本文研究了基于第一性原理平面波赝势及虚晶近似方法的镨(Pr)元素替位掺杂SmCo5体系(PrxSm1−xCo5)的体系的电子结构和磁性。采用CASTEP软件包,基于LDA + U并进行自旋极化计算,研究了不同掺杂参数下PrxSm1−xCo5 (x = 0 − 0.2)体系的能量...本文研究了基于第一性原理平面波赝势及虚晶近似方法的镨(Pr)元素替位掺杂SmCo5体系(PrxSm1−xCo5)的体系的电子结构和磁性。采用CASTEP软件包,基于LDA + U并进行自旋极化计算,研究了不同掺杂参数下PrxSm1−xCo5 (x = 0 − 0.2)体系的能量、分态密度、波尔磁矩等性质,研究表明,PrxSm1−xCo5体系的总态密度在−40 eV附近主要由s轨道贡献,总态密度在−20 eV附近主要由p轨道贡献,d轨道主要来自于Co及Pr/Sm原子,而f轨道贡献则来自于Pr/Sm原子且其自旋向下的密度远高于其自旋向上的密度,同时,随着镨元素掺杂比例的提高,晶格常数(a, c)以及晶胞体积(V)逐步增大,同时体系总能量逐步升高,同时,随着掺杂比例的不断变化,体系的波尔磁矩结果呈现出波动变化的特点,本文的研究有助于优化钐钴永磁体的设计。In this paper, the system energy of praseodymium (Pr) elemental substitution doped SmCo5 system (PrxSm1−xCo5) based on first-principles and virtual-crystal approximation method was studied. The energy, fractional density and Bohr magnetic moment of PrxSm1−xCo5 (x = 0 − 0.2) system under different doping parameters were studied by using CASTEP software package, based on LDA + U and spin polarization calculation, and the results show that the total density of states of the PrxSm1−xCo5 system is mainly contributed by the s orbital around −40 eV, the total density of states near −20 eV is mainly contributed by the p orbital, the d orbital is mainly contributed by Co and Pr/Sm atoms, and the f orbital is contributed by Pr/Sm atoms and its spin down density is much higher than its spin up density. At the same time, the total energy of the system is gradually decreasing, indicating that the system is more stable, and with the continuous change of the doping ratio, the Bohr magnetic moment results of the system show the characteristics of fluctuating changes, and the research in this paper is helpful to optimize the design of samarium cobalt permanent magnets.展开更多
“完”和“了”是现代汉语体貌系统中重要的组成成分。文章将运用对比分析法、文献研究法和定性研究法,以这两个体貌标记“完1”与“了1”为研究对象,结合语料从句法和语义角度比较研究他们在语法程度以及句子中意义的差异,并且在此基...“完”和“了”是现代汉语体貌系统中重要的组成成分。文章将运用对比分析法、文献研究法和定性研究法,以这两个体貌标记“完1”与“了1”为研究对象,结合语料从句法和语义角度比较研究他们在语法程度以及句子中意义的差异,并且在此基础上通过分析两者之间的互换现象,总结归纳后试图找出其中的替换规律,探究两者不能互换的原因。得出初步结论:当“完1”或“了1”所在小句中省略宾语,由于受到动词类型,宾语等因素的影响,事件强调的焦点在“完1”上,插入其他体貌标记词,以及动词为强持续活动动词这四种情况下时两者不能互换。“Wan1” and “le1” are important components in the aspect system of modern Chinese. This paper will use comparative analysis, literature research and qualitative research methods and take these two aspect markers “wan1” and “le1” as the research object, and combine the corpus to compare and study their differences in grammar degree and meaning in sentences from the perspective of syntax and semantics. On this basis, by analyzing the interchangeability between the two, the paper tries to find out the substitution rule and explore the reasons why the two cannot be interchangeable. The preliminary conclusion is that when the object is omitted in the clause of “wan1” or “le1”, the emphasis of the event is on the “wan1”, other physical markers are inserted, and the verb is a strong continuous activity verb, the two cannot be interchangeable, because the verb type, object and other factors affect them.展开更多
Angiotensin II (Ang II) is the main mediator of the Renin-Angiotensin-System acting on AT<sub>1</sub> and other AT receptors. It is regarded as a pleiotropic agent that induces many actions, including func...Angiotensin II (Ang II) is the main mediator of the Renin-Angiotensin-System acting on AT<sub>1</sub> and other AT receptors. It is regarded as a pleiotropic agent that induces many actions, including functioning as a growth factor, and as a contractile hormone, among others. The aim of this work was to examine the impact of Ang II on the expression and function of α<sub>1</sub>-adrenergic receptors (α<sub>1</sub>-ARs) in