综合利用地球化学、扫描电镜、岩心薄片、测井等资料以及油井生产数据等,对鄂尔多斯盆地陕北地区三叠系延长组7段储层特征、烃源岩特征和致密油分布特征进行了分析,从烃源岩展布、输导体系和源-储组合关系3个方面对致密油差异富集控制...综合利用地球化学、扫描电镜、岩心薄片、测井等资料以及油井生产数据等,对鄂尔多斯盆地陕北地区三叠系延长组7段储层特征、烃源岩特征和致密油分布特征进行了分析,从烃源岩展布、输导体系和源-储组合关系3个方面对致密油差异富集控制因素进行了探讨,并总结了成藏模式。研究结果表明:(1)陕北地区长7段致密砂岩储层主要分布在一亚段(长71)和二亚段(长72),以灰色—灰白色长石砂岩和岩屑长石砂岩为主,长71和长72平均孔隙度分别为5.56%和7.32%,平均渗透率分别为0.097 m D和0.110 m D,长72储层物性更好;孔隙空间以溶孔为主,发育少量粒间孔。(2)研究区烃类主要来源于本地长72顶部和长73这2套烃源岩,平均厚度大于20 m,有机质丰度高,平均TOC值为3.02%,干酪根类型以Ⅰ型和Ⅱ1型为主,处于生烃高峰期,平均生烃量为270.2×10^(4)t/km^(2),长73烃源岩生烃潜力更大,供烃至长72储层,长71致密油来源于长72烃源岩;新安边地区三角洲前缘亚相末端的长72储层中致密油由湖盆烃源岩侧向供烃。(3)研究区致密油富集受烃源岩展布、砂体连通性以及源-储组合共同控制,在长72更富集,在新安边地区分布面积最大,安塞地区无大规模致密油聚集;纵向上和平面上致密油的聚集差异受控于烃源岩厚度和源-储组合关系,下生上储、上下生油而中间储集和砂泥互层时含油性更好;新安边地区三角洲前缘亚相末端的长72致密油聚集规模大于三角洲前缘主体,是由于三角洲前缘末端发育的局部连通砂体阻碍了湖盆烃类物质的侧向运移。(4)研究区致密油为“源控-砂控”成藏模式,远源河道优势砂体尖灭处和近源局部连通的砂体是有利勘探区。展开更多
Introduction: Acute tubular necrosis (ATN) is the most prevalent cause of acute renal failure (ARF). Mesenchymal stem cell transplantation has been studied as a potential treatment for renal dysfunction due to ATN. In...Introduction: Acute tubular necrosis (ATN) is the most prevalent cause of acute renal failure (ARF). Mesenchymal stem cell transplantation has been studied as a potential treatment for renal dysfunction due to ATN. Inducible nitric oxide synthase (iNOS), bone morphogenetic protein-7 (BMP-7) and B-cell lymphoma 2 (Bcl-2) are surrogate markers of renal tubular epithelial regeneration and subsequent recovery of renal function following ATN. Methods: Serum creatinine (Scr) and blood urea nitrogen (BUN), as well as expression of iNOS, BMP-7 and Bcl-2 in gentamycin-induced ATN rat kidneys was investigated after human umbilical cord-derived mesenchymal stem cell (HUC-MSC) transplantation. Immunohistochemical staining was performed in 3 groups of rats: gentamycin-induced ATN treated with HUC-MSC, gentamycin-induced ATN without HUC-MSC, and untreated rats not receiving any treatments. Results: HUC-MSC transplantation led to a reduction in Scr and BUN in the kidneys of rats with gentamycin-induced ATN. Expression of iNOS in the HUC-MSC treated group occurred later and the expression levels were much lower during gentamycin-induced ATN compared to rats with ATN that were not treated with HUC-MSC. The expression of BMP-7 and Bcl-2 in the MSC-transplanted group was significantly increased compared to both control groups of rats with injured and healthy renal tubules. Conclusions: HUC-MSCs induce renal protection in a rat model of gentamycin-induced ATN, which is associated with reduced iNOS expression and up-regulation of Bcl-2 and BMP-7.展开更多
