In this in-depth exploration, I delve into the complex implications and costs of cybersecurity breaches. Venturing beyond just the immediate repercussions, the research unearths both the overt and concealed long-term ...In this in-depth exploration, I delve into the complex implications and costs of cybersecurity breaches. Venturing beyond just the immediate repercussions, the research unearths both the overt and concealed long-term consequences that businesses encounter. This study integrates findings from various research, including quantitative reports, drawing upon real-world incidents faced by both small and large enterprises. This investigation emphasizes the profound intangible costs, such as trade name devaluation and potential damage to brand reputation, which can persist long after the breach. By collating insights from industry experts and a myriad of research, the study provides a comprehensive perspective on the profound, multi-dimensional impacts of cybersecurity incidents. The overarching aim is to underscore the often-underestimated scope and depth of these breaches, emphasizing the entire timeline post-incident and the urgent need for fortified preventative and reactive measures in the digital domain.展开更多
The presented paper is dedicated to a new ret-rospective view on the history of natural sci-ences in XX-XXI cc, partially including the sci-ence philosophy (mainly, the problems of the scientific realism, i.e. the cor...The presented paper is dedicated to a new ret-rospective view on the history of natural sci-ences in XX-XXI cc, partially including the sci-ence philosophy (mainly, the problems of the scientific realism, i.e. the correspondence of science to reality) and also a novel scheme for different classes of sciences with different ob-jects and paradigms. There are analyzed the chosen “great” and “grand” problems of phys-ics (including the comprehension of quantum mechanics, with a recently elaborated new chapter, connected with time as a quantum obs- ervable and time analysis of quantum processes) and also of natural sciences as a whole. The particular attention is paid to the interpretation questions and slightly to the aspects, inevitably connected with the world- views of the res- earchers (which do often constitute a part of the interpretation questions).展开更多
This paper examines how cybersecurity is developing and how it relates to more conventional information security. Although information security and cyber security are sometimes used synonymously, this study contends t...This paper examines how cybersecurity is developing and how it relates to more conventional information security. Although information security and cyber security are sometimes used synonymously, this study contends that they are not the same. The concept of cyber security is explored, which goes beyond protecting information resources to include a wider variety of assets, including people [1]. Protecting information assets is the main goal of traditional information security, with consideration to the human element and how people fit into the security process. On the other hand, cyber security adds a new level of complexity, as people might unintentionally contribute to or become targets of cyberattacks. This aspect presents moral questions since it is becoming more widely accepted that society has a duty to protect weaker members of society, including children [1]. The study emphasizes how important cyber security is on a larger scale, with many countries creating plans and laws to counteract cyberattacks. Nevertheless, a lot of these sources frequently neglect to define the differences or the relationship between information security and cyber security [1]. The paper focus on differentiating between cybersecurity and information security on a larger scale. The study also highlights other areas of cybersecurity which includes defending people, social norms, and vital infrastructure from threats that arise from online in addition to information and technology protection. It contends that ethical issues and the human factor are becoming more and more important in protecting assets in the digital age, and that cyber security is a paradigm shift in this regard [1].展开更多
The article hypothesizes that DE and DM (UCM) are a “Form of Motion of a Special Nature”, where “Form of Motion” means “Eternal Motion” as the power of dynamics of different levels and varying degrees of self-su...The article hypothesizes that DE and DM (UCM) are a “Form of Motion of a Special Nature”, where “Form of Motion” means “Eternal Motion” as the power of dynamics of different levels and varying degrees of self-sufficiency, and by “Special Nature”, gravitational and two other properties of matter, “tied” to the “Eternal Movement” and completely dependent on it. Carriers of key properties of a “Special Nature” have been established: “0”-DE particles and “3”-DM particles (UDM). The unity of their inherent “motionally-gravitational” properties and the peculiarity of the relationship between “motion” and “gravity” are revealed: the higher the intensity of “Eternal Motion”, the stronger the gravitational properties of matter are manifested (and vice versa). The relationship of “time” with the “vibration frequency” and the “mass” of photons with the “degree of bonding and deformation properties of the field” is shown. The maximum level of gravity has been determined, which allows Nature to successfully create the Universe: such a landmark is the proximity to the property of the Primary Source—the “pure graviton” of the OSP space, the most powerful “motionally-gravitational” particle of the Universe. The reasons for the emergence of such an identity of the gravitational properties of particles with the indicators of a “pure graviton” are established: for “0”-DE particles, this is the acquisition of the function of “freedom of movement”;for “3”-DM particles (UDM), the creation of a special structure—a “double field” (“Main” and “Small”). The presence in the “double field” of specific “tools” for the creation of the worlds of the Universe—gravitational “waves” gives rise to impulses (shocks) of varying intensity and shape. A list of functions performed by “waves” in the “Main” and “Small” fields has been compiled. The specific conditions for the formation of “UDM Streams”, their transformation into a “Vortex” and, under the influence of a powerful Initial Impulse (push), sending them to the “place” of the creation of galaxies, are shown. It is suggested that there is a “Cycle of Matter in Nature” in the closed structure of our Universe due to the “work” of “waves” and the functioning of special “factories” in the form of exotic space objects—Black holes.展开更多
