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复方中药滴眼液治疗单纯疱疹性角膜炎临床观察 被引量:1
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作者 杨整军 张智军 《中国中医眼科杂志》 2005年第1期8-10,共3页
目的观察复方中药滴眼液对单纯疱疹性角膜炎的治疗效果。方法对单纯疱疹性角膜炎120例136只眼随机分为治疗组70只眼,接受复方中药滴眼液治疗;对照组66只眼接受无环鸟苷滴眼液治疗,治疗1~3周比较两组疗效。结果对照组有效率为712%,治疗... 目的观察复方中药滴眼液对单纯疱疹性角膜炎的治疗效果。方法对单纯疱疹性角膜炎120例136只眼随机分为治疗组70只眼,接受复方中药滴眼液治疗;对照组66只眼接受无环鸟苷滴眼液治疗,治疗1~3周比较两组疗效。结果对照组有效率为712%,治疗组有效率率971%,组间差异有极显著性意义(U=653,P<0001)。两组达到最好疗效时间比较差异具有非常显著性意义(U=265,P<001)。结论复方中药滴眼液对单纯疱疹性角膜炎有明显疗效。 展开更多
关键词 复方中药滴眼液 单纯疱疹性角膜炎
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Population pharmacokinetics of paeoniflorin in guanxin Ⅱ prescription 被引量:3
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作者 陈文倩 胡渝慧 +4 位作者 张彦青 张关敏 李良 杨维宁 卢炜 《Journal of Chinese Pharmaceutical Sciences》 CAS 2008年第1期55-63,共9页
To evaluate the effect of components in Guanxin Ⅱ prescription on the pharmacokinetic profiles of paeoniflorin. Plasma concentration of Paeoniflorin in rats after intravenous injection of Paronia Pall Extract (PPE)... To evaluate the effect of components in Guanxin Ⅱ prescription on the pharmacokinetic profiles of paeoniflorin. Plasma concentration of Paeoniflorin in rats after intravenous injection of Paronia Pall Extract (PPE) and oral administration of PPE and three types of decoctions in Guanxin Ⅱ prescription, respectively, were determined by HPLC analyses. NONMEM (nonlinear mixed-effect modeling) method was used to analyze full set of pharmacokinetic data directly. A two-compartment model with first-order degradation in absorption compartment was employed for the data analysis. The mean of population parameters, CL1, V1, CL2, V2, Ka0, and Kal, were measured to be 0.509 L/h, 0.104 L, 0.113 L/h, 0.123 L, 0.135/h, and 0.0135/h, respectively. Inter-individual variabilities were estimated and dose formulation (DF) was identified as a significant covariate of Ka 1, Ka0, and V1. It is concluded that the pharmacokinetic behaviors of paeoniflorin in rats can alter with different dose formulations. 展开更多
关键词 PAEONIFLORIN Population pharmacokinetics Traditional Chinese Medicine Guanxin Compound formulae
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电感耦合等离子体原子发射光谱法测定铈矿中微量的砷、锑 被引量:10
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作者 陈景文 曹淑红 杨春生 《分析试验室》 CAS CSCD 北大核心 2002年第6期85-86,共2页
采用过氧化钠熔融试样 ,用盐酸调节试液酸度 ,对电感耦合等离子体原子发射光谱 (ICP AES)法同时测定铈矿中微量砷和锑进行了研究 ,考察了铈基体及共存元素 。
关键词 测定 电感耦合等离子体原子发射光谱 铈矿 痕量分析
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祛瘀合剂对实验性家兔血栓素B_2和6-酮-前列腺素F_(1a)及病理形态学的影响 被引量:1
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作者 戴春福 《福建中医药大学学报》 1992年第1期31-33,39,共4页
分别用祛瘀合剂及凉营合剂治疗大肠杆菌内毒素性家兔温病营分证血瘀病变,结果前者在降低TXB_2和6-K-PGF_(1a)含量及改善病理形态学改变方面明显优于后者。说明祛瘀之品对实验性家兔的TXB_2·6-K-PGF_(1a)真平衡失调有较好的调节作用... 分别用祛瘀合剂及凉营合剂治疗大肠杆菌内毒素性家兔温病营分证血瘀病变,结果前者在降低TXB_2和6-K-PGF_(1a)含量及改善病理形态学改变方面明显优于后者。说明祛瘀之品对实验性家兔的TXB_2·6-K-PGF_(1a)真平衡失调有较好的调节作用,并能显著地改善动物脏器组织病理形态学改变。 展开更多
关键词 血栓素B2/生物合成 6-酮-前列腺素Fla/生物合成 营分病/代谢营分病/病理学 营分病/中医药疗法 活血祛瘀药[剂] @祛瘀合剂复方(中药)
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Screening of Chinese Herbal Medicines Resistant to Chicken Escherichia coli and Infectious Laryngotracheitis Virus
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作者 史秋梅 高桂生 +2 位作者 高光平 张艳英 沈萍 《Agricultural Science & Technology》 CAS 2012年第11期2415-2418,共4页
