Objective:To evaluate efficacy of the stereotactic body radiotherapy for patients with hepatocellular carcinoma. Methods:Twenty-seven patients with hepatocellular carcinoma were treated by technique of stereotactic bo...Objective:To evaluate efficacy of the stereotactic body radiotherapy for patients with hepatocellular carcinoma. Methods:Twenty-seven patients with hepatocellular carcinoma were treated by technique of stereotactic body radiotherapy. Planning of treatment was made and the prescribed dose was adjusted depending on the site of the tumor,clinical target volume(GTV),Kanofsky Performance and aim of treatment.Planning target volume received 50%–80%of the prescribed dose for 3.2–4.2 Gy per-fraction.Treatment total dose was 32–42 Gy(median dose 40 Gy)in daily fractions of 3.2–4.2 Gy for five fractions one week.Results:All the patients completed the planned radiotherapy.The tumor response rate was CR 25.9%,PR 55.6%,NR 18.59%;the response rate(CR+PR)was 81.5%.Half-year local recurrence-free survival rate was 75%;1-year local recurrence-free survival rate was 22%.There were no serious complications during radiotherapy and follow- up.Pain relieve rate in liver region was 83.3%.Conclusion:Stereotactic body radiotherapy can improve the local control and quality of life on the treatment of primary hepatic neoplasm while not increasing the treatment complication.展开更多
Objective： To evaluate the feasibility of the whole body gamma knife in the treatment of malignant solid tumors. Methods： 643 patients diagnosed by pathology or cytology were treated with the whole body gamma knife....Objective： To evaluate the feasibility of the whole body gamma knife in the treatment of malignant solid tumors. Methods： 643 patients diagnosed by pathology or cytology were treated with the whole body gamma knife. They received a total dose from 40-60 Gy/2-3 w, 3-10 Gy/fraction, 5 fractions/week. Results： The rates of response, complete remission, partial remission, no remission, and tumor progression were 94.6%, 39.2%, 55.4%, 5.1% and 0.3%, respectively. Conclusion： Whole body γ-radiation system （y-knife） was an effective method in treatment of patients with malignant tumor.展开更多
Objective： To evaluate the therapeutic efficacy of low-grade glioma （WHO grades Ⅰ-Ⅱ） patients treated with gamma knife radiosurgery and study on the efficacy evaluation method and radiobiological effect. Methods...Objective： To evaluate the therapeutic efficacy of low-grade glioma （WHO grades Ⅰ-Ⅱ） patients treated with gamma knife radiosurgery and study on the efficacy evaluation method and radiobiological effect. Methods： 140 MRI data of 52 patients after gamma knife radiosurgery were analyzed in tumor size, necrosis or cyst formation, radiation-induced edema and MRI contrast enhancement and circumsciption change for therapeutic efficacy was evaluated. Results： The efficiency rate was 84.3%. The salient efficiency rates were 54.3% for total and 30%, 36.4%, 50%, 68%, 69.2%, and 73.1% for segmenting, respectively. Aggrandizement of tumor related to MRI contrast enhancement and necrosis or cyst formation. Radiation-induced oedema occurred for 32.7%. The MRI contrast enhancement occurred for 57.7% and showed special lace-like ring while some piece-like. Conclusion： Evaluation by MRI has showed gamma knife radiosurgery is efficient for low-grade glioma. The segmenting salient efficiency rate that increase with time is better for evaluation than the efficiency rate especially for long-term MRI follow-up. Radiobiological effect affect the efficacy evaluation. MRI contrast enhancement appears after therapy and shows special as lace-like ring and partly minificates or vanishes subsequently.展开更多
This paper introduces a design to improve the radiotherapy accuracy of gamma knife. In this design, sensor is used to collect respiratory parameters and tumor displacement (caused by human respiration) model is establ...This paper introduces a design to improve the radiotherapy accuracy of gamma knife. In this design, sensor is used to collect respiratory parameters and tumor displacement (caused by human respiration) model is established through optimization modeling. At the same time, data are transferred to single chip microcomputer (SCM) system by pressure sensor and then stepping motor is controlled by SCM. Finally, the intelligent positioning bed is under the control of stepping motor. As a result, the intelligent positioning bed can move reverse to respiratory law. The experimental results showed that this method can reduce the influence of respiration on tumor displacement, improving the accuracy of intelligent positioning bed with simple circuit and low cost at the same time.展开更多