In this paper, the performance of a waste rock transportation process in an open pit mine was assessed by using cycle time data. A computerized truck-excavator dispatch system was used to record the cycle times. The p...In this paper, the performance of a waste rock transportation process in an open pit mine was assessed by using cycle time data. A computerized truck-excavator dispatch system was used to record the cycle times. The process was broken into seven steps (or components of the total cycle), durations of which were recorded for a period of 1 month, leading to N = 60,690 data points or dispatches. The open pit mine studied consisted of 12 waste types loaded by 14 excavators and hauled by 49 trucks (at a trucks-to-excavator ratio of 3.5:1) in 75 changing locations. The string-type data was coded using integers to allow a FORTRAN code to extract process performance parameters using statistical analysis. The study established a wide range of parameters including: the waste material generation rate (about 1.73 million t/month, 81% comprising waste rock), truck fill factor, f, total cycle time (Tct), production capacity, theoretical cycle time, non-productive cycle time Tnp, and cycle time performance ratio (CTPR), denoted as Tpr. The factors affecting the process performance include: truck model, excavator model, location (haul distance and road conditions) and material type. For a fixed material type and tonnage, the PDFs of the cycle time components were logarithmic in nature, capable of differentiating performance variations under different factors. It was concluded that the performance of the waste material transportation system in this mine was determined to be acceptable due to mean value of Tpr = 2.432 being closer to unity. Reduction measures were suggested to minimize the cycle time for the process bottlenecks determined from Pareto analysis (that is, full haul, empty haul and loading processes).展开更多
This study presents the effect of excavator model, loading operation location, shift availability and truck-shovel combination on loading cycle time and productivity of an open-pit mine. The loading cycle time was use...This study presents the effect of excavator model, loading operation location, shift availability and truck-shovel combination on loading cycle time and productivity of an open-pit mine. The loading cycle time was used to assess the material loading system performance which is one of the key components of the total cycle time for material transportation in an open-pit mine. Loading is among the components of cycle time during which material is being handled. The data analyzed?was?collected from a computerized dispatch system at GGM from which 62,000 loading dispatches per month involving several shifts, 14 excavators and 49 trucks were loaded. About 4465 dispatches per excavator and 1276 dispatches per truck were assessed using loading cycle time data for each dispatch for a period of four months (between August and December). Under fixed tonnage loaded and waste type (33 t of non-acid forming waste rock),?it was observed that loading cycle time depends on excavator model, location and truck being loaded. Average cycle times, PDFS?and CDFS of loading cycle time series were used to identify differences in performance under different situations. It was concluded that shift availability for excavators, loading location, excavator model and truck-shovel combinations strongly affect the productivity during loading process in an open-pit mine.展开更多
Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative diseases.However,little is k...Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative diseases.However,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°C.We aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large cohort.Plasma samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline project.These samples were stored at-80°C for up to 6 years before being used in this study.Our results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage time.However,the level of total tau showed a negative correlation with sample storage time.Notably,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage time.This was not observed in individuals with cognitive impairment.Consequently,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage time.Therefore,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's disease.Furthermore,in cohort studies,it is important to consider the impact of storage time on the overall results.展开更多
Concrete structures may suffer considerable restraint stresses during their hardening period. This is caused by several deformation impacts, especially temperature field changings due to hydration heat and volume chan...Concrete structures may suffer considerable restraint stresses during their hardening period. This is caused by several deformation impacts, especially temperature field changings due to hydration heat and volume changes due to autogenous shrinkage. Mainly affected are massive concrete members, but also the application of new concrete types or the erection of outstanding constructions requires further investigations in this context. 3D-FEM analyses of hydration heat induced temperature development in combination with the well known shrinkage give sufficient results for the deformation impact. The according elastic restraint stresses can be determined with consideration of the concrete’s rising elastic modulus and the restraint degree of the system. But due to duration of the heat flow process, the height of restraint stresses is strongly dependent from the viscoelasticity of the concrete. The viscoelastic effects consist of many components constituted by changing material properties influencing themselves. In practice, different simplified approaches are available for considering this in calculations. Their implementation in time step analyses is not generally admitted and requires expertise. In contrast, present research develops material models needing specific input parameters for every use case. This contribution focuses on a practicable approach considering the superposition of the viscoelastic behaviour of every stress increment in time step FEM analysis. The differentiation between the pure viscoelastic material behaviour (as it is given in the codes for idealistic conditions like creep or relaxation) and the according viscoelastic system response (addicted to the systems variable restraint degree) allows the transfer of this model into practice. As one application example of this approach, the compatibility check and the FEM-based recalculation of the monitoring program of a massive power plant slab will be presented.展开更多