cultured rat aorta, and aorta-derived smooth muscle cells. Isolated Wistar rat aorta was incubated for 24 h in DMEM at 37˚C, then subjected to isometric tension and to the action of added norepinephrine, in concentration-response curves. Ang II was added (1 × 10<sup>−5</sup> M), and in some experiments, 5-Methylurapidil (α<sub>1A</sub>-AR antagonist), AH11110A (α<sub>1B</sub>-AR antagonist), or BMY-7378 (α<sub>1D</sub>-AR antagonist), were used to identify the α<sub>1</sub>-AR involved in the response. Desensitization of the contractile response to norepinephrine was observed due to incubation time, and by the Ang II action. α<sub>1D</sub>-AR was protected from desensitization by BMY-7378;while RS-100329 and prazosin partially mitigated desensitization. In another set of experiments, isolated aorta-derived smooth muscle cells were exposed to Ang II and α<sub>1</sub>-ARs proteins were evaluated. α<sub>1D</sub>-AR increased at 30 and 60 min post Ang II exposure, the α<sub>1A</sub>-AR diminished from 1 to 4 h, while α<sub>1B</sub>-AR remained unchanged over 24 h of Ang II exposure. Ang II induced an increase of α<sub>1D</sub>-AR at short times, and BMY-7378 protected α<sub>1D</sub>-AR from desensitization.展开更多
Aim: This study aimed to investigate the protective effects of flavonoids from the stem and leaves of Scutellaria baicalensis Georgi (SSFs) against Aβ<sub>1-42</sub>-induced oligodendrocytes (OL) damage. ...Aim: This study aimed to investigate the protective effects of flavonoids from the stem and leaves of Scutellaria baicalensis Georgi (SSFs) against Aβ<sub>1-42</sub>-induced oligodendrocytes (OL) damage. Methods: Immunofluorescence was used for the detection of myelin-associated glycoprotein (MAG), a characteristic protein of rat oligodendrocytes (OLN-93 cells). To evaluate the potential protective effects of SSFs on OLN-93 cells injured by Aβ<sub>1-42</sub>, an injury model was established by subjecting OLN-93 cells to Aβ<sub>1-42</sub> exposed. Cell morphology was examined using an inverted microscope, while cell viability was assessed using the colorimetric method of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). Additionally, lactate dehydrogenase (LDH) was measured using the pyruvic acid reduction assay. The Ginkgo biloba leaf extract (GBE) injection was used as a positive control. Results: A total of >95% of the MAG immunofluorescence-positive cells were identified as oligodendrocytes. Gradually increasing concentrations of SSFs impaired the cells, and the maximum nondetrimental dose for OLN-93 cells was 75 mg/L. This study assessed the effects of SSFs on OLN-93 cells damaged by Aβ<sub>1-42</sub>. The results indicated that SSFs significantly improved OLN-93 cell morphological abnormal changes, increased the OLN-93 cell survival rate, and reduced LDH release. Conclusion: SSFs can alleviate Aβ<sub>1-42</sub>-induced damage of OL.展开更多
Introduction: Hypertensive disorder in pregnancy affects 4 to 6 percent of all pregnancies and carries risks for the both baby and the mother. Only a few groups of women who are at high-risk pregnancies are received p...Introduction: Hypertensive disorder in pregnancy affects 4 to 6 percent of all pregnancies and carries risks for the both baby and the mother. Only a few groups of women who are at high-risk pregnancies are received prophylaxis Aspirin, more than 15 percent of women develop pre-eclampsia with a single minor risk factor. Methods: This descriptive cross-sectional study was conducted to compare the 1<sup>st</sup> trimester NLR value of normotensive, pregnancy induced