[Objective] This study aimed to screen Chinese herbal medicines resistant to Chicken Escherichia coli and infectious laryngotracheitis virus. [Methed] Conven- tional punch method, test tube method and plate dilution m... [Objective] This study aimed to screen Chinese herbal medicines resistant to Chicken Escherichia coli and infectious laryngotracheitis virus. [Methed] Conven- tional punch method, test tube method and plate dilution method were adopted for in vitro susceptibility test of chicken E, coil strains O5 and O8 using 13 kinds of Chi- nese herbal medicines including Sanguisorba officinalis, Coptis chinensis, Anemar- rhena asphodeloides, Strobilanthes cusia, Agastache rugosa, etc.; chicken embryo inoculation experiment was adopted to screen Chinese herbal medicines resistant to chicken infectious laryngotracheitis virus. [Result] Sanguisorba officinalis, Fructus mume, Rheum officinale, Coptis chinensis, Herba Taraxaci, Anemarrhena asphode- Ioides, Scutellaria baicalensis and Rhizoma Fagopyri Cymosi had ideal antibacterial effect against chicken E. coil strain O5; Sanguisorba officinalis, Fructus mume, Rheum officinale, Coptis chinensis, Herba taraxaci and Rhizoma Fagopyri Cymosi had ideal antibacterial effect against chicken E. coil strain 08; other Chinese herbal medicines showed relatively poor or no antibacterial effect. Results of chicken embryo inoculation experiment showed that nine kinds of Chinese herbal medicines showed relatively strong anti-lLTV effect, including Forsythia suspensa, Radix Isatidis, Fofium isatidis, Flos Ionicerae, Radix codonopsis, Radix astragali, Atractylodes, Radix gly- cyrrhizae, and Pericarpium granati. [Conclusion] The study laid the foundation for fur- ther development of Chinese herbal compound preparations to treat chicken cofibacil- Iosis, infectious laryngotracheitis and other bacterial, viral diseases. 展开更多
关键词 Chinese herbal medicine SCREENING Escherichia coli Chicken infectiouslaryngotracheitis virus
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中药复方治疗轻度认知障碍的研究进展 被引量:2
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作者 史静超 高晓霞 +3 位作者 李浩 张斌 秦雪梅 杜冠华 《中药药理与临床》 CSCD 北大核心 2017年第5期215-220,共6页
轻度认知障碍(MCI)是介于正常认知与痴呆之间的一种状态,MCI患者是患痴呆的高危人群。早期诊断及治疗轻度认知障碍具有重要的临床和现实意义。然而,MCI病机复杂,目前常用西药均不能够彻底治愈MCI,仅能不同程度的改善患者症状或延缓病情... 轻度认知障碍(MCI)是介于正常认知与痴呆之间的一种状态,MCI患者是患痴呆的高危人群。早期诊断及治疗轻度认知障碍具有重要的临床和现实意义。然而,MCI病机复杂,目前常用西药均不能够彻底治愈MCI,仅能不同程度的改善患者症状或延缓病情发展。随着中医药治疗MCI的研究不断深入,证实中药复方在改善MCI患者症状,尤其是中医证候,以及用药安全方面显示出优势。本文总结分析了MCI的中医证候和中药复方治疗MCI的临床、药理研究工作,为开展中药复方治疗MCI的研究工作提供参考。 展开更多
关键词 轻度认知障碍 中药复方
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祛痰化瘀中药复方对心房颤动模型大鼠心肌超微结构及氧化应激的影响 被引量:3
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作者 肖福龙 宫丽鸿 +1 位作者 吴启华 赵帅 《中医杂志》 CSCD 北大核心 2022年第23期2266-2271,共6页
目的 探讨祛痰化瘀中药复方治疗心房颤动(AF)的可能作用机制。方法 60只雄性SD大鼠随机分为空白组,模型组,维拉帕米组及祛痰化瘀高、中、低剂量组,每组10只。除空白组外其余各组大鼠采用尾静脉注射乙酰胆碱(Ach,66μg/ml)-氯化钙(CaCl2,... 目的 探讨祛痰化瘀中药复方治疗心房颤动(AF)的可能作用机制。方法 60只雄性SD大鼠随机分为空白组,模型组,维拉帕米组及祛痰化瘀高、中、低剂量组,每组10只。除空白组外其余各组大鼠采用尾静脉注射乙酰胆碱(Ach,66μg/ml)-氯化钙(CaCl2,10 mg/ml)混合液连续7天建立AF大鼠模型。从造模第2天起,祛痰化瘀高、中、低剂量组大鼠分别给予祛痰化瘀中药复方41.25、20.63、10.31 g/(kg·d)灌胃,维拉帕米组给予维拉帕米溶液25 mg/(kg·d)灌胃,空白组和模型组灌服8.93 ml/(kg·d)生理盐水,连续灌胃2周。最后一次灌胃后12 h记录各组大鼠肢体Ⅱ导联心电图,监测AF持续时间;透射电镜下观察各组大鼠心肌超微结构变化;ELISA法检测大鼠血清中晚期氧化蛋白产物(AOPP)、丙二醛(MDA)、活性氧(ROS)、超氧化物歧化酶(SOD)含量。结果 空白组大鼠为正常心电图,心房肌细胞的肌小节完整清晰,线粒体结构正常。与空白组相比,模型组大鼠心电图显示为AF心律,血清中AOPP、MDA、ROS含量升高,SOD含量降低(P<0.05或P<0.01),心房肌细胞的肌小节断裂,“Z”带不连续,排列混乱,“I”带模糊不清,线粒体肿胀、增多。与模型组比较,各给药组大鼠AF持续时间明显缩短;祛痰化瘀高、中剂量组大鼠血清AOPP、ROS、MDA含量降低,SOD含量升高(P<0.05或P<0.01),维拉帕米组大鼠血清AOPP、ROS含量降低,SOD含量升高(P<0.05);祛痰化瘀高、中剂量组和维拉帕米组大鼠心房肌细胞的肌小节轻微断裂,排列相对整齐,线粒体稍有肿胀、增多,结构相对完整,而祛痰化瘀低剂量组大鼠心肌超微结果改善不明显。结论 祛痰化瘀中药复方可以缩短心房颤动持续时间,改善心肌损伤,其机制可能与抑制氧化应激有关,且以高中剂量效果为佳。 展开更多