In this paper, we identify a set of factors that may be used to forecast software productivity and software development time. Software productivity was measured in function points per person hours, and software develo...In this paper, we identify a set of factors that may be used to forecast software productivity and software development time. Software productivity was measured in function points per person hours, and software development time was measured in number of elapsed days. Using field data on over 130 field software projects from various industries, we empirically test the impact of team size, integrated computer aided software engineering (ICASE) tools, software development type, software development platform, and programming language type on the software development productivity and development time. Our results indicate that team size, software development type, software development platform, and programming language type significantly impact software development productivity. However, only team size significantly impacts software development time. Our results indicate that effective management of software development teams, and using different management strategies for different software development type environments may improve software development productivity.展开更多
Analyzed the relation between time delay difference and time delay estimation errors, based on the principles of three-point locating, a reformed threshold method for time delay difference estimation of impulse signal...Analyzed the relation between time delay difference and time delay estimation errors, based on the principles of three-point locating, a reformed threshold method for time delay difference estimation of impulse signals, called as amendment estimation for short, is developed by introducing channel equalization technique to its conventional version, named as direct estimation in this paper, to improve the estimation stability. After inherent relationship between time delay and phase shift of signals is analyzed, an integer period error compensation method utilized the diversities of both contribution share and contribution mode of concerned estimates is proposed under the condition of high precision phase lag estimation. Finally, a cooperative multi-threshold estimation method composed of amendment and direct estimations to process impulse signals with three thresholds is established. In sea trials data tests of passive locating, this method improves the estimation precision of time delay difference efficiently. The experiments verify the theoretical predictions.展开更多
Various optimal boundary control problems for linear infinite order distributed hyperbolic systems involving constant time lags are considered. Constraints on controls are imposed. Necessary and sufficient optimality ...Various optimal boundary control problems for linear infinite order distributed hyperbolic systems involving constant time lags are considered. Constraints on controls are imposed. Necessary and sufficient optimality conditions for the Neumann problem with the quadratic performance functional are derived.展开更多
Intrinsic time quantum geometrodynamics is a formulation of quantum gravity naturally adapted to 3 + 1 dimensions. In this paper we construct its analogous 2 + 1 formulation, taking note of the mathematical structures...Intrinsic time quantum geometrodynamics is a formulation of quantum gravity naturally adapted to 3 + 1 dimensions. In this paper we construct its analogous 2 + 1 formulation, taking note of the mathematical structures which are preserved. We apply the resulting construction to convert the BTZ black hole metric to ITQG framework. We then modify the BTZ black hole in order to investigate the existence of the P-V criticality in ITQG theory.展开更多
The importance of dissolved organic phosphorus(DOP) as a potential nutrient source for primary producers in marine systems has been recognized for up to eight decades, but currently, the understanding of the biogeoche...The importance of dissolved organic phosphorus(DOP) as a potential nutrient source for primary producers in marine systems has been recognized for up to eight decades, but currently, the understanding of the biogeochemistry of DOP is in its infancy. In the present study, monthly data between 2000 and 2014 were used to analyze the temporal and spatial distributions of DOP in the Mir Bay, the northern South China Sea. The DOP residence time(TDOP) was also investigated using a simple regression analysis in combination with chlorophyll a(Chl a) measurements while excess DOP(ΔDOP), produced by the biogeochemical processes of autotrophic production and heterotrophic removal, was determined using a two-component mixing mass-balance model in combination with salinity measurements. The results showed that the DOP concentration was(0.017±0.010) mg/L higher in the surface-water compared with the bottom-water and higher in the inner Tolo Harbour and waters adjacent to Shatoujiao compared with the main zone of the bay. Although seasonal changes and annual variability in the DOP were small, the surface DOP concentration was higher in the wet season(April–September)than in the dry season(October–March) due to the impacts of seaward discharges and atmospheric deposition into the bay. Measurement and regression results showed that the DOP release rate from phytoplankton production was about 1.83(gP)/(gChl a) and the TDOP was about 7 d, which implied that the DOP cycle in the bay was rapid. The ΔDOP was calculated from the model to be about 0.000 mg/L in the main zone of the bay and about 0.002 mg/L in the inner Tolo Harbour and waters adjacent to Shaotoujiao, suggesting that the autotrophic production of DOP was almost balanced by the heterotrophic removal in the main zone of the bay and dominated in the inner Tolo Harbour and waters adjacent to Shaotoujiao. In conclusion, the Mirs Bay is very productive and fairly heterotrophic.展开更多
The space-time fractional advection dispersion equations are linear partial pseudo-differential equations with spatial fractional derivatives in time and in space and are used to model transport at the earth surface. ...The space-time fractional advection dispersion equations are linear partial pseudo-differential equations with spatial fractional derivatives in time and in space and are used to model transport at the earth surface. The time fractional order is denoted by β∈ and ?is devoted to the space fractional order. The time fractional advection dispersion equations describe particle motion with memory in time. Space-fractional advection dispersion equations arise when velocity variations are heavy-tailed and describe particle motion that accounts for variation in the flow field over entire system. In this paper, I focus on finding the precise explicit discrete approximate solutions to these models for some values of ?with ?, ?while the Cauchy case as ?and the classical case as ?with ?are studied separately. I compare the numerical results of these models for different values of ?and ?and for some other related changes. The approximate solutions of these models are also discussed as a random walk with or without a memory depending on the value of . Then I prove that the discrete solution in the Fourierlaplace space of theses models converges in distribution to the Fourier-Laplace transform of the corresponding fractional differential equations for all the fractional values of ?and .展开更多