hypertensive and pre-eclamptic pregnant women. The study was conducted with a sample of 416, antenatal patients who were admitted to ward 25, at Colombo North Teaching Hospital Ragama. Data was collected as separated three groups. NLR value was calculated separately and ANOVA test was used to analyze the 3 categorical data. Post HOC test was done to assess the multiple comparison. Results: The prevalence rates of pregnancy induced hypertension and pre-eclampsia among the pregnant women were 8.6% and 5.7%. The mean NLR values of normotensive group was 2.708, pregnancy induced hypertensive group was 2.650 and pre eclamptic group was 3.789. There was a significant difference in NLR value between pre eclamptic group and other two groups with P value of Conclusion: The 1<sup>st</sup> trimester NLR value of pre eclamptic patients significantly increased compared to normotensive women.展开更多
文摘本文研究了基于第一性原理平面波赝势及虚晶近似方法的镨(Pr)元素替位掺杂SmCo5体系(PrxSm1−xCo5)的体系的电子结构和磁性。采用CASTEP软件包,基于LDA + U并进行自旋极化计算,研究了不同掺杂参数下PrxSm1−xCo5 (x = 0 − 0.2)体系的能量、分态密度、波尔磁矩等性质,研究表明,PrxSm1−xCo5体系的总态密度在−40 eV附近主要由s轨道贡献,总态密度在−20 eV附近主要由p轨道贡献,d轨道主要来自于Co及Pr/Sm原子,而f轨道贡献则来自于Pr/Sm原子且其自旋向下的密度远高于其自旋向上的密度,同时,随着镨元素掺杂比例的提高,晶格常数(a, c)以及晶胞体积(V)逐步增大,同时体系总能量逐步升高,同时,随着掺杂比例的不断变化,体系的波尔磁矩结果呈现出波动变化的特点,本文的研究有助于优化钐钴永磁体的设计。In this paper, the system energy of praseodymium (Pr) elemental substitution doped SmCo5 system (PrxSm1−xCo5) based on first-principles and virtual-crystal approximation method was studied. The energy, fractional density and Bohr magnetic moment of PrxSm1−xCo5 (x = 0 − 0.2) system under different doping parameters were studied by using CASTEP software package, based on LDA + U and spin polarization calculation, and the results show that the total density of states of the PrxSm1−xCo5 system is mainly contributed by the s orbital around −40 eV, the total density of states near −20 eV is mainly contributed by the p orbital, the d orbital is mainly contributed by Co and Pr/Sm atoms, and the f orbital is contributed by Pr/Sm atoms and its spin down density is much higher than its spin up density. At the same time, the total energy of the system is gradually decreasing, indicating that the system is more stable, and with the continuous change of the doping ratio, the Bohr magnetic moment results of the system show the characteristics of fluctuating changes, and the research in this paper is helpful to optimize the design of samarium cobalt permanent magnets.
文摘“完”和“了”是现代汉语体貌系统中重要的组成成分。文章将运用对比分析法、文献研究法和定性研究法,以这两个体貌标记“完1”与“了1”为研究对象,结合语料从句法和语义角度比较研究他们在语法程度以及句子中意义的差异,并且在此基础上通过分析两者之间的互换现象,总结归纳后试图找出其中的替换规律,探究两者不能互换的原因。得出初步结论:当“完1”或“了1”所在小句中省略宾语,由于受到动词类型,宾语等因素的影响,事件强调的焦点在“完1”上,插入其他体貌标记词,以及动词为强持续活动动词这四种情况下时两者不能互换。“Wan1” and “le1” are important components in the aspect system of modern Chinese. This paper will use comparative analysis, literature research and qualitative research methods and take these two aspect markers “wan1” and “le1” as the research object, and combine the corpus to compare and study their differences in grammar degree and meaning in sentences from the perspective of syntax and semantics. On this basis, by analyzing the interchangeability between the two, the paper tries to find out the substitution rule and explore the reasons why the two cannot be interchangeable. The preliminary conclusion is that when the object is omitted in the clause of “wan1” or “le1”, the emphasis of the event is on the “wan1”, other physical markers are inserted, and the verb is a strong continuous activity verb, the two cannot be interchangeable, because the verb type, object and other factors affect them.
