紫癜汤治疗小儿过敏性紫癜60例

目的:观察凉血祛风、祛瘀消斑类中药配伍治疗过敏性紫癜的疗效。方法:采用自拟紫癜汤(紫草、丹皮、水牛角、生地、蝉脱、连翘、防风、白僵蚕、茜草、白茅根、丹参、甘草)治疗本病60例。结果:总有效率为97%。提示:本方对本病有凉血祛风,祛瘀消斑的功效;有抗过敏、抗病毒、抗感染、抗惊厥、镇静、改善微循环,调节免疫功能的作用。

A treatment for Henoch-Schonlein purpura based on Shaoyang Channels： a hypothesis and case report

Henoch-Schonlein purpura （HSP） is an IgA-mediated vasculitis which is easy to relapse. A lot of patients have to useglucocorticoids, immunosuppressive drugs and other drugs which will bring sorts of serious side effects. Unfortunately,most of patients have to face the hurt of abdominal pain, arthritis, purpuric rash and renal involvement again after relapse.We have used Xiaochaihu decoration which is a famous formula in Shanghanlun to cure most of patients, especially whowith abdominal pain and purpuric rash. Due to the fact that this formula belongs to the Shaoyang Channels, interestingly,we find that these symptoms are located in regions close to the Shaoyang Channels. So that is the reason why Xiaochaihu decoration could work.

紫癜汤加减治疗儿童紫癜性肾炎血热妄行证45例临床观察

目的 观察紫癜汤加减治疗儿童紫癜性肾炎(HSPN)血热妄行证的临床疗效。方法 选取2018年12月至2020年12月嵊州市妇幼保健院儿科收治的HSPN血热妄行证患儿90例,采用随机数字表法分为对照组和治疗组,各45例。对照组予双嘧达莫片、卡托普利片、醋酸泼尼松龙片口服,治疗组在对照组治疗方法的基础上给予紫癜汤加减治疗。2组均30 d为1个疗程,治疗2个疗程后统计疗效。结果 对照组总有效率为75.56%(34/45),治疗组为91.11%(41/45),2组比较,差异有统计学意义(P<0.05)。治疗前,2组主症、次症积分及中医证候总积分比较,差异无统计学意义(P>0.05),具有可比性;治疗后,2组上述积分均显著下降,与同组治疗前比较,差异有统计学意义(P<0.05),且治疗组下降更显著(P<0.05)。治疗前,2组24 h尿蛋白定量、每高倍镜下红细胞计数、β微球蛋白(β-MG)水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后,2组上述指标均显著下降,与同组治疗前比较,差异有统计学意义(P<0.05),且治疗组下降更显著(P<0.05)。治疗前,2组CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后,2组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平明显升高,CD8^(+)水平明显下降,与同组治疗前比较,差异有统计学意义(P<0.05),且治疗组升高或下降更显著(P<0.05)。结论 紫癜汤加减治疗儿童HSPN血热妄行证,能明显缓解临床症状,减轻血尿和蛋白尿,调节免疫功能及保护肾功能,疗效显著,值得临床推广应用。