复律汤治疗频发室性早搏30例

目的:观察益气温阳,安神定志类中药配伍组方治疗频发室性早搏的疗效。方法:治疗组服用复律汤(黄芪、人参、苦参、黄连、川芎、葛根、远志、三七、水蛭等),对照组口服普罗帕酮、谷维素。结果:远期疗效比较治疗组总有效率90%,对照组总有效率66.67%。提示:本方具有补益阳气,化瘀通脉,安神定志的作用。治疗频发室性早搏疗效显著。

复律汤治疗心肌炎过早搏动32例

目的:观察复律汤治疗心肌炎过早搏动的临床疗效。方法:将64例心肌炎早搏患者随机分为复律汤(桂枝、党参、麦冬、龙眼肉、酸枣仁、炙甘草等)治疗组和心律平对照组各32例。结果:治疗组总有效率90.6%,对照组71.9%,差异有显著性意义(P<0.05)。提示:复律汤治疗心肌炎早搏疗效优于单纯应用抗心律失常药。

生脉复律汤辅助治疗非ST段抬高型心肌梗死并室性早搏的疗效及对动态心电图指标、血清NF-κB、IL-6水平的影响

目的 探讨生脉复律汤辅助治疗非ST段抬高型心肌梗死(NSTEMI)并室性早搏(VPB)的疗效及对动态心电图指标、血清核因子κB(NF-κB)、白细胞介素-6(IL-6)、肌钙蛋白I(cTnI)水平的影响。方法 2020年4月—2021年4月在医院确诊的80例NSTEMI并VPB气阴两虚证患者,采用简单随机分组将所有纳入患者分为观察组40例和对照组40例。对照组给予盐酸胺碘酮片治疗,观察组在对照组的基础上给予生脉复律汤辅助治疗。治疗1个月后,分析比较两组患者临床治疗效果,比较治疗前后动态心电图指标[全部正常R-R间期标准差(SDNN)、每5 min R-R间期的标准差(SDANNI)、正常相邻R-R间期差值的均方根(rMSSD)、正常相邻R-R间期差值>50 ms的百分比(PNN50)]、中医证候评分、血清NF-κB、IL-6、cTnI水平差异,并记录治疗期间两组患者不良反应发生情况。结果 治疗后观察组患者临床治疗有效率显著高于对照组(P<0.05);治疗后两组患者的中医证候评分、动态心电图指标、血清NF-κB、IL-6、cTnI水平均减少程度明显优于对照组(P<0.05);观察组患者治疗过程中不良反应发生率为明显低于对照组(P<0.05)。结论 生脉复律汤辅助辅助治疗NSTEMI并VPB气阴两虚证患者有显著的治疗效果,能通过改善患者体内炎症微环境,修复患者心肌损伤,改善患者的心脏功能,且能有效降低不良反应。

益气化瘀复律汤治疗冠心病室性早搏30例

目的:研究观察和验证益气化瘀复律汤治疗冠心病室性早搏的疗效。方法:将60例随机分为治疗组30例,口服益气化瘀复律汤;对照组30例口服参龙宁心胶囊。结果:治疗组总有效率为92．0％,明显高于对照组(P<0．01)。结论:益气化瘀复律汤治疗冠心病室性早搏疗效肯定。

Effects of Dingjifumai Decoction on Electrocardiogram and sodium potassium pump of rats with ventricular arrhythmia

Objective:To investigate the effect of Dingjifumai Decoction(DJFM)on Electrocardiogram(ECG)and sodium potassium pump in rats with ventricular arrhythmia.Methods:Forty healthy male SD rats(200±20g)were randomly divided into blank group,model group,Metoprolol group and DJFM group.Ten rats in each group were fed with normal diet and free drinking water.Each group was given gavage,and the amount of gavage in each group was calculated according to body weight.In the model group,0.001%Aconitine was injected into the tail vein at 30ug/kg.In the Metoprolol group,Metoprolol suspension was given according to the standard of 5.2mg/kg per day.In the DJFM group,DJFM was given at 17.6g/kg per day.After 2 weeks of administration,the biologic experiment system BL-420F was used to monitor the II lead ECG curve,and the ECG changes were observed and recorded.Then,the left ventricle of the rat was taken,and part of the heart tissue sodium potassium pump was detected.Results:(1)The effect of DJFM on ECG of rats with ventricular arrhythmia:After intravenous injection of aconitine,the incidence of Ventricular Premature beat(VP),Ventricular Tachycardia(VT),Ventricular Fibrillation(VF)in the model group was 100%,suggesting that the model building of rats with ventricular arrhythmia was successful.(2)VP,VT,and VF time:Compared with model group,DJFM group and Metoprolol group can significantly delay the VP,VT and VF,the difference was statistically significant(P<0.05).The effect of DJFM group and Metoprolol group on delaying the appearance of VP,VT and VF was the same,there was no significant difference(P>0.05).(3)The effect of DJFM on sodium potassium pump in rat ventricular arrhythmia heart tissues:Compared with the blank group,the sodium potassium pump value in the model group was significantly decreased,and the difference was statistically significant(P<0.05).Compared with the model group,the sodium potassium pump value of the tissues in the Metoprolol group and the DJFM group increased,and the difference was statistically significant(P<0.05).There was no significant difference in sodium potassium pump between the Metoprolol group and the DJFM group(P>0.05).Conclusion:1.The rat model of ventricular arrhythmia can be successfully prepared by intravenous injection of Aconitine.2.DJFM can prolong the occurrence time of cardiac arrhythmias caused by aconitine in rats,such as VP,VT,VF,et al.The mechanism may be related to fast Na^+channel,and it may prevent and control arrhythmias by inhibiting Na^+influx and reducing the fast response cellular self-discipline.3.DJFM can protect the myocardial tissue sodium potassium pump,which can protect the myocardial cells and improve the myocardial metabolism.