To investigate whether the expression of exogenous heme oxygenase-1 (HO-1) gene within vascular smooth muscle cells (VSMC) could protect the cells from free radical attack and inhibit cell proliferation, we establishe...To investigate whether the expression of exogenous heme oxygenase-1 (HO-1) gene within vascular smooth muscle cells (VSMC) could protect the cells from free radical attack and inhibit cell proliferation, we established an in vitro transfection of human HO-1 gene into rat VSMC mediated by a retroviral vector. The results showed that the profound expression of HO-1 protein as well as HO activity was 1.8- and 2.0-fold increased respectively in the transfected cells compared to the non-transfected ones. The treatment of VSMC with different concentrations of H2O2 led to the remarkable cell damage as indicated by survival rate and LDH leakage. However, the resistance of the HO-1 transfected VSMC against H2O2 was significantly raised. This protective effect was dramatically diminished when the transfected VSMC were pretreated with ZnPP-IX, a specific inhibitor of HO, for 24 h. In addition, we found that the growth potential of the transfected cells was significantly inhibited directly by increased activity of HO-1, and this effect might be related to decreased phosphorylation of MAPK. These results suggest that the overexpression of introduced hHO-1 is potentially able to reduce the risk factors of atherosclerosis, partially due to its cellular protection against oxidative injury and to its inhibitory effect on cellular proliferation.展开更多
We study waiting time problems for first-order Markov dependent trials via conditional probability generating functions. Our models involve α frequency cells and β run cells with prescribed quotas and an additional ...We study waiting time problems for first-order Markov dependent trials via conditional probability generating functions. Our models involve α frequency cells and β run cells with prescribed quotas and an additional γ slack cells without quotas. For any given and , in our Model I we determine the waiting time until at least frequency cells and at least run cells reach their quotas. For any given τ ≤ α + β, in our Model II we determine the waiting time until τ cells reach their quotas. Computer algorithms are developed to calculate the distributions, expectations and standard deviations of the waiting time random variables of the two models. Numerical results demonstrate the efficiency of the algorithms.展开更多
Based on the Mach’s principle, black holes warp the space time in a way that geodesic for every object which is moving toward black hole starts to bend and object starts to rotate around the black hole. Even light ca...Based on the Mach’s principle, black holes warp the space time in a way that geodesic for every object which is moving toward black hole starts to bend and object starts to rotate around the black hole. Even light cannot be able to escape from the strong gravitational field of black hole and all the light like paths will warp so as to fall farther to the hole. Before arriving to the Schwarzschild’s Sphere, object faces with length extension because of the difference between amount of tidal forces on the nearest and furthest points of object that take the object apart and after passing the Schwarzschild’s sphere, based on the Special relativity of Einstein, the parts of object face with length contraction. In comparison between strange stars and black holes we conclude that core of strange stars has a temperature and pressure not sufficient for up and down quarks and they turn into strange ones. However, in core of black holes, because of massive stars and hot gases falling into it, they are always in a high temperature and pressure. So they can be made up of up and down quarks. At the Ergo sphere Region of black hole, a particle that gets into it will divide into 2 pieces, one of them falls into the black hole and another gets out of the Schwarzschild sphere very fast and it’s called the black hole radiation. According to the Diagram drawn by R. Rafini and J. Weeler, an object gets out of white hole in past space-time, it can be able to send signals to us and we can receive it but black hole which is located in future space-time, after object enters to the Schwarzschild’s Sphere, the signals it sends won’t be received. In order to reach the third space-time which is like a mirror to our universe, our speed needs to exceed the speed of light to pass the Einstein-Rosen Bridge. As a conclusion, structure of black holes can be made up of up and down quarks and everything falls into the black hole, collapses and turns into a bunch of quarks. Space-time around black holes, based on Rafini-Weeler diagram, is like a frontier between our space-time and other space-times. So it can be possible to reach past space-time and other space-times.展开更多
As a highly efficient absorbing boundary condition, Perfectly Matched Layer (PML) has been widely used in Finite Difference Time Domain (FDTD) simulation of Ground Penetrating Radar (GPR) based on the first order elec...As a highly efficient absorbing boundary condition, Perfectly Matched Layer (PML) has been widely used in Finite Difference Time Domain (FDTD) simulation of Ground Penetrating Radar (GPR) based on the first order electromagnetic wave equation. However, the PML boundary condition is difficult to apply in GPR Finite Element Time Domain (FETD) simulation based on the second order electromagnetic wave equation. This paper developed a non-split perfectly matched layer (NPML) boundary condition for GPR FETD simulation based on the second order electromagnetic wave equation. Taking two-dimensional TM wave equation as an example, the second order frequency domain equation of GPR was derived according to the definition of complex extending coordinate transformation. Then it transformed into time domain by means of auxiliary differential equation method, and its FETD equation is derived based on Galerkin method. On this basis, a GPR FETD forward program based on NPML boundary condition is developed. The merits of NPML boundary condition are certified by compared with wave field snapshots, signal and reflection errors of homogeneous medium model with split and non-split PML boundary conditions. The comparison demonstrated that the NPML algorithm can reduce memory occupation and improve calculation efficiency. Furthermore, numerical simulation of a complex model verifies the good absorption effects of the NPML boundary condition in complex structures.展开更多
