大黄牡丹汤不同给药途径治疗阑尾脓肿的临床疗效观察

目的:进一步观察大黄牡丹汤口服、保留灌汤、口服+保留灌肠不同给药途径治疗阑尾脓肿的疗效。方法:将108例阑尾脓肿患者随机分为3组,A组给予常规抗生素联合大黄牡丹汤口服治疗;B组给予常规抗生素联合大黄牡丹汤保留灌肠治疗;C组在常规抗生素治疗的基础上予大黄牡丹汤口服+保留灌肠治疗,3组均用药12天。对3组患者症状、体征改善时间,血白细胞及C反应蛋白水平,阑尾B超检查结果进行分析。结果:大黄牡丹汤口服+保留灌肠组患者治疗总有效率为91.7%,优于A组(63.90%)、B组(75.06%),差异均有统计学意义(P<0.05);口服+灌肠组患者C反应蛋白水平与单纯口服、灌肠治疗组比较差异有统计学意义(P<0.05);口服+灌肠组患者症状、体征消失时间及平均治愈时间显著低于单纯口服组和灌肠组(P<0.05)。结论:采用大黄牡丹汤口服+灌肠给药途径治疗阑尾脓肿效果优于单纯口服或灌肠给药,缩短了病人疗程,提高了治疗效果,值得推广应用。

Influence of intranasal medication on the structure of the nasal mucosa

OBJECTIVE: To study the influence of intranasal medication on the structure, pathology and reversibility of the nasal mucosa to provide a basis for the feasibility of intranasal route of drug administration. METHODS: Nasal drops of gentamicin were placed in the nasal cavity of rabbits for 3, 5, 7, 14 and 28 days. After that, the drops were stopped and drugs protecting the nasomucosa were used for one and three weeks. After being sacrificed over time, the nasomucosa of the rabbit was observed under optical and electron microscopes. RESULTS: Damage to the nasal mucosa appeared to different extents with prolonged use of nasal drops. Within 3 - 7 days of applying the drug, damages to the nasal mucosa gradually appeared, and after two and four weeks, were most serious. After stopping the drug, the nasal mucosa was gradually restored. CONCLUSION: Damages of drugs to the nasal mucosa could be restored. The intranasal route of drug administration would be feasible and clinically applicable.