关键词 心房颤动 心电图 氧化应激 心肌超微结构 祛痰化瘀
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Herbal medicines for the management of irritable bowelsyndrome:A comprehensive review 被引量:12
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作者 Roja Rahimi Mohammad Abdollahi 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第7期589-600,共12页
Irritable bowel syndrome (IBS) is a functional gut disorder with high prevalence.Because of various factors involved in its pathophysiology and disappointing results from conventional IBS medications,the treatment of ... Irritable bowel syndrome (IBS) is a functional gut disorder with high prevalence.Because of various factors involved in its pathophysiology and disappointing results from conventional IBS medications,the treatment of IBS is challenging and use of complementary and alternative medicines especially herbal therapies is increasing.In this paper,electronic databases including PubMed,Scopus,and Cochrane library were searched to obtain any in vitro,in vivo or human studies evaluating single or compound herbal preparations in the management of IBS.One in vitro,3 in vivo and 23 human studies were included and systematically reviewed.The majority of studies are about essential oil of Menta piperita as a single preparation and STW 5 as a compound preparation.Some evaluated herbs such as Curcuma xanthorriza and Fumaria officinalis did not demonstrate any benefits in IBS.However,it seems there are many other herbal preparations such as those proposed in traditional medicine of different countries that could be studied and investigated for their efficacy in management of IBS. 展开更多
关键词 Herbal medicines Irritable bowel syndrome Systematic review
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Traditional Chinese medicine compounds for the treatment of functional dyspepsia:an updated meta-analysis of randomized,double-blind,placebo-controlled trials 被引量:6
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作者 LUO Xiaoying YANG Yang +4 位作者 MAO Xinyong SONG Gengqing LIU Qian JIANG Tianyuan WEI Wei 《Digital Chinese Medicine》 2021年第4期273-289,共17页
Objective To evaluate the efficacy and safety of traditional Chinese medicine(TCM)compounds for the treatment of functional dyspepsia(FD).Methods The Pub Med,Embase,Cochrane Library,Web of Science,Chinese Biomedical D... Objective To evaluate the efficacy and safety of traditional Chinese medicine(TCM)compounds for the treatment of functional dyspepsia(FD).Methods The Pub Med,Embase,Cochrane Library,Web of Science,Chinese Biomedical Database(CBM),Wanfang Data,China National Knowledge Infrastructure(CNKI),and China Science and Technology Journal Database(VIP)were searched to collect randomized,double-blind,and placebo-controlled trials of FD treated with TCM compounds.The search duration was from the establishment of the database to March 2,2021.After two researchers independently screened the literature,extracted the data,and evaluated the bias risk included in the study,they used Rev Man 5.4 software for meta-analysis.Results