This paper presents a novel framework for understanding time as an emergent phenomenon arising from quantum information dynamics. We propose that the flow of time and its directional arrow are intrinsically linked to ...This paper presents a novel framework for understanding time as an emergent phenomenon arising from quantum information dynamics. We propose that the flow of time and its directional arrow are intrinsically linked to the growth of quantum complexity and the evolution of entanglement entropy in physical systems. By integrating principles from quantum mechanics, information theory, and holography, we develop a comprehensive theory that explains how time can emerge from timeless quantum processes. Our approach unifies concepts from quantum mechanics, general relativity, and thermodynamics, providing new perspectives on longstanding puzzles such as the black hole information paradox and the arrow of time. We derive modified Friedmann equations that incorporate quantum information measures, offering novel insights into cosmic evolution and the nature of dark energy. The paper presents a series of experimental proposals to test key aspects of this theory, ranging from quantum simulations to cosmological observations. Our framework suggests a deeply information-theoretic view of the universe, challenging our understanding of the nature of reality and opening new avenues for technological applications in quantum computing and sensing. This work contributes to the ongoing quest for a unified theory of quantum gravity and information, potentially with far-reaching implications for our understanding of space, time, and the fundamental structure of the cosmos.展开更多
文摘In this in-depth exploration, I delve into the complex implications and costs of cybersecurity breaches. Venturing beyond just the immediate repercussions, the research unearths both the overt and concealed long-term consequences that businesses encounter. This study integrates findings from various research, including quantitative reports, drawing upon real-world incidents faced by both small and large enterprises. This investigation emphasizes the profound intangible costs, such as trade name devaluation and potential damage to brand reputation, which can persist long after the breach. By collating insights from industry experts and a myriad of research, the study provides a comprehensive perspective on the profound, multi-dimensional impacts of cybersecurity incidents. The overarching aim is to underscore the often-underestimated scope and depth of these breaches, emphasizing the entire timeline post-incident and the urgent need for fortified preventative and reactive measures in the digital domain.
文摘The presented paper is dedicated to a new ret-rospective view on the history of natural sci-ences in XX-XXI cc, partially including the sci-ence philosophy (mainly, the problems of the scientific realism, i.e. the correspondence of science to reality) and also a novel scheme for different classes of sciences with different ob-jects and paradigms. There are analyzed the chosen “great” and “grand” problems of phys-ics (including the comprehension of quantum mechanics, with a recently elaborated new chapter, connected with time as a quantum obs- ervable and time analysis of quantum processes) and also of natural sciences as a whole. The particular attention is paid to the interpretation questions and slightly to the aspects, inevitably connected with the world- views of the res- earchers (which do often constitute a part of the interpretation questions).
文摘This paper examines how cybersecurity is developing and how it relates to more conventional information security. Although information security and cyber security are sometimes used synonymously, this study contends that they are not the same. The concept of cyber security is explored, which goes beyond protecting information resources to include a wider variety of assets, including people [1]. Protecting information assets is the main goal of traditional information security, with consideration to the human element and how people fit into the security process. On the other hand, cyber security adds a new level of complexity, as people might unintentionally contribute to or become targets of cyberattacks. This aspect presents moral questions since it is becoming more widely accepted that society has a duty to protect weaker members of society, including children [1]. The study emphasizes how important cyber security is on a larger scale, with many countries creating plans and laws to counteract cyberattacks. Nevertheless, a lot of these sources frequently neglect to define the differences or the relationship between information security and cyber security [1]. The paper focus on differentiating between cybersecurity and information security on a larger scale. The study also highlights other areas of cybersecurity which includes defending people, social norms, and vital infrastructure from threats that arise from online in addition to information and technology protection. It contends that ethical issues and the human factor are becoming more and more important in protecting assets in the digital age, and that cyber security is a paradigm shift in this regard [1].
文摘The article hypothesizes that DE and DM (UCM) are a “Form of Motion of a Special Nature”, where “Form of Motion” means “Eternal Motion” as the power of dynamics of different levels and varying degrees of self-sufficiency, and by “Special Nature”, gravitational and two other properties of matter, “tied” to the “Eternal Movement” and completely dependent on it. Carriers of key properties of a “Special Nature” have been established: “0”-DE particles and “3”-DM particles (UDM). The unity of their inherent “motionally-gravitational” properties and the peculiarity of the relationship between “motion” and “gravity” are revealed: the higher the intensity of “Eternal Motion”, the stronger the gravitational properties of matter are manifested (and vice versa). The relationship of “time” with the “vibration frequency” and the “mass” of photons with the “degree of bonding and deformation properties of the field” is shown. The maximum level of gravity has been determined, which allows Nature to successfully create the Universe: such a landmark is the proximity to the property of the Primary Source—the “pure graviton” of the OSP space, the most powerful “motionally-gravitational” particle of the Universe. The reasons for the emergence of such an identity of the gravitational properties of particles with the indicators of a “pure graviton” are established: for “0”-DE particles, this is the acquisition of the function of “freedom of movement”;for “3”-DM particles (UDM), the creation of a special structure—a “double field” (“Main” and “Small”). The presence in the “double field” of specific “tools” for the creation of the worlds of the Universe—gravitational “waves” gives rise to impulses (shocks) of varying intensity and shape. A list of functions performed by “waves” in the “Main” and “Small” fields has been compiled. The specific conditions for the formation of “UDM Streams”, their transformation into a “Vortex” and, under the influence of a powerful Initial Impulse (push), sending them to the “place” of the creation of galaxies, are shown. It is suggested that there is a “Cycle of Matter in Nature” in the closed structure of our Universe due to the “work” of “waves” and the functioning of special “factories” in the form of exotic space objects—Black holes.
