目的探讨小柴胡三仁汤化裁治疗直肠癌术后湿热蕴结型便秘的疗效及对胃动素(motilin,MTL)、血管活性肠肽(vasoactive intestinal peptide,VIP)、P物质(substance P,SP)的影响。方法将2017年4月—2019年5月该院收治的湿热蕴结型便秘患者共...目的探讨小柴胡三仁汤化裁治疗直肠癌术后湿热蕴结型便秘的疗效及对胃动素(motilin,MTL)、血管活性肠肽(vasoactive intestinal peptide,VIP)、P物质(substance P,SP)的影响。方法将2017年4月—2019年5月该院收治的湿热蕴结型便秘患者共计79例,按照随机数字表法分组,对照组39例采用莫沙必利15 mg/d治疗;观察组40例采用小柴胡三仁汤化裁治疗,每日1剂,持续治疗4周。记录血清MTL、SP、VIP、便秘症状严重度评分(constipation symptom severity score,SS)、便秘患者生活质量量表(quality of life scale for patients with constipation,PAC-QOL)及中医证候积分,比较两组间的临床疗效。结果与治疗前比,两组治疗后血清MTL、VIP水平降低,血清SP升高;与对照组比,观察组治疗后血清MTL、VIP水平较低,血清SP较高,差异有统计学意义(P<0.05)。与治疗前比,两组治疗后SS评分、PAC-QOL评分降低;与对照组比,观察组治疗后SS评分、PAC-QOL评分较低,差异有统计学意义(P<0.05)。与治疗前比,两组治疗后大便艰涩、腹胀腹痛、面红身热、口干口臭等中医证候积分降低;与对照组比,观察组治疗后大便艰涩、腹胀腹痛、面红身热、口干口臭等中医证候积分较低,差异有统计学意义(P<0.05)。对照组有效率79.49%低于观察组95.00%,差异有统计学意义(P<0.05)。结论小柴胡三仁汤化裁治疗直肠癌术后湿热蕴结型便秘的疗效显著,可改善MTL、SP、VIP及中医证候,提高生活质量,值得推广。展开更多
The classified prescriptions from Chaihu decoction have been widely used in ancient and modern times.In spite of many previous research studies,the extensiveness and diversity of their applications have not been syste...The classified prescriptions from Chaihu decoction have been widely used in ancient and modern times.In spite of many previous research studies,the extensiveness and diversity of their applications have not been systematically studied.The author applied Chaihu Wendan decoction to treat phlegm and qi stagnation in the middle energizer,applied Chaihu Guizhi decoction to treat simultaneous disease of Shaoyang and Taiyang,applied Chaihu Xiexin decoction to treat simultaneous disease of the spleen,stomach,liver,and gallbladder,applied Chaihu Ermiao powder to treat simultaneous disease of hand Shaoyang and foot Taiyin,applied Chaihu Erchen decoction to treat simultaneous disease of Shaoyang and Taiyin,applied Chailing decoction to treat simultaneous disease of hand Shaoyin and foot Taiyang,applied Chaihu Guizhi Ganjiang decoction to treat Shaoyang and Taiyin cold fluid retention and heat stagnation syndrome of Shaoyang complicated with Taiyin,applied Chaihu Xingren decoction to treat simultaneous disease of hand Shaoyang and hand Taiyin,applied Chaihu Sanren decoction to treat the disease caused by damp-heat stagnation in the hand Shaoyang and the foot Taiyin,and applied Chaihu Ganlu Xiaodu pellet to treat the diseases of hand Shaoyang and foot Yangming.The effects were all remarkable.展开更多
文摘目的探讨小柴胡三仁汤化裁治疗直肠癌术后湿热蕴结型便秘的疗效及对胃动素(motilin,MTL)、血管活性肠肽(vasoactive intestinal peptide,VIP)、P物质(substance P,SP)的影响。方法将2017年4月—2019年5月该院收治的湿热蕴结型便秘患者共计79例,按照随机数字表法分组,对照组39例采用莫沙必利15 mg/d治疗;观察组40例采用小柴胡三仁汤化裁治疗,每日1剂,持续治疗4周。记录血清MTL、SP、VIP、便秘症状严重度评分(constipation symptom severity score,SS)、便秘患者生活质量量表(quality of life scale for patients with constipation,PAC-QOL)及中医证候积分,比较两组间的临床疗效。结果与治疗前比,两组治疗后血清MTL、VIP水平降低,血清SP升高;与对照组比,观察组治疗后血清MTL、VIP水平较低,血清SP较高,差异有统计学意义(P<0.05)。与治疗前比,两组治疗后SS评分、PAC-QOL评分降低;与对照组比,观察组治疗后SS评分、PAC-QOL评分较低,差异有统计学意义(P<0.05)。与治疗前比,两组治疗后大便艰涩、腹胀腹痛、面红身热、口干口臭等中医证候积分降低;与对照组比,观察组治疗后大便艰涩、腹胀腹痛、面红身热、口干口臭等中医证候积分较低,差异有统计学意义(P<0.05)。对照组有效率79.49%低于观察组95.00%,差异有统计学意义(P<0.05)。结论小柴胡三仁汤化裁治疗直肠癌术后湿热蕴结型便秘的疗效显著,可改善MTL、SP、VIP及中医证候,提高生活质量,值得推广。
基金supported by Jiangxi Provincial Health Department Chinese Medicine Research Program Project{[2004]No.28}.
文摘The classified prescriptions from Chaihu decoction have been widely used in ancient and modern times.In spite of many previous research studies,the extensiveness and diversity of their applications have not been systematically studied.The author applied Chaihu Wendan decoction to treat phlegm and qi stagnation in the middle energizer,applied Chaihu Guizhi decoction to treat simultaneous disease of Shaoyang and Taiyang,applied Chaihu Xiexin decoction to treat simultaneous disease of the spleen,stomach,liver,and gallbladder,applied Chaihu Ermiao powder to treat simultaneous disease of hand Shaoyang and foot Taiyin,applied Chaihu Erchen decoction to treat simultaneous disease of Shaoyang and Taiyin,applied Chailing decoction to treat simultaneous disease of hand Shaoyin and foot Taiyang,applied Chaihu Guizhi Ganjiang decoction to treat Shaoyang and Taiyin cold fluid retention and heat stagnation syndrome of Shaoyang complicated with Taiyin,applied Chaihu Xingren decoction to treat simultaneous disease of hand Shaoyang and hand Taiyin,applied Chaihu Sanren decoction to treat the disease caused by damp-heat stagnation in the hand Shaoyang and the foot Taiyin,and applied Chaihu Ganlu Xiaodu pellet to treat the diseases of hand Shaoyang and foot Yangming.The effects were all remarkable.