A total of 23 clinical trials were included,including 2898 patients.Meta-analysis showed that the overall remission rate of FD treated with TCM compounds was significantly higher than that of placebo(73.8%vs.46.2%)[RR=1.50,95%CI(1.29,1.76),P<0.00001].Among the single symptoms,TCM compounds were superior to the placebo in improving epigastric pain[MD=﹣0.99,95%CI(﹣1.37,﹣0.61),P<0.00001],epigastric burning sensation[MD=﹣0.32,95%CI(﹣0.59,﹣0.05),P=0.02],postprandial fullness discomfort[MD=﹣1.59,95%CI(﹣1.96,﹣1.21),P<0.00001],and early satiety symptoms[MD=﹣0.93,95%CI(﹣1.32,﹣0.54),P<0.00001].Compared with the placebo,TCM compounds treatment can obviously improve TCM syndrome in patients with FD[MD=﹣5.58,95%CI(﹣7.55,﹣3.61),P<0.00001],gastric emptying rate[MD=12.22,95%CI(8.90,15.55),P<0.00001],and helped to improve patients’quality of life[MD=11.27,95%CI(0.10,22.43),P=0.05].No severe adverse events were reported between the two groups[RR=1.34,95%CI(0.91,1.96),P=0.14].Conclusion Our results showed that TCM compounds treatment could significantly alleviate FD symptoms,improve gastric emptying in FD patients,and help to improve their quality of life.No severe adverse reactions have been reported in clinical applications.Due to the limitation of the quantity and quality of the included studies,the above conclusions need to be verified by more high-quality studies. 展开更多
关键词 Functional dyspepsia Traditional Chinese medicine compounds PLACEBO EFFECTIVENESS Security
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The exciting and magical journey of components from compound formulae to where they fight 被引量:3
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作者 Ning Meng Yun Lyu +3 位作者 Xiaoyu Zhang Xin Chai Kefeng Li Yuefei Wang 《Acupuncture and Herbal Medicine》 2022年第4期240-252,共13页
With its long-term empirical clinical practice and increasing number of health benefits reported,Chinese Materia Medica(CMM)is gaining increasing global acceptance.Importantly,the identification of chemical constituen... With its long-term empirical clinical practice and increasing number of health benefits reported,Chinese Materia Medica(CMM)is gaining increasing global acceptance.Importantly,the identification of chemical constituents in vitro and exposed forms in vivo is a prerequisite for understanding how CMM formulae prevent and treat diseases.This review systematically summarizes the exciting and magical journey of CMM components from compound formulae to where they fight,the possible structural transformation of CMM components in vitro and in vivo,and their pharmacological contribution.When a decoction is prepared,significant chemical reactions are observed,including degradation and production of polymers and self-assembling supramolecules,leading to the construction of a component library with diverse decoction structures.After ingestion,compounds pass through the intestinal and blood-brain barriers and undergo a more wonderful journey involving the gut microbiota,microbial enzymes,and endogenous drug-metabolizing enzymes(mainly liver enzymes).At this stage,they are modified and assembled into novel and complex compounds,such as newly generated metabolites,conjugates,and self-assembling superamolecules.This review might provide a strategic orientation to explore the active compounds of CMM formulae in vivo. 展开更多