文摘In this paper, the performance of a waste rock transportation process in an open pit mine was assessed by using cycle time data. A computerized truck-excavator dispatch system was used to record the cycle times. The process was broken into seven steps (or components of the total cycle), durations of which were recorded for a period of 1 month, leading to N = 60,690 data points or dispatches. The open pit mine studied consisted of 12 waste types loaded by 14 excavators and hauled by 49 trucks (at a trucks-to-excavator ratio of 3.5:1) in 75 changing locations. The string-type data was coded using integers to allow a FORTRAN code to extract process performance parameters using statistical analysis. The study established a wide range of parameters including: the waste material generation rate (about 1.73 million t/month, 81% comprising waste rock), truck fill factor, f, total cycle time (Tct), production capacity, theoretical cycle time, non-productive cycle time Tnp, and cycle time performance ratio (CTPR), denoted as Tpr. The factors affecting the process performance include: truck model, excavator model, location (haul distance and road conditions) and material type. For a fixed material type and tonnage, the PDFs of the cycle time components were logarithmic in nature, capable of differentiating performance variations under different factors. It was concluded that the performance of the waste material transportation system in this mine was determined to be acceptable due to mean value of Tpr = 2.432 being closer to unity. Reduction measures were suggested to minimize the cycle time for the process bottlenecks determined from Pareto analysis (that is, full haul, empty haul and loading processes).
文摘This study presents the effect of excavator model, loading operation location, shift availability and truck-shovel combination on loading cycle time and productivity of an open-pit mine. The loading cycle time was used to assess the material loading system performance which is one of the key components of the total cycle time for material transportation in an open-pit mine. Loading is among the components of cycle time during which material is being handled. The data analyzed?was?collected from a computerized dispatch system at GGM from which 62,000 loading dispatches per month involving several shifts, 14 excavators and 49 trucks were loaded. About 4465 dispatches per excavator and 1276 dispatches per truck were assessed using loading cycle time data for each dispatch for a period of four months (between August and December). Under fixed tonnage loaded and waste type (33 t of non-acid forming waste rock),?it was observed that loading cycle time depends on excavator model, location and truck being loaded. Average cycle times, PDFS?and CDFS of loading cycle time series were used to identify differences in performance under different situations. It was concluded that shift availability for excavators, loading location, excavator model and truck-shovel combinations strongly affect the productivity during loading process in an open-pit mine.
基金supported by the National Key Research&Development Program of China,Nos.2021YFC2501205(to YC),2022YFC24069004(to JL)the STI2030-Major Project,Nos.2021ZD0201101(to YC),2022ZD0211800(to YH)+2 种基金the National Natural Science Foundation of China(Major International Joint Research Project),No.82020108013(to YH)the Sino-German Center for Research Promotion,No.M-0759(to YH)a grant from Beijing Municipal Science&Technology Commission(Beijing Brain Initiative),No.Z201100005520018(to JL)。
文摘Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative diseases.However,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°C.We aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large cohort.Plasma samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline project.These samples were stored at-80°C for up to 6 years before being used in this study.Our results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage time.However,the level of total tau showed a negative correlation with sample storage time.Notably,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage time.This was not observed in individuals with cognitive impairment.Consequently,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage time.Therefore,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's disease.Furthermore,in cohort studies,it is important to consider the impact of storage time on the overall results.
文摘Concrete structures may suffer considerable restraint stresses during their hardening period. This is caused by several deformation impacts, especially temperature field changings due to hydration heat and volume changes due to autogenous shrinkage. Mainly affected are massive concrete members, but also the application of new concrete types or the erection of outstanding constructions requires further investigations in this context. 3D-FEM analyses of hydration heat induced temperature development in combination with the well known shrinkage give sufficient results for the deformation impact. The according elastic restraint stresses can be determined with consideration of the concrete’s rising elastic modulus and the restraint degree of the system. But due to duration of the heat flow process, the height of restraint stresses is strongly dependent from the viscoelasticity of the concrete. The viscoelastic effects consist of many components constituted by changing material properties influencing themselves. In practice, different simplified approaches are available for considering this in calculations. Their implementation in time step analyses is not generally admitted and requires expertise. In contrast, present research develops material models needing specific input parameters for every use case. This contribution focuses on a practicable approach considering the superposition of the viscoelastic behaviour of every stress increment in time step FEM analysis. The differentiation between the pure viscoelastic material behaviour (as it is given in the codes for idealistic conditions like creep or relaxation) and the according viscoelastic system response (addicted to the systems variable restraint degree) allows the transfer of this model into practice. As one application example of this approach, the compatibility check and the FEM-based recalculation of the monitoring program of a massive power plant slab will be presented.