应用基于气相色谱-质谱联用(GC-MS)的代谢组学方法结合细胞周期实验,研究羽扇豆醇体外抑制人乳腺癌细胞MCF-7增殖的作用机理。代谢组学的研究结果表明:通过正交偏最小方差判别分析(OPLS-DA)可以很好地区分羽扇豆醇作用的MCF-7细胞代谢...应用基于气相色谱-质谱联用(GC-MS)的代谢组学方法结合细胞周期实验,研究羽扇豆醇体外抑制人乳腺癌细胞MCF-7增殖的作用机理。代谢组学的研究结果表明:通过正交偏最小方差判别分析(OPLS-DA)可以很好地区分羽扇豆醇作用的MCF-7细胞代谢谱与对照组细胞代谢谱,模型参数为:R2 Ycum=0.988,Q2 Ycum=0.964。VIP(variable importance in the projection)值大于1的差异代谢物进一步用t检验进行单位分析,选择t<0.05(VIP>1)的代谢物作为羽扇豆醇作用组的生物标志物,得到琥珀酸、磷酸、亮氨酸、异亮氨酸等11种代谢差异物。结合羽扇豆醇将细胞周期抑制在G1期这一现象,推测羽扇豆醇可能是主要抑制了三羧酸循环中的琥珀酰辅酶A的生成和底物磷酸化生成ATP的反应来抑制MCF-7细胞的增殖。本实验从代谢组学角度为乳腺癌抗肿瘤机制提供新的线索。展开更多
The so-calledPhiladelphia(Ph) chromosome is present in more than 90% of chronic myeloid leukemia (CML) cases. It results in juxtaposition of the 5' part of the BCR gene on chromosome 22 and the 3' part of the ...The so-calledPhiladelphia(Ph) chromosome is present in more than 90% of chronic myeloid leukemia (CML) cases. It results in juxtaposition of the 5' part of the BCR gene on chromosome 22 and the 3' part of the ABL1 gene on chromosome 9. An additional acquired monosomy 7 or deletion of 7q is associated with poor prognosis in a variety of myeloid disorders. Here we report a novel Ph chromosome positive CML case with a ring chromosome 7 [r(7)]. Immunophenotyping was compatible with CML, although 4.5% of total leucocytes appeared like acute myelogeneous leukemia (AML) subtype M2. The r(7) was characterized in detail by array-proven multicolor banding (aMCB), the latter being of enormous significance to characterize breakpoint regions in detail. Underlying mechanisms and prognostic are discussed, as ring chromosomes are rare cytogenetic abnormalities in hematopoietic malignancies.展开更多
文摘综合利用地球化学、扫描电镜、岩心薄片、测井等资料以及油井生产数据等,对鄂尔多斯盆地陕北地区三叠系延长组7段储层特征、烃源岩特征和致密油分布特征进行了分析,从烃源岩展布、输导体系和源-储组合关系3个方面对致密油差异富集控制因素进行了探讨,并总结了成藏模式。研究结果表明:(1)陕北地区长7段致密砂岩储层主要分布在一亚段(长71)和二亚段(长72),以灰色—灰白色长石砂岩和岩屑长石砂岩为主,长71和长72平均孔隙度分别为5.56%和7.32%,平均渗透率分别为0.097 m D和0.110 m D,长72储层物性更好;孔隙空间以溶孔为主,发育少量粒间孔。(2)研究区烃类主要来源于本地长72顶部和长73这2套烃源岩,平均厚度大于20 m,有机质丰度高,平均TOC值为3.02%,干酪根类型以Ⅰ型和Ⅱ1型为主,处于生烃高峰期,平均生烃量为270.2×10^(4)t/km^(2),长73烃源岩生烃潜力更大,供烃至长72储层,长71致密油来源于长72烃源岩;新安边地区三角洲前缘亚相末端的长72储层中致密油由湖盆烃源岩侧向供烃。(3)研究区致密油富集受烃源岩展布、砂体连通性以及源-储组合共同控制,在长72更富集,在新安边地区分布面积最大,安塞地区无大规模致密油聚集;纵向上和平面上致密油的聚集差异受控于烃源岩厚度和源-储组合关系,下生上储、上下生油而中间储集和砂泥互层时含油性更好;新安边地区三角洲前缘亚相末端的长72致密油聚集规模大于三角洲前缘主体,是由于三角洲前缘末端发育的局部连通砂体阻碍了湖盆烃类物质的侧向运移。(4)研究区致密油为“源控-砂控”成藏模式,远源河道优势砂体尖灭处和近源局部连通的砂体是有利勘探区。