关键词 Chinese Material Medica FORMULAE Gut microbiota Metabolites Prototype components Self-assembling supramolecule
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Evaluation of Antitumor,Immunomodulatory and Free Radical Scavenging Effects of A New Herbal Prescription Seaweed Complex Preparation 被引量:3
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作者 LIU Xin SHAO Changlun +2 位作者 KONG Wenwen FANG Yuchun WANG Changyun 《Journal of Ocean University of China》 SCIE CAS 2013年第3期515-520,共6页
Seaweed Complex Preparation (SCP) is a clinical traditional Chinese medicine preparation which is composed of seven traditional Chinese herbs, and it has been used for treatment of lung cancer, liver cancer and dige... Seaweed Complex Preparation (SCP) is a clinical traditional Chinese medicine preparation which is composed of seven traditional Chinese herbs, and it has been used for treatment of lung cancer, liver cancer and digestive cancer. However, little infor- mation is available about the pharmacodynamic basis. The antitumor, immunomodulatory and free radical scavenging effects of SCP were evaluated in this study. Transplanted tumor in vivo method was used to determine the antitumor effect. The effects on spleno- cyte proliferation and phagocytosis of macrophages in tumor-bearing mice were measured by the MTT method and the phagocytizing cock red blood cell (CRBC) method respectively. The scavenging activities of SCP on DPPH and hydroxyl radicals in vitro were investigated. It was found that the medium-dose and high-dose of SCP could significantly inhibit the growth of transplanted hepatic tumor of murine hepatocarcinoma cell line H22, and promote proliferation of splenocytes and phagocytosis of macrophages. SCP possessed noticeable scavenging activities on DPPH and hydroxyl radicals. The antiturnor effects of SCP might be achieved by im- proving immune system and scavenging free radicals, which is in accordance with the viewpoint of traditional Chinese medicine in promoting the body resistance and eliminating pathogenic factors for cancer treatment. 展开更多
关键词 traditional Chinese medicine preparation Seaweed complex preparation ANTITUMOR IMMUNOMODULATORY free radicalscavenging
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胆道消石汤治疗肝内胆管结石15例疗效观察
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作者 杜建 林熙 《福建中医药大学学报》 1992年第1期10-11,共2页
作者自拟胆道消石汤治疗15例肝内胆管结石有效10例,无效5例。与对照组14例使用天津胆道排石汤对比,两组有效率有显著差异。提示自拟胆道消石汤在临床上有进一步应用和研究的价值。本文还就肝内结石的中医病名提出讨论。
关键词 胆管 肝内/药物作用 胆总管结石/中医药疗法 @复方(中药) 胆道消石汤 通利 消散
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Study of Linearization of Hill Dose-Effect Curve with Metabolic Velocity Instead of Drug Concentration
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作者 Run-Nan LIU Yu TANG +7 位作者 Ping-An LIU Wen-Long LIU Qi-Meng FAN Si-Yang CHEN Peng HE Hai-Ying LI Fu-Yuan HE Kai-Wen DENG 《Digital Chinese Medicine》 2018年第3期198-210,共13页
