冷哮丸对动物咳嗽的影响

目的 :观察冷哮丸全方及拆方的止咳作用及其机理。方法 :用小鼠氨水引咳法、豚鼠枸橼酸引咳法及电刺激猫喉上神经引咳法。结果 :全方组、拆方 1组及拆方 2组对氨水所致小鼠咳嗽及枸橼所致豚鼠咳嗽均有显著的止咳作用。对电刺激猫喉上神经所致咳嗽 ,只有全方组能使其咳嗽阈值明显提高 ,拆方 1及拆方 2无此作用。结论 :冷哮丸有止咳作用 ,全方的止咳作用部位可能在中枢。

儿童哮喘发作期冷热哮证免疫、肾上腺皮质功能及血小板活化状态的临床研究

对 61例儿童支气管哮喘发作期冷热哮证患者及 3 0例正常儿童的血清 Ig E、白细胞介素 -4 (IL-4 )、皮质醇、血小板表面α颗粒膜蛋白 (α-GMP-1 4 0 )进行测定 ,并进行比较 ,结果表明儿童支气管哮喘发作期冷热哮证患者血清 Ig E、白细胞介素 -4、血小板表面 α颗粒膜蛋白的含量较正常组明显增高 ,血皮质醇显著降低。冷哮证与热哮证比较 ,冷哮证血清 Ig E、α-GMP-1 4 0含量较热哮证显著升高 ,血皮质醇较热哮证显著降低。冷热哮证IL-4比较无统计学差异。提示儿童哮喘发作期冷、热哮证的微观机制与 Ig E、血皮质醇及α-GMP-1 4 0有密切关系。

Effect of "Yang-warming and kidney essence-replenishing" herbal paste on cold-related asthma exacerbation

OBJECTIVE: To observe the effect of "Yang-warming and kidney essence-replenishing" herbal paste on cold-related asthma exacerbation. METHODS: One hundred and fifty one patients with moderate to severe persistent asthma were randomly divided into a treatment group (n=74) and a control group (n=69). Both groups were given basic treatment according to the Global Initiative for Asthma scheme. The treatment group was also treated with herbal paste in the winter. The frequency of asthma exacerbation, cold and cold-re-lated asthma exacerbation, scores of the asthma control test (ACT), and kidney-deficiency syndrome during the one-year follow-up in each group were recorded. RESULTS: Compared with the control group, the onset frequencies of catching cold, asthma exacerbation, cold-related asthma exacerbation, and kidney-deficiency syndrome score were significantly reduced. There was no significant difference in scores of ACT between the two groups. CONCLUSION: "Yang-warming and kidney essence-replenishing" herbal paste could reduce cold-related asthma exacerbation.