文摘Objective:To evaluate efficacy of the stereotactic body radiotherapy for patients with hepatocellular carcinoma. Methods:Twenty-seven patients with hepatocellular carcinoma were treated by technique of stereotactic body radiotherapy. Planning of treatment was made and the prescribed dose was adjusted depending on the site of the tumor,clinical target volume(GTV),Kanofsky Performance and aim of treatment.Planning target volume received 50%–80%of the prescribed dose for 3.2–4.2 Gy per-fraction.Treatment total dose was 32–42 Gy(median dose 40 Gy)in daily fractions of 3.2–4.2 Gy for five fractions one week.Results:All the patients completed the planned radiotherapy.The tumor response rate was CR 25.9%,PR 55.6%,NR 18.59%;the response rate(CR+PR)was 81.5%.Half-year local recurrence-free survival rate was 75%;1-year local recurrence-free survival rate was 22%.There were no serious complications during radiotherapy and follow- up.Pain relieve rate in liver region was 83.3%.Conclusion:Stereotactic body radiotherapy can improve the local control and quality of life on the treatment of primary hepatic neoplasm while not increasing the treatment complication.
文摘Objective： To evaluate the feasibility of the whole body gamma knife in the treatment of malignant solid tumors. Methods： 643 patients diagnosed by pathology or cytology were treated with the whole body gamma knife. They received a total dose from 40-60 Gy/2-3 w, 3-10 Gy/fraction, 5 fractions/week. Results： The rates of response, complete remission, partial remission, no remission, and tumor progression were 94.6%, 39.2%, 55.4%, 5.1% and 0.3%, respectively. Conclusion： Whole body γ-radiation system （y-knife） was an effective method in treatment of patients with malignant tumor.
基金Guangzhou Medical Science Project (No. 2006-YB-169)
文摘Objective： To evaluate the therapeutic efficacy of low-grade glioma （WHO grades Ⅰ-Ⅱ） patients treated with gamma knife radiosurgery and study on the efficacy evaluation method and radiobiological effect. Methods： 140 MRI data of 52 patients after gamma knife radiosurgery were analyzed in tumor size, necrosis or cyst formation, radiation-induced edema and MRI contrast enhancement and circumsciption change for therapeutic efficacy was evaluated. Results： The efficiency rate was 84.3%. The salient efficiency rates were 54.3% for total and 30%, 36.4%, 50%, 68%, 69.2%, and 73.1% for segmenting, respectively. Aggrandizement of tumor related to MRI contrast enhancement and necrosis or cyst formation. Radiation-induced oedema occurred for 32.7%. The MRI contrast enhancement occurred for 57.7% and showed special lace-like ring while some piece-like. Conclusion： Evaluation by MRI has showed gamma knife radiosurgery is efficient for low-grade glioma. The segmenting salient efficiency rate that increase with time is better for evaluation than the efficiency rate especially for long-term MRI follow-up. Radiobiological effect affect the efficacy evaluation. MRI contrast enhancement appears after therapy and shows special as lace-like ring and partly minificates or vanishes subsequently.
文摘This paper introduces a design to improve the radiotherapy accuracy of gamma knife. In this design, sensor is used to collect respiratory parameters and tumor displacement (caused by human respiration) model is established through optimization modeling. At the same time, data are transferred to single chip microcomputer (SCM) system by pressure sensor and then stepping motor is controlled by SCM. Finally, the intelligent positioning bed is under the control of stepping motor. As a result, the intelligent positioning bed can move reverse to respiratory law. The experimental results showed that this method can reduce the influence of respiration on tumor displacement, improving the accuracy of intelligent positioning bed with simple circuit and low cost at the same time.