Objective To explore the velocity-effect relationship in order to the establish linearization of effect on an equation with regard to the consistency of the Hill dose-effect expression with the metabolic kinetics of r... Objective To explore the velocity-effect relationship in order to the establish linearization of effect on an equation with regard to the consistency of the Hill dose-effect expression with the metabolic kinetics of receptors.Methods The linear velocity-effect expression was obtained by solving multivariant differential equation groups,which were established to compare the coincidences and basic relations between the Hill dose-effect and metabolic kinetic Michaelis-Menten equation for receptors.The validation test was conducted with acetylcholine,adrenaline,and their mixture as model drugs.Results The linear velocity-effect modelling was represented in vivo or in vitro,for single and multidrug systems.Pharmacodynamic parameters,especially suitable for multicomponent CMM formulas,could be determined and calculated for single or multicomponent formulas at high saturating or low linear concentration for receptors.The validation test showed that the pharmacodynamic parameters of acetylcholine were:k,2.675×10^-3s^-1;ka,5.786×10^-9s^-1;km,2.500×10^-7s^-1;α,4.619×10^9张s·mg^-1;E0,13张(P<0.01)and those of adrenaline were:k,1.415×10^-3s^-1;ka,5.846×10^-9s^-1;km,2.300×10^-7s^-1;α,-1.627×10^9张s·m g^-1;E0,9.2张(P<0.01).For the mixture of the two components,the values were:α,1.375×1010张s·m g^-1;-6.150×10^9张s m g^-1for acetylcholine and adrenaline,respectively,and E0was7.08张in both,with the other parameters unchanged(P<0.01).Conclusion The velocity-effect equation can linearize the Hill dose-effect relationship,which can be applied to study the pharmacodynamics and availability of CMM formulations in vivo and in vitro. 展开更多
关键词 Hill dose-effect equation Velocity-effect equation Pharmacodynamics with chromatographic fingerprint (PDCF) Pharmacy metrology with chromatographic fingerprint (PMCF) Pharmacokinetics with chromatographic fingerprint (PKCF) Availability of CMM formulas Acetylcholine ADRENALIN Quantitative pharmacology
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The herbal compound geniposide rescues formaldehyde-induced apoptosis in N2a neuroblastoma cells 被引量:15
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作者 CHEN JinYan SUN MengRu +7 位作者 WANG XingHua LU Jing WEI Yan TAN Yan LIU Ying GTZ Jürgen HE RongQiao HUA Qian 《Science China(Life Sciences)》 SCIE CAS 2014年第4期412-421,1-3,共10页
The herbal medicine Tong Luo Jiu Nao (TLJN) contains geniposide (GP) and ginsenoside Rgl at a molar ratio of i0:1. Rgl is the major component of another herbal medicine, panax notoginseng saponin (PNS). TLJN ha... The herbal medicine Tong Luo Jiu Nao (TLJN) contains geniposide (GP) and ginsenoside Rgl at a molar ratio of i0:1. Rgl is the major component of another herbal medicine, panax notoginseng saponin (PNS). TLJN has been shown to strengthen brain function in humans, and in animals it improves learning and memory. We have previously shown that TLJN reduces amyloi- dogenic processing in Alzheimer's disease (AD) mouse models. Together this suggests TLJN may be a potential treatment for patients with dementia. Because chronic damage of the central nervous system by formaldehyde (FA) has been presented as a risk factor for age-associated cognitive dysfunction, in the present study we investigated the protective effect of both TLJN and GP in neuron-like cells exposed to FA. FA-exposed murine N2a neuroblastoma cells were incubated with TLJN, its main in- gredient GP, as well as PNS, to measure cell viability and morphology, the rate of apoptosis and expression of genes encoding Akt, FOXO3, Bcl2 and p53. The CCK-8 assay, cytoskeletal