunities field the tectonophysical of methods for obtaining important data on kinematics and dynamics of massifs of rocks, tectonic blocks, and features of their deformation. Such studying of the massif of rocks before the beginning and in the course of performance of work on objects of the national economy is important for the choice of design and optimum parameters of laying of excavations, control of a condition of their boards and walls, definition of strategy of safety of conducting mining operations and also seismic stability of constructions.

Mechanical tension promotes skin nerve regeneration by upregulating nerve growth factor expression

This study aimed to explore the role of mechanical tension in hypertrophic scars and the change in nerve density using hematoxylin-eosin staining and S100 immunohistochemistry, and to observe the expression of nerve growth factor by western blot analysis. The results demonstrated that mechanical tension contributed to the formation of a hyperplastic scar in the back skin of rats, in conjunction with increases in both nerve density and nerve growth factor expression in the scar tissue. These experimental findings indicate that the cutaneous nervous system plays a role in hypertrophic scar formation caused by mechanical tension.

A Comment on the Hubble Expansion Parameter Tension

We point out that the recent baryon acoustic oscillation measurement by the Dark Energy Survey collaboration relieves the Hubble expansion parameter tension.

Effect of wire tension on different output responses during wire electric discharge machining on AISI 304 stainless steel

WEDM is used in machining conductive materials where it is required to obtained complicated and intricate shapes with high accuracy.Various applications are in the field of automobile,medical industries,aerospace etc.WEDM is an economical machining option with short product development cycle.Surface roughness,kerf width,Material removal rate,Recast layer hardness and surface microhardness in WEDM are most important responses.In this paper,effect of varied Wire tension on SR,KW,MRR,RCL hardness and surface microhardness on AISI 304 have been investigated.Pulse on time,pulse off time,current and dielectric fluid are taken as fixed parameter.Results show that Wire tension influences the SR,MRR and Surface microhardness and has no effect on kerf width in case of Stainless steel304.