文摘Introduction: Acute tubular necrosis (ATN) is the most prevalent cause of acute renal failure (ARF). Mesenchymal stem cell transplantation has been studied as a potential treatment for renal dysfunction due to ATN. Inducible nitric oxide synthase (iNOS), bone morphogenetic protein-7 (BMP-7) and B-cell lymphoma 2 (Bcl-2) are surrogate markers of renal tubular epithelial regeneration and subsequent recovery of renal function following ATN. Methods: Serum creatinine (Scr) and blood urea nitrogen (BUN), as well as expression of iNOS, BMP-7 and Bcl-2 in gentamycin-induced ATN rat kidneys was investigated after human umbilical cord-derived mesenchymal stem cell (HUC-MSC) transplantation. Immunohistochemical staining was performed in 3 groups of rats: gentamycin-induced ATN treated with HUC-MSC, gentamycin-induced ATN without HUC-MSC, and untreated rats not receiving any treatments. Results: HUC-MSC transplantation led to a reduction in Scr and BUN in the kidneys of rats with gentamycin-induced ATN. Expression of iNOS in the HUC-MSC treated group occurred later and the expression levels were much lower during gentamycin-induced ATN compared to rats with ATN that were not treated with HUC-MSC. The expression of BMP-7 and Bcl-2 in the MSC-transplanted group was significantly increased compared to both control groups of rats with injured and healthy renal tubules. Conclusions: HUC-MSCs induce renal protection in a rat model of gentamycin-induced ATN, which is associated with reduced iNOS expression and up-regulation of Bcl-2 and BMP-7.
文摘应用基于气相色谱-质谱联用(GC-MS)的代谢组学方法结合细胞周期实验,研究羽扇豆醇体外抑制人乳腺癌细胞MCF-7增殖的作用机理。代谢组学的研究结果表明:通过正交偏最小方差判别分析(OPLS-DA)可以很好地区分羽扇豆醇作用的MCF-7细胞代谢谱与对照组细胞代谢谱,模型参数为:R2 Ycum=0.988,Q2 Ycum=0.964。VIP(variable importance in the projection)值大于1的差异代谢物进一步用t检验进行单位分析,选择t<0.05(VIP>1)的代谢物作为羽扇豆醇作用组的生物标志物,得到琥珀酸、磷酸、亮氨酸、异亮氨酸等11种代谢差异物。结合羽扇豆醇将细胞周期抑制在G1期这一现象,推测羽扇豆醇可能是主要抑制了三羧酸循环中的琥珀酰辅酶A的生成和底物磷酸化生成ATP的反应来抑制MCF-7细胞的增殖。本实验从代谢组学角度为乳腺癌抗肿瘤机制提供新的线索。
文摘The so-calledPhiladelphia(Ph) chromosome is present in more than 90% of chronic myeloid leukemia (CML) cases. It results in juxtaposition of the 5' part of the BCR gene on chromosome 22 and the 3' part of the ABL1 gene on chromosome 9. An additional acquired monosomy 7 or deletion of 7q is associated with poor prognosis in a variety of myeloid disorders. Here we report a novel Ph chromosome positive CML case with a ring chromosome 7 [r(7)]. Immunophenotyping was compatible with CML, although 4.5% of total leucocytes appeared like acute myelogeneous leukemia (AML) subtype M2. The r(7) was characterized in detail by array-proven multicolor banding (aMCB), the latter being of enormous significance to characterize breakpoint regions in detail. Underlying mechanisms and prognostic are discussed, as ring chromosomes are rare cytogenetic abnormalities in hematopoietic malignancies.