staining and flow cytometry were used to test cell viability, mor- phology and apoptosis, respectively. Fluorescent quantitative real-time PCR (qRT-PCR) was used to monitor changes in gene expression, and HPLC to determine the rate of FA clearance. Treatment of N2a cells with 0.09 mmol L-1 FA for 24 h signifi- cantly reduced cell viability, changed cell morphology and promoted apoptosis. Both TLJN and GP conferred neuroprotection to FA-treated N2a cells, whereas PNS, which had to be used at lower concentrations because of its toxicity, did not. Our data demonstrate that TLJN can rescue neuronal damage caused by FA and that its main ingredient, GP, has a major role in this ef- ficacy. This presents purified GP as a drug or lead compound for the treatment of AD. 展开更多
关键词 Alzheimer's disease apoptosis FORMALDEHYDE GENIPOSIDE NEUROPROTECTION panax notoginseng saponin Tong Luo Jiu Nao
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A traditional Chinese herbal medicine compound preparation versus interventional therapy after resection of small hepatocellular carcinoma:22-year follow-up 被引量:8
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作者 孙振 梁水庭 +7 位作者 翟笑枫 郎庆波 周庆辉 岳小强 贺佳 徐静 朱役 凌昌全 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2012年第2期156-163,共8页
OBJECTIVE:To compare the long-term effectiveness of compound Ruanjianhugan(RJH)tablets and interventional therapy(IT) in patients after resection of small hepatocellular carcinoma(HCC).METHODS:A retrospective study wa... OBJECTIVE:To compare the long-term effectiveness of compound Ruanjianhugan(RJH)tablets and interventional therapy(IT) in patients after resection of small hepatocellular carcinoma(HCC).METHODS:A retrospective study was conducted in 399 patients after resection of small HCC who were admitted between January 1987 and December 2008 in the Department of Hepatobiliary Surgery and Center of Minimlly Invasive Surgery,First Affiliated Hospital of Guangxi Medical University.Four groups were based on different therapy modes:a TCM-only(TCMO) group,a TCM combined with interventional therapy(TCM-IT) group,an interventional therapy-only(ITO) group,and a simple operation(SO) group.Prognostic factors were correlated with overall survival(OS) and OS rates were calculated with the Kaplan-Meier method,and multivariate analyses for factors affecting survival were evaluated by the Cox proportional hazard model.RESULTS:The median OS was 151.20 months in the TCM-IT group,43.87 months in the ITO group,and 20.77 months in the SO group.All survival rates of the TCMO group were higher than those of the other three groups(>50%).The 5-,10-,and 15-year OS in the TCMO and ITO patients were 83.94%,45.50%,and 71.22% and 33.34%,55.58%,and 9.26%,respectively(risk ratio,0.209;95% confidence interval,0.126-0.347;P=0.000).Multivariate analysis revealed that the independent risk factors were therapy mode(P=0.000),sex(P=0.005),family history(P=0.011),TNM Classification of Malignant Tumor staging(P=0.000),medical care-seeking behavior(P=0.021),and maximum diameter(P=0.030).CONCLUSION:Long-term oral use of compound RJH tablets may improve OS for small HCC after resection compared with IT. 展开更多
关键词 Hepatocellular carcinoma Interventional therapy Herbal therapy Traditional Chinese medicine Prognostic factors
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