文摘Angiotensin II (Ang II) is the main mediator of the Renin-Angiotensin-System acting on AT<sub>1</sub> and other AT receptors. It is regarded as a pleiotropic agent that induces many actions, including functioning as a growth factor, and as a contractile hormone, among others. The aim of this work was to examine the impact of Ang II on the expression and function of α<sub>1</sub>-adrenergic receptors (α<sub>1</sub>-ARs) in cultured rat aorta, and aorta-derived smooth muscle cells. Isolated Wistar rat aorta was incubated for 24 h in DMEM at 37˚C, then subjected to isometric tension and to the action of added norepinephrine, in concentration-response curves. Ang II was added (1 × 10<sup>−5</sup> M), and in some experiments, 5-Methylurapidil (α<sub>1A</sub>-AR antagonist), AH11110A (α<sub>1B</sub>-AR antagonist), or BMY-7378 (α<sub>1D</sub>-AR antagonist), were used to identify the α<sub>1</sub>-AR involved in the response. Desensitization of the contractile response to norepinephrine was observed due to incubation time, and by the Ang II action. α<sub>1D</sub>-AR was protected from desensitization by BMY-7378;while RS-100329 and prazosin partially mitigated desensitization. In another set of experiments, isolated aorta-derived smooth muscle cells were exposed to Ang II and α<sub>1</sub>-ARs proteins were evaluated. α<sub>1D</sub>-AR increased at 30 and 60 min post Ang II exposure, the α<sub>1A</sub>-AR diminished from 1 to 4 h, while α<sub>1B</sub>-AR remained unchanged over 24 h of Ang II exposure. Ang II induced an increase of α<sub>1D</sub>-AR at short times, and BMY-7378 protected α<sub>1D</sub>-AR from desensitization.
文摘Aim: This study aimed to investigate the protective effects of flavonoids from the stem and leaves of Scutellaria baicalensis Georgi (SSFs) against Aβ<sub>1-42</sub>-induced oligodendrocytes (OL) damage. Methods: Immunofluorescence was used for the detection of myelin-associated glycoprotein (MAG), a characteristic protein of rat oligodendrocytes (OLN-93 cells). To evaluate the potential protective effects of SSFs on OLN-93 cells injured by Aβ<sub>1-42</sub>, an injury model was established by subjecting OLN-93 cells to Aβ<sub>1-42</sub> exposed. Cell morphology was examined using an inverted microscope, while cell viability was assessed using the colorimetric method of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). Additionally, lactate dehydrogenase (LDH) was measured using the pyruvic acid reduction assay. The Ginkgo biloba leaf extract (GBE) injection was used as a positive control. Results: A total of >95% of the MAG immunofluorescence-positive cells were identified as oligodendrocytes. Gradually increasing concentrations of SSFs impaired the cells, and the maximum nondetrimental dose for OLN-93 cells was 75 mg/L. This study assessed the effects of SSFs on OLN-93 cells damaged by Aβ<sub>1-42</sub>. The results indicated that SSFs significantly improved OLN-93 cell morphological abnormal changes, increased the OLN-93 cell survival rate, and reduced LDH release. Conclusion: SSFs can alleviate Aβ<sub>1-42</sub>-induced damage of OL.
文摘Introduction: Hypertensive disorder in pregnancy affects 4 to 6 percent of all pregnancies and carries risks for the both baby and the mother. Only a few groups of women who are at high-risk pregnancies are received prophylaxis Aspirin, more than 15 percent of women develop pre-eclampsia with a single minor risk factor. Methods: This descriptive cross-sectional study was conducted to compare the 1<sup>st</sup> trimester NLR value of normotensive, pregnancy induced hypertensive and pre-eclamptic pregnant women. The study was conducted with a sample of 416, antenatal patients who were admitted to ward 25, at Colombo North Teaching Hospital Ragama. Data was collected as separated three groups. NLR value was calculated separately and ANOVA test was used to analyze the 3 categorical data. Post HOC test was done to assess the multiple comparison. Results: The prevalence rates of pregnancy induced hypertension and pre-eclampsia among the pregnant women were 8.6% and 5.7%. The mean NLR values of normotensive group was 2.708, pregnancy induced hypertensive group was 2.650 and pre eclamptic group was 3.789. There was a significant difference in NLR value between pre eclamptic group and other two groups with P value of Conclusion: The 1<sup>st</sup> trimester NLR value of pre eclamptic patients significantly increased compared to normotensive women.
