Ginkgo paste improves tinea corporis in a guinea pig model

To investigate the effects of Ginkgo paste for external use on tinea corporis in a guinea pig model.The guinea pig tinea corporis model were induced by infection with Trichophyton mentagrophytes strains.And then,high and low doses of Ginkgo water-paste and alcohol-paste were administrated to the animals.The symptom,tinea corporis skin lesions and histopathological aspects of guinea pig were analyzed.High and low doses of Ginkgo alcohol-paste and Ginkgo water-paste could significantly reduced the tinea corporis symptom(P<0.01),increased negative rate of strain culture(P<0.01),and improved pathological changes of tinea corporis(P<0.01).The best efficacy was observed in high dose ginkgo alcohol paste group.These results suggest that Ginkgo paste exhibits the efficacy to treat tinea corporis in a guinea pig model.

千金子醋糊外用对豚鼠体癣模型的影响

目的探讨千金子醋糊外用对豚鼠体癣模型的影响。方法采用须癣毛癣菌接种于豚鼠皮肤创面制作体癣模型,观察千金子醋糊大、小剂量组(0.2 5,0.15 g·m L-1)外用对体癣模型豚鼠体癣症状积分、病灶皮肤逆培养、病灶局部病理变化的影响。结果大、小剂量千金子醋糊外用可显著降低体癣模型豚鼠的体癣症状积分(P<0.0 1,P<0.0 5);明显提高病灶皮肤逆培养转阴率(P<0.0 5);显著改善体癣病灶局部病理变化(P<0.0 1)。结论千金子醋糊外用对豚鼠体癣模型有较好的治疗作用。

癣药膏的抗炎抗菌及急性毒性实验

为研究中药癣药膏的主要药效及急性毒性反应 ,我们采用小鼠耳廓肿胀法、平皿挖洞灌药法对其进行抗炎抗菌试验 ,并观察癣药膏用于完整皮肤与破损皮肤的毒性作用。结果发现癣药膏能明显降低二甲苯造成的小鼠耳廓肿胀程度 ,对多种真菌呈抑制作用 ,且无明显毒性反应 ,为中药治疗手足癣的临床应用提供了实验依据。

布替萘芬联合硼酸治疗浸渍糜烂型足癣疗效观察

目的:观察1%盐酸布替萘芬乳膏联合3%硼酸液治疗浸渍糜烂型足癣的疗效。方法:浸渍糜烂型足癣患者104例,随机分成两组,治疗组56例,先用3%硼酸浸泡患处,20分钟/次,2次/日,每次浸泡后均晾干后局部外用1%盐酸布替萘芬乳膏,疗程2周;对照组48例,仅局部外用1%盐酸布替萘芬乳膏,2次/日,疗程2周。结果:治疗组治愈率67,9%,有效率96.4%,真菌清除率94.6%;对照组治愈率52.1%,有效率85.4%,真菌清除率83.3%。两组临床疗效及真菌学疗效比较,差异均具有显著性意义(X^2=6.24,P<0.05;X^2=4.16,P<0.05)。结论:1%盐酸布替萘芬乳膏联合3%硼酸液治疗浸渍糜烂型足癣,起效快、疗程短、疗效好。

千金子醋糊外用对大鼠体癣的影响

目的:探讨千金子醋糊外用对大鼠体癣的影响。方法:采用须癣毛癣菌菌种接种于皮肤创面感染制作大鼠体癣模型,观察大、小剂量千金子醋糊对大鼠体癣模型治疗前后症状积分、体癣病灶皮肤逆培养及病理组织学的影响。结果:与模型组比较,大、小剂量千金子醋糊可显著降低体癣症状积分(P<0.01,P<0.05),可明显增高皮肤逆培养转阴率(P<0.05),明显改善体癣症状的病理变化(P<0.01)。以大剂量千金子醋糊组的效果较好。结论:千金子醋糊外用对大鼠体癣模型有显著治疗效果。