文摘In this paper, we identify a set of factors that may be used to forecast software productivity and software development time. Software productivity was measured in function points per person hours, and software development time was measured in number of elapsed days. Using field data on over 130 field software projects from various industries, we empirically test the impact of team size, integrated computer aided software engineering (ICASE) tools, software development type, software development platform, and programming language type on the software development productivity and development time. Our results indicate that team size, software development type, software development platform, and programming language type significantly impact software development productivity. However, only team size significantly impacts software development time. Our results indicate that effective management of software development teams, and using different management strategies for different software development type environments may improve software development productivity.
文摘Analyzed the relation between time delay difference and time delay estimation errors, based on the principles of three-point locating, a reformed threshold method for time delay difference estimation of impulse signals, called as amendment estimation for short, is developed by introducing channel equalization technique to its conventional version, named as direct estimation in this paper, to improve the estimation stability. After inherent relationship between time delay and phase shift of signals is analyzed, an integer period error compensation method utilized the diversities of both contribution share and contribution mode of concerned estimates is proposed under the condition of high precision phase lag estimation. Finally, a cooperative multi-threshold estimation method composed of amendment and direct estimations to process impulse signals with three thresholds is established. In sea trials data tests of passive locating, this method improves the estimation precision of time delay difference efficiently. The experiments verify the theoretical predictions.
文摘Various optimal boundary control problems for linear infinite order distributed hyperbolic systems involving constant time lags are considered. Constraints on controls are imposed. Necessary and sufficient optimality conditions for the Neumann problem with the quadratic performance functional are derived.
文摘Intrinsic time quantum geometrodynamics is a formulation of quantum gravity naturally adapted to 3 + 1 dimensions. In this paper we construct its analogous 2 + 1 formulation, taking note of the mathematical structures which are preserved. We apply the resulting construction to convert the BTZ black hole metric to ITQG framework. We then modify the BTZ black hole in order to investigate the existence of the P-V criticality in ITQG theory.
基金The National Key Basic Research Special Foundation of China under contract No.2013CB965101the Marine Science and Technology Foundation of the South China Sea Sub-administration,SOA,China under contract No.1624
文摘The importance of dissolved organic phosphorus(DOP) as a potential nutrient source for primary producers in marine systems has been recognized for up to eight decades, but currently, the understanding of the biogeochemistry of DOP is in its infancy. In the present study, monthly data between 2000 and 2014 were used to analyze the temporal and spatial distributions of DOP in the Mir Bay, the northern South China Sea. The DOP residence time(TDOP) was also investigated using a simple regression analysis in combination with chlorophyll a(Chl a) measurements while excess DOP(ΔDOP), produced by the biogeochemical processes of autotrophic production and heterotrophic removal, was determined using a two-component mixing mass-balance model in combination with salinity measurements. The results showed that the DOP concentration was(0.017±0.010) mg/L higher in the surface-water compared with the bottom-water and higher in the inner Tolo Harbour and waters adjacent to Shatoujiao compared with the main zone of the bay. Although seasonal changes and annual variability in the DOP were small, the surface DOP concentration was higher in the wet season(April–September)than in the dry season(October–March) due to the impacts of seaward discharges and atmospheric deposition into the bay. Measurement and regression results showed that the DOP release rate from phytoplankton production was about 1.83(gP)/(gChl a) and the TDOP was about 7 d, which implied that the DOP cycle in the bay was rapid. The ΔDOP was calculated from the model to be about 0.000 mg/L in the main zone of the bay and about 0.002 mg/L in the inner Tolo Harbour and waters adjacent to Shaotoujiao, suggesting that the autotrophic production of DOP was almost balanced by the heterotrophic removal in the main zone of the bay and dominated in the inner Tolo Harbour and waters adjacent to Shaotoujiao. In conclusion, the Mirs Bay is very productive and fairly heterotrophic.
文摘The space-time fractional advection dispersion equations are linear partial pseudo-differential equations with spatial fractional derivatives in time and in space and are used to model transport at the earth surface. The time fractional order is denoted by β∈ and ?is devoted to the space fractional order. The time fractional advection dispersion equations describe particle motion with memory in time. Space-fractional advection dispersion equations arise when velocity variations are heavy-tailed and describe particle motion that accounts for variation in the flow field over entire system. In this paper, I focus on finding the precise explicit discrete approximate solutions to these models for some values of ?with ?, ?while the Cauchy case as ?and the classical case as ?with ?are studied separately. I compare the numerical results of these models for different values of ?and ?and for some other related changes. The approximate solutions of these models are also discussed as a random walk with or without a memory depending on the value of . Then I prove that the discrete solution in the Fourierlaplace space of theses models converges in distribution to the Fourier-Laplace transform of the corresponding fractional differential equations for all the fractional values of ?and .
基金This work was kindly supported by Na-tional Natural Science Foundation of China(No.39670308)
文摘To investigate whether the expression of exogenous heme oxygenase-1 (HO-1) gene within vascular smooth muscle cells (VSMC) could protect the cells from free radical attack and inhibit cell proliferation, we established an in vitro transfection of human HO-1 gene into rat VSMC mediated by a retroviral vector. The results showed that the profound expression of HO-1 protein as well as HO activity was 1.8- and 2.0-fold increased respectively in the transfected cells compared to the non-transfected ones. The treatment of VSMC with different concentrations of H2O2 led to the remarkable cell damage as indicated by survival rate and LDH leakage. However, the resistance of the HO-1 transfected VSMC against H2O2 was significantly raised. This protective effect was dramatically diminished when the transfected VSMC were pretreated with ZnPP-IX, a specific inhibitor of HO, for 24 h. In addition, we found that the growth potential of the transfected cells was significantly inhibited directly by increased activity of HO-1, and this effect might be related to decreased phosphorylation of MAPK. These results suggest that the overexpression of introduced hHO-1 is potentially able to reduce the risk factors of atherosclerosis, partially due to its cellular protection against oxidative injury and to its inhibitory effect on cellular proliferation.
文摘We study waiting time problems for first-order Markov dependent trials via conditional probability generating functions. Our models involve α frequency cells and β run cells with prescribed quotas and an additional γ slack cells without quotas. For any given and , in our Model I we determine the waiting time until at least frequency cells and at least run cells reach their quotas. For any given τ ≤ α + β, in our Model II we determine the waiting time until τ cells reach their quotas. Computer algorithms are developed to calculate the distributions, expectations and standard deviations of the waiting time random variables of the two models. Numerical results demonstrate the efficiency of the algorithms.
文摘Based on the Mach’s principle, black holes warp the space time in a way that geodesic for every object which is moving toward black hole starts to bend and object starts to rotate around the black hole. Even light cannot be able to escape from the strong gravitational field of black hole and all the light like paths will warp so as to fall farther to the hole. Before arriving to the Schwarzschild’s Sphere, object faces with length extension because of the difference between amount of tidal forces on the nearest and furthest points of object that take the object apart and after passing the Schwarzschild’s sphere, based on the Special relativity of Einstein, the parts of object face with length contraction. In comparison between strange stars and black holes we conclude that core of strange stars has a temperature and pressure not sufficient for up and down quarks and they turn into strange ones. However, in core of black holes, because of massive stars and hot gases falling into it, they are always in a high temperature and pressure. So they can be made up of up and down quarks. At the Ergo sphere Region of black hole, a particle that gets into it will divide into 2 pieces, one of them falls into the black hole and another gets out of the Schwarzschild sphere very fast and it’s called the black hole radiation. According to the Diagram drawn by R. Rafini and J. Weeler, an object gets out of white hole in past space-time, it can be able to send signals to us and we can receive it but black hole which is located in future space-time, after object enters to the Schwarzschild’s Sphere, the signals it sends won’t be received. In order to reach the third space-time which is like a mirror to our universe, our speed needs to exceed the speed of light to pass the Einstein-Rosen Bridge. As a conclusion, structure of black holes can be made up of up and down quarks and everything falls into the black hole, collapses and turns into a bunch of quarks. Space-time around black holes, based on Rafini-Weeler diagram, is like a frontier between our space-time and other space-times. So it can be possible to reach past space-time and other space-times.
文摘As a highly efficient absorbing boundary condition, Perfectly Matched Layer (PML) has been widely used in Finite Difference Time Domain (FDTD) simulation of Ground Penetrating Radar (GPR) based on the first order electromagnetic wave equation. However, the PML boundary condition is difficult to apply in GPR Finite Element Time Domain (FETD) simulation based on the second order electromagnetic wave equation. This paper developed a non-split perfectly matched layer (NPML) boundary condition for GPR FETD simulation based on the second order electromagnetic wave equation. Taking two-dimensional TM wave equation as an example, the second order frequency domain equation of GPR was derived according to the definition of complex extending coordinate transformation. Then it transformed into time domain by means of auxiliary differential equation method, and its FETD equation is derived based on Galerkin method. On this basis, a GPR FETD forward program based on NPML boundary condition is developed. The merits of NPML boundary condition are certified by compared with wave field snapshots, signal and reflection errors of homogeneous medium model with split and non-split PML boundary conditions. The comparison demonstrated that the NPML algorithm can reduce memory occupation and improve calculation efficiency. Furthermore, numerical simulation of a complex model verifies the good absorption effects of the NPML boundary condition in complex structures.
文摘This paper presents a novel framework for understanding time as an emergent phenomenon arising from quantum information dynamics. We propose that the flow of time and its directional arrow are intrinsically linked to the growth of quantum complexity and the evolution of entanglement entropy in physical systems. By integrating principles from quantum mechanics, information theory, and holography, we develop a comprehensive theory that explains how time can emerge from timeless quantum processes. Our approach unifies concepts from quantum mechanics, general relativity, and thermodynamics, providing new perspectives on longstanding puzzles such as the black hole information paradox and the arrow of time. We derive modified Friedmann equations that incorporate quantum information measures, offering novel insights into cosmic evolution and the nature of dark energy. The paper presents a series of experimental proposals to test key aspects of this theory, ranging from quantum simulations to cosmological observations. Our framework suggests a deeply information-theoretic view of the universe, challenging our understanding of the nature of reality and opening new avenues for technological applications in quantum computing and sensing. This work contributes to the ongoing quest for a unified theory of quantum gravity and information, potentially with far-reaching implications for our understanding of space, time, and the fundamental